公开(公告)号：WO2012052904A1

公开(公告)日：2012-04-26

申请号：PCT/IB2011/054587

申请日：2011-10-17

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  MITTAL, Chetan ,  RAJU, Balasundar, Iyyavu

Inventor： MITTAL, Chetan ,  RAJU, Balasundar, Iyyavu

IPC: A61B8/08

CPC classification number: A61B8/0866 ,  A61B8/08 ,  A61B8/4427 ,  A61B8/46 ,  A61B8/488 ,  A61B8/54

Abstract: A fetal movement monitoring method that limits the ultrasound radiation to safe levels and conforms to the ALARA principle is disclosed. The disclosed method of monitoring fetal movements by Doppler ultrasound comprises accumulating the time for which ultrasound is radiated into a subject, comparing the accumulated time with a first reference total time, counting the number of fetal movements in the subject, comparing the number of movements with a reference number, deciding at least one of a further action of the device and an action to be recommended to the subject and conveying at least one of a further action of the device, an information to the subject about the counted fetal movements and an action recommended to the subject. A Doppler ultrasound device for monitoring fetal movements in a subject is also disclosed.

Abstract translation: 公开了一种将超声辐射限制在安全水平并符合ALARA原理的胎动监测方法。 所公开的通过多普勒超声检测胎儿运动的方法包括将超声辐射到受试者的时间累积，将累积时间与第一参考总时间进行比较，对受试者的胎动数进行计数，将运动次数与 参考号码，决定该设备的进一步动作中的至少一个以及要向该对象推荐的动作中的至少一个，并且传达该设备的进一步动作中的至少一个，关于该计数的胎儿动作的信息，以及动作 推荐给主题。 还公开了一种用于监测受试者中胎儿运动的多普勒超声装置。

公开(公告)号：WO2011083409A1

公开(公告)日：2011-07-14

申请号：PCT/IB2011/050001

申请日：2011-01-03

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  DHAND, Harsh ,  VEPA, Jithendra ,  BUSSA, Nagaraju ,  MITTAL, Chetan

Inventor： DHAND, Harsh ,  VEPA, Jithendra ,  BUSSA, Nagaraju ,  MITTAL, Chetan

IPC: A61B5/0408 ,  A61B7/00 ,  A61B7/04 ,  A61B5/0205 ,  A61B5/0402

CPC classification number: A61B5/04082 ,  A61B5/0205 ,  A61B5/6834 ,  A61B7/00 ,  A61B2560/0443 ,  A61B2560/06 ,  A61B2562/0204 ,  A61B2562/06 ,  A61B2562/187

Abstract: The medical skin-contact sensor device (1) for retrieving two different types of signals comprises a housing (10), a first sensor (20) for retrieving a first kind of signals and a second sensor (30) for retrieving a second type of signals. The first sensor (20) is rigidly attached to the housing (10), such that the first sensor (20) is in contact with the skin (2) of a patient when the sensor device (1) is applied to the patient. The second sensor (30) is attached to the housing (10) via at least one spring (35), such that the second sensor (30) is pressed to the skin (2) of the patient when the sensor device (1) is applied.

Abstract translation: 用于检索两种不同类型信号的医用皮肤接触传感器装置（1）包括壳体（10），用于检索第一类信号的第一传感器（20）和用于检索第二类型信号的第二传感器（30） 信号。 第一传感器（20）刚性地附接到壳体（10），使得当传感器装置（1）被施加到患者时，第一传感器（20）与患者的皮肤（2）接触。 所述第二传感器（30）经由至少一个弹簧（35）附接到所述壳体（10），使得当所述传感器装置（1）为（1））时所述第二传感器（30）被压向所述患者的皮肤 应用。

公开(公告)号：WO2009147549A1

公开(公告)日：2009-12-10

申请号：PCT/IB2009/052010

申请日：2009-05-14

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  DIMITROVA, Nevenka ,  MITTAL, Chetan

Inventor： DIMITROVA, Nevenka ,  MITTAL, Chetan

IPC: C12N15/62 ,  C07K14/71 ,  C07K14/435 ,  C12Q1/68 ,  G01N33/50

CPC classification number: C12N15/62 ,  C07K14/43595 ,  C07K14/71 ,  C07K2319/60 ,  C12Q1/6897 ,  C12Q2537/164 ,  C12Q2525/207 ,  C12Q2525/143

Abstract: The present invention relates to a method of non-invasively monitoring the expression of a gene of interest in a cell when contacting said cell with a compound influencing the expression of said gene of interest. The present invention is also concerned with different isolated nucleic acid molecules comprising a coding sequence. Said coding sequence comprises a gene of interest-sequence encoding a gene of interest-polypeptide fused to a reporter sequence encoding a fluorescent reporter polypeptide and is operatively coupled to a promoter sequence. The present invention is also concerned with the use of a method and a nucleic acid molecule of the invention for delivering a compound influencing the expression of a gene of interest in a cell, monitoring the delivery of said compound as well as monitoring the influence on the expression of said gene of interest induced by said compound at the same time.

