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公开(公告)号：WO2006081651A1
公开(公告)日：2006-08-10
申请号：PCT/CA2006/000063
申请日：2006-01-19
Applicant: NOVX SYSTEMS INC. , TALEBPOUR, Samad , LEONARD, Stephen, W. , EMADI-KONJIN, Pasha
Inventor： TALEBPOUR, Samad , LEONARD, Stephen, W. , EMADI-KONJIN, Pasha
IPC: G01N33/544 , G01N33/573
CPC classification number: G01N33/54393 , G01N33/5306 , G01N2600/00
Abstract: The present invention provides a method for the detection of an analyte in a specimen comprising two steps. First, the specimen is contacted with a substrate having receptors bound thereon, having higher affinity for cross-reactive substances than for the analyte, in order to increase the ratio of the analyte to the cross-reactive substances. Then, the treated specimen is assayed by using another receptor while decreasing the effects of the cross-reactive substance contained in the original specimen. The receptors in the first step are preferably molecular imprinted polymers that are capable of absorbing multiple cross-reactive substances.
Abstract translation: 本发明提供一种用于检测样品中分析物的方法，包括两个步骤。 首先，将样品与具有结合于其上的受体的底物接触，对于交叉反应性物质的亲和性高于分析物，以增加分析物与交叉反应物质的比例。 然后，通过使用另一种受体同时降低原始样品中包含的交叉反应物质的影响来测定处理的样品。 第一步中的受体优选是能够吸收多个交叉反应物质的分子印迹聚合物。
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公开(公告)号：WO2003009508A1
公开(公告)日：2003-01-30
申请号：PCT/CA2002/001065
申请日：2002-07-12
Applicant: NOVX SYSTEMS INC.
Inventor： TALEBPOUR, Samad , ALAVIE, Tino , XU, Ming, Gang
IPC: H04J14/02
CPC classification number: H04Q11/0005 , G02B6/02085 , G02B6/022 , G02B6/2932 , G02B6/29322 , G02B6/29395 , G02B6/29398 , G02F1/0115 , G02F1/0134 , G02F2201/307 , H04J14/0208 , H04J14/0212 , H04J14/0213 , H04Q2011/0022 , H04Q2011/0075
Abstract: The present invention relates to a method and devices for multiplexing and demultiplexing optical signals. The present invention relates to a method and devices for integrating the multiplexer and demultiplexer functionality with the switch array. The wavelength switchable optical filter comprises an optical waveguide having a grating along a section thereof, the grating comprising a pre-selected number of spaced sub-gratings with each sub-grating have a sub-grating period, the grating has a spectral response characterized by a pre-selected number of spaced band-pass windows spanning a pre-selected wavelength range. The optical filter includes modifying means connected to the optical waveguide for modifying the sub-grating period, refractive index or a combination thereof for selectively opening or closing each of said band pass windows independently of all the other band pass windows.
Abstract translation: 本发明涉及一种用于复用和解复用光信号的方法和装置。 本发明涉及用于将多路复用器和解复用器功能与开关阵列集成的方法和装置。 波长可切换光学滤波器包括具有沿着其一部分的光栅的光波导，该光栅包括预选数量的间隔子光栅，每个子光栅具有子光栅周期，光栅具有以下特征的光谱响应： 预选数量的跨越预选波长范围的间隔的带通窗口。 光学滤波器包括连接到光波导的修改装置，用于修改子光栅周期，折射率或其组合，用于独立于所有其它带通窗口选择性地打开或关闭每个所述带通窗口。
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3.发明申请METHOD OF COMPENSATION OF DOSE-RESPONSE CURVE OF AN ASSAY FOR SENSITIVITY TO PERTURBING VARIABLES 审中-公开补偿灵敏度测量变量的剂量响应曲线的方法
公开(公告)号：WO2008109977A1
公开(公告)日：2008-09-18
申请号：PCT/CA2007/000398
申请日：2007-03-12
Applicant: NOVX SYSTEMS INC. , LEONARD, Stephen, W. , TALEBPOUR, Samad
Inventor： LEONARD, Stephen, W. , TALEBPOUR, Samad
CPC classification number: G01N21/274 , G01N21/276 , G01N2201/1211
Abstract: The present invention provides assays and methods of compensating for changes in the dose-response curve of an assay where such changes are due to variations in a perturbing variable such as, but not limited to temperature. This is achieved by a two-step method, the first step of which involves measurements of the dose-response curve, and thus the individual assay parameters, at many different values of the perturbing variable, spanning the expected range of the perturbing variable. In the second step, unknown samples are assayed simultaneously with a known standard at a chosen analyte concentration. During this measurement, the value of the perturbing variable is unknown and the dose-response curve is therefore also unknown. The different dose-response curves from the first step are used to determine a mathematical relationship between the assay parameters and the assay signal of the known standard. With this relationship, in which the value of the perturbing variable is implicit rather than explicit, assay parameters that are valid for the unknown value of the perturbing variable can be obtained by substituting the value of the assay signal from the known standard (measured when assaying the unknown samples) into the mathematical relationship and solving for the assay parameters. The method enables an accurate determination of the analyte concentration even when the perturbing variable is changing or fluctuating from one sample measurement to another. Once the first step is completed, the second step can be performed repeatedly to measure unknown samples with accuracy.
