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1.发明申请SYNERGISTIC BINDER COMPOSITION, METHOD FOR MAKING SAME, AND TABLETS OF AN ACTIVE AND SAID BINDER HAVING ADVANTAGEOUS HARDNESS AND FRIABILITY 审中-公开具有有益硬度和可塑性的活性粘合剂组合物及其制备方法和片剂
公开(公告)号：WO2007064397A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/038194
申请日：2006-09-28
Applicant: ISP INVESTMENTS INC. , MINGTAI CHEMICAL CO., LTD. , HALDAR, Rama , RAY, Dipan, B. , BEE, Timothy, G. , ETIENNE, Sidney , CHENG, Su-Jane
Inventor： HALDAR, Rama , RAY, Dipan, B. , BEE, Timothy, G. , ETIENNE, Sidney , CHENG, Su-Jane
CPC classification number: A61K9/2095 , A61K9/1641 , A61K9/1652 , A61K9/2031 , A61K9/2054 , A61K9/2077
Abstract: Tablets of a pharmaceutical, nutritional or vitamin active compound or composition, e.g. a poorly compressible drug are made by direct compression using a synergistic binder composition of co-processed (a) copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) and (b) microcrystalline cellulose (MCC), in a wt. ratio of (a):(b) of 1 -30:99-70, which is spray dried to provide a readily compressible excipient binder powder for such active. The tablets obtained herein have advantageous hardness and friability at an acceptable compression force.
Abstract translation: 药物，营养或维生素活性化合物或组合物的片剂，例如片剂。 （a）乙烯基吡咯烷酮（VP）和乙酸乙烯酯（VA）的共聚物和（b）微晶纤维素（MCC）的协同粘合剂组合物通过直接压制制备不良可压缩药物， （a）：（b）的比例为1-30：99-70，其被喷雾干燥以提供用于这种活性物质的易于压缩的赋形剂粘合剂粉末。 本文获得的片剂在可接受的压缩力下具有有利的硬度和脆性。
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Patent Agency Ranking2.发明申请
公开(公告)号：WO2007032969A3
公开(公告)日：2007-03-22
申请号：PCT/US2006/034585
申请日：2006-09-06
Applicant: ISP INVESTMENTS INC. , HALDAR, Rama , RAY, Dipan, B. , DREFKO, William , ETIENNE, Sidney
Inventor： HALDAR, Rama , RAY, Dipan, B. , DREFKO, William , ETIENNE, Sidney
Abstract: A process and apparatus for forming agglomerates of a powder composition of an active and binder such as a homopolymer or copolymer which includes passing the composition through a hot roller compactor to heat said binder material above its glass transition temperature.
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3.发明申请PROCESS AND APPARATUS FOR FORMING AGGLOMERATES OF A POWDER COMPOSITION OF AN ACTIVE AND BINDER 审中-公开用于形成活性和结合剂粉末组合物的组合物的方法和装置
公开(公告)号：WO2007032969A2
公开(公告)日：2007-03-22
申请号：PCT/US2006034585
申请日：2006-09-06
Applicant: ISP INVESTMENTS INC , HALDAR RAMA , RAY DIPAN B , DREFKO WILLIAM , ETIENNE SIDNEY
Inventor： HALDAR RAMA , RAY DIPAN B , DREFKO WILLIAM , ETIENNE SIDNEY
IPC: C11D17/00
CPC classification number: A61K9/2095 , A61K9/1635 , A61K9/1694 , A61K9/2027
Abstract: A process and apparatus for forming agglomerates of a powder composition of an active and binder such as a homopolymer or copolymer which includes passing the composition through a hot roller compactor to heat said binder material above its glass transition temperature.
