公开(公告)号：WO2022187986A1

公开(公告)日：2022-09-15

申请号：PCT/CN2021/079425

申请日：2021-03-06

Applicant: INTEL CORPORATION ,  SUBRAHMANYAM, Prabhakar ,  CHAO, Tong Wa ,  PANG, Ying-Feng ,  XIA, Yi ,  MOHAMMED, Rahima, K. ,  POLYANKO, Victor, P. ,  SAHAN, Ridvan, A. ,  ZHANG, Guangying ,  YING, Guoliang ,  WANG, Chuanlou ,  LU, Jun ,  DU, Liguang ,  WEI, Peng ,  QUE, Xiang

Inventor： SUBRAHMANYAM, Prabhakar ,  CHAO, Tong Wa ,  PANG, Ying-Feng ,  XIA, Yi ,  MOHAMMED, Rahima, K. ,  POLYANKO, Victor, P. ,  SAHAN, Ridvan, A. ,  ZHANG, Guangying ,  YING, Guoliang ,  WANG, Chuanlou ,  LU, Jun ,  DU, Liguang ,  WEI, Peng ,  QUE, Xiang

IPC: H01L23/427 ,  G06F1/20

Abstract: Techniques for heat sinks and cold plates for compute systems are disclosed. In one embodiment, a heat sink includes two sub-heat sinks that are mechanically connected but thermally isolated. The two sub-heat sinks can independently cool different dies on the same integrated circuit component. In another embodiment, a system includes an integrated circuit component that is cooled by a first water block and a second water block. The first water block forms a loop with a gap in it, and the second water block has a pedestal that extends through the gap in the first water block to contact the integrated circuit component. The first water block and the second water block can independently cool different dies on the same integrated circuit component.

公开(公告)号：WO2014134821A1

公开(公告)日：2014-09-12

申请号：PCT/CN2013/072337

申请日：2013-03-08

Applicant: HONEYWELL INTERNATIONAL INC. ,  LU, Jun ,  SINGH, Rajiv Ratna ,  LU, Zhili ,  SEETON, Christopher J. ,  ZHOU, Yong ,  WANG, Ronny ,  LIN, Yun

Inventor： LU, Jun ,  SINGH, Rajiv Ratna ,  LU, Zhili ,  SEETON, Christopher J. ,  ZHOU, Yong ,  WANG, Ronny ,  LIN, Yun

IPC: C09K5/04

CPC classification number: C09K5/045 ,  C09K2205/104 ,  C09K2205/12 ,  C09K2205/13 ,  C09K2205/40

Abstract: Disclosed are heat transfer compositions and methods wherein the compositions include CO2; one or more additional components selected from R-116, R-23, a C1-C5 substituted or unsubstituted, saturated or unsaturated hydrocarbon (other than R-116, R-23), a noble gas or combinations thereof. Such compositions, in certain aspects of the invention, may be used as a replacement refrigerant for R-508B, particularly, though not exclusively, in low or ultralow temperature refrigeration applications.

Abstract translation: 公开了传热组合物和方法，其中组合物包括CO 2; 一种或多种选自R-116，R-23，C1-C5取代或未取代的饱和或不饱和烃（R-116，R-23除外），惰性气体或其组合的另外的组分。 在本发明的某些方面，这些组合物可用作R-508B的替代制冷剂，特别是在低或低温制冷应用中，但不限于此。

公开(公告)号：WO2013159318A1

公开(公告)日：2013-10-31

申请号：PCT/CN2012/074796

申请日：2012-04-27

Applicant: HONEYWELL INTERNATIONAL INC. ,  LIU, Yong ,  LU, Jun

Inventor： LIU, Yong ,  LU, Jun

IPC: G06K7/10

CPC classification number: G06K9/183 ,  G06K7/10792 ,  G06K7/10861 ,  H04N5/23229

Abstract: A system and method for decoding an image of decodable indicia, the computer system that includes receiving a request to decode an image, disabling the automatic focus on a camera in a client, setting the focus to a predetermined focus point that is close to the camera lens, capturing the image, locating the decodable indicia in the image and decoding the image of decodable indicia.

