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公开(公告)号：WO2007149802A3
公开(公告)日：2008-04-10
申请号：PCT/US2007071433
申请日：2007-06-18
申请人： 3M INNOVATIVE PROPERTIES CO , GORSKI KEVIN S , ORTIZ RONNIE , STOESZ JAMES D , ZARRAGA ISIDRO ANGELO E
CPC分类号： A61K9/06 , A61K9/0019 , A61K9/0024 , A61K2039/55511
摘要： The present invention provides pharmaceutical compositions that include an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel. In another aspect, the present invention also provides a method of eliciting an antigen-specific immune response in a subject. Generally, the method includes administering to the subject a pharmaceutical composition comprising an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel, in an amount effective to generate an immune response in the subject against the antigen. In yet another aspect, the present invention also provides a method of treating a condition in a subject. Generally, the method includes administering to the subject a pharmaceutical composition comprising an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel, in an amount effective to ameliorate at least one symptom or clinical sign of the condition.
摘要翻译： 本发明提供药物组合物，其包含IRM-PEG复合物和抗原，一起配制在热反应凝胶中。 另一方面，本发明还提供在受试者中引发抗原特异性免疫应答的方法。 通常，该方法包括向受试者施用包含IRM-PEG复合物和抗原的药物组合物，该组合物和抗原一起配制在热反应性凝胶中，其数量有效地在受试者中针对抗原产生免疫应答。 在另一方面，本发明还提供了治疗受试者的病症的方法。 通常，该方法包括向受试者施用包含IRM-PEG复合物和抗原的药物组合物，该组合物和抗原一起配制在热反应凝胶中，其量可以有效地改善至少一种症状或临床症状。
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公开(公告)号：WO2007149802A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/071433
申请日：2007-06-18
申请人： 3M INNOVATIVE PROPERTIES COMPANY , GORSKI, Kevin S. , ORTIZ, Ronnie , STOESZ, James D. , ZARRAGA, Isidro Angelo E.
CPC分类号： A61K9/06 , A61K9/0019 , A61K9/0024 , A61K2039/55511
摘要： The present invention provides pharmaceutical compositions that include an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel. In another aspect, the present invention also provides a method of eliciting an antigen-specific immune response in a subject. Generally, the method includes administering to the subject a pharmaceutical composition comprising an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel, in an amount effective to generate an immune response in the subject against the antigen. In yet another aspect, the present invention also provides a method of treating a condition in a subject. Generally, the method includes administering to the subject a pharmaceutical composition comprising an IRM-PEG complex and an antigen, formulated together in a thermoresponsive gel, in an amount effective to ameliorate at least one symptom or clinical sign of the condition.
摘要翻译： 本发明提供药物组合物，其包含IRM-PEG复合物和抗原，一起配制在热反应凝胶中。 另一方面，本发明还提供在受试者中引发抗原特异性免疫应答的方法。 通常，该方法包括向受试者施用包含IRM-PEG复合物和抗原的药物组合物，该组合物和抗原一起配制在热反应性凝胶中，其数量有效地在受试者中针对抗原产生免疫应答。 在另一方面，本发明还提供了治疗受试者的病症的方法。 通常，该方法包括向受试者施用包含IRM-PEG复合物和抗原的药物组合物，该组合物和抗原一起配制在热反应凝胶中，其量可以有效地改善至少一种症状或临床症状。
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3.发明申请METHODS, COMPOSITIONS, AND PREPARATIONS FOR DELIVERY OF IMMUNE RESPONSE MODIFIERS 审中-公开免疫反应调节剂的输送方法，组合物和制剂
公开(公告)号：WO2005110013A3
公开(公告)日：2006-03-16
申请号：PCT/US2005011997
申请日：2005-04-08
CPC分类号： A61K39/39 , A61K31/4745 , A61K39/0011 , A61K47/60 , A61K2039/55511 , A61K2039/55555
摘要： A soluble IRM-polymer complex, preparations thereof, and methods of use, wherein the soluble IRM-polymer complex includes one or more IRM compounds attached (e.g., covalently attached) to a polymer (e.g., an alkylene oxide-containing polymer).
