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    COMPOSITIONS AND METHODS FOR USING ALTERNATING ELECTRIC FIELDS TO DISRUPT LIPID CAPSULES
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR USING ALTERNATING ELECTRIC FIELDS TO DISRUPT LIPID CAPSULES 审中-公开

    公开(公告)号：WO2023275648A1

    公开(公告)日：2023-01-05

    申请号：PCT/IB2022/055587

    申请日：2022-06-16

    Applicant: NOVOCURE GMBH

    Inventor： AVIGDOR, Lilach ,  VOLOSHIN-SELA, Tali ,  WEINBERG, Uri

    IPC: A61N1/36 ,  A61K8/11 ,  A61K9/127 ,  A61N1/06 ,  A61N1/40 ,  A61N1/32 ,  A61K9/00 ,  A61K41/0028 ,  A61K9/0009 ,  A61K9/4816 ,  A61N1/325 ,  A61N1/327 ,  A61N1/36002 ,  A61N1/403

    Abstract: Disclosed are methods of delivering a therapeutic to a target site of a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic from lipid capsule at the target site of the subject. Disclosed are methods of increasing target site specific release of a therapeutic agent in a subject comprising administering a lipid capsule to a target site of a subject, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site of the subject, thereby increasing the target site specific release of the therapeutic agent. Disclosed are methods of treating comprise administering a lipid capsule to a target site of a subject in need thereof, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field, at a frequency for a period of time, to the target site of the subject in need thereof, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site of the subject in need thereof. Disclosed are methods of killing a cell comprising administering a lipid capsule to a target site, wherein the lipid capsule comprises a therapeutic agent; and applying an alternating electric field for a period of time, to the target site, wherein the alternating electric field releases the therapeutic agent from the lipid capsule at the target site, wherein the target site comprises a cell, wherein the therapeutic kills the cell.

    ELECTRODE ARRAYS FOR ELECTROPORATION, AND RELATED SYSTEMS AND METHODS
    5.
    发明申请
    ELECTRODE ARRAYS FOR ELECTROPORATION, AND RELATED SYSTEMS AND METHODS 审中-公开

    公开(公告)号：WO2023278795A1

    公开(公告)日：2023-01-05

    申请号：PCT/US2022/035856

    申请日：2022-06-30

    Applicant: INOVIO PHARMACEUTICALS, INC.

    Inventor： MCCOY, Jay ,  FISHER, Paul

    IPC: A61N1/32 ,  A61N1/04 ,  A61N1/18 ,  A61M2037/0007 ,  A61M37/00 ,  A61N1/0502 ,  A61N1/327

    Abstract: An electrode array for use with an electroporation device includes a support member having a top surface and a bottom surface and defines a plurality of injection channels extending from the top surface to the bottom surface. A plurality of needle electrodes are coupled to the support member, such that distal ends of the plurality of needle electrodes extend to a needle depth below the bottom surface. The plurality of needle electrodes are arranged in a matrix pattern having rows of the needle electrodes and columns of the needle electrodes disposed along the support member. The plurality of injection channels are dispersed within the matrix pattern.

    USING ALTERNATING ELECTRIC FIELDS AT DIFFERENT FREQUENCIES TO INCREASE THE PERMEABILITY OF THE BLOOD BRAIN BARRIER AND ALSO TO PROVIDE OTHER BENEFITS
    6.
    发明申请
    USING ALTERNATING ELECTRIC FIELDS AT DIFFERENT FREQUENCIES TO INCREASE THE PERMEABILITY OF THE BLOOD BRAIN BARRIER AND ALSO TO PROVIDE OTHER BENEFITS 审中-公开

    公开(公告)号：WO2023275804A1

    公开(公告)日：2023-01-05

    申请号：PCT/IB2022/056081

    申请日：2022-06-29

    Applicant: NOVOCURE GMBH

    Inventor： VOLOSHIN-SELA, Tali ,  AVIGDOR, Lilach

    IPC: A61N1/32 ,  A61N1/327 ,  A61N1/40

    Abstract: Certain drugs and other molecules cannot ordinarily traverse the blood brain barrier (BBB). However, when alternating electric fields at certain first frequencies (e.g., 100 kHz) are applied to the brain, the BBB becomes permeable to those molecules. Moreover, certain drugs and other molecules cannot ordinarily traverse cell membranes. However, when alternating electric fields at certain second frequencies are applied to the cells (e.g., 150 kHz for uterine sarcoma cells), the cell membranes become permeable to those molecules. To get a certain drug past both the BBB and the relevant cell membranes, the permeability of both of those barriers can be overcome by sequentially (or simultaneously) applying alternating electric fields at both the first frequency and the second frequency.

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