公开(公告)号：WO2011037791A1

公开(公告)日：2011-03-31

申请号：PCT/US2010/048849

申请日：2010-09-15

Applicant: MERCK SHARP & DOHME CORP. ,  SHEN, Xun ,  LOBO, Sharon ,  NI, Yan ,  SITLANI, Ayesha ,  PANDIT, Shilpa ,  LEWIS, Dale ,  MCCABE, Timothy ,  CONDRA, Jon ,  WANG, Fubao ,  CUBBON, Rose

Inventor： SHEN, Xun ,  LOBO, Sharon ,  NI, Yan ,  SITLANI, Ayesha ,  PANDIT, Shilpa ,  LEWIS, Dale ,  MCCABE, Timothy ,  CONDRA, Jon ,  WANG, Fubao ,  CUBBON, Rose

IPC: C07K16/40 ,  C07H21/00

CPC classification number: C07K16/40 ,  C07K2317/76

Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 (PCSK9) are disclosed. Said antagonists are effective in the inhibition of PCSK9 function and thereby provide compositions of matter useful for the treatment of conditions associated with PCSK9 activity. The present invention further discloses nucleic acids encoding PCSK9 antagonists as well as methods of making and using PCSK9 antagonists.

Abstract translation: 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（PCSK9）的拮抗剂。 所述拮抗剂在抑制PCSK9功能方面是有效的，从而提供可用于治疗与PCSK9活性相关的病症的物质组合物。 本发明还公开了编码PCSK9拮抗剂的核酸以及制备和使用PCSK9拮抗剂的方法。

公开(公告)号：WO2015062023A1

公开(公告)日：2015-05-07

申请号：PCT/CN2013/086320

申请日：2013-10-31

Applicant: GE LIGHTING SOLUTIONS, LLC ,  WANG, Suping ,  NALL, Jeffrey Marc ,  SPAHNIE, Brian Morgan ,  ZHANG, Xiaojuan ,  NI, Yan ,  XIE, Shanshan

Inventor： WANG, Suping ,  NALL, Jeffrey Marc ,  SPAHNIE, Brian Morgan ,  ZHANG, Xiaojuan ,  NI, Yan ,  XIE, Shanshan

IPC: F21V5/04

CPC classification number: F21V5/08 ,  F21V5/007 ,  F21V5/04 ,  F21Y2101/00 ,  F21Y2101/02 ,  G02B19/0014 ,  G02B19/0066 ,  G09F13/04 ,  G09F2013/049

Abstract: An LED light module for illuminating a target plane is provided. The LED light module (110,130) includes a first LED source, a second LED source disposed adjacent the first LED source, a first lens (124) covering the first LED source, and a second lens (126) covering the second LED source. The first lens (124) is configured to direct first light beams emitted from the first light source to the target plane (140). The second lens (126) is configured to direct second light beams emitted from the second light source to the target plane (140). At least one of the first and second lenses is shaped to have an asymmetrical profile. A backlighting system and a fixture incorporating the LED light module are also provided.

Abstract translation: 提供了用于照射目标平面的LED灯模块。 LED灯模块（110,130）包括第一LED源，与第一LED源相邻设置的第二LED源，覆盖第一LED源的第一透镜（124）和覆盖第二LED源的第二透镜（126）。 第一透镜（124）被配置为将从第一光源发射的第一光束引导到目标平面（140）。 第二透镜（126）被配置为将从第二光源发射的第二光束引导到目标平面（140）。 第一和第二透镜中的至少一个被成形为具有不对称轮廓。 还提供了一种背光系统和结合有LED灯模块的灯具。

公开(公告)号：WO2011053783A2

公开(公告)日：2011-05-05

申请号：PCT/US2010/054714

申请日：2010-10-29

Applicant: MERCK SHARP & DOHME CORP. ,  LUO, Peter Peizhi ,  NI, Yan ,  WANG, Kevin Caili ,  HSIEH, Mark ,  WANG, Xinwei ,  DONG, Feng ,  GOLOSOV, Andrei ,  WANG, Weirong ,  LI, Yan ,  ZHONG, Pingyu ,  PETERSON, Laurence, B. ,  CUBBON, Rose ,  SHARMA, Sujata ,  CONDRA, Jon ,  LU, Jun ,  PARTHASARATHY, Gopalakrishnan ,  SOISSON, Stephen ,  BYRNE, Noel

