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公开(公告)号：WO2012106722A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/024005
申请日：2012-02-06
Applicant: OPTIMER PHARMACEUTICALS, INC. , ICHIKAWA, Yoshi , GORBACH, Sherwood
Inventor： ICHIKAWA, Yoshi , GORBACH, Sherwood
CPC classification number: A61K31/7048 , A61K31/351 , A61K31/58 , A61K31/606 , A61K45/06 , Y02A50/401 , A61K2300/00
Abstract: The present invention relates to methods of treating a bacterial infection in a subject in need thereof comprising administering to the subject an effective amount of the compound of Formula (I) and an anti-inflammatory agent. The present invention provides pharmaceutical compositions comprising an effective amount of the compound of Formula (I) and an anti-inflammatory agent.
Abstract translation: 本发明涉及治疗有需要的受试者的细菌感染的方法，其包括向受试者施用有效量的式（I）化合物和抗炎剂。 本发明提供包含有效量的式（I）化合物和抗炎剂的药物组合物。
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公开(公告)号：WO2004014295A3
公开(公告)日：2005-04-14
申请号：PCT/US0321977
申请日：2003-07-15
Applicant: OPTIMER PHARMACEUTICALS INC , SHUE YOUE-KONG , DU CHI-JEN FRANK , CHIOU MING-HIS , WU MEI-CHIAO , CHEN YUAN-TING , OKUMU FRANKLIN W , DUFFIELD JONATHAN JAMES
Inventor： SHUE YOUE-KONG , DU CHI-JEN FRANK , CHIOU MING-HIS , WU MEI-CHIAO , CHEN YUAN-TING , OKUMU FRANKLIN W , DUFFIELD JONATHAN JAMES
IPC: C12P1/04 , A61K31/7048 , A61K39/00 , A61P1/00 , A61P31/04 , C07H17/08 , C12N1/20 , C12P19/62 , C12R1/01 , C12P17/18 , A61K31/70
Abstract: Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies hamdenensis having the ability to produce and accumulate one or more Tiacumicin in a nutrient medium comprising a carbon source, a nitrogen source, trace elements such as inorganic salts, and an adsorbent, wherein said nitrogen source comprises fish powder, and wherein said Tiacumicin is produced in a yield greater than about 50 mg/L broth.
Abstract translation: 通过培养属于Dactylosporangium aurantiacum subspecies hamdenensis的微生物生产和回收的方法，方法和材料，其具有在包含碳源，氮源，痕量的营养培养基中产生和积累一种或多种Tiacumicin的能力 元素如无机盐和吸附剂，其中所述氮源包括鱼粉，并且其中以大于约50mg / L肉汤的产量产生所述塔库霉素。
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公开(公告)号：WO2012106722A3
公开(公告)日：2013-01-10
申请号：PCT/US2012024005
申请日：2012-02-06
Applicant: OPTIMER PHARMACEUTICALS INC , ICHIKAWA YOSHI , GORBACH SHERWOOD
Inventor： ICHIKAWA YOSHI , GORBACH SHERWOOD
CPC classification number: A61K31/7048 , A61K31/351 , A61K31/58 , A61K31/606 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to methods of treating a bacterial infection in a subject in need thereof comprising administering to the subject an effective amount of the compound of Formula (I) and an anti-inflammatory agent. The present invention provides pharmaceutical compositions comprising an effective amount of the compound of Formula (I) and an anti-inflammatory agent.
Abstract translation: 本发明涉及治疗有需要的受试者的细菌感染的方法，其包括向受试者施用有效量的式（I）化合物和抗炎剂。 本发明提供包含有效量的式（I）化合物和抗炎剂的药物组合物。
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公开(公告)号：WO2005044197A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/036551
申请日：2004-11-01
Applicant: OPTIMER PHARMACEUTICALS, INC. , DUFFIELD, Jonathan , MARBY, Kenneth , O'HARE, Sean , HWANG, Chan-Kou , ICHIKAWA, Yoshitaka
Inventor： DUFFIELD, Jonathan , MARBY, Kenneth , O'HARE, Sean , HWANG, Chan-Kou , ICHIKAWA, Yoshitaka
IPC: A61K
CPC classification number: C07K9/001
Abstract: The present invention relates to novel glycopeptides having improved pharmacokinetic properties, improved stability, methods of preparing said novel glycopeptides, and methods to use said novel glycopeptides.
Abstract translation: 本发明涉及具有改善的药代动力学性质，改进的稳定性的新型糖肽，制备所述新型糖肽的方法以及使用所述新型糖肽的方法。
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公开(公告)号：WO2011146624A9
公开(公告)日：2012-05-10
申请号：PCT/US2011037006
申请日：2011-05-18
Applicant: OPTIMER PHARMACEUTICALS INC , SHUE YOUE-KONG , GORBACH SHERWOOD , SEARS PAMELA
Inventor： SHUE YOUE-KONG , GORBACH SHERWOOD , SEARS PAMELA
IPC: A61K31/35 , A61K31/045 , A61K31/055 , A61K31/366 , A61P1/04 , A61P31/00
CPC classification number: C07H17/08 , A61K31/7034
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Patent Agency Ranking6.发明申请TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTION IN PATIENTS UNDERGOING ANTIBIOTIC THERAPY 审中-公开治疗抗生素治疗的患者眼内感染的治疗
公开(公告)号：WO2011146621A9
公开(公告)日：2012-04-12
申请号：PCT/US2011037003
申请日：2011-05-18
Applicant: OPTIMER PHARMACEUTICALS INC , SHUE YOUE-KONG , GORBACH SHERWOOD , SEARS PAMELA
Inventor： SHUE YOUE-KONG , GORBACH SHERWOOD , SEARS PAMELA
IPC: A61K31/35 , A61K31/366 , A61K31/7036 , A61P31/00 , A61P31/04
CPC classification number: A61K31/7048 , A61K31/35 , A61K31/366 , A61K31/7036 , A61K45/06 , A61K2300/00
Abstract: The present invention relates to methods of treating Clostridium difficile infection in a subject receiving antibiotic therapy for a different infection comprising administering to the subject an effective amount of the compounds described herein.
