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公开(公告)号：WO2012031011A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/050047
申请日：2011-08-31
Applicant: COMPLETE GENOMICS, INC. , STAKER, Bryan P.
Inventor： STAKER, Bryan P.
CPC classification number: G01N21/6452 , B01J19/0046 , B01J2219/00531 , B01J2219/00659 , B01J2219/00662 , B01J2219/00693 , C40B20/02 , G01N21/6428 , G01N21/6458
Abstract: An array chip useful for biochemical assays is provided wherein the chip includes a field region arranged with attachment sites according to a first pitch and at least one track region having a one-dimensional spot pattern arranged according to a second pitch that is less dense and is a non-integer multiple of the first pitch so that one-dimensional Moiré averaging may be applied in the track region, thereby to attain alignment of the chip to the optical instrumentation with a higher density of attachment sites.
Abstract translation: 提供了一种可用于生物化学测定的阵列芯片，其中芯片包括根据第一间距布置有附接位置的场区域和至少一个具有根据第二间距排列的一维点图案的轨道区域，该第二间距不太密集， 第一节距的非整数倍，使得可以在轨道区域中施加一维莫尔平均，从而以更高密度的附着位置实现芯片与光学仪器的对准。
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公开(公告)号：WO2011129710A4
公开(公告)日：2012-01-12
申请号：PCT/NZ2011000052
申请日：2011-04-15
Applicant: DIGITAL SENSING LTD , HAYNES ANDREW , PARTRIDGE ASHTON CYRIL , WU YINQIU
Inventor： HAYNES ANDREW , PARTRIDGE ASHTON CYRIL , WU YINQIU
CPC classification number: C12Q1/6837 , B01J19/0046 , B01J2219/00531 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , C12Q1/6834 , G01N33/54393 , C12Q2565/513
Abstract: Disclosed is a method of producing a two dimensional microarray using a three dimensional or structured microarray. The invention involves forming defined functionalized areas by layering an inert material over the surface structures of the three dimensional microarray. Sufficient of the inert material and of the top of the surface structures are then removed to expose defined areas of the surface structures within the inert material.
Abstract translation: 公开了使用三维或结构化微阵列制备二维微阵列的方法。 本发明涉及通过在三维微阵列的表面结构上层叠惰性材料来形成限定的官能化区域。 然后去除足够的惰性材料和表面结构的顶部以露出惰性材料内的表面结构的限定区域。
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公开(公告)号：WO2011129710A1
公开(公告)日：2011-10-20
申请号：PCT/NZ2011/000052
申请日：2011-04-15
Applicant: DIGITAL SENSING LIMITED , HAYNES, Andrew , PARTRIDGE, Ashton, Cyril , WU, Yinqiu
Inventor： HAYNES, Andrew , PARTRIDGE, Ashton, Cyril , WU, Yinqiu
CPC classification number: C12Q1/6837 , B01J19/0046 , B01J2219/00531 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , C12Q1/6834 , G01N33/54393 , C12Q2565/513
Abstract: Disclosed is a method of producing a two dimensional microarray using a three dimensional or structured microarray. The invention involves forming defined functionalized areas by layering an inert material over the surface structures of the three dimensional microarray. Sufficient of the inert material and of the top of the surface structures are then removed to expose defined areas of the surface structures within the inert material.
Abstract translation: 公开了使用三维或结构化微阵列制备二维微阵列的方法。 本发明涉及通过在三维微阵列的表面结构上层叠惰性材料来形成限定的官能化区域。 然后去除足够的惰性材料和表面结构的顶部以露出惰性材料内的表面结构的限定区域。
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公开(公告)号：WO0040593A3
公开(公告)日：2000-12-28
申请号：PCT/US0000535
申请日：2000-01-10
Applicant: SURMODICS INC
Inventor： CHAPPA RALPH A , HU SHEAU-PING , SWAN DALE G , SWANSON MELVIN J , GUIRE PATRICK E
IPC: G01N33/53 , C07B61/00 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N1/28 , G01N21/78 , G01N33/566 , G01N37/00
CPC classification number: B82Y30/00 , B01J2219/00317 , B01J2219/00531 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , C07B2200/11 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12Q1/6834 , C40B40/06 , C40B60/14 , C07C49/813
Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.
