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1.发明申请GLYCOSYLATED PEPTIDE ANTAGONISTS OF THE BRADYKININ B1 RECEPTOR 审中-公开BRADYKININ B1受体的GLYCOSYLATED PEPTIDE ANTAGONISTS
公开(公告)号：WO2008011168A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/016489
申请日：2007-07-20
Applicant: Amgen Inc. , D'AMICO, Derin C. , ASKEW, Benny C. , ICHIKAWA, Yoshitaka , DUFFIELD, Jonathan
Inventor： D'AMICO, Derin C. , ASKEW, Benny C. , ICHIKAWA, Yoshitaka , DUFFIELD, Jonathan
Abstract: A compositions of matter and pharmaceutical compositions are disclosed, which in various embodiments, comprise biologically active glycosylated peptides that can be used therapeutically or prophylactically against diseases or conditions linked to bradykinin B1 receptor as the causative agent. A method of treating, preventing, or ameliorating a disease or condition associated with B1 activity is also disclosed.
Abstract translation: 公开了物质和药物组合物的组合物，其在各种实施方案中包含可用于治疗或预防性地用于与缓激肽B1受体作为致病因子连接的疾病或病症的生物活性糖基化肽。 还公开了治疗，预防或改善与B1活性相关的疾病或病症的方法。
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公开(公告)号：WO2007061741A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/044479
申请日：2006-11-16
Applicant: ARENA PHARMACEUTICALS, INC. , SANTORA, Vincent J. , COVEL, Jonathan A. , HAYASHI, Rena , WEBB, Robert R. , REN, Albert S. , CHEN, Weichao G. , DUFFIELD, Jonathan J. , IBARRA, Jason B. , PULLEY, Michelle , SEMPLE, Graeme , WEINHOUSE, Michael I.
Inventor： SANTORA, Vincent J. , COVEL, Jonathan A. , HAYASHI, Rena , WEBB, Robert R. , REN, Albert S. , CHEN, Weichao G. , DUFFIELD, Jonathan J. , IBARRA, Jason B. , PULLEY, Michelle , SEMPLE, Graeme , WEINHOUSE, Michael I.
IPC: C07D209/52 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/10 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/04 , A61K31/403 , A61K31/422 , A61K31/4402 , A61K31/4406 , A61K31/4409
Abstract: The present invention relates to certain fused heterobicyclic derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the H3 receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, motion sickness and vertigo, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.
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公开(公告)号：WO2005044197A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/036551
申请日：2004-11-01
Applicant: OPTIMER PHARMACEUTICALS, INC. , DUFFIELD, Jonathan , MARBY, Kenneth , O'HARE, Sean , HWANG, Chan-Kou , ICHIKAWA, Yoshitaka
Inventor： DUFFIELD, Jonathan , MARBY, Kenneth , O'HARE, Sean , HWANG, Chan-Kou , ICHIKAWA, Yoshitaka
IPC: A61K
CPC classification number: C07K9/001
Abstract: The present invention relates to novel glycopeptides having improved pharmacokinetic properties, improved stability, methods of preparing said novel glycopeptides, and methods to use said novel glycopeptides.
Abstract translation: 本发明涉及具有改善的药代动力学性质，改进的稳定性的新型糖肽，制备所述新型糖肽的方法以及使用所述新型糖肽的方法。
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4.发明申请
公开(公告)号：WO2008011168A3
公开(公告)日：2008-06-05
申请号：PCT/US2007016489
申请日：2007-07-20
Applicant: AMGEN INC , D AMICO DERIN C , ASKEW BENNY C , ICHIKAWA YOSHITAKA , DUFFIELD JONATHAN
Inventor： D AMICO DERIN C , ASKEW BENNY C , ICHIKAWA YOSHITAKA , DUFFIELD JONATHAN
Abstract: A compositions of matter and pharmaceutical compositions are disclosed, which in various embodiments, comprise biologically active glycosylated peptides that can be used therapeutically or prophylactically against diseases or conditions linked to bradykinin B1 receptor as the causative agent. A method of treating, preventing, or ameliorating a disease or condition associated with B1 activity is also disclosed.
