公开(公告)号：WO2008036967A2

公开(公告)日：2008-03-27

申请号：PCT/US2007079286

申请日：2007-09-24

Applicant: REDDY US THERAPEUTICS INC ,  REDDY DUMBALA SRINIVAS ,  PADMALAYAM INDIRA ,  BHUNIYA DEBNATH ,  PILLARISETTI SIVARAM ,  CHAKRABARTI RANJAN

Inventor： REDDY DUMBALA SRINIVAS ,  PADMALAYAM INDIRA ,  BHUNIYA DEBNATH ,  PILLARISETTI SIVARAM ,  CHAKRABARTI RANJAN

IPC: A61K31/405

CPC classification number: C07D209/12 ,  C07D209/18 ,  C07D401/06

Abstract: This invention provides a compound of formula (I), which is a free species and/or a pharmaceutically-acceptable salt or a stereoisomer of the compound of formula (I). Another aspect of the present invention provides the compound of the formula (I) as a Lipoic acid synthase (LASY) inducer

Abstract translation: 本发明提供式（I）化合物，其是式（I）化合物的游离物质和/或药学上可接受的盐或立体异构体。 本发明的另一方面提供了作为硫辛酸合酶（LASY）诱导剂的式（I）化合物

公开(公告)号：WO2008036967A3

公开(公告)日：2008-03-27

申请号：PCT/US2007/079286

申请日：2007-09-24

Applicant: Reddy US Therapeutics, Inc. ,  REDDY, Dumbala Srinivas ,  PADMALAYAM, Indira ,  BHUNIYA, Debnath ,  PILLARISETTI, Sivaram ,  CHAKRABARTI, Ranjan

Inventor： REDDY, Dumbala Srinivas ,  PADMALAYAM, Indira ,  BHUNIYA, Debnath ,  PILLARISETTI, Sivaram ,  CHAKRABARTI, Ranjan

IPC: C07D209/14 ,  C07D209/12 ,  A61K31/404

Abstract: This invention provides a compound of formula (I), which is a free species and/or a pharmaceutically-acceptable salt or a stereoisomer of the compound of formula (I). Another aspect of the present invention provides the compound of the formula (I) as a Lipoic acid synthase (LASY) inducer

公开(公告)号：WO2008036966A2

公开(公告)日：2008-03-27

申请号：PCT/US2007/079284

申请日：2007-09-24

Applicant: Reddy US Therapeutics, Inc. ,  PADMALAYAM, Indira ,  BHUNIYA, Debnath ,  REDDY, Dumbala Srinivas ,  KHANNA, Ish, K. ,  SAXENA, Uday ,  PILLARISETTI, Sivaram

Inventor： PADMALAYAM, Indira ,  BHUNIYA, Debnath ,  REDDY, Dumbala Srinivas ,  KHANNA, Ish, K. ,  SAXENA, Uday ,  PILLARISETTI, Sivaram

IPC: A61K31/385

CPC classification number: A61K31/385 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: This invention provides a method of reducing inflammation in a living cell of a subject. This method increases the level of lipoic acid synthase within the living cell thereby causing the reduction of the inflammation. Various embodiments and variants are contemplated, some of which are set forth in claim format at the end of this document. The aspects, embodiments, and variants so exemplified in the claims format should not be understood as limiting the invention.

Abstract translation: 本发明提供减少受试者活细胞中的炎症的方法。 该方法提高了活细胞内硫辛酸合成酶的水平，从而导致炎症的减少。 考虑了各种实施例和变型，其中一些在本文件结尾处以权利要求格式阐述。 在权利要求书格式中如此举例说明的方面，实施例和变型不应被理解为限制本发明。

公开(公告)号：WO2008036966A3

公开(公告)日：2008-11-06

申请号：PCT/US2007079284

申请日：2007-09-24

Applicant: REDDY US THERAPEUTICS INC ,  PADMALAYAM INDIRA ,  BHUNIYA DEBNATH ,  REDDY DUMBALA SRINIVAS ,  KHANNA ISH K ,  SAXENA UDAY ,  PILLARISETTI SIVARAM

Inventor： PADMALAYAM INDIRA ,  BHUNIYA DEBNATH ,  REDDY DUMBALA SRINIVAS ,  KHANNA ISH K ,  SAXENA UDAY ,  PILLARISETTI SIVARAM

IPC: A61K31/00 ,  A61K31/405

CPC classification number: A61K31/385 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: This invention provides a method of reducing inflammation in a living cell of a subject. This method increases the level of lipoic acid synthase within the living cell thereby causing the reduction of the inflammation. Various embodiments and variants are contemplated, some of which are set forth in claim format at the end of this document. The aspects, embodiments, and variants so exemplified in the claims format should not be understood as limiting the invention.

Abstract translation: 本发明提供了减少受试者的活细胞中的炎症的方法。 该方法增加了活细胞内硫辛酸合酶的水平，从而导致炎症的减轻。 设想了各种实施例和变体，其中的一些在本文件结尾处以权利要求格式阐述。 在权利要求格式中如此示例的方面，实施例和变体不应被理解为限制本发明。