Abstract translation: 一种用于对可解码标记的图像进行解码的系统和方法，所述计算机系统包括接收对图像进行解码的请求，禁用对客户机中的相机的自动对焦，将焦点设置为靠近相机的预定焦点 镜头，捕捉图像，将可解码的标记定位在图像中并解码可解码标记的图像。

公开(公告)号：WO2013016689A3

公开(公告)日：2013-04-25

申请号：PCT/US2012048693

申请日：2012-07-27

Applicant: UNIV LELAND STANFORD JUNIOR ,  UNIV SYDNEY ,  KEALL PAUL J ,  O'BRIEN RICKY ,  COOPER BENJAMIN ,  LU JUN ,  WILLAMSON JEFFREY F

Inventor： KEALL PAUL J ,  O'BRIEN RICKY ,  COOPER BENJAMIN ,  LU JUN ,  WILLAMSON JEFFREY F

IPC: A61B6/03

CPC classification number: A61B6/541 ,  A61B6/4085 ,  A61B6/486 ,  A61B6/5205 ,  A61B6/5264 ,  A61B6/583 ,  A61N2005/1061

Abstract: A method of optimizing 4D cone beam computed tomography (4DCBCT) imaging is provided that includes using a scanner to generate projections of a target, where the projections are used to form a cone beam computed tomography (CBCT) scan of the target, where the CBCT includes a 3D image of the target, and using an appropriately programmed computer to control rotation speed of a gantry and projection acquisition of the CBCT in real-time according to a measured patient respiratory signal, where the real-time acquisition of the CBCT forms an optimized 4DCBCT image set.

Abstract translation: 提供了优化4D锥形束计算机断层摄影（4DCBCT）成像的方法，其包括使用扫描仪来产生靶的投影，其中所述突起用于形成靶的锥束计算机断层摄影（CBCT）扫描，其中CBCT 包括目标的3D图像，并且使用适当编程的计算机根据所测量的患者呼吸信号实时地控制台架的转速和CBCT的投影采集，其中CBCT的实时采集形成 优化的4DCBCT图像集。

公开(公告)号：WO2011097078A1

公开(公告)日：2011-08-11

申请号：PCT/US2011/022109

申请日：2011-01-21

Applicant: EBAY INC. ,  NI, Bin ,  LAGUNAS, Diego ,  LU, Jun ,  REDDY, Venu ,  KUMAR, Ramamurthy ,  ROMDHANE, Sami Ben

Inventor： NI, Bin ,  LAGUNAS, Diego ,  LU, Jun ,  REDDY, Venu ,  KUMAR, Ramamurthy ,  ROMDHANE, Sami Ben

IPC: G06F13/00

CPC classification number: G06F9/547 ,  G06F8/60 ,  H04L65/1063 ,  H04L67/04 ,  H04L67/1002

Abstract: A method to optimize calls to a service by components of an application running on an application server is provided. The method includes receiving a first call and a second call, the first call made to a service by a first one of a plurality of components included in the application, and the second call made to the service by a second one of the plurality of components; selecting one of a plurality of optimizations, the plurality of optimizations including orchestrating the first call and the second call into a third call to the service; and, in response to the selecting of the orchestrating of the first call and the second call into the third call as the one of the plurality of optimizations, orchestrating the first call and the second call into the third call.

Abstract translation: 提供了一种通过应用程序服务器上运行的应用程序的组件优化对服务的调用的方法。 该方法包括接收第一呼叫和第二呼叫，由应用程序中包含的多个组件中的第一个组件进行的对服务的第一呼叫，以及由多个组件中的第二个组件对该服务进行的第二呼叫 ; 选择多个优化中的一个，所述多个优化包括将所述第一呼叫和所述第二呼叫协调为对所述服务的第三呼叫; 并且响应于将所述第一呼叫的协调选择和所述第三呼叫中的所述第二呼叫作为所述多个优化中的一个进行优化，将所述第一呼叫和所述第二呼叫编排到所述第三呼叫中。

公开(公告)号：WO2011053783A2

公开(公告)日：2011-05-05

申请号：PCT/US2010/054714

申请日：2010-10-29

Applicant: MERCK SHARP & DOHME CORP. ,  LUO, Peter Peizhi ,  NI, Yan ,  WANG, Kevin Caili ,  HSIEH, Mark ,  WANG, Xinwei ,  DONG, Feng ,  GOLOSOV, Andrei ,  WANG, Weirong ,  LI, Yan ,  ZHONG, Pingyu ,  PETERSON, Laurence, B. ,  CUBBON, Rose ,  SHARMA, Sujata ,  CONDRA, Jon ,  LU, Jun ,  PARTHASARATHY, Gopalakrishnan ,  SOISSON, Stephen ,  BYRNE, Noel

Inventor： LUO, Peter Peizhi ,  NI, Yan ,  WANG, Kevin Caili ,  HSIEH, Mark ,  WANG, Xinwei ,  DONG, Feng ,  GOLOSOV, Andrei ,  WANG, Weirong ,  LI, Yan ,  ZHONG, Pingyu ,  PETERSON, Laurence, B. ,  CUBBON, Rose ,  SHARMA, Sujata ,  CONDRA, Jon ,  LU, Jun ,  PARTHASARATHY, Gopalakrishnan ,  SOISSON, Stephen ,  BYRNE, Noel

IPC: A61K39/395

CPC classification number: C07K16/40 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/76 ,  C07K2317/94 ,  C07K2319/00

Abstract: Antagonists of human proprotein convertase subtilisin-kexin type 9 ("PCSK9") are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.