Abstract translation: 公开了物质组合物和药物组合物，其在各种实施方案中包含生物活性糖基化肽，其可以在治疗上或预防上用作与作为致病因子的缓激肽B1受体相关的疾病或病症。 还公开了治疗，预防或改善与B1活性有关的疾病或病症的方法。
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公开(公告)号：WO2004014295A2
公开(公告)日：2004-02-19
申请号：PCT/US2003/021977
申请日：2003-07-15
Applicant: OPTIMER PHARMACEUTICALS, INC. , SHUE, Youe-Kong , DU, Chi-Jen, Frank , CHIOU, Ming-His , WU, Mei-Chiao , CHEN, Yuan-Ting , OKUMU, Franklin, W. , DUFFIELD, Jonathan, James
Inventor： SHUE, Youe-Kong , DU, Chi-Jen, Frank , CHIOU, Ming-His , WU, Mei-Chiao , CHEN, Yuan-Ting , OKUMU, Franklin, W. , DUFFIELD, Jonathan, James
IPC: A61K
Abstract: Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies hamdenensis having the ability to produce and accumulate one or more Tiacumicin in a nutrient medium comprising a carbon source, a nitrogen source, trace elements such as inorganic salts, and an adsorbent, wherein said nitrogen source comprises fish powder, and wherein said Tiacumicin is produced in a yield greater than about 50 mg/L broth.
Abstract translation: 通过培养属于具有产生和积累一种或多种Tiacumicin的营养培养基的能力的属于Dactylosporangium aurantiacum亚种hamdenensis的微生物生产和回收的塔库霉素的方法，方法和材料，所述培养基包含碳源，氮源，痕量 元素如无机盐和吸附剂，其中所述氮源包括鱼粉，并且其中以大于约50mg / L肉汤的产量生产所述塔库霉素。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2005044197A3
公开(公告)日：2005-08-18
申请号：PCT/US2004036551
申请日：2004-11-01
Applicant: OPTIMER PHARMACEUTICALS INC , DUFFIELD JONATHAN , MARBY KENNETH , O'HARE SEAN , HWANG CHAN-KOU , ICHIKAWA YOSHITAKA
Inventor： DUFFIELD JONATHAN , MARBY KENNETH , O'HARE SEAN , HWANG CHAN-KOU , ICHIKAWA YOSHITAKA
IPC: A61K20060101 , A61K38/14 , A61K38/16 , C07K9/00 , C07K14/00
CPC classification number: C07K9/001
Abstract: The present invention relates to novel glycopeptides having improved pharmacokinetic properties, improved stability, methods of preparing said novel glycopeptides, and methods to use said novel glycopeptides.
Abstract translation: 本发明涉及具有改善的药代动力学性质，改进的稳定性，制备所述新型糖肽的方法的新型糖肽和使用所述新型糖肽的方法。
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7.发明申请MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开H3受体调节剂可用于治疗与其有关的疾病
公开(公告)号：WO2007061741A2
公开(公告)日：2007-05-31
申请号：PCT/US2006044479
申请日：2006-11-16
Applicant: ARENA PHARM INC , SANTORA VINCENT J , COVEL JONATHAN A , HAYASHI RENA , WEBB ROBERT R , REN ALBERT S , CHEN WEICHAO G , DUFFIELD JONATHAN J , IBARRA JASON B , PULLEY MICHELLE , SEMPLE GRAEME , WEINHOUSE MICHAEL I
Inventor： SANTORA VINCENT J , COVEL JONATHAN A , HAYASHI RENA , WEBB ROBERT R , REN ALBERT S , CHEN WEICHAO G , DUFFIELD JONATHAN J , IBARRA JASON B , PULLEY MICHELLE , SEMPLE GRAEME , WEINHOUSE MICHAEL I
CPC classification number: C07D209/52 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/10 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/04
Abstract: The present invention relates to certain fused heterobicyclic derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the H3 receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, motion sickness and vertigo, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.
