公开(公告)号：WO2016094415A1

公开(公告)日：2016-06-16

申请号：PCT/US2015/064519

申请日：2015-12-08

Applicant: NEPHROGENESIS, LLC

Inventor： TUMLIN, James A.

IPC: A61K38/00

CPC classification number: A61K31/198 ,  A61K31/131 ,  A61K31/275 ,  A61K31/375 ,  A61K38/00 ,  A61K38/44 ,  A61K45/06 ,  C12Y104/03013 ,  A61K2300/00

Abstract: The present disclosure relates to a method of maintaining luminal patency of a blood vessel following vessel injury, the method including administering a composition comprising at least one lysyl oxidase inhibitor and D-penicillamine to a subject in need thereof Compositions to support the methods are also provided.

Abstract translation: 本公开涉及一种在血管损伤后保持血管的通畅性的方法，所述方法包括向需要的受试者施用包含至少一种赖氨酰氧化酶抑制剂和D-青霉胺的组合物。还提供了支持该方法的组合物 。

公开(公告)号：WO2015095553A9

公开(公告)日：2017-07-27

申请号：PCT/US2014071212

申请日：2014-12-18

Applicant: NEPHROGENESIS LLC

Inventor： TUMLIN JAMES

IPC: A61K38/17 ,  A61P39/06

CPC classification number: A61M1/1676 ,  A61M1/16 ,  A61M1/3496 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3649 ,  A61M1/3679 ,  B01D61/243 ,  B01D71/16 ,  B01D71/42 ,  B01D71/56 ,  B01D71/68 ,  B01D2311/2626 ,  B01D2311/2688 ,  B01J2220/4856

Abstract: The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein.

Abstract translation: 本公开涉及透析装置，其包含具有至少一种来自脂笼蛋白家族的蛋白质的膜。 本公开还涉及利用本文所述的透析装置从目标受试者去除非极性，疏水性和/或蛋白质结合的尿毒症毒素的方法。

公开(公告)号：WO2015095553A1

公开(公告)日：2015-06-25

申请号：PCT/US2014/071212

申请日：2014-12-18

Applicant: NEPHROGENESIS, LLC

Inventor： TUMLIN, James

IPC: A61K38/17 ,  A61P39/06

CPC classification number: A61M1/1676 ,  A61M1/16 ,  A61M1/3496 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3649 ,  A61M1/3679 ,  B01D61/243 ,  B01D71/16 ,  B01D71/42 ,  B01D71/56 ,  B01D71/68 ,  B01D2311/2626 ,  B01D2311/2688 ,  B01J2220/4856

Abstract: The present disclosure relates to a dialysis apparatus comprising a membrane having at least one protein from the lipocalin family bound thereon. The disclosure further relates to methods of removing non-polar, hydrophobic and/or protein bound uremic toxins from a target subject utilizing the dialysis apparatus described herein.

Abstract translation: 本公开涉及一种透析装置，其包括具有结合于其上的脂笼蛋白家族的至少一种蛋白质的膜。 本公开还涉及使用本文所述的透析装置从目标受试者去除非极性，疏水和/或蛋白结合的尿毒症毒素的方法。