公开(公告)号：WO2007064397A2

公开(公告)日：2007-06-07

申请号：PCT/US2006/038194

申请日：2006-09-28

Applicant: ISP INVESTMENTS INC. ,  MINGTAI CHEMICAL CO., LTD. ,  HALDAR, Rama ,  RAY, Dipan, B. ,  BEE, Timothy, G. ,  ETIENNE, Sidney ,  CHENG, Su-Jane

Inventor： HALDAR, Rama ,  RAY, Dipan, B. ,  BEE, Timothy, G. ,  ETIENNE, Sidney ,  CHENG, Su-Jane

IPC: A61K9/20 ,  B27N3/00

CPC classification number: A61K9/2095 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2077

Abstract: Tablets of a pharmaceutical, nutritional or vitamin active compound or composition, e.g. a poorly compressible drug are made by direct compression using a synergistic binder composition of co-processed (a) copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) and (b) microcrystalline cellulose (MCC), in a wt. ratio of (a):(b) of 1 -30:99-70, which is spray dried to provide a readily compressible excipient binder powder for such active. The tablets obtained herein have advantageous hardness and friability at an acceptable compression force.

Abstract translation: 药物，营养或维生素活性化合物或组合物的片剂，例如片剂。 （a）乙烯基吡咯烷酮（VP）和乙酸乙烯酯（VA）的共聚物和（b）微晶纤维素（MCC）的协同粘合剂组合物通过直接压制制备不良可压缩药物， （a）：（b）的比例为1-30：99-70，其被喷雾干燥以提供用于这种活性物质的易于压缩的赋形剂粘合剂粉末。 本文获得的片剂在可接受的压缩力下具有有利的硬度和脆性。

公开(公告)号：WO2007064397A3

公开(公告)日：2007-07-19

申请号：PCT/US2006038194

申请日：2006-09-28

Applicant: ISP INVESTMENTS INC ,  MINGTAI CHEMICAL CO LTD ,  HALDAR RAMA ,  RAY DIPAN B ,  BEE TIMOTHY G ,  ETIENNE SIDNEY ,  CHENG SU-JANE

Inventor： HALDAR RAMA ,  RAY DIPAN B ,  BEE TIMOTHY G ,  ETIENNE SIDNEY ,  CHENG SU-JANE

IPC: A61K31/79 ,  A61K8/81 ,  A61K31/74

CPC classification number: A61K9/2095 ,  A61K9/1641 ,  A61K9/1652 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2077

Abstract: Tablets of a pharmaceutical, nutritional or vitamin active compound or composition, e.g. a poorly compressible drug are made by direct compression using a synergistic binder composition of co-processed (a) copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) and (b) microcrystalline cellulose (MCC), in a wt. ratio of (a):(b) of 1 -30:99-70, which is spray dried to provide a readily compressible excipient binder powder for such active. The tablets obtained herein have advantageous hardness and friability at an acceptable compression force.

Abstract translation: 药物，营养或维生素活性化合物或组合物的片剂，例如 通过使用乙烯基吡咯烷酮（VP）和乙酸乙烯酯（VA）和（b）微晶纤维素（MCC））的共加成（a）共聚物的协同粘合剂组合物直接压制制备差的可压缩药物。 （a）：（b）的比例为1：30：99-70，其被喷雾干燥以提供用于这种活性物质的容易压缩的赋形剂粘合剂粉末。 本文获得的片剂在可接受的压缩力下具有有利的硬度和脆性。