公开(公告)号：WO2010141365A2

公开(公告)日：2010-12-09

申请号：PCT/US2010036625

申请日：2010-05-28

Applicant: UNIV CORNELL ,  NITKOWSKI ARTHUR ,  LIPSON MICHAL

Inventor： NITKOWSKI ARTHUR ,  LIPSON MICHAL

IPC: G01N35/00 ,  G01N21/47 ,  G01N21/63 ,  G01N33/487

CPC classification number: G01N21/05 ,  B01L3/502715 ,  B01L2400/0454 ,  G01N21/53 ,  G01N21/7703 ,  G01N21/7746 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/7789

Abstract: An integrated optofluidic system for trapping and transporting particles for analysis is provided comprising a planar substrate; a microfluidic channel; and a waveguide integrated with the channel. A microsphere particle in the integrated optofluidic system can act as a cavity, allowing light to circulate many thousands of times around the circumference of the microsphere. Optical trapping and transport is used for nanoscale positioning to excite the microsphere resonances. Sensitive measurements on molecules can be accomplished by monitoring changes in whispering gallery modes (WGMs) that propagate around the circumference of the microsphere. By using a broadband or supercontinuum light source, a microsphere can be trapped and many WGM resonances can be excited through the visible and near-infrared wavelengths simultaneously. After the resonances are measured using the waveguide transmission, the microsphere can be freed by decreasing the optical power and the process repeated with a different microsphere.

Abstract translation: 提供了用于捕获和传送用于分析的颗粒的集成光流体系统，其包括平面基板; 微流通道; 以及与通道集成的波导。 集成光流体系统中的微球颗粒可以作为空腔，使得光可以围绕微球的圆周循环数千次。 光学捕获和传输用于纳米级定位以激发微球谐振。 可以通过监测围绕微球周围传播的耳语画廊模式（WGM）的变化来实现对分子的敏感测量。 通过使用宽带或超连续光源，可以捕获微球，并且可以同时通过可见光和近红外波长激发许多WGM谐振。 在使用波导传输测量谐振之后，可以通过降低光功率来释放微球，并且用不同的微球重复该过程。

公开(公告)号：WO2010141365A3

公开(公告)日：2010-12-09

申请号：PCT/US2010/036625

申请日：2010-05-28

Applicant: CORNELL UNIVERSITY ,  NITKOWSKI, Arthur ,  LIPSON, Michal

Inventor： NITKOWSKI, Arthur ,  LIPSON, Michal

IPC: G01N35/00 ,  G01N21/47 ,  G01N21/63 ,  G01N33/487

Abstract: An integrated optofluidic system for trapping and transporting particles for analysis is provided comprising a planar substrate; a microfluidic channel; and a waveguide integrated with the channel. A microsphere particle in the integrated optofluidic system can act as a cavity, allowing light to circulate many thousands of times around the circumference of the microsphere. Optical trapping and transport is used for nanoscale positioning to excite the microsphere resonances. Sensitive measurements on molecules can be accomplished by monitoring changes in whispering gallery modes (WGMs) that propagate around the circumference of the microsphere. By using a broadband or supercontinuum light source, a microsphere can be trapped and many WGM resonances can be excited through the visible and near-infrared wavelengths simultaneously. After the resonances are measured using the waveguide transmission, the microsphere can be freed by decreasing the optical power and the process repeated with a different microsphere.

公开(公告)号：WO2012162808A1

公开(公告)日：2012-12-06

申请号：PCT/CA2012/000524

申请日：2012-05-30

Applicant: TORNADO MEDICAL SYSTEMS, INC. ,  NITKOWSKI, Arthur ,  HAJIAN, Arsen

Inventor： NITKOWSKI, Arthur ,  HAJIAN, Arsen

IPC: G01J3/45 ,  G01J3/12

CPC classification number: G01J3/45 ,  G01J3/0218 ,  G01J3/18 ,  G01J3/4531

Abstract: A spectrometer is provided, the spectrometer having an interferometer generating an interferogram by splitting an interferometer input signal between a reference arm and a variable delay arm, and introducing a delay between the split interferometer input signals prior to interfering the split interferometer input signals. The spectrometer additionally has a controllable delay element operable to adjust the delay introduced by the interferometer and a dispersive element outputting a plurality of narrowband outputs representative of a received broadband input signal. The interferometer and dispersive element are optically connected to output a plurality of narrowband interferograms representative of a spectra of a spectrometer input signal received by the spectrometer, and the plurality of narrowband interferograms are received by a detector array for analysis.

Abstract translation: 提供了一种光谱仪，该光谱仪具有通过在参考臂和可变延迟臂之间分割干涉仪输入信号而产生干涉图的干涉仪，并且在干扰分离干涉仪输入信号之前在分离干涉仪输入信号之间引入延迟。 光谱仪还具有可控延迟元件，其可操作以调节由干涉仪引入的延迟和输出表示所接收的宽带输入信号的多个窄带输出的色散元件。 干涉仪和色散元件被光学连接以输出表示由光谱仪接收的光谱仪输入信号的光谱的多个窄带干涉图，并且多个窄带干涉图被检测器阵列接收用于分析。

公开(公告)号：WO2012162809A1

公开(公告)日：2012-12-06

申请号：PCT/CA2012/000525

申请日：2012-05-30

Applicant: TORNADO MEDICAL SYSTEMS, INC. ,  NITKOWSKI, Arthur ,  HAJIAN, Arsen

Inventor： NITKOWSKI, Arthur ,  HAJIAN, Arsen

IPC: G01B9/02 ,  G01J3/45

CPC classification number: G01J9/02 ,  A61B5/0066 ,  G01B9/02004 ,  G01B9/02044 ,  G01B9/02051 ,  G01B9/02091 ,  G01B2290/40 ,  G01J3/0218 ,  G01J3/0259 ,  G01J3/0291 ,  G01J3/4531 ,  G01J3/4532 ,  G01J2003/451

Abstract: An interferometer comprising a planar substrate is provided. The interferometer has a splitter formed on the planar substrate to split a received optical signal, a sample arm formed on the planar substrate to receive a first portion of the split optical signal and direct the first portion toward a sample, a reference arm formed on the planar substrate to receive a second portion of the split optical signal, and a detector element to receive an interferogram generated by interfering the second portion of the split optical signal with a received sample signal generated by the first portion of the split signal interacting with the sample.

Abstract translation: 提供了包括平面基板的干涉仪。 所述干涉仪具有形成在所述平面基板上以分割接收到的光信号的分离器，形成在所述平面基板上的样本臂，以接收所述分割光信号的第一部分并将所述第一部分引向样本， 平面基板以接收分离光信号的第二部分，以及检测器元件，用于接收通过将分离光信号的第二部分与由样本相互作用的分离信号的第一部分产生的接收采样信号而产生的干涉图 。