公开(公告)号：WO2008036967A2

公开(公告)日：2008-03-27

申请号：PCT/US2007079286

申请日：2007-09-24

Applicant: REDDY US THERAPEUTICS INC ,  REDDY DUMBALA SRINIVAS ,  PADMALAYAM INDIRA ,  BHUNIYA DEBNATH ,  PILLARISETTI SIVARAM ,  CHAKRABARTI RANJAN

Inventor： REDDY DUMBALA SRINIVAS ,  PADMALAYAM INDIRA ,  BHUNIYA DEBNATH ,  PILLARISETTI SIVARAM ,  CHAKRABARTI RANJAN

IPC: A61K31/405

CPC classification number: C07D209/12 ,  C07D209/18 ,  C07D401/06

Abstract: This invention provides a compound of formula (I), which is a free species and/or a pharmaceutically-acceptable salt or a stereoisomer of the compound of formula (I). Another aspect of the present invention provides the compound of the formula (I) as a Lipoic acid synthase (LASY) inducer

Abstract translation: 本发明提供式（I）化合物，其是式（I）化合物的游离物质和/或药学上可接受的盐或立体异构体。 本发明的另一方面提供了作为硫辛酸合酶（LASY）诱导剂的式（I）化合物

公开(公告)号：WO2007075194A1

公开(公告)日：2007-07-05

申请号：PCT/US2006/025427

申请日：2006-06-29

Applicant: REDDY US THERAPEUTICS, INC. ,  BARUAH, Anima ,  DE, Dibyendu ,  KHANNA, Ish, Kumar ,  PILLARISETTI, Sivaram ,  ALEXANDER, Christopher, W. ,  SREENU, Jennepali

Inventor： BARUAH, Anima ,  DE, Dibyendu ,  KHANNA, Ish, Kumar ,  PILLARISETTI, Sivaram ,  ALEXANDER, Christopher, W. ,  SREENU, Jennepali

IPC: A01N43/66 ,  A01N43/54 ,  A01N43/42 ,  A01N43/40 ,  A61K31/44 ,  A61K31/47 ,  C07D221/06 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D513/02 ,  C07D515/02 ,  C07D215/00 ,  C07D215/38 ,  C07D215/46 ,  C07D215/04 ,  C07D417/00 ,  C07D211/72 ,  C07D211/84 ,  C07D213/62 ,  C07D403/00 ,  C07D239/02

CPC classification number: C07D215/36 ,  C07D215/38 ,  C07D215/48 ,  C07D221/06 ,  C07D401/12 ,  C07D403/12 ,  C07D471/04

Abstract: The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

Abstract translation: 本发明尤其提供了新的苄胺化合物，包含苄胺化合物的组合物，制备苄胺化合物的方法，以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的各种病症或疾病的方法。

公开(公告)号：WO0223197A3

公开(公告)日：2003-07-24

申请号：PCT/US0128862

申请日：2001-09-14

Applicant: REDDY US THERAPEUTICS INC ,  PILLARISETTI SIVARAM ,  SAXENA UDAY ,  WANG DONGYAN

Inventor： PILLARISETTI SIVARAM ,  SAXENA UDAY

IPC: C12Q1/527 ,  G01N33/573 ,  G01N33/574 ,  C12Q1/34

CPC classification number: G01N33/573 ,  G01N33/574 ,  G01N33/57484 ,  G01N2333/924

Abstract: The present invention is directed to compositions and methods for measuring enzymatic activity, particularly glycosidase activity. Methods of the present invention include assays for quantitatively determining the amount of glycosidase activity in a sample. The present invention also provides methods for the diagnosis of metastatic and inflammatory processes in vitro and in vivo. The present invention further provides compositions and methods for high throughput assays for identifying compounds that effect glycosidase activity.

Abstract translation: 本发明涉及用于测量酶活性，特别是糖苷酶活性的组合物和方法。 本发明的方法包括用于定量测定样品中糖苷酶活性的量的测定法。 本发明还提供用于诊断体外和体内转移和炎症过程的方法。 本发明还提供用于鉴定影响糖苷酶活性的化合物的高通量测定的组合物和方法。

公开(公告)号：WO2010134938A1

公开(公告)日：2010-11-25

申请号：PCT/US2009/066333

申请日：2009-12-02

Applicant: DR. REDDY'S LABORATORIES LTD. ,  DR. REDDY'S LABORATORIES, INC. ,  VOOTURI, Rajesh ,  SINGARE, Dhananjay ,  DAMLE, Shantanu Yeshwant ,  KARATGI, Pradeep Jairao ,  MARELLA, Sesha Sai ,  BHAGWATWAR, Harshal Prabhakar ,  KHANNA, Ish Kumar ,  PILLAI, Raviraj Sukumar ,  PILLARISETTI, Sivaram

Inventor： VOOTURI, Rajesh ,  SINGARE, Dhananjay ,  DAMLE, Shantanu Yeshwant ,  KARATGI, Pradeep Jairao ,  MARELLA, Sesha Sai ,  BHAGWATWAR, Harshal Prabhakar ,  KHANNA, Ish Kumar ,  PILLAI, Raviraj Sukumar ,  PILLARISETTI, Sivaram

IPC: A61K9/32 ,  A61K9/22 ,  A61K31/44 ,  A61K9/14 ,  A61K9/20 ,  A61K9/26 ,  A61K9/28 ,  A61K31/60

CPC classification number: A61K9/2846 ,  A61K9/1635 ,  A61K9/2027 ,  A61K9/209 ,  A61K9/2886 ,  A61K31/44 ,  A61K31/455 ,  A61K31/60

Abstract: Pharmaceutical formulations comprising niacin in a matrix comprising a hydrophobic polymer that modifies release of niacin.