Abstract translation: 本发明涉及调节H3受体活性的式（Ia）的某些稠合杂双环衍生物及其药物组合物。 其化合物和药物组合物涉及用于治疗H3相关病症例如认知障碍，癫痫症，脑创伤，抑郁症，肥胖症，晕动病和眩晕，睡眠和觉醒失调例如发作性睡病，偏头痛， 工作综合症，作为药物副作用的困倦，保持警惕以帮助完成任务等，猝倒，睡眠过度，嗜睡综合征，时差，睡眠呼吸暂停等，注意力缺陷多动障碍（ADHD），精神分裂症 ，过敏，上呼吸道过敏反应，过敏性鼻炎，鼻充血，痴呆，阿尔茨海默病等。
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公开(公告)号：WO2004014295A3
公开(公告)日：2005-04-14
申请号：PCT/US0321977
申请日：2003-07-15
Applicant: OPTIMER PHARMACEUTICALS INC , SHUE YOUE-KONG , DU CHI-JEN FRANK , CHIOU MING-HIS , WU MEI-CHIAO , CHEN YUAN-TING , OKUMU FRANKLIN W , DUFFIELD JONATHAN JAMES
Inventor： SHUE YOUE-KONG , DU CHI-JEN FRANK , CHIOU MING-HIS , WU MEI-CHIAO , CHEN YUAN-TING , OKUMU FRANKLIN W , DUFFIELD JONATHAN JAMES
IPC: C12P1/04 , A61K31/7048 , A61K39/00 , A61P1/00 , A61P31/04 , C07H17/08 , C12N1/20 , C12P19/62 , C12R1/01 , C12P17/18 , A61K31/70
Abstract: Methods, processes and materials for the production and recovery of Tiacumicins produced by culturing a microorganism belonging to the species Dactylosporangium aurantiacum subspecies hamdenensis having the ability to produce and accumulate one or more Tiacumicin in a nutrient medium comprising a carbon source, a nitrogen source, trace elements such as inorganic salts, and an adsorbent, wherein said nitrogen source comprises fish powder, and wherein said Tiacumicin is produced in a yield greater than about 50 mg/L broth.
Abstract translation: 通过培养属于Dactylosporangium aurantiacum subspecies hamdenensis的微生物生产和回收的方法，方法和材料，其具有在包含碳源，氮源，痕量的营养培养基中产生和积累一种或多种Tiacumicin的能力 元素如无机盐和吸附剂，其中所述氮源包括鱼粉，并且其中以大于约50mg / L肉汤的产量产生所述塔库霉素。
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公开(公告)号：WO2004080391A3
公开(公告)日：2005-02-17
申请号：PCT/US2004006645
申请日：2004-03-05
Applicant: OPTIMER PHARMACEUTICALS INC , LIANG CHANG-HSING , DUFFIELD JONATHAN , ROMERO ALEX , CHIU YU-HUNG , RABUKA DAVID , YAO SULAN , SUCHECK STEVE , MARBY KENNETH , SHUE YOUE-KONG , ICHIKAWA YOSHIAKI , HWANG CHAN-KOU
Inventor： LIANG CHANG-HSING , DUFFIELD JONATHAN , ROMERO ALEX , CHIU YU-HUNG , RABUKA DAVID , YAO SULAN , SUCHECK STEVE , MARBY KENNETH , SHUE YOUE-KONG , ICHIKAWA YOSHIAKI , HWANG CHAN-KOU
IPC: A61K20060101 , A61K31/33 , A61K31/335 , A61K31/555 , A61K31/70 , C07D225/00 , C07D267/02 , C07D281/02 , C07D295/00 , C07H17/08
CPC classification number: C07D498/04 , C07H17/08
Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides for preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
Abstract translation: 本发明涉及新型大环内酯类，制备新型大环内酯类，使用这种新型大环内酯类来预防，治疗或改善各种病症，以及使用这种新型大环内酯类作为抗菌剂。
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公开(公告)号：WO2004080391A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/006645
申请日：2004-03-05
Applicant: OPTIMER PHARMACEUTICALS, INC. , LIANG, Chang-Hsing , DUFFIELD, Jonathan , ROMERO, Alex , CHIU, Yu-Hung , RABUKA, David , YAO, Sulan , SUCHECK, Steve , MARBY, Kenneth , SHUE, Youe-Kong , ICHIKAWA, Yoshiaki , HWANG, Chan-Kou
Inventor： LIANG, Chang-Hsing , DUFFIELD, Jonathan , ROMERO, Alex , CHIU, Yu-Hung , RABUKA, David , YAO, Sulan , SUCHECK, Steve , MARBY, Kenneth , SHUE, Youe-Kong , ICHIKAWA, Yoshiaki , HWANG, Chan-Kou
IPC: A61K
CPC classification number: C07D498/04 , C07H17/08
Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides for preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
Abstract translation: 本发明涉及新型大环内酯类，制备新型大环内酯类，使用这种新型大环内酯类来预防，治疗或改善各种病症，以及使用这种新型大环内酯类作为抗菌剂。
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