公开(公告)号：WO2006061600A1

公开(公告)日：2006-06-15

申请号：PCT/GB2005/004681

申请日：2005-12-07

Applicant: UNIVERSITY OF SOUTHAMPTON ,  MORGAN, Hywel ,  NEYLON, David, Cameron ,  ROACH, Peter ,  ZHELUDEV, Nikolay ,  CAVALLI-PETRAGLIA, Gabriel ,  GALITONOV, Gerasim, Stoychev

Inventor： MORGAN, Hywel ,  NEYLON, David, Cameron ,  ROACH, Peter ,  ZHELUDEV, Nikolay ,  CAVALLI-PETRAGLIA, Gabriel ,  GALITONOV, Gerasim, Stoychev

IPC: B01J19/00 ,  G03F7/40

CPC classification number: B82Y30/00 ,  B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00497 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00531 ,  B01J2219/00533 ,  B01J2219/00545 ,  B01J2219/00547 ,  B01J2219/00554 ,  B01J2219/00558 ,  B01J2219/0056 ,  B01J2219/00563 ,  B01J2219/00574 ,  B01J2219/0059 ,  B01J2219/00592 ,  B01J2219/00596 ,  B01J2219/00711 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  C40B40/06 ,  C40B40/10 ,  C40B60/14 ,  G01N35/00732 ,  G01N2035/00772 ,  G03F7/40

Abstract: The invention relates to a process for the preparation of particles (73) suitable for use as supports for solid supported chemical reactions. The use of a metal-containing sacrificial layer to liberate the photolithographically-produced particles (73) results in their having superior utility in multi-step reaction sequences. The particles may comprise a predetermined diffraction pattern identifier. A method for reading such an encoding is also disclosed.

Abstract translation: 本发明涉及一种制备适合用作固体支持化学反应载体的颗粒（73）的方法。 使用含金属的牺牲层释放光刻产生的颗粒（73）导致它们在多步反应序列中具有优越的用途。 颗粒可以包括预定的衍射图案标识符。 还公开了一种用于读取这种编码的方法。

公开(公告)号：WO2011095821A1

公开(公告)日：2011-08-11

申请号：PCT/GB2011/050198

申请日：2011-02-04

Applicant: UNIVERSITY OF SOUTHAMPTON ,  FLOQUET, Cedric Florian Aymeric ,  MORGAN, Hywel ,  SIEBEN, Vincent Joseph ,  OGILVIE, Iain Rodney George ,  MOWLEM, Matthew Charles

Inventor： FLOQUET, Cedric Florian Aymeric ,  MORGAN, Hywel ,  SIEBEN, Vincent Joseph ,  OGILVIE, Iain Rodney George ,  MOWLEM, Matthew Charles

IPC: G01N21/03 ,  G01N21/05

CPC classification number: G01N21/17 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/12 ,  G01N21/0303 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2021/0389 ,  G01N2201/064

Abstract: An absorption cell for microfluidic chemical analysis made from tinted or coloured polymers, for example polymethylmethacrylate (PMMA), in which microfluidic channels are cut. Light is coupled into the absorption cell via two windows (typically 200 um thick) that are retained at either end of the channel. Absorption is measured using a light source, such as a light emitting diode (LED) and a photodiode butted against the windows. Spurious scattered and/or reflected light is absorbed by the coloured polymer over the length of the measurement cell, while very little light loss occurs at the coupling windows.