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公开(公告)号：WO2005112990A3
公开(公告)日：2005-12-01
申请号：PCT/US2005/016750
申请日：2005-05-13
Applicant: OPTIMER PHARMACEUTICALS, INC. , SHUE, Youe-Kong , BABAKHANI, Farah, Kondori , OKUMU, Franklin, W. , SEARS, Pamela, Suzanne , MILLER-SHANGLE, Starr, Louise , WALSH, Robert, Brian
Inventor： SHUE, Youe-Kong , BABAKHANI, Farah, Kondori , OKUMU, Franklin, W. , SEARS, Pamela, Suzanne , MILLER-SHANGLE, Starr, Louise , WALSH, Robert, Brian
IPC: A61K31/00
Abstract: This invention relates to the treatment or prevention of diseases associated with the use of antibiotics or cancer chemotherapies or antiviral therapies, such as colitis, pseudomembranous colitis, antibiotic associated diarrhea and infections due to C. difficile, C. perfringens, Staphylococcus species including methicillin-resistant Staphylococcus aureus (MRSA) or Enterococcus including vancomycin-resistant enterococci (VRE) with Compound I.
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8.发明申请
公开(公告)号：WO2005044197A3
公开(公告)日：2005-08-18
申请号：PCT/US2004036551
申请日：2004-11-01
Applicant: OPTIMER PHARMACEUTICALS INC , DUFFIELD JONATHAN , MARBY KENNETH , O'HARE SEAN , HWANG CHAN-KOU , ICHIKAWA YOSHITAKA
Inventor： DUFFIELD JONATHAN , MARBY KENNETH , O'HARE SEAN , HWANG CHAN-KOU , ICHIKAWA YOSHITAKA
IPC: A61K20060101 , A61K38/14 , A61K38/16 , C07K9/00 , C07K14/00
CPC classification number: C07K9/001
Abstract: The present invention relates to novel glycopeptides having improved pharmacokinetic properties, improved stability, methods of preparing said novel glycopeptides, and methods to use said novel glycopeptides.
Abstract translation: 本发明涉及具有改善的药代动力学性质，改进的稳定性，制备所述新型糖肽的方法的新型糖肽和使用所述新型糖肽的方法。
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9.发明申请TREATMENT OF DEGENERAATIVE CARTILAGE CONDITIONS IN A MAMMAL WITH GLYCOSIDASE INHIBITORS 审中-公开用谷氨酰胺酶抑制剂治疗乳腺癌患者的退化性病情
公开(公告)号：WO2005072268A2
公开(公告)日：2005-08-11
申请号：PCT/US2005/002017
申请日：2005-01-20
Applicant: OPTIMER PHARMACEUTICALS, INC. , ICHIKAWA, Yoshitaka , SHUE, Youe-Kong , ORIDA, Norman, K. , LOTZ, Martin , WONG, Chi-Huey , OKUMU, Franklin, W. , HWANG, San-Bao
Inventor： ICHIKAWA, Yoshitaka , SHUE, Youe-Kong , ORIDA, Norman, K. , LOTZ, Martin , WONG, Chi-Huey , OKUMU, Franklin, W. , HWANG, San-Bao
CPC classification number: A61K45/06 , A61K9/0019 , A61K31/00 , A61K31/336 , A61K31/40 , A61K31/4015 , A61K31/435 , A61K31/445 , A61K31/4745 , A61K31/55 , A61K31/70 , A61K31/7008 , A61K2300/00
Abstract: This invention relates to treating, preventing, and lessening the severity of conditions selected from the group consisting of osteoarthritis, rheumatoid arthritis, synovitis, subchondral bone edema, and cartilage degradation with administration of glycosidase inhibitors.
Abstract translation: 本发明涉及治疗，预防和减轻选自骨关节炎，类风湿性关节炎，滑膜炎，软骨下骨水肿和通过施用糖苷酶抑制剂的软骨降解的病症的严重性。
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10.发明申请TREATMENT OF CLOSTRIDIUM DIFFICILE INFECTION IN PATIENTS UNDERGOING ANTIBIOTIC THERAPY 审中-公开治疗抗生素治疗的患者眼内感染的治疗
公开(公告)号：WO2011146621A2
公开(公告)日：2011-11-24
申请号：PCT/US2011/037003
申请日：2011-05-18
Applicant: OPTIMER PHARMACEUTICALS, INC. , SHUE, Youe-Kong , GORBACH, Sherwood , SEARS, Pamela
Inventor： SHUE, Youe-Kong , GORBACH, Sherwood , SEARS, Pamela
CPC classification number: A61K31/7048 , A61K31/35 , A61K31/366 , A61K31/7036 , A61K45/06 , Y02A50/401 , Y02A50/411 , Y02A50/47 , Y02A50/473 , Y02A50/478 , Y02A50/481 , A61K2300/00
Abstract: The present invention relates to methods of treating Clostridium difficile infection in a subject receiving antibiotic therapy for a different infection comprising administering to the subject an effective amount of the compounds described herein.
Abstract translation: 本发明涉及在接受针对不同感染的抗生素治疗的受试者中治疗艰难梭菌感染的方法，其包括向受试者施用有效量的本文所述的化合物。
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