Inventor： LUO, Peter Peizhi ,  NI, Yan ,  WANG, Kevin Caili ,  HSIEH, Mark ,  WANG, Xinwei ,  DONG, Feng ,  GOLOSOV, Andrei ,  WANG, Weirong ,  LI, Yan ,  ZHONG, Pingyu ,  PETERSON, Laurence, B. ,  CUBBON, Rose ,  SHARMA, Sujata ,  CONDRA, Jon ,  LU, Jun ,  PARTHASARATHY, Gopalakrishnan ,  SOISSON, Stephen ,  BYRNE, Noel

IPC: A61K39/395

CPC classification number: C07K16/40 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/94 ,  C07K2319/00

Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 ("PCSK9") are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

Abstract translation: 披露了人类前蛋白转化酶枯草杆菌蛋白酶 - kexin 9型的拮抗剂（“PCSK9”）。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，并因此提供了用于治疗与PCSK9活性相关的病症的期望的拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并且形成本公开的重要的另外方面。

公开(公告)号：WO2011053759A1

公开(公告)日：2011-05-05

申请号：PCT/US2010/054640

申请日：2010-10-29

Applicant: MERCK SHARP & DOHME CORP. ,  LUO, Peter Peizhi ,  NI, Yan ,  WANG, Kevin Caili ,  HSIEH, Mark ,  WANG, Xinwei ,  DONG, Feng ,  GOLOSOV, Andrei ,  WANG, Weirong ,  LI, Yan ,  ZHONG, Pingyu ,  PETERSON, Laurence, B. ,  CUBBON, Rose

Inventor： LUO, Peter Peizhi ,  NI, Yan ,  WANG, Kevin Caili ,  HSIEH, Mark ,  WANG, Xinwei ,  DONG, Feng ,  GOLOSOV, Andrei ,  WANG, Weirong ,  LI, Yan ,  ZHONG, Pingyu ,  PETERSON, Laurence, B. ,  CUBBON, Rose

IPC: A61K39/395

CPC classification number: C07K16/40 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92 ,  C07K2317/94

Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 ("PCSK9") are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

Abstract translation: 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

公开(公告)号：WO2016095184A1

公开(公告)日：2016-06-23

申请号：PCT/CN2014/094306

申请日：2014-12-19

Applicant: GE LIGHTING SOLUTIONS, LLC ,  SPAHNIE, Brian Morgan ,  WANG, Xin ,  WANG, Suping ,  FENG, Yongli ,  NI, Yan

Inventor： SPAHNIE, Brian Morgan ,  WANG, Xin ,  WANG, Suping ,  FENG, Yongli ,  NI, Yan

IPC: F21V5/00

CPC classification number: F21V5/007 ,  F21K9/90 ,  F21V17/06 ,  F21V17/101 ,  F21V31/005 ,  F21Y2105/10 ,  F21Y2115/10

Abstract: A light module assembly (100) includes a lens (104), a circuit board (200), and an overmold body (102). The lens (104) includes one or more pooling structures (218, 220) formed by transversely oriented exterior surfaces (402, 404) of the lens (104). The circuit board (200) is coupled to the lens (104) and has one or more light-generating devices (106) disposed on the circuit board (200). The overmold body (102) is coupled to the lens (104) to form an interface (214) between the lens (104) and the overmold body (102). The interface (214) between the lens (104) and the ovemold body (102) includes or defines moisture ingress path (216) into the circuit board (200). The one or more pooling structures (218, 220) prevent passage of moisture along the moisture ingress path (216) past the one or more pooling structures (218, 220) to the circuit board (200).