Abstract translation: 用于由有色或有色聚合物（例如聚甲基丙烯酸甲酯（PMMA））制成的微流控化学分析的吸收单元，其中切割微流体通道。 光通过保留在通道任一端的两个窗口（通常为200μm厚）耦合到吸收单元中。 使用光源测量吸收，例如发光二极管（LED）和光电二极管对着窗户。 杂散散射和/或反射光在测量单元的长度上被有色聚合物吸收，而在耦合窗处发生很少的光损失。

公开(公告)号：WO2011146920A2

公开(公告)日：2011-11-24

申请号：PCT/US2011/037554

申请日：2011-05-23

Applicant: E INK CORPORATION ,  TELFER, Stephen, J. ,  PAOLINI, JR., Richard, J. ,  SAINIS, Sunil, Krishna ,  HILL, Randall, M. ,  MORAN, Isaac, W. ,  YEZEK, Lee ,  BOUCHARD, Alain ,  VETTERLING, William ,  HARRIS, George, G. ,  MORGAN, Hywel ,  SLOMINSKI, Luke ,  ANSETH, Jay, William ,  QUIMBY, Jennifer ,  HERB, Craig, A.

Inventor： TELFER, Stephen, J. ,  PAOLINI, JR., Richard, J. ,  SAINIS, Sunil, Krishna ,  HILL, Randall, M. ,  MORAN, Isaac, W. ,  YEZEK, Lee ,  BOUCHARD, Alain ,  VETTERLING, William ,  HARRIS, George, G. ,  MORGAN, Hywel ,  SLOMINSKI, Luke ,  ANSETH, Jay, William ,  QUIMBY, Jennifer ,  HERB, Craig, A.

CPC classification number: G02F1/167 ,  G02F1/01 ,  G02F1/1347 ,  G02F2001/1672 ,  G02F2001/1676 ,  G02F2001/1678 ,  G02F2201/16 ,  G02F2203/30 ,  G02F2203/34

Abstract: An electro-optic display comprising at least two separate layers of electro-optic material, with one of these layers being capable of displaying at least one optical state which cannot be displayed by the other layer. The display is driven by a single set of electrodes between which both layers are sandwiched, the two layers being controllable at least partially independently of one another. Another form of the invention uses three different types of particles within a single electrophoretic layer, with the three types of particles being arranged to shutter independently of one another.

Abstract translation: 一种电光显示器，其包括至少两个独立的电光材料层，其中一层能够显示不能被另一层显示的至少一种光学状态。 显示器由单组电极驱动，两组之间夹在两组之间，两层可彼此至少部分地相互控制。 本发明的另一种形式在单个电泳层内使用三种不同类型的颗粒，其中三种类型的颗粒被布置为彼此独立地开闭。

公开(公告)号：WO2010140127A1

公开(公告)日：2010-12-09

申请号：PCT/IB2010/052460

申请日：2010-06-02

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  MORGAN, Hywel

Inventor： MORGAN, Hywel

IPC: G01N15/10 ,  G01N33/50

CPC classification number: G01N33/56972 ,  B01L3/502761 ,  G01N15/1056 ,  G01N33/585 ,  G01N2015/0069 ,  G01N2015/008 ,  G01N2015/129 ,  G01N2333/70514

Abstract: An analysis method for identifying and counting particles expressing a specific antigenic marker is proposed. One example (but not exclusive) is CD4+T- lymphocyte analysis in blood. The method comprises obtaining a sample comprising particles in suspension, labeling the particles expressing the specific marker with an impedance label, and measuring the labeled sample using a dual frequency system to discriminate at least the labeled particles expressing the specific marker. The method allows an accurate count of particles e.g. the number CD4+ T-lymphocytes in a blood flow. A corresponding device is also provided.

Abstract translation: 提出了一种用于鉴定和计数表达特定抗原标记物的分析方法。 一个例子（但不排除）是血液中的CD4 + T淋巴细胞分析。 该方法包括获得包含悬浮液中的颗粒的样品，用阻抗标记物标记表达特定标记的颗粒，并使用双频系统测量标记的样品，以至少区分表达特定标记物的标记颗粒。 该方法允许精确计数颗粒，例如 血液中CD4 + T淋巴细胞数。 还提供了相应的设备。

