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    HYBRID ELECTROLYTE
    1.
    发明申请
    HYBRID ELECTROLYTE 审中-公开

    公开(公告)号：WO2023031600A1

    公开(公告)日：2023-03-09

    申请号：PCT/GB2022/052223

    申请日：2022-08-31

    Applicant: UNIVERSITY OF SOUTHAMPTON

    Inventor： PADMANABHAN, Vivek Jayavalli ,  MEDDINGS, Nina Catherine ,  GARCIA-ARAEZ GARCIA DEL VALLE, Nuria

    IPC: H01M10/0525 ,  H01M10/056 ,  H01M10/42

    Abstract: The invention relates to a hybrid solid-liquid electrolyte comprising a solid electrolyte and a liquid electrolyte, wherein the solid electrolyte contacts the liquid electrolyte to form a solid/liquid electrolyte interphase, and wherein the liquid electrolyte comprises: at least one organic solvent; at least one salt; and an additive, wherein the additive comprises water, and wherein the areal resistance at the solid/liquid electrolyte interphase of the hybrid solid-liquid electrolyte is reduced relative to the areal resistance at the solid/liquid electrolyte interphase of an equivalent hybrid solid-liquid electrolyte in which the liquid electrolyte does not comprise the additive.

    PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE
    2.
    发明申请
    PEPTIDES BINDING TO HYPOXIA INDUCIBLE FACTORS AND THEIR USE 审中-公开

    公开(公告)号：WO2022180410A1

    公开(公告)日：2022-09-01

    申请号：PCT/GB2022/050523

    申请日：2022-02-25

    Applicant: UNIVERSITY OF SOUTHAMPTON

    Inventor： TAVASSOLI, Ali

    IPC: C07K5/083

    Abstract: The present invention provides a series of tripeptides according to the compound of formula (I) that inhibit the interaction of both HIF-1α and HIF-2α with HIf-1 β by binding to the PAS-B domain of the α subunit of HIF. The tripeptides and methods disclosed herein are useful in treating diseases or conditions that involve the response to hypoxia.

    REFERENCE ELECTRODE & ION SELECTIVE MEMBRANE
    3.
    发明申请
    REFERENCE ELECTRODE & ION SELECTIVE MEMBRANE 审中-公开

    公开(公告)号：WO2022123210A1

    公开(公告)日：2022-06-16

    申请号：PCT/GB2021/053065

    申请日：2021-11-25

    Applicant: UNIVERSITY OF SOUTHAMPTON [GB]/[GB]

    Inventor： MINGELS, Roeland Hubertus Gerardus ,  MORGAN, Hywel

    IPC: G01N27/333 ,  G01N27/327 ,  A61B5/1468 ,  A61B5/00

    Abstract: An integrated reference electrode for use in an electrochemical measurement system, comprising: a reference electrode in combination with a hygroscopic hydrogel electrolyte impregnated and contained in a porous framework, wherein the hygroscopic hydrogel electrolyte is adapted to contact the reference electrode when in a hydrated state. Also, an ion selective membrane with an aromatic epoxy polymer made from one or more monomers having at least one epoxide group, and a chloride salt or a silver - silver chloride physically trapped in the aromatic epoxy polymer. On contact with water the aromatic epoxy polymer forms a network of channels for ion exchange. The membrane may be used between an electrolyte and an external fluid environment; or the membrane may be coated upon the surface of a reference electrode.

    METHOD FOR FABRICATION OF RIDGE WAVEGUIDES
    5.
    发明申请
    METHOD FOR FABRICATION OF RIDGE WAVEGUIDES 审中-公开

    公开(公告)号：WO2020254799A1

    公开(公告)日：2020-12-24

    申请号：PCT/GB2020/051459

    申请日：2020-06-17

    Applicant: UNIVERSITY OF SOUTHAMPTON

    Inventor： CARPENTER, Lewis Glynn ,  BERRY, Sam Adam ,  GAWITH, Corin Barry Edmund ,  SMITH, Peter George Robin

    IPC: G02F1/355 ,  G02F1/377

    Abstract: A method for fabricating an optical waveguide comprises: providing a sample of lithium niobate doped with magnesium oxide and having at least one grating of periodic domain inversion defined therein; applying a layer of metallic zinc to a surface of the sample over the at least one grating using sputter deposition; heating the sample in an atmosphere of pure oxygen to cause the zinc to indiffuse into the lithium niobate to form a waveguiding layer of increased refractive index under the surface of the sample; and using a dicing blade to cut two substantially parallel channels along a length direction of the at least one grating, to define a ridge waveguide between the two channels.

    CARTILAGE TISSUE
    6.
    发明申请
    CARTILAGE TISSUE 审中-公开

    公开(公告)号：WO2020161502A1

    公开(公告)日：2020-08-13

    申请号：PCT/GB2020/050285

    申请日：2020-02-07

    Applicant: UNIVERSITY OF SOUTHAMPTON

    Inventor： HOUGHTON, Franchesca D ,  TARE, Rahul S ,  GRIFFITH, Lauren A

    IPC: C12N5/077

    Abstract: The invention relates to a method for producing cartilage from pluripotent stem cells (PSCs), the method comprising providing chondrocytes by: 1) providing pluripotent stem cells (PSCs); 2) inducing differentiation of the PSCs into a primitive streak/mesendoderm by culturing the PSCs in hypoxic conditions, in a (mesendodermic) culture media comprising: i) a Wingless/Integrated (WNT) family member, ii) an Activin family member, and iii) a Fibroblast Growth Factor (FGF) family member; 3) inducing differentiation of the primitive streak/mesendoderm into a mesoderm by culturing the primitive streak/mesendoderm in hypoxic conditions, in a (mesodermic) culture media comprising: i) a FGF family member, ii) a bone morphogenetic protein (BMP) family member, iii) Follistatin, and iv) a Neurotrophin (NT); and 4) inducing differentiation of the mesoderm into chondrocytes by culturing the mesoderm in hypoxic conditions, in a (chondroinductive) culture media comprising: i) a FGF family member, ii) a BMP family member, iii) a Neurotrophin, and iv) a Growth/Differentiation Factor (GDF) family member; and forming a pellet of the chondrocytes and culturing the pellet of the chondrocytes in a culture media under hypoxic conditions to produce the cartilage. The invention further relates to methods of chondrocyte production, synthetically produced cartilage, and use in therapy.

    PHOTONIC CHIP AND METHOD OF MANUFACTURE
    7.
    发明申请
    PHOTONIC CHIP AND METHOD OF MANUFACTURE 审中-公开

    公开(公告)号：WO2020127812A1

    公开(公告)日：2020-06-25

    申请号：PCT/EP2019/086429

    申请日：2019-12-19

    Applicant: UNIVERSITY OF SOUTHAMPTON

    Inventor： REED, Graham ,  THOMSON, David

    IPC: G02B6/122 ,  G02B6/12 ,  G02B6/13

    Abstract: A silicon photonic chip is provided comprising a top silicon device layer; an insulating layer beneath the top silicon device layer; an intermediate silicon device layer beneath the insulating layer; a further insulating layer beneath the intermediate silicon device layer; a silicon substrate beneath the further insulating layer; and a first silicon waveguide, the first silicon waveguide being partially formed by a portion of the intermediate silicon device layer.

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