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    ALTERED HOST CELL PATHWAY FOR IMPROVED ETHANOL PRODUCTION
    1.
    发明申请
    ALTERED HOST CELL PATHWAY FOR IMPROVED ETHANOL PRODUCTION 审中-公开
    改进的主机细胞途径改进乙醇生产

    公开(公告)号：WO2015148272A1

    公开(公告)日：2015-10-01

    申请号：PCT/US2015/021558

    申请日：2015-03-19

    Applicant: DANISCO US INC.

    Inventor： MIASNIKOV, Andrei ,  MUNOS, Jeffrey W.

    IPC: C12N9/88 ,  C12P7/06

    CPC classification number: C12P7/10 ,  C12N9/0008 ,  C12N9/1018 ,  C12N9/1029 ,  C12N9/88 ,  C12N15/52 ,  C12P7/06 ,  C12Y102/0101 ,  C12Y203/01008 ,  C12Y401/02009 ,  Y02E50/16 ,  Y02E50/17

    Abstract: A recombinant yeast cell, fermentation compositions, and methods of use thereof are provided. The recombinant yeast cell includes at least one heterologous nucleic acid encoding one or more polypeptide having phosphoketolase activity; phosphotransacetylase activity; and/or acetylating acetaldehyde dehydrogenase activity, wherein the cell does not include a heterologous modified xylose reductase gene, and wherein the cell is capable of increased biochemical end product production in a fermentation process when compared to a parent yeast cell.

    Abstract translation: 提供重组酵母细胞，发酵组合物及其使用方法。 重组酵母细胞包括至少一种编码一种或多种具有磷酸酮醇酶活性的多肽的异源核酸; 磷酸转乙酰酶活性; 和/或乙酰化乙醛脱氢酶活性，其中所述细胞不包括异源修饰的木糖还原酶基因，并且其中当与亲本酵母细胞相比时，所述细胞能够在发酵过程中增加生物化学终产物产生。

    PRODUCTION OF MALONYL-COA DERIVED PRODUCTS VIA ANAEROBIC PATHWAYS
    3.
    发明申请
    PRODUCTION OF MALONYL-COA DERIVED PRODUCTS VIA ANAEROBIC PATHWAYS 审中-公开
    通过厌氧途径生产马来酰亚胺衍生产品

    公开(公告)号：WO2012019175A8

    公开(公告)日：2012-08-30

    申请号：PCT/US2011046869

    申请日：2011-08-05

    Applicant: MASCOMA CORP ,  SILLERS WILLIAM RYAN ,  TRIPATHI SHITAL A ,  SHAW IV ARTHUR J ,  ARGYROS AARON ,  HOGSETT DAVID A

    Inventor： SILLERS WILLIAM RYAN ,  TRIPATHI SHITAL A ,  SHAW IV ARTHUR J ,  ARGYROS AARON ,  HOGSETT DAVID A

    IPC: C12N9/88 ,  C12N1/22 ,  C12N9/10 ,  C12P5/00 ,  C12Q1/48 ,  D21C5/00

    CPC classification number: C12P17/182 ,  C12N1/22 ,  C12N9/1018 ,  C12N9/88 ,  C12P7/6409 ,  G01N2333/91034

    Abstract: The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention.

    Abstract translation: 本发明提供了在厌氧条件下和ATP的净产生下将生物质和其他碳水化合物来源转化成丙二酰辅酶A衍生产物如烃和其他生物产物的新型代谢途径。 更具体地，本发明提供了一种重组微生物，其包含在一个或多个工程化代谢途径中起作用以实现碳水化合物源转化为例如长链烃和烃衍生物的一种或多种天然和/或异源酶，其中 一种或多种天然和/或异源酶被激活，上调，下调或缺失。 本发明还提供将生物质转化为丙二酰辅酶A衍生产物的方法，其包括使碳水化合物源与本发明的重组微生物接触。

    CORYNEBACTERIUM GLUTAMICUM VARIETY PRODUCING L-ARGININE AND METHOD FOR FABRICATING THE SAME
    4.
    发明申请
    CORYNEBACTERIUM GLUTAMICUM VARIETY PRODUCING L-ARGININE AND METHOD FOR FABRICATING THE SAME 审中-公开
    生产L-阿魏酸的罗丹明葡萄球菌及其制备方法

    公开(公告)号：WO2008088149A1

    公开(公告)日：2008-07-24

    申请号：PCT/KR2008/000205

    申请日：2008-01-11

    Applicant: CJ CHEILJEDANG CORPORATION ,  KIM, Hye Won ,  CHOI, Hyejin ,  LEE, Ji-Hye ,  HWANG, Soo Youn ,  LEE, Sun Young

    Inventor： KIM, Hye Won ,  CHOI, Hyejin ,  LEE, Ji-Hye ,  HWANG, Soo Youn ,  LEE, Sun Young