Abstract translation: 用于将目标分子（例如核酸）共价连接到基底表面上的方法和试剂组合物。 试剂组合物包括能够共价结合靶分子的基团。 任选地，组合物可以含有用于将试剂组合物附着到表面上的光反应性基团。 试剂组合物可用于提供用于制备核酸微阵列的活性载玻片。
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公开(公告)号：WO00040593A2
公开(公告)日：2000-07-13
申请号：PCT/US2000/000535
申请日：2000-01-10
IPC: G01N33/53 , C07B61/00 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12M1/00 , C12N15/09 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N1/28 , G01N21/78 , G01N33/566 , G01N37/00
CPC classification number: B82Y30/00 , B01J2219/00317 , B01J2219/00531 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00711 , B01J2219/00716 , B01J2219/00722 , C07B2200/11 , C07C45/63 , C07C235/84 , C07C323/42 , C07H21/00 , C12Q1/6834 , C40B40/06 , C40B60/14 , C07C49/813
Abstract: Method and reagent composition for covalent attachment of target molecules, such as nucleic acids, onto the surface of a substrate. The reagent composition includes groups capable of covalently binding to the target molecule. Optionally, the composition can contain photoreactive groups for use in attaching the reagent composition to the surface. The reagent composition can be used to provide activated slides for use in preparing microarrays of nucleic acids.
Abstract translation: 本发明涉及用于将目标分子如核酸共价结合至底物表面的试剂方法和组合物。 试剂组合物包括能够共价结合靶分子的基团。 组合物可以任选地包含用于将试剂组合物固定到表面的光反应性基团。 试剂组合物可用于制备用于制备有序核酸微阵列组的活化载玻片。
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Patent Agency Ranking
公开(公告)号：WO1993022480A1
公开(公告)日：1993-11-11
申请号：PCT/GB1993000857
申请日：1993-04-23
Applicant: ISIS INNOVATION LIMITED , SOUTHERN, Edwin
Inventor： ISIS INNOVATION LIMITED
IPC: C25D05/02
CPC classification number: B01J19/0046 , B01J2219/0043 , B01J2219/00527 , B01J2219/00531 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00628 , B01J2219/00653 , B01J2219/00659 , B01J2219/00713 , B01J2219/00722 , C07H21/00 , C40B40/06 , C40B60/14
Abstract: A method of electrochemically patterning a surface comprises providing an electrolyte overlying the surface and an array of electrodes adjacent the surface and in contact with the electrolyte, and altering the potential of one or more electrodes of the array so as to deposit or remove or chemically modify a substance on the surface adjacent the electrode. Several such treatments can be performed in sequence, using different electrodes of the array. The method is particularly suitable for step-wise chemical synthesis e.g. of oligonucleotides or other oligomers tethered to the surface. Electrode arrays for use in the method are also claimed.
Abstract translation: 电化学图案化表面的方法包括提供覆盖表面的电解质和邻近表面并与电解质接触的电极阵列，并且改变阵列的一个或多个电极的电位以便沉积或去除或化学修饰 在邻近电极的表面上的物质。 可以使用阵列的不同电极来顺序地执行几种这样的处理。 该方法特别适用于逐步化学合成，例如 的寡核苷酸或其他低聚物连接到表面。 还要求用于该方法的电极阵列。
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公开(公告)号：WO1992010092A1
公开(公告)日：1992-06-25
申请号：PCT/US1991008693
申请日：1991-11-20
Applicant: AFFYMAX TECHNOLOGIES N.V. , FODOR, Stephen, P., A. , STRYER, Lubert , WINKLER, James, L. , HOLMES, Christopher, W. , SOLAS, Dennis, W.
Inventor： AFFYMAX TECHNOLOGIES N.V.
IPC: A01N01/02
CPC classification number: G01N21/6452 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C07B2200/11 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K7/06 , C40B40/06 , C40B40/10 , C40B60/14 , G01N21/6428 , G03F7/00 , G03F7/265 , Y02P20/55
Abstract: A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are utilized in one embodiment. A reactor system, photoremovable protecting groups, and improved data collection and handling techniques are also disclosed. A technique for screening linker molecules is also provided.