Abstract translation: 本发明提供了用于补偿测定的剂量 - 反应曲线的变化的测定和方法，其中这些变化是由于扰动变量（例如但不限于温度）的变化引起的。 这通过两步法实现，其第一步涉及剂量 - 响应曲线的测量，并且因此涉及扰动变量的许多不同值的单独测定参数，跨越扰动变量的预期范围。 在第二步中，未知样品在选定的分析物浓度下与已知标准同时测定。 在此测量期间，扰动变量的值是未知的，因此剂量 - 反应曲线也是未知的。 使用来自第一步的不同剂量 - 响应曲线来确定测定参数与已知标准的测定信号之间的数学关系。 通过这种关系，其中扰动变量的值是隐含的而不是显式的，可以通过用来自已知标准的测定信号的值（测定时测量）获得对扰动变量的未知值有效的测定参数 未知样品）进入数学关系并解决测定参数。 该方法即使当扰动变量从一个样品测量改变或波动到另一个样品测量时，也能够精确地确定分析物浓度。 一旦完成第一步，可以重复执行第二步，准确测量未知样品。
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Patent Agency Ranking
公开(公告)号：WO2006094375A1
公开(公告)日：2006-09-14
申请号：PCT/CA2006/000099
申请日：2006-01-26
Applicant: NOVX SYSTEMS INC. , TALEBPOUR, Samad
Inventor： TALEBPOUR, Samad
CPC classification number: G01N35/00693 , G01N2035/00702
Abstract: The present invention provides a method to calibrate an assay for variations or fluctuations in an assay parameter such as, but not limited to, temperature that affect the measured assay signal and thereby to calculate an analyte concentration with improved accuracy. The method is preferably performed in a manner such that the measured signal from a single additional standard per batch is sufficient to provide the required calibration.
Abstract translation: 本发明提供了一种用于校准化验参数中的变化或波动的方法，所述化验参数例如但不限于影响所测量的化验信号的温度，并由此通过改进来计算分析物浓度 准确性。 该方法优选以这样的方式进行，即每批来自单个附加标准的测量信号足以提供所需的校准。
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公开(公告)号：WO2006092036A1
公开(公告)日：2006-09-08
申请号：PCT/CA2006/000083
申请日：2006-01-23
Applicant: NOVX SYSTEMS INC. , TALEBPOUR, Samad , LEONARD, Stephen, W.
Inventor： TALEBPOUR, Samad , LEONARD, Stephen, W.
IPC: G01N33/543
CPC classification number: G01N33/536
Abstract: The present invention provides a method of performing a competitive assay for the detection and quantification of an analyte over an extended dynamic range. This is achieved by a multi-step sample addition method whereby different concentrations of sample are added at different times during the assay that produces a dose-response curve with multiple windows of detection. This multi-step sample addition method causes the dose-response curve of the composite assay to broaden, dramatically increasing the assay dynamic range.
Abstract translation: 本发明提供了一种在扩展的动态范围内进行用于检测和定量分析物的竞争性测定的方法。 这通过多步骤样品添加方法来实现，其中在测定期间在不同时间添加不同浓度的样品，其产生具有多个检测窗口的剂量 - 反应曲线。 这种多步骤样品添加方法使得复合测定的剂量 - 反应曲线变宽，显着增加了测定动态范围。
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公开(公告)号：WO2007098576A1
公开(公告)日：2007-09-07
申请号：PCT/CA2007/000293
申请日：2007-02-26
Applicant: NOVX SYSTEMS INC. , TALEBPOUR, Samad , LEONARD, Stephen, W. , BECKLEY, Keith , MAASKANT, Robert
Inventor： TALEBPOUR, Samad , LEONARD, Stephen, W. , BECKLEY, Keith , MAASKANT, Robert
CPC classification number: B01L3/50853 , B01L2200/148 , B01L2200/16 , B01L2300/044 , B01L2300/0829
Abstract: The present invention provides a microplate-based assay kit that incorporates all assay reagents and standards in a simple and efficient format and may be used in biochemical assays. The assay kit includes pre-filled, pre-sealed and barcoded microplates with a standard physical footprint for use in a microplate-based automated analyzer system which enables simple and efficient operation by an unskilled user via per-use factory-sealed and barcoded reagent and calibrator microplates. Such microplates allow the user to run a broad test menu without the need to monitor the arrangement and supply of internally stored reagents and standards, thus greatly simplifying the user experience and eliminating the need for highly skilled users.