    IPC: C12N15/74

    CPC classification number: C12N9/1018

    Abstract: The present invention relates to an L-arginine producing mutant strain, and a method for fabricating the same. In particular, the present invention relates to a polynucleotide comprising an argF2 gene( Ncg 10990 ) that is a putative gene of ornithine carbamoyltransferase involved in arginine biosynthesis of Corynebacterium glutamicum , a polypeptide encoded by the polynucleotide, a recombinant vector comprising the polynucleotide, a transformant capable of producing L-arginine in a high yield, which is prepared by introducing the recombinant vector into an L-arginine producing host microorganism, and a method for producing L-arginine by culturing the transformant. The transformant of the present invention overexpresses the argF2 gene to produce L-arginine in a high yield, thereby being used in medicinal and pharmaceutical industries.

    Abstract translation: 本发明涉及L-精氨酸生产突变菌株及其制造方法。 特别地，本发明涉及包含ArgF2基因（Ncg 10990）的多核苷酸，其是参与谷氨酸棒杆菌的精氨酸生物合成的鸟氨酸氨基甲酰基转移酶的假定基因，由多核苷酸编码的多肽，包含多核苷酸的重组载体，转化体 能够通过将重组载体导入L-精氨酸生产宿主微生物而制备的高产率L-精氨酸，以及通过培养转化体生产L-精氨酸的方法。 本发明的转化体以高收率过表达argF2基因产生L-精氨酸，从而用于药用和制药工业。

    EXPRESSION VECTOR CONTAINING UREA CYCLE ENZYME GENE, TRANSFORMANT THEREOF, AND USE OF TRANSFORMANT FOR PROTEIN OVER-EXPRESSION
    7.
    发明申请
    EXPRESSION VECTOR CONTAINING UREA CYCLE ENZYME GENE, TRANSFORMANT THEREOF, AND USE OF TRANSFORMANT FOR PROTEIN OVER-EXPRESSION 审中-公开
    包含尿素循环酶基因的表达载体，其变体及其用于蛋白质超表达的变体

    公开(公告)号：WO02016626A1

    公开(公告)日：2002-02-28

    申请号：PCT/KR2001/001434

    申请日：2001-08-24

    IPC: C12N9/10 ,  C12P21/00 ,  C12N15/85

    CPC classification number: C12N9/1018 ,  C12P21/00

    Abstract: The present invention relates to expression vectors containing in vivo urea cycle enzyme gene; transformants thereof; and the use of transformants for protein overexpression. During the overexpression of protein, if the animal cell transformed with expression vectors of the present invention is used, amounts of ammonia accumulation within cell culture medium will decrease and cell growth rate will increase, thus, it is advantageous to be capable of obtaining desired protein in high yields.

    Abstract translation: 本发明涉及含有体内尿素循环酶基因的表达载体; 转化体 并使用转化体进行蛋白质过表达。 在蛋白质的过表达中，如果使用本发明的表达载体转化的动物细胞，则细胞培养液中的氨积累量将降低，细胞生长速度增加，因此有利的是能够获得所需的蛋白质 产量高。

    TRANSGENIC ANIMALS PRODUCED BY HOMOLOGOUS SEQUENCE TARGETING
    8.
    发明申请
    TRANSGENIC ANIMALS PRODUCED BY HOMOLOGOUS SEQUENCE TARGETING 审中-公开
    由同源顺序目标产生的转基因动物

    公开(公告)号：WO9960108A2

    公开(公告)日：1999-11-25

    申请号：PCT/US9910731

    申请日：1999-05-14

    Applicant: STANFORD RES INST INT

    Inventor： PATI SUSHMA ,  ZARLING DAVID

    IPC: A01K67/027 ,  A61K48/00 ,  C07K14/47 ,  C12N9/10 ,  C12N15/90 ,  C12N15/00

    CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A01K2217/075 ,  A61K48/00 ,  C07K14/4712 ,  C07K14/4746 ,  C12N9/1018 ,  C12N15/907

    Abstract: The invention relates to methods and compositions for producing transgenic animals by targeted homologous recombination comprising targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a target cell by homologous pairing, particularly for altering an endogenous DNA sequence, such as a chromosomal DNA sequence. In certain embodiments, the invention relates to compositions that contain exogenous targeting polynucleotides, complementary pairs of exogenous targeting polynucleotides, chemical substituents of such polynucleotides, and recombinase proteins used in the methods of the invention.

    Abstract translation: 本发明涉及通过靶向同源重组产生转基因动物的方法和组合物，其包括通过同源配对将外源多核苷酸或外源互补多核苷酸对靶向靶细胞中的预定内源性DNA靶序列，特别是用于改变内源DNA序列，例如 染色体DNA序列。 在某些实施方案中，本发明涉及含有外源靶向多核苷酸，外源靶向多核苷酸的互补对，这种多核苷酸的化学取代基和本发明方法中使用的重组酶的组合物。

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