摘要翻译： 可溶性IRM-聚合物复合物，其制备方法和使用方法，其中可溶性IRM-聚合物复合物包括与聚合物（例如含烯化氧的聚合物）连接（例如共价连接）的一种或多种IRM化合物。
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4.发明申请METHODS, COMPOSITIONS, AND PREPARATIONS FOR DELIVERY OF IMMUNE RESPONSE MODIFIERS 审中-公开免疫反应调节剂的输送方法，组合物和制剂
公开(公告)号：WO2005110013A2
公开(公告)日：2005-11-24
申请号：PCT/US2005/011997
申请日：2005-04-08
申请人： 3M INNOVATIVE PROPERTIES COMPANY , ZARRAGA, Isidro, Angelo, E. , STOESZ, James, D. , ORTIZ, Ronnie
IPC分类号： A61K31/4745 , A61K39/00 , A61K39/39
CPC分类号： A61K39/39 , A61K31/4745 , A61K39/0011 , A61K47/60 , A61K2039/55511 , A61K2039/55555
摘要： A soluble IRM-polymer complex, preparations thereof, and methods of use, wherein the soluble IRM-polymer complex includes one or more IRM compounds attached (e.g., covalently attached) to a polymer (e.g., an alkylene oxide-containing polymer).
摘要翻译： 可溶性IRM-聚合物复合物，其制备方法和使用方法，其中可溶性IRM-聚合物复合物包括与聚合物（例如含烯化氧的聚合物）连接（例如共价连接）的一种或多种IRM化合物。
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5.发明申请BIS [4-AMINO-2-(ETHOXYMETHYL)-1-(2-HYDROXY-2-METHYLPROPYL)-1H-IMIDAZO[4,5-c]QUINOLIN-5-IUM] 4-[(3-CARBOXYLATO-2-HYDROXYNAPHTHALEN-1-YL)METHYL]-3-HYDROXYNAPHTHALENE-2-CARBOXYLATE COMPOSITIONS AND METHODS 审中-公开BIS [4-氨基-2-（乙氧基甲基）-1-（2-羟基-2-甲基丙酰基）-1H-咪唑并[4,5-c]喹啉-5-基] 4 - [（3-羧基-2- 羟基苯甲酸1-YL）甲基] -3-羟基苯甲酸-2-羧酸酯组合物和方法
公开(公告)号：WO2011084726A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/061196
申请日：2010-12-20
申请人： 3M INNOVATIVE PROPERTIES COMPANY , WU, Zheng, Zhi , ORTIZ, Ronnie , ZARRAGA, Isidro, Angelo, E. , HARRISON, Lester, I. , BEAURLINE, Joseph, M.
发明人： WU, Zheng, Zhi , ORTIZ, Ronnie , ZARRAGA, Isidro, Angelo, E. , HARRISON, Lester, I. , BEAURLINE, Joseph, M.
IPC分类号： C07D471/04 , A61K39/39 , A61P35/00 , A61K31/4745 , A61P31/12 , C07C65/11
CPC分类号： C07D471/04 , A61K31/4745 , A61K39/39 , A61K2039/55511 , C07C65/11 , Y02A50/412
摘要： A compound of formula: Pharmaceutical compositions containing the compound, and methods of inducing cytokine biosynthesis in an animal, treating a viral infection and/or treating a neoplastic disease in an animal by administering an effective amount of the compound to the animal are also disclosed.
摘要翻译： 还公开了下列化合物：还给出了含有该化合物的药物组合物，以及在动物中诱导细胞因子生物合成的方法，通过向动物施用有效量的化合物来治疗动物的病毒感染和/或治疗肿瘤性疾病。
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公开(公告)号：WO2005001022A2
公开(公告)日：2005-01-06
申请号：PCT/US2004/011085
申请日：2004-04-09
申请人： 3M INNOVATIVE PROPERTIES COMPANY , MILLER, Richard, L. , TOMAI, Mark, A. , KEDL, Ross, M. , ZARRAGA, Isidro, Angelo, E. , ORTIZ, Ronnie , STOESZ, James, D.
发明人： MILLER, Richard, L. , TOMAI, Mark, A. , KEDL, Ross, M. , ZARRAGA, Isidro, Angelo, E. , ORTIZ, Ronnie , STOESZ, James, D.
IPC分类号： C12N
CPC分类号： A61K47/6907 , A61K47/543
摘要： Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.