Abstract translation: 本发明涉及当使所述细胞与影响目标基因表达的化合物接触时非侵入性地监测细胞中目的基因的表达的方法。 本发明还涉及包含编码序列的不同分离的核酸分子。 所述编码序列包含编​​码与编码荧光报道多肽的报告基因融合的感兴趣基因多肽的目标基因序列，并且可操作地偶联至启动子序列。 本发明还涉及本发明的方法和核酸分子用于递送影响细胞中目的基因表达的化合物，监测所述化合物的递送以及监测对所述化合物的影响 所述化合物同时诱导的所述感兴趣的基因的表达。

公开(公告)号：WO2010070572A1

公开(公告)日：2010-06-24

申请号：PCT/IB2009/055734

申请日：2009-12-14

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  DIMITROVA, Nevenka ,  MITTAL, Chetan ,  KAMALAKARAN, Sitharthan

Inventor： DIMITROVA, Nevenka ,  MITTAL, Chetan ,  KAMALAKARAN, Sitharthan

IPC: C12Q1/68

CPC classification number: C12Q1/6827 ,  C12Q2523/125

Abstract: The present invention relates to a method for the detection of a DNA methylation signature associated with the presence of or the predisposition to develop a disorder, the method comprising the identification of one or more candidate genes exhibiting differential DNA methylation in target and reference samples as well as the respective determination of the nucleic acid sites in said candidate genes that are differentially methylated and the recognition sites for DNA binding factors, said DNA binding factors each recognizing such a differentially methylated nucleic acid site, wherein the patterns of differentially methylated nucleic acid sites and of DNA binding factor recognition sites obtained together represent a DNA methylation signature that is indicative for the presence of or the predisposition to develop a disorder in a target sample.

Abstract translation: 本发明涉及一种用于检测与发生病症的存在或倾向相关的DNA甲基化特征的方法，所述方法包括鉴定靶和参照样品中显示差异DNA甲基化的一个或多个候选基因 作为差异甲基化的所述候选基因中的核酸位点和DNA结合因子的识别位点的各自测定，所述DNA结合因子各自识别这样的差异甲基化核酸位点，其中差异甲基化的核酸位点和 一起获得的DNA结合因子识别位点代表一种DNA甲基化特征，其指示在目标样品中存在发生障碍的倾向或倾向。

公开(公告)号：WO2009005897A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/063162

申请日：2008-05-09

Applicant: I3 NANOTEC LLC ,  GOEL, Manish ,  MITTAL, Chetan, P.

Inventor： GOEL, Manish ,  MITTAL, Chetan, P.

IPC: B01D3/02

CPC classification number: B01D3/145 ,  B01D3/002 ,  B01D3/14 ,  B01D61/025 ,  B01D61/027 ,  B01D61/145 ,  B01D61/147 ,  B01D61/362 ,  B01D61/58

Abstract: A system and process that are a hybrid of distillation and membrane separations offers a highly efficient means of separating a fluid feed mixture into organic, solid, and aqueous components. The distillation section is followed by two membrane separation sections operated in parallel, with the distillation section separating the feed mixture into an organics-rich fraction and an organics-depleted and solids-rich fraction. One membrane section operates on the organics-rich fraction and separates it into a more organics-rich sub-fraction and a water-rich, organics-depleted sub-fraction, while the other membrane section operates on the organics-depleted, solids-rich fraction from the distillation section and separates it into a solids-rich sub-fraction and a solids-depleted, water-rich sub-fraction.

Abstract translation: 作为蒸馏和膜分离的混合物的系统和方法提供了将流体进料混合物分离成有机，固体和水性组分的高效手段。 蒸馏段之后是两个平行操作的膜分离段，蒸馏段将进料混合物分离成富有机物部分和富有机物的富含部分。 一个膜段用于富有机物部分，并将其分离成更富有机物的亚馏分和富含水的富有机物的亚馏分，而另一个膜部分对有机物贫乏的固体富含 馏分从蒸馏段中分离出来，并将其分离成富含固体的亚馏分和固体贫乏的富水子馏分。

公开(公告)号：WO2009153722A1

公开(公告)日：2009-12-23

申请号：PCT/IB2009/052517

申请日：2009-06-12

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  BUCUR, Anca, I., D. ,  VAN LEEUWEN, Jasper, J., A. ,  DIMITROVA, Nevenka ,  MITTAL, Chetan

Inventor： BUCUR, Anca, I., D. ,  VAN LEEUWEN, Jasper, J., A. ,  DIMITROVA, Nevenka ,  MITTAL, Chetan

IPC: G06F19/00

CPC classification number: G06F19/22 ,  G06F19/24 ,  G06F19/26

Abstract: The present invention relates a method for analyzing a DNA sequence. The DNA sequence by converting the DNA sequence into a plurality of binary indicator sequences (BIS), and applying short term Fourier transform (STFT) on the binary indicator sequences. A binning function (BF) is applied to the Fourier coefficients (Usk_X(k)) and thereby modifying the corresponding Fourier coefficients (Usk_X(k)). Finally, substantially equal modified Fourier coefficients (Usk_X(k)) is found. The invention provides the user with a much improved ability to see unique strong patterns in vast amount of DNA sequence data.

