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1.发明申请
公开(公告)号：WO9932448A8
公开(公告)日：2001-04-19
申请号：PCT/US9827298
申请日：1998-12-21
Applicant: AMGEN INC , MANTLO NATHAN B , HWANG CHAN KOU , SPOHR ULRIKE D
Inventor： MANTLO NATHAN B , HWANG CHAN KOU , SPOHR ULRIKE D
IPC: A61K31/4409 , A61K31/4418 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/501 , A61K31/506 , A61P3/10 , A61P19/10 , A61P25/04 , A61P29/00 , A61P31/12 , A61P35/00 , A61P43/00 , C07D213/64 , C07D213/74 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , A61K31/44 , A61K31/50
CPC classification number: C07D213/64 , C07D213/74 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14
Abstract: Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF- alpha , IL-1 beta , IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 选择的新型取代的吡啶和哒嗪化合物可有效预防和治疗诸如TNF-α，IL-1β，IL-6和/或IL-8介导的疾病以及其它疾病如癌症，疼痛和糖尿病 。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及炎症，癌症，疼痛，糖尿病等的疾病的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：WO2009061894A1
公开(公告)日：2009-05-14
申请号：PCT/US2008/082597
申请日：2008-11-06
Applicant: PHARMAESSENTIA CORPORATION , CHU, Chi-Yuan , LEE, Wei-Der , LI, Wensen , HWANG, Chan Kou
Inventor： CHU, Chi-Yuan , LEE, Wei-Der , LI, Wensen , HWANG, Chan Kou
IPC: A61K31/7076 , A61K38/20 , A61K38/21
Abstract: This invention relates to a process of stereoselectively synthesizing -nucleoside, e.g., 2'-deoxy-2,2'-difluorocytidine.
Abstract translation: 本发明涉及立体选择性合成核苷的方法，例如2'-脱氧-2,2'-二氟胞苷。
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Patent Agency Ranking3.发明申请
公开(公告)号：WO2005044197A3
公开(公告)日：2005-08-18
申请号：PCT/US2004036551
申请日：2004-11-01
Applicant: OPTIMER PHARMACEUTICALS INC , DUFFIELD JONATHAN , MARBY KENNETH , O'HARE SEAN , HWANG CHAN-KOU , ICHIKAWA YOSHITAKA
Inventor： DUFFIELD JONATHAN , MARBY KENNETH , O'HARE SEAN , HWANG CHAN-KOU , ICHIKAWA YOSHITAKA
IPC: A61K20060101 , A61K38/14 , A61K38/16 , C07K9/00 , C07K14/00
CPC classification number: C07K9/001
Abstract: The present invention relates to novel glycopeptides having improved pharmacokinetic properties, improved stability, methods of preparing said novel glycopeptides, and methods to use said novel glycopeptides.
Abstract translation: 本发明涉及具有改善的药代动力学性质，改进的稳定性，制备所述新型糖肽的方法的新型糖肽和使用所述新型糖肽的方法。
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公开(公告)号：WO2005044197A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/036551
申请日：2004-11-01
Applicant: OPTIMER PHARMACEUTICALS, INC. , DUFFIELD, Jonathan , MARBY, Kenneth , O'HARE, Sean , HWANG, Chan-Kou , ICHIKAWA, Yoshitaka
Inventor： DUFFIELD, Jonathan , MARBY, Kenneth , O'HARE, Sean , HWANG, Chan-Kou , ICHIKAWA, Yoshitaka
IPC: A61K
CPC classification number: C07K9/001
Abstract: The present invention relates to novel glycopeptides having improved pharmacokinetic properties, improved stability, methods of preparing said novel glycopeptides, and methods to use said novel glycopeptides.
Abstract translation: 本发明涉及具有改善的药代动力学性质，改进的稳定性的新型糖肽，制备所述新型糖肽的方法以及使用所述新型糖肽的方法。
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公开(公告)号：WO2006085838A1
公开(公告)日：2006-08-17
申请号：PCT/US2005/002887
申请日：2005-01-31
Applicant: OPTIMER PHARMACEUTICALS, INC. , SHUE, Youe-Kong , HWANG, Chan-Kou , CHIU, Yu-Hung , ROMERO, Alex , BABAKHANI, Farah , SEARS, Pamela , OKUMU, Franklin
Inventor： SHUE, Youe-Kong , HWANG, Chan-Kou , CHIU, Yu-Hung , ROMERO, Alex , BABAKHANI, Farah , SEARS, Pamela , OKUMU, Franklin
IPC: A01N43/04
Abstract: The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
Abstract translation: 本发明一般涉及称为塔库霉素的18元大环抗微生物剂，特别是OPT-80（其几乎完全由R-Tiacumicin B组成），包含OPT-80的药物组合物和使用OPT-80的方法。 特别地，该化合物是用于治疗细菌感染，特别是艰难梭菌感染的有效药物。
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公开(公告)号：WO2004080391A3
公开(公告)日：2005-02-17
申请号：PCT/US2004006645
申请日：2004-03-05
Applicant: OPTIMER PHARMACEUTICALS INC , LIANG CHANG-HSING , DUFFIELD JONATHAN , ROMERO ALEX , CHIU YU-HUNG , RABUKA DAVID , YAO SULAN , SUCHECK STEVE , MARBY KENNETH , SHUE YOUE-KONG , ICHIKAWA YOSHIAKI , HWANG CHAN-KOU
Inventor： LIANG CHANG-HSING , DUFFIELD JONATHAN , ROMERO ALEX , CHIU YU-HUNG , RABUKA DAVID , YAO SULAN , SUCHECK STEVE , MARBY KENNETH , SHUE YOUE-KONG , ICHIKAWA YOSHIAKI , HWANG CHAN-KOU
IPC: A61K20060101 , A61K31/33 , A61K31/335 , A61K31/555 , A61K31/70 , C07D225/00 , C07D267/02 , C07D281/02 , C07D295/00 , C07H17/08
CPC classification number: C07D498/04 , C07H17/08
Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides for preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
Abstract translation: 本发明涉及新型大环内酯类，制备新型大环内酯类，使用这种新型大环内酯类来预防，治疗或改善各种病症，以及使用这种新型大环内酯类作为抗菌剂。
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公开(公告)号：WO2004080391A2
公开(公告)日：2004-09-23
申请号：PCT/US2004/006645
申请日：2004-03-05
Applicant: OPTIMER PHARMACEUTICALS, INC. , LIANG, Chang-Hsing , DUFFIELD, Jonathan , ROMERO, Alex , CHIU, Yu-Hung , RABUKA, David , YAO, Sulan , SUCHECK, Steve , MARBY, Kenneth , SHUE, Youe-Kong , ICHIKAWA, Yoshiaki , HWANG, Chan-Kou
Inventor： LIANG, Chang-Hsing , DUFFIELD, Jonathan , ROMERO, Alex , CHIU, Yu-Hung , RABUKA, David , YAO, Sulan , SUCHECK, Steve , MARBY, Kenneth , SHUE, Youe-Kong , ICHIKAWA, Yoshiaki , HWANG, Chan-Kou
IPC: A61K
CPC classification number: C07D498/04 , C07H17/08
Abstract: This invention relates to novel macrolides, to the preparation of novel macrolides, to the use of such novel macrolides for preventing, treating, or ameliorating various conditions, and to the use of such novel macrolides as antibacterial agents.
Abstract translation: 本发明涉及新型大环内酯类，制备新型大环内酯类，使用这种新型大环内酯类来预防，治疗或改善各种病症，以及使用这种新型大环内酯类作为抗菌剂。
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