Abstract translation: 本发明提供了一种基于微板的测定试剂盒，其以简单且有效的形式并入所有测定试剂和标准品，并可用于生物化学测定。 测定试剂盒包括预填充的预密封和条形码微孔板，具有用于基于微孔板的自动分析仪系统的标准物理尺寸，使得非熟练使用者能够通过使用工厂密封和条形码的试剂进行简单有效的操作， 校准器微孔板。 这样的微板允许用户运行广泛的测试菜单，而不需要监视内部存储的试剂和标准的布置和供应，从而大大简化了用户体验并且消除了对高技能用户的需要。
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公开(公告)号：WO2006094375A9
公开(公告)日：2006-10-26
申请号：PCT/CA2006000099
申请日：2006-01-26
Applicant: NOVX SYSTEMS INC , TALEBPOUR SAMAD
Inventor： TALEBPOUR SAMAD
CPC classification number: G01N35/00693 , G01N2035/00702
Abstract: The present invention provides a method to calibrate an assay for variations or fluctuations in an assay parameter such as, but not limited to, temperature that affect the measured assay signal and thereby to calculate an analyte concentration with improved accuracy. The method is preferably performed in a manner such that the measured signal from a single additional standard per batch is sufficient to provide the required calibration.
Abstract translation: 本发明提供了一种用于校准测定参数中的变化或波动的方法，所述测定参数例如但不限于影响测量的测定信号的温度，从而以改进的精度计算分析物浓度。 该方法优选以使得每批次的单个附加标准的测量信号足以提供所需校准的方式进行。
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公开(公告)号：WO2006094388A1
公开(公告)日：2006-09-14
申请号：PCT/CA2006/000321
申请日：2006-03-07
Applicant: NOVX SYSTEMS INC. , ALAVIE, Tino , BECKLEY, Keith , HUDSON, Andrew , LEONARD, Stephen, W. , MAASKANT, Robert , TALEBPOUR, Samad , YANG, William
Inventor： ALAVIE, Tino , BECKLEY, Keith , HUDSON, Andrew , LEONARD, Stephen, W. , MAASKANT, Robert , TALEBPOUR, Samad , YANG, William
CPC classification number: G01N35/0092 , G01N21/253 , G01N35/028 , G01N35/109 , G01N2001/288 , G01N2035/00326 , G01N2035/0422 , G01N2035/0465 , Y10T436/11 , Y10T436/111666 , Y10T436/113332 , Y10T436/2575
Abstract: The present invention provides a bar-code driven, completely automated, microplate-based analyzer system for performing chemical, biochemical or biological assays. The analyzer is a modular, bench-top instrument that compactly integrates subsystems for sample dispensing, liquid handling, microplate transport, thermal incubation, vortexing, solid phase separation and optical reading. An internal processor is included for automating the instrument, and a user interface to facilitate communication with the operator via a touch-sensitive liquid-crystal display (LCD), and communicating with a remote network via multiple protocols. The analyzer includes firmware resident within the processing system and the user interface allows the operator to select pre-defined assay batch protocols and the user interface is configured in such as way so as to restrict an operator from programming the firmware.
Abstract translation: 本发明提供了用于进行化学，生物化学或生物测定的条形码驱动的，完全自动化的基于微孔板的分析仪系统。 分析仪是一种模块化的台式仪器，可紧凑集成样品分配，液体处理，微孔板输送，热孵育，涡旋，固相分离和光学读取的子系统。 包括用于使仪器自动化的内部处理器，以及用于通过触敏液晶显示器（LCD）促进与操作者通信的用户接口，以及经由多个协议与远程网络通信。 分析器包括驻留在处理系统内的固件，用户界面允许操作员选择预定义的测试批处理协议，并且用户界面被配置为以限制操作者编程固件的方式。
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