Abstract translation: 创造大规模化学多样性的综合战略。 使用固相化学，光不稳定保护基团和光刻法来实现光定向空间可寻址并行化学合成。 在一个实施例中使用二进制掩蔽技术。 还公开了反应器系统，可光除保护组以及改进的数据收集和处理技术。 还提供了筛选接头分子的技术。
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公开(公告)号：WO2011035177A2
公开(公告)日：2011-03-24
申请号：PCT/US2010/049362
申请日：2010-09-17
Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , KHADEMHOSSEINI, Ali , WU, Jinhui , WHEELDON, Ian, Richard
Inventor： KHADEMHOSSEINI, Ali , WU, Jinhui , WHEELDON, Ian, Richard
CPC classification number: G01N33/5008 , B01J2219/00317 , B01J2219/00509 , B01J2219/00531 , B01J2219/00702 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743
Abstract: The invention provides a high throughput screening device having a microwell microarray and a printed microarray of test compound deposits. The layout of the test compound deposits matches the layout of the microwells such that each deposit addresses a single microwell when the two arrays are contacted with each other. The invention further provides methods of screening test compounds for biological activity using the device. The invention also provides methods of fabricating the device.
Abstract translation: 本发明提供了具有微孔微阵列和测试化合物沉积物的印刷微阵列的高通量筛选装置。 测试化合物沉积物的布局与微孔的布局匹配，使得当两个阵列彼此接触时每个沉积物处理单个微孔。 本发明还提供使用该装置筛选测试化合物的生物活性的方法。 本发明还提供了制造该装置的方法。
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公开(公告)号：WO2008043303A1
公开(公告)日：2008-04-17
申请号：PCT/CN2007/070824
申请日：2007-09-29
Applicant: ACCELERGY SHANGHAI R & D CENTER CO., LTD. , WANG, Wenge , WANG, Wenhui , WANG, Guilin , XU, Xixiang , RENATE, Schwiedernoch , ZHAO, Xianzhong , XU, Sibiao , XIE, Guangping
Inventor： WANG, Wenge , WANG, Wenhui , WANG, Guilin , XU, Xixiang , RENATE, Schwiedernoch , ZHAO, Xianzhong , XU, Sibiao , XIE, Guangping
CPC classification number: G01N35/02 , B01J2219/00328 , B01J2219/00495 , B01J2219/00531 , B01J2219/00659 , B01J2219/00682 , B01J2219/00684 , B01J2219/00747 , G01N31/10 , G01N2035/00158
Abstract: A testing system (1000) for testing a plurality of samples on a substrate (300) comprises an enclosed cavity (100) having a first region (1020) and a second region (1010). A pretreatment unit (102) is provided to pretreat the samples while the substrate (300) is in the first region. A test unit (101) is provided to receive the substrate (300) after the samples are pretreated and to test the samples while the substrate is in the second region. The test unit (101) includes a test mechanism for determining characteristics of the samples while the substrate (300) is in the second region.
Abstract translation: 用于测试衬底（300）上的多个样品的测试系统（1000）包括具有第一区域（1020）和第二区域（1010）的封闭空腔（100）。 提供预处理单元（102）以在衬底（300）处于第一区域的同时预处理样品。 提供测试单元（101）以在样品预处理之后接收衬底（300），并且在衬底处于第二区域的同时测试样品。 测试单元（101）包括用于在衬底（300）处于第二区域时确定样本的特性的测试机构。
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公开(公告)号：WO2003087291A2
公开(公告)日：2003-10-23
申请号：PCT/US2003/010958
申请日：2003-04-10
Applicant: SPIRE CORPORATION
Inventor： LITTLE, Roger, G.
IPC: C12G1/68
CPC classification number: B82Y30/00 , B01J19/0046 , B01J2219/00445 , B01J2219/00529 , B01J2219/00531 , B01J2219/00576 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00632 , B01J2219/00637 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , C40B40/06 , C40B60/14
Abstract: The present invention provides substrates having a plurality of micro-locations on its surface. Each micro-location has an effective dose of an ion beam treatment such that the plurality of the micro-locations exhibit an affinity to a compound that is different from the affinity of the remainder of the substrate surface to that compound. The substrates of the invention can be utilized to form microarrays of biological molecules, such as oligonucleotides or peptides. Such microarrays can find a variety of applications. For example, they can be employed in large scale hybridization assays in many genetic applications, such as mapping of genomes, monitoring of gene expression, DNA sequencing, genetic diagnosis, and genotyping of organisms.
Abstract translation: 本发明提供了在其表面上具有多个微位置的基板。 每个微位置具有有效剂量的离子束处理，使得多个微位置显示出与不同于该化合物的其余底物表面的亲和性的化合物的亲和力。 本发明的底物可用于形成生物分子的微阵列，例如寡核苷酸或肽。 这样的微阵列可以找到各种应用。 例如，它们可以用于许多遗传应用中的大规模杂交测定，例如基因组的测绘，基因表达的监测，DNA测序，遗传诊断和生物体的基因分型。
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