Abstract translation: 一种用于形成活性物质和粘合剂如均聚物或共聚物的粉末组合物的附聚物的方法和装置，其包括使组合物通过热辊压实机将所述粘合剂材料加热到高于其玻璃化转变温度。
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4.发明申请MELTABLE BINDER FOR MELT GRANULATION AND/OR PELLETIZATION 审中-公开MELTABLE BINDER FOR MELT GRANDULATION AND / OR PELLETIZZATION
公开(公告)号：WO2008115979A3
公开(公告)日：2009-08-27
申请号：PCT/US2008057477
申请日：2008-03-19
Applicant: ISP INVESTMENTS INC , RAY DIPAN B , HALDAR RAMA , HENG PAUL WAN SIA , CHEONG WAI SEE , LOH ZHI HUI , ANTHONY YOLANDE
Inventor： RAY DIPAN B , HALDAR RAMA , HENG PAUL WAN SIA , CHEONG WAI SEE , LOH ZHI HUI , ANTHONY YOLANDE
IPC: A61K9/16
CPC classification number: A61K9/2027 , A61K9/1635
Abstract: A low melting binder composition for preparation of pharmaceutical tablets and/or granules which comprises a polymer and a hydrophobic meltable binder.
Abstract translation: 用于制备药物片剂和/或颗粒的低熔点粘合剂组合物，其包含聚合物和可疏水的可熔融粘合剂。
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5.发明申请MELTABLE BINDER FOR MELT GRANULATION AND/OR PELLETIZATION 审中-公开MELTABLE BINDER FOR MELT GRANDULATION AND / OR PELLETIZZATION
公开(公告)号：WO2008115979A2
公开(公告)日：2008-09-25
申请号：PCT/US2008/057477
申请日：2008-03-19
Applicant: ISP INVESTMENTS INC. , HENG, Paul, Wan Sia , CHEONG, Wai, See , LOH, Zhi, Hui , RAY, Dipan, B. , HALDAR, Rama , ANTHONY, Yolande
Inventor： HENG, Paul, Wan Sia , CHEONG, Wai, See , LOH, Zhi, Hui , RAY, Dipan, B. , HALDAR, Rama , ANTHONY, Yolande
IPC: A61K9/16
CPC classification number: A61K9/2027 , A61K9/1635
Abstract: A low melting binder composition for preparation of pharmaceutical tablets and/or granules which comprises a polymer and a hydrophobic meltable binder.
Abstract translation: 用于制备药物片剂和/或颗粒的低熔点粘合剂组合物，其包含聚合物和疏水性可熔融粘合剂。
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6.发明申请SYNERGISTIC BINDER COMPOSITION, METHOD FOR MAKING SAME, AND TABLETS OF AN ACTIVE AND SAID BINDER HAVING ADVANTAGEOUS HARDNESS AND FRIABILITY 审中-公开合成粘合剂组合物，制备方法和具有有利硬度和可食性的活性和粘合剂的片剂
公开(公告)号：WO2007064397A3
公开(公告)日：2007-07-19
申请号：PCT/US2006038194
申请日：2006-09-28
Applicant: ISP INVESTMENTS INC , MINGTAI CHEMICAL CO LTD , HALDAR RAMA , RAY DIPAN B , BEE TIMOTHY G , ETIENNE SIDNEY , CHENG SU-JANE
Inventor： HALDAR RAMA , RAY DIPAN B , BEE TIMOTHY G , ETIENNE SIDNEY , CHENG SU-JANE
CPC classification number: A61K9/2095 , A61K9/1641 , A61K9/1652 , A61K9/2031 , A61K9/2054 , A61K9/2077
Abstract: Tablets of a pharmaceutical, nutritional or vitamin active compound or composition, e.g. a poorly compressible drug are made by direct compression using a synergistic binder composition of co-processed (a) copolymer of vinylpyrrolidone (VP) and vinyl acetate (VA) and (b) microcrystalline cellulose (MCC), in a wt. ratio of (a):(b) of 1 -30:99-70, which is spray dried to provide a readily compressible excipient binder powder for such active. The tablets obtained herein have advantageous hardness and friability at an acceptable compression force.
Abstract translation: 药物，营养或维生素活性化合物或组合物的片剂，例如 通过使用乙烯基吡咯烷酮（VP）和乙酸乙烯酯（VA）和（b）微晶纤维素（MCC））的共加成（a）共聚物的协同粘合剂组合物直接压制制备差的可压缩药物。 （a）：（b）的比例为1：30：99-70，其被喷雾干燥以提供用于这种活性物质的容易压缩的赋形剂粘合剂粉末。 本文获得的片剂在可接受的压缩力下具有有利的硬度和脆性。
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