Abstract translation: 本发明涉及DNA序列分析方法。 DNA序列通过将DNA序列转化为多个二进制指示符序列（BIS），并在二进制指示符序列上应用短期傅里叶变换（STFT）。 分数函数（BF）被应用于傅里叶系数（Usk_X（k）），从而修改对应的傅里叶系数（Usk_X（k））。 最后，找到基本相等的修正傅里叶系数（Usk_X（k））。 本发明为用户提供了大量改进的在大量DNA序列数据中看到独特强大模式的能力。

公开(公告)号：WO2009150594A1

公开(公告)日：2009-12-17

申请号：PCT/IB2009/052390

申请日：2009-06-05

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  MITTAL, Chetan ,  KASSIES, Roelf

Inventor： MITTAL, Chetan ,  KASSIES, Roelf

IPC: A61M37/00 ,  A61M5/30 ,  F04B19/00

CPC classification number: A61M25/0082 ,  A61M5/30 ,  A61M25/0075 ,  A61M37/00 ,  A61M2025/0042 ,  A61M2025/0093 ,  A61M2205/0294

Abstract: The application relates to the field of micro- jet drug delivery devices, in particular it relates to a micro- jet drug delivery device for local submucosal drug applications. A pressure drop occurs in a micro- jet drug delivery device implemented in a catheter when a fluid is pumped out of a pump chamber located at a proximal end of a catheter to a nozzle being located at the distal end of the catheter. In order to prevent such pressure drop it is suggested to provide a micro -jet drug delivery device comprising a catheter (1) having a distal end (14) and a proximal end (15), a micro -jet pump (2) located in the catheter comprising a pump cavity, wherein the pump cavity is located closer to the distal end than to the proximal end, a drug reservoir (22) located at the proximal end of the catheter, and a tube connecting the drug reservoir and the micro- jet -pump.

Abstract translation: 本申请涉及微喷药物递送装置的领域，特别涉及用于局部粘膜下药物应用的微喷药物递送装置。 当将流体从位于导管的近端处的泵室泵出到位于导管远端的喷嘴时，在导管中实施的微喷射药物输送装置中发生压降。 为了防止这种压降，建议提供一种包括具有远端（14）和近端（15）的导管（1）的微喷射药物输送装置，位于 所述导管包括泵腔，其中所述泵腔位于比所述近端更靠近所述远端的位置，位于所述导管的近端处的药物储存器（22），以及连接所述药物储存器和所述微腔的管， 喷射泵。

公开(公告)号：WO2009022279A2

公开(公告)日：2009-02-19

申请号：PCT/IB2008/053204

申请日：2008-08-11

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N. V. ,  MITTAL, Chetan

Inventor： MITTAL, Chetan

IPC: A61K49/00

CPC classification number: A61K49/0021

Abstract: The subject of this invention is to provide a compound and a contrast agent comprising a compound for a rapid, non-invasive examination process in the diagnosis of increased vascularity of lesions, especially cancerous lesions. The contrast agents comprising a compound and compounds used for diagnosis of lesions are compounds having a quinoline ring whereas the compounds may emit fluorescence in a range from 300 to 1200 nm. A method of diagnosing lesions is also subject of the present invention.

Abstract translation: 本发明的主题是提供一种化合物和造影剂，其包含用于快速，非侵入性检查过程的化合物，用于诊断增加的损伤血管，特别是癌性病变。 包含化合物和用于诊断病变的化合物的造影剂是具有喹啉环的化合物，而化合物可以发射在300至1200nm范围内的荧光。 诊断病变的方法也是本发明的主题。

公开(公告)号：WO2009022279A3

公开(公告)日：2009-04-09

申请号：PCT/IB2008053204

申请日：2008-08-11

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  MITTAL CHETAN

Inventor： MITTAL CHETAN

IPC: A61K49/00

CPC classification number: A61K49/0021

Abstract: The subject of this invention is to provide a compound and a contrast agent comprising a compound for a rapid, non-invasive examination process in the diagnosis of increased vascularity of lesions, especially cancerous lesions. The contrast agents comprising a compound and compounds used for diagnosis of lesions are compounds having a quinoline ring whereas the compounds may emit fluorescence in a range from 300 to 1200 nm. A method of diagnosing lesions is also subject of the present invention.

Abstract translation: 本发明的主题是提供一种化合物和造影剂，其包含用于快速，非侵入性检查过程的化合物，用于诊断病变特别是癌性病变的血管性增加。 包含用于诊断损伤的化合物和化合物的造影剂是具有喹啉环的化合物，而化合物可以发射300-1200nm的荧光。 诊断病变的方法也是本发明的主题。