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    ELECTRODE ASSEMBLY FOR APPLYING TUMOR TREATING FIELDS (TTFIELDS) THAT INCLUDE A SHEET OF GRAPHITE
    1.
    发明申请
    ELECTRODE ASSEMBLY FOR APPLYING TUMOR TREATING FIELDS (TTFIELDS) THAT INCLUDE A SHEET OF GRAPHITE 审中-公开

    公开(公告)号：WO2023012708A1

    公开(公告)日：2023-02-09

    申请号：PCT/IB2022/057234

    申请日：2022-08-04

    Applicant: NOVOCURE GMBH

    Inventor： WASSERMAN, Yoram ,  OBUCHOVSKY, Stas ,  KUPLENNIK, Nataliya ,  SHAPIRO, David

    IPC: A61N1/36 ,  A61N1/04

    Abstract: Alternating electric fields (e.g., TTFields) may be applied to a subject's body using one or more electrode assemblies that includes a sheet of graphite, at least one layer of conductive material disposed on the front face of the sheet of graphite, and an electrode element positioned behind the sheet of graphite. The electrode element has a front face disposed in electrical contact with the rear face of the sheet of graphite. The sheet of graphite spreads both heat and current out in directions that are parallel to the front face of the sheet, which eliminates or at least minimizes hot spots on the electrode assembly. This in turn makes it possible to increase the current without exceeding a temperature safety threshold (e.g., 41° C).

    USING ALTERNATING ELECTRIC FIELDS AT DIFFERENT FREQUENCIES TO INCREASE THE PERMEABILITY OF THE BLOOD BRAIN BARRIER AND ALSO TO PROVIDE OTHER BENEFITS
    2.
    发明申请
    USING ALTERNATING ELECTRIC FIELDS AT DIFFERENT FREQUENCIES TO INCREASE THE PERMEABILITY OF THE BLOOD BRAIN BARRIER AND ALSO TO PROVIDE OTHER BENEFITS 审中-公开

    公开(公告)号：WO2023275804A1

    公开(公告)日：2023-01-05

    申请号：PCT/IB2022/056081

    申请日：2022-06-29

    Applicant: NOVOCURE GMBH

    Inventor： VOLOSHIN-SELA, Tali ,  AVIGDOR, Lilach

    IPC: A61N1/32 ,  A61N1/327 ,  A61N1/40

    Abstract: Certain drugs and other molecules cannot ordinarily traverse the blood brain barrier (BBB). However, when alternating electric fields at certain first frequencies (e.g., 100 kHz) are applied to the brain, the BBB becomes permeable to those molecules. Moreover, certain drugs and other molecules cannot ordinarily traverse cell membranes. However, when alternating electric fields at certain second frequencies are applied to the cells (e.g., 150 kHz for uterine sarcoma cells), the cell membranes become permeable to those molecules. To get a certain drug past both the BBB and the relevant cell membranes, the permeability of both of those barriers can be overcome by sequentially (or simultaneously) applying alternating electric fields at both the first frequency and the second frequency.

    METHOD AND APPARATUS FOR DETECTING AND RESPONDING TO CHANGES IN SUBJECTS
    4.
    发明申请
    METHOD AND APPARATUS FOR DETECTING AND RESPONDING TO CHANGES IN SUBJECTS 审中-公开

    公开(公告)号：WO2022201060A1

    公开(公告)日：2022-09-29

    申请号：PCT/IB2022/052655

    申请日：2022-03-23

    Applicant: NOVOCURE GMBH

    Inventor： SHAMIR, Reuven Ruby ,  WASSERMAN, Yoram ,  BOMZON, Zeev ,  PELES ZEEVI, Oren ,  MARCIANO, Tal

    IPC: A61N1/36 ,  A61N1/40

    Abstract: A method of applying tumor treating fields to a region of interest of a subject's body corresponding to a tumor, the method including: alternately applying to the region of interest a first electric field between a first pair of locations of the subject's body and a second electric field between a second pair of locations of the subject's body; detecting a change in the region of interest of the subject's body; ceasing applying the first and second electric fields; selecting, based on the detected change, a third pair of locations of the subject's body and a fourth pair of locations of the subject's body, the third and fourth pairs of locations being different than the first and second pairs of locations; and alternately applying to the region of interest a third electric field between the third pair of locations and a fourth electric field between the fourth pair of locations.

    INCREASING THE EFFICACY OF TUMOR TREATING FIELDS (TTFIELDS) BY APPLYING THE TTFIELDS AT PEAK INTENSITY LESS THAN HALF THE TIME
    5.
    发明申请
    INCREASING THE EFFICACY OF TUMOR TREATING FIELDS (TTFIELDS) BY APPLYING THE TTFIELDS AT PEAK INTENSITY LESS THAN HALF THE TIME 审中-公开

    公开(公告)号：WO2022112945A1

    公开(公告)日：2022-06-02

    申请号：PCT/IB2021/060876

    申请日：2021-11-23

    Applicant: NOVOCURE GMBH

    Inventor： GILADI, Moshe ,  DOR-ON, Eyal ,  ZEEVI, Einav ,  ENGELMAN, Rotem

    IPC: A61N1/36 ,  A61N1/40

    Abstract: An alternating electric field may be applied to a target region in a living body or to cells in vitro. The alternating electric field is applied during a first interval of time that is at least 1 hour long. The first interval of time includes a plurality of (e.g., 10) non-overlapping sub-intervals of time per hour. In each of the sub-intervals of time, (a) the alternating electric field has a frequency between 50 kHz and 1 MHz (e.g., 50-500 kHz, or 100-300 kHz), (b) the alternating electric field has a respective peak intensity of at least 0.1 V/cm in at least a portion of the target region, and (c) the alternating electric field remains at the respective peak intensity less than 75% the time (e.g., 25% or 33% of the time).

    METHODS AND COMPOSITIONS FOR TREATING CORONAVIRUS
    6.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING CORONAVIRUS 审中-公开

    公开(公告)号：WO2022058960A1

    公开(公告)日：2022-03-24

    申请号：PCT/IB2021/058509

    申请日：2021-09-17

    Applicant: NOVOCURE GMBH

    Inventor： VOLOSHIN-SELA, Tali ,  AVIGDOR, Lilach ,  PORAT, Yaara ,  GILADI, Moshe ,  MUMBLAT, Helena

    IPC: A61N1/40

    Abstract: Disclosed are methods of inhibiting a coronavirus from infecting or replicating in a cell comprising exposing the cell to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, wherein the frequency and field strength of the alternating electric field inhibits coronavirus infection or replication. Disclosed are methods of reducing coronavirus copy number per cell comprising exposing the cell to an alternating electric field for a period of time, the alternating electric field having a frequency and field strength, wherein the frequency and field strength of the alternating electric field reduces coronavirus copy number in the cell. Disclosed are methods of treating a subject infected with coronavirus comprising applying an alternating electric field to a target site of the subject for a period of time, the alternating electric field having a frequency and field strength, wherein the target site comprises one or more coronavirus infected cells.

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