Abstract translation: 披露了人类前蛋白转化酶枯草杆菌蛋白酶 - kexin 9型的拮抗剂（“PCSK9”）。 所公开的拮抗剂在抑制PCSK9功能方面是有效的，并因此提供了用于治疗与PCSK9活性相关的病症的期望的拮抗剂。 本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。 还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并且形成本公开的重要的另外方面。

公开(公告)号：WO2010017551A3

公开(公告)日：2010-06-10

申请号：PCT/US2009053290

申请日：2009-08-10

Applicant: GEN HOSPITAL CORP ,  MASSACHUSETTS INST TECHNOLOGY ,  SCADDEN DAVID ,  GUO SHANGQIN ,  LU JUN

Inventor： SCADDEN DAVID ,  GUO SHANGQIN ,  LU JUN

IPC: C12N5/02 ,  C12N5/071 ,  C12N5/0789 ,  C12N15/113 ,  C12N15/63

CPC classification number: C12N15/113 ,  C12N5/0647 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2501/65

Abstract: Embodiments of the invention relate to methods and compositions for the expansion of hematopoietic stem cell (HSC) self renewal. The microRNA-125a is a master control of HSC self-renewal. Increased expression of mir-125a increased HSC self-renewal by 6-30 folds. Increased expression of mir-125a can be used to expand HSC ex vivo and in vivo.

Abstract translation: 本发明的实施方案涉及用于扩增造血干细胞（HSC）自我更新的方法和组合物。 microRNA-125a是HSC自我更新的主要控制。 mir-125a的表达增加使HSC自我更新增加6-30倍。 mir-125a的增加的表达可用于离体和体内扩增HSC。

公开(公告)号：WO2009070359A1

公开(公告)日：2009-06-04

申请号：PCT/US2008/074924

申请日：2008-08-29

Applicant: ALPHA & OMEGA SEMICONDUCTOR, LTD. ,  LU, Jun ,  CHANG, Allen ,  ZHANG, Xiaotian

Inventor： LU, Jun ,  CHANG, Allen ,  ZHANG, Xiaotian

IPC: H01L23/12

CPC classification number: H02J7/0031 ,  H01L23/4952 ,  H01L23/49524 ,  H01L23/49562 ,  H01L23/49575 ,  H01L23/58 ,  H01L24/37 ,  H01L24/40 ,  H01L24/41 ,  H01L24/45 ,  H01L24/48 ,  H01L24/49 ,  H01L24/73 ,  H01L24/91 ,  H01L25/071 ,  H01L25/074 ,  H01L25/18 ,  H01L2224/32145 ,  H01L2224/32245 ,  H01L2224/37124 ,  H01L2224/40247 ,  H01L2224/45014 ,  H01L2224/45124 ,  H01L2224/45144 ,  H01L2224/45147 ,  H01L2224/48091 ,  H01L2224/48145 ,  H01L2224/48247 ,  H01L2224/48465 ,  H01L2224/4903 ,  H01L2224/49051 ,  H01L2224/49111 ,  H01L2224/49171 ,  H01L2224/49431 ,  H01L2224/73221 ,  H01L2224/73265 ,  H01L2224/83801 ,  H01L2224/8385 ,  H01L2225/06562 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01014 ,  H01L2924/01015 ,  H01L2924/01022 ,  H01L2924/01023 ,  H01L2924/01027 ,  H01L2924/01028 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01075 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/014 ,  H01L2924/07802 ,  H01L2924/1306 ,  H01L2924/13091 ,  H01L2924/14 ,  H01L2924/181 ,  H01L2924/19041 ,  H01L2924/19043 ,  H01L2924/00014 ,  H01L2924/00012 ,  H01L2924/00

Abstract: A stacked-die package for battery protection is disclosed. The battery protection package includes a power control integrated circuit (IC) stacked on top of integrated dual common-drain metal oxide semiconductor field effect transistors (MOSFETs) or two discrete MOSFETs. The power control IC is either stacked on top of one MOSFET or on top of and overlapping both two MOSFETs.