Abstract translation: 光模块组件（100）包括透镜（104），电路板（200）和包覆模制体（102）。 透镜（104）包括由透镜（104）的横向定向的外表面（402,404）形成的一个或多个汇集结构（218,220）。 电路板（200）耦合到透镜（104）并且具有设置在电路板（200）上的一个或多个发光装置（106）。 包覆成型体102耦合到透镜104，以在透镜104和包覆成型体102之间形成界面214。 透镜（104）和成像体（102）之间的界面（214）包括或限定到电路板（200）中的湿气进入路径（216）。 一个或多个汇集结构（218,220）防止湿气沿着水分进入路径（216）通过一个或多个汇集结构（218,220）到达电路板（200）。

公开(公告)号：WO2011053783A3

公开(公告)日：2011-07-28

申请号：PCT/US2010054714

申请日：2010-10-29

Applicant: MERCK SHARP & DOHME ,  LUO PETER PEIZHI ,  NI YAN ,  WANG KEVIN CAILI ,  HSIEH MARK ,  WANG XINWEI ,  DONG FENG ,  GOLOSOV ANDREI ,  WANG WEIRONG ,  LI YAN ,  ZHONG PINGYU ,  PETERSON LAURENCE B ,  CUBBON ROSE ,  SHARMA SUJATA ,  CONDRA JON ,  LU JUN ,  PARTHASARATHY GOPALAKRISHNAN ,  SOISSON STEPHEN ,  BYRNE NOEL

Inventor： LUO PETER PEIZHI ,  NI YAN ,  WANG KEVIN CAILI ,  HSIEH MARK ,  WANG XINWEI ,  DONG FENG ,  GOLOSOV ANDREI ,  WANG WEIRONG ,  LI YAN ,  ZHONG PINGYU ,  PETERSON LAURENCE B ,  CUBBON ROSE ,  SHARMA SUJATA ,  CONDRA JON ,  LU JUN ,  PARTHASARATHY GOPALAKRISHNAN ,  SOISSON STEPHEN ,  BYRNE NOEL

IPC: A61K39/395 ,  C07K16/00

CPC classification number: C07K16/40 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/94 ,  C07K2319/00

Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 ("PCSK9") are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

Abstract translation: 公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并且形成了本公开的重要的附加方面。

公开(公告)号：WO2010068526A1

公开(公告)日：2010-06-17

申请号：PCT/US2009/066303

申请日：2009-12-02

Applicant: MERCK SHARP & DOHME CORP. ,  NI, Yan ,  SITLANI, Ayesha ,  PANDIT, Shilpa ,  LEWIS, Dale ,  SHEN, Xun ,  LOBO, Sharon ,  MCCABE, Timothy ,  CONDRA, Jon ,  CUBBON, Rose

Inventor： NI, Yan ,  SITLANI, Ayesha ,  PANDIT, Shilpa ,  LEWIS, Dale ,  SHEN, Xun ,  LOBO, Sharon ,  MCCABE, Timothy ,  CONDRA, Jon ,  CUBBON, Rose

IPC: G01N33/53

CPC classification number: C07K16/40 ,  C07K2317/55 ,  G01N33/543 ,  G01N33/573 ,  G01N2333/96433

Abstract: Methods of using PCSK9 antagonists More specifically, methods for measuring circulating PCSK9 levels in a biological sample by means of an immunoassay The immunoassay used can be a solid phase immunoassay, such as a dissociation-enhanced lanthanide fluorescence immunoassay utilizing an E07 capture antibody or coating and a G08 or H23 detecting antibody.

Abstract translation: 使用PCSK9拮抗剂的方法更具体地，通过免疫测定法测量生物样品中的循环PCSK9水平的方法所用的免疫测定可以是固相免疫测定，例如利用E07捕获抗体或涂层的解离增强镧系荧光免疫测定， G08或H23检测抗体。

公开(公告)号：WO2011053665A1

公开(公告)日：2011-05-05

申请号：PCT/US2010/054376

申请日：2010-10-28

Applicant: MERCK SHARP & DOHME CORP. ,  NI, Yan, G. ,  PANDIT, Shilpa

Inventor： NI, Yan, G. ,  PANDIT, Shilpa

IPC: G01N33/53 ,  C12P21/08

CPC classification number: G01N33/573 ,  G01N33/6893 ,  G01N2333/96433 ,  G01N2800/32

Abstract: Methods of using PCSK9 antagonists. More specifically, methods for measuring circulating PCSK9 levels in a biological sample by means of an immunoassay.

Abstract translation: 使用PCSK9拮抗剂的方法。 更具体地，通过免疫测定来测量生物样品中的循环PCSK9水平的方法。