摘要翻译： 用于通过在局部组织区域内沉积IRM储库制剂来增强对IRM化合物的免疫应答的方法和组合物，所述IRM储库制剂提供活性IRM在局部组织区域内的延长滞留时间。
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公开(公告)号：WO2005001022A3
公开(公告)日：2005-09-15
申请号：PCT/US2004011085
申请日：2004-04-09
申请人： 3M INNOVATIVE PROPERTIES CO , MILLER RICHARD L , TOMAI MARK A , KEDL ROSS M , ZARRAGA ISIDRO ANGELO E , ORTIZ RONNIE , STOESZ JAMES D , WIGHTMAN PAUL D
发明人： MILLER RICHARD L , TOMAI MARK A , KEDL ROSS M , ZARRAGA ISIDRO ANGELO E , ORTIZ RONNIE , STOESZ JAMES D , WIGHTMAN PAUL D
CPC分类号： A61K47/6907 , A61K47/543
摘要： Methods and compositions for enhancing the immune response to an IRM compound by depositing within a localized tissue region an IRM depot preparation that provides an extended residence time of active IRM within the localized tissue region.
摘要翻译： 通过在局部组织区域内沉积IRM贮库制剂来提供IRM化合物的免疫应答的方法和组合物，其提供活性IRM在局部组织区域内延长的停留时间。
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8.发明申请SUSTAINED RELEASE COMPOSITION COMPRISING AN AMINE AS ACTIVE AGENT AND A SALT OF A CYCLIC ORGANIC ACID 审中-公开包含胺作为活性剂和循环有机酸的盐的持续释放组合物
公开(公告)号：WO2012003231A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042428
申请日：2011-06-29
申请人： UPSHER-SMITH LABORATORIES, INC. , ORTIZ, Ronnie , JENSEN, James, S. , LUNDELL, Kristopher, R. , O'NEILL, Victoria, Ann , MAHONEY, Sean
发明人： ORTIZ, Ronnie , JENSEN, James, S. , LUNDELL, Kristopher, R. , O'NEILL, Victoria, Ann , MAHONEY, Sean
IPC分类号： A61K9/20 , A61K31/135 , A61K31/485
CPC分类号： A61K9/2013 , A61K9/2054 , A61K31/135 , A61K31/137 , A61K31/192 , A61K31/485
摘要： The present invention provides sustained-release oral pharmaceutical compositions and methods of use. The sustained-release oral pharmaceutical compositions include an amine-containing compound (e.g., an opioid) (including salts thereof) and a pharmaceutically acceptable salt of a non-NSAID cyclic organic acid compound.
摘要翻译： 本发明提供持续释放的口服药物组合物和使用方法。 持续释放的口服药物组合物包括含有胺的化合物（例如阿片样物质）（包括其盐）和非NSAID环状有机酸化合物的药学上可接受的盐。
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9.发明申请4-AMINO-2-(ETHOXYMETHYL)-1-(2-HYDROXY-2-METHYLPROPYL)-1H-IMIDAZO[4,5-c]QUINOLIN-5-IUM 1-HYDROXYNAPHTHALENE-2-CARBOXYLATE COMPOSITIONS AND METHODS 审中-公开4-氨基-2-（乙氧基甲基）-1-（2-羟基-2-甲基丙烯酰基）-1H-咪唑并[4,5-c]喹啉-5-基-1-羟基苯甲酸-2-羧酸酯组合物和方法
公开(公告)号：WO2011084725A1
公开(公告)日：2011-07-14
申请号：PCT/US2010/061194
申请日：2010-12-20
申请人： 3M INNOVATIVE PROPERTIES COMPANY , WU, Zheng Zhi , ORTIZ, Ronnie , HARRISON, Lester, I. , BEAURLINE, Joseph, M.
IPC分类号： C07D471/04 , A61K39/39 , A61P35/00 , A61K31/4745 , A61P31/12 , C07C65/11
CPC分类号： C07D471/04 , A61K31/4745 , A61K39/39 , A61K2039/55511 , C07C65/11 , Y02A50/41 , Y02A50/412
摘要： A compound of formula:[ I ] Pharmaceutical compositions containing the compound, and methods of inducing cytokine biosynthesis in an animal, treating a viral infection and/or treating a neoplastic disease in an animal by administering an effective amount of the compound to the animal are also disclosed.
摘要翻译： 式I化合物：含有该化合物的药物组合物，以及在动物中诱导细胞因子生物合成的方法，通过向动物施用有效量的化合物来治疗动物的病变感染和/或治疗肿瘤性疾病是 也披露。
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