Abstract translation: 公开了一种用于电池保护的堆叠式封装。 电池保护封装包括堆叠在集成的双公共漏极金属氧化物半导体场效应晶体管（MOSFET）或两个分立MOSFET之上的功率控制集成电路（IC）。 功率控制IC或者堆叠在一个MOSFET的顶部，或者两个MOSFET的顶部和两个MOSFET重叠。

公开(公告)号：WO2007079625A8

公开(公告)日：2008-08-07

申请号：PCT/CN2006001097

申请日：2006-05-25

Applicant: ANGANG STEEL CO LTD ,  SUN JIANLUN ,  ZHANG WANSHAN ,  GUANG JU ,  YANG XU ,  CHEN XIN ,  SUN QUN ,  WANG KEQIANG ,  LIU LIQUN ,  ZHAI YONGBIN ,  FU GUOLI ,  LU JUN ,  YANG MINGKAI

Inventor： SUN JIANLUN ,  ZHANG WANSHAN ,  GUANG JU ,  YANG XU ,  CHEN XIN ,  SUN QUN ,  WANG KEQIANG ,  LIU LIQUN ,  ZHAI YONGBIN ,  FU GUOLI ,  LU JUN ,  YANG MINGKAI

IPC: C22C38/04 ,  B21B1/26 ,  B21B1/46 ,  C21D8/02

CPC classification number: B21B3/02 ,  C21D8/0215 ,  C21D8/0226 ,  C21D8/0415 ,  C21D8/0426 ,  C21D9/48 ,  C21D2211/005 ,  C22C38/02 ,  C22C38/04

Abstract: An ultrafine grain steel sheet produced by continuous casting and rolling a medium-thin slab and its manufacture process. The composition of the steel is (in wt%): C 0.12-0.18%, Si 0.15-0.35%, Mn 0.65-1.20%, P=0.02%, S=0.015%, balance Fe and impurities. The manufacture process includes: hot loading the cast ingot directly at a temperature above 800°C, heating to 1100-1280°C; rough rolling the slab to 30-60mm; finish rolling in multi-passes with large accumulated deformation with an inlet temperature of 920-1050°C and an outlet temperature of 750-850°C, in which the average deformation rate of the steel sheet between finish rolling mills is 1-10/s; laminar cooling at a rate of 10-45°C/s, reeling at 400-620°C. The hot-continuous-rolling steel sheet is 2-18mm in thickness, and have an average grain size of 3-7µm, yield strength up to above 400MPa, tensile strength of 510-580MPa, and elongation beyond 26%.

Abstract translation: 通过连续铸造和轧制中薄板坯制造的超细晶粒钢板及其制造方法。 钢的组成为（重量％）：C 0.12-0.18％，Si 0.15-0.35％，Mn 0.65-1.20％，P = 0.02％，S = 0.015％，余量为Fe和杂质。 制造工艺包括：将铸锭直接在800℃以上的温度下加热，加热至1100-1280℃; 将板坯粗轧至30-60mm; 入口温度为920-1050℃，出口温度为750-850℃的大型积聚变形的多道次精轧，其中精轧机间钢板的平均变形率为1-10 / S; 以10-45℃/ s的速率层流冷却，在400-620℃下卷取。 热轧连续轧制钢板的厚度为2-18mm，平均粒径为3-7μm，屈服强度高达400MPa，拉伸强度为510-580MPa，伸长率超过26％。

公开(公告)号：WO2007137255A3

公开(公告)日：2007-11-29

申请号：PCT/US2007/069455

申请日：2007-05-22

Applicant: THIOREDOXIN SYSTEMS AB ,  THYOGEN PHARMACEUTICALS, INC. ,  HOLMGREN, Arne ,  LU, Jun ,  VLAMIS-GARDIKAS, Alexios ,  ZHAO, Rong ,  KANDASAMY, K. ,  ENGMAN, Lars ,  ENGSTRAND, Lars ,  HOFFNER, Sven

Inventor： HOLMGREN, Arne ,  LU, Jun ,  VLAMIS-GARDIKAS, Alexios ,  ZHAO, Rong ,  KANDASAMY, K. ,  ENGMAN, Lars ,  ENGSTRAND, Lars ,  HOFFNER, Sven

IPC: A61K31/555 ,  A61K31/385 ,  A61K31/38

Abstract: The mechanism of action of Ebselen differentiates between bacterial and mammalian thioredoxin reductase (TrxR). It displays fast oxidation of mammalian Trx and via the NADPH-TrxR catalyzed turnover of ebselen selenol with hydrogen peroxide, and therefore are mammalian antioxidants. Ebselen, and its diselenide, are strong competitive inhibitors of E.coli TrxR with K i of 0.14 µM and 0.46 µM, respectively. E.coli mutants lacking glutathione reductase or glutathione were much more sensitive to inhibition by ebselen. Since either glutaredoxin or thioredoxin systems are electron donors to ribonucleotide reductase, ebselen targets primarily glutathione and glutaredoxin-negative bacteria, a class which includes major pathogens. Ebselen, and similar compounds are therefore useful as antibacterial agents, even for multiresistant strains. Two major pathogenic bacteria, which previously had not been known to be sensitive to ebselen, Mycobacterium tuberculosis (tuberculosis) and Helicobacter pylori (stomach ulcer and cancer), were shown to be excellent targets. Helicobacter pylori was also sensitive to ebsulfur.