公开(公告)号：WO2011146920A3

公开(公告)日：2012-02-23

申请号：PCT/US2011037554

申请日：2011-05-23

Applicant: E INK CORP ,  TELFER STEPHEN J ,  PAOLINI JR RICHARD J ,  SAINIS SUNIL KRISHNA ,  HILL RANDALL M ,  MORAN ISAAC W ,  YEZEK LEE ,  BOUCHARD ALAIN ,  VETTERLING WILLIAM ,  HARRIS GEORGE G ,  MORGAN HYWEL ,  SLOMINSKI LUKE ,  ANSETH JAY WILLIAM ,  QUIMBY JENNIFER ,  HERB CRAIG A

Inventor： TELFER STEPHEN J ,  PAOLINI JR RICHARD J ,  SAINIS SUNIL KRISHNA ,  HILL RANDALL M ,  MORAN ISAAC W ,  YEZEK LEE ,  BOUCHARD ALAIN ,  VETTERLING WILLIAM ,  HARRIS GEORGE G ,  MORGAN HYWEL ,  SLOMINSKI LUKE ,  ANSETH JAY WILLIAM ,  QUIMBY JENNIFER ,  HERB CRAIG A

IPC: G02F1/15 ,  G02F1/01 ,  G02F1/167 ,  G02F1/17

CPC classification number: G02F1/167 ,  G02F1/01 ,  G02F1/1347 ,  G02F2001/1672 ,  G02F2001/1676 ,  G02F2001/1678 ,  G02F2201/16 ,  G02F2203/30 ,  G02F2203/34

Abstract: An electro-optic display comprising at least two separate layers of electro-optic material, with one of these layers being capable of displaying at least one optical state which cannot be displayed by the other layer. The display is driven by a single set of electrodes between which both layers are sandwiched, the two layers being controllable at least partially independently of one another. Another form of the invention uses three different types of particles within a single electrophoretic layer, with the three types of particles being arranged to shutter independently of one another.

Abstract translation: 一种电光显示器，其包括至少两个独立的电光材料层，其中一层能够显示不能被另一层显示的至少一种光学状态。 显示器由单组电极驱动，两组之间夹在两组之间，两层可彼此至少部分地相互控制。 本发明的另一种形式在单个电泳层内使用三种不同类型的颗粒，其中三种类型的颗粒被布置为彼此独立地开闭。

公开(公告)号：WO1995016204A1

公开(公告)日：1995-06-15

申请号：PCT/GB1994002680

申请日：1994-12-07

Applicant: UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW ,  MORGAN, Hywel ,  PRITCHARD, David, John ,  COOPER, Jonathon, Mark

Inventor： UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW

IPC: G01N33/543

CPC classification number: B82Y10/00 ,  G01N33/54353

Abstract: There is described a device which has a surface coated with a biomolecule in a pre-determined pattern. The molecule is attached to the surface via a photosensitive binding moiety itself attached to the surface via a linking moiety. Preferably the linking moiety is avidin or a derivative thereof and the photosensitive binding moiety is photobiotin or a derivative thereof. The pattern of binding of the biomolecule is determined by the selective irradiation of non-irradiation of the photosensitive binding moiety. In a preferred embodiment two or more different ligands are bound to the surface in a pre-determined pattern. The device according to the invention may be of use in multi-analyte sensors in molecular electronics, in directional propagation of cell growth and in altering the behaviour of cells. The device may also be used to bind nucleotides which are subsequently manipulated or used as a probe or template.

Abstract translation: 描述了具有以预定图案涂覆有生物分子的表面的装置。 分子通过经由连接部分附着于表面的光敏结合部分附着于表面。 优选地，连接部分是抗生物素蛋白或其衍生物，光敏结合部分是光生物素或其衍生物。 通过选择性地照射光敏结合部分的照射来确定生物分子的结合模式。 在优选的实施方案中，两种或更多种不同的配体以预定的图案结合到表面。 根据本发明的装置可以在分子电子学中的多分析物传感器，细胞生长的定向增殖和改变细胞行为中使用。 该装置还可用于结合随后被操纵或用作探针或模板的核苷酸。