Abstract translation: 包含烟酸在包含改性烟酸释放的疏水性聚合物的基质中的药物制剂。

公开(公告)号：WO2008036966A3

公开(公告)日：2008-11-06

申请号：PCT/US2007079284

申请日：2007-09-24

Applicant: REDDY US THERAPEUTICS INC ,  PADMALAYAM INDIRA ,  BHUNIYA DEBNATH ,  REDDY DUMBALA SRINIVAS ,  KHANNA ISH K ,  SAXENA UDAY ,  PILLARISETTI SIVARAM

Inventor： PADMALAYAM INDIRA ,  BHUNIYA DEBNATH ,  REDDY DUMBALA SRINIVAS ,  KHANNA ISH K ,  SAXENA UDAY ,  PILLARISETTI SIVARAM

IPC: A61K31/00 ,  A61K31/405

CPC classification number: A61K31/385 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158

Abstract: This invention provides a method of reducing inflammation in a living cell of a subject. This method increases the level of lipoic acid synthase within the living cell thereby causing the reduction of the inflammation. Various embodiments and variants are contemplated, some of which are set forth in claim format at the end of this document. The aspects, embodiments, and variants so exemplified in the claims format should not be understood as limiting the invention.

Abstract translation: 本发明提供了减少受试者的活细胞中的炎症的方法。 该方法增加了活细胞内硫辛酸合酶的水平，从而导致炎症的减轻。 设想了各种实施例和变体，其中的一些在本文件结尾处以权利要求格式阐述。 在权利要求格式中如此示例的方面，实施例和变体不应被理解为限制本发明。

公开(公告)号：WO2006034473A3

公开(公告)日：2006-12-14

申请号：PCT/US2005034243

申请日：2005-09-23

Applicant: REDDY US THERAPEUTICS INC ,  PAL MANOJIT ,  KALLEDA SRINIVAS ,  PADAKANTI SRINIVAS ,  KUMAR SWAMY NALIVELA ,  YELESWARAPU KOTESWAR RAO ,  ALEXANDER CHRISTOPHER W ,  KHANNA ISH KUMAR ,  IQBAL JAVED ,  PILLARISETTI SIVARAM ,  BARANGE DEEPAK

Inventor： PAL MANOJIT ,  KALLEDA SRINIVAS ,  PADAKANTI SRINIVAS ,  KUMAR SWAMY NALIVELA ,  YELESWARAPU KOTESWAR RAO ,  ALEXANDER CHRISTOPHER W ,  KHANNA ISH KUMAR ,  IQBAL JAVED ,  PILLARISETTI SIVARAM ,  BARANGE DEEPAK

IPC: A61K31/506 ,  C07D239/46 ,  C07D403/04

CPC classification number: C07D405/14 ,  C07D239/30 ,  C07D239/40 ,  C07D239/42 ,  C07D239/46 ,  C07D239/47 ,  C07D239/48 ,  C07D239/50 ,  C07D239/54 ,  C07D401/04 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

Abstract translation: 本发明提供新的杂环化合物，特别是取代的嘧啶，用于制备和使用这些杂环化合物的方法和组合物，以及用于治疗各种疾病和疾病状态的方法，包括动脉粥样硬化，关节炎，再狭窄，糖尿病性肾病或血脂异常或疾病 由Perlecan低表达介导的状态。

公开(公告)号：WO2006073610A8

公开(公告)日：2006-09-08

申请号：PCT/US2005042736

申请日：2005-11-23

Applicant: REDDY US THERAPEUTICS INC ,  PAL MANOJIT ,  RAO YELESWARAPU KOTESWAR ,  KHANNA ISH KUMAR ,  SWAMY NALIVELA KUMARA ,  SUBRAMANIAN VENKATARAMAN ,  BATCHU VENKATESWARA RAO ,  IQBAL JAVED ,  PILLARISETTI SIVARAM

Inventor： PAL MANOJIT ,  RAO YELESWARAPU KOTESWAR ,  KHANNA ISH KUMAR ,  SWAMY NALIVELA KUMARA ,  SUBRAMANIAN VENKATARAMAN ,  BATCHU VENKATESWARA RAO ,  IQBAL JAVED ,  PILLARISETTI SIVARAM

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D471/04 ,  C07D487/04

Abstract: The present invention provides, among other things, new bicyclo heterocyclic compounds, compositions comprising these heterocyclic compounds, methods of making the heterocyclic compounds, and methods of using these heterocyclic compounds for treating a variety of conditions and disease states associated with, for example, cellular proliferation, inflammation, glycosidase expression, or the low expression of Perlecan.

Abstract translation: 本发明尤其提供了新的双环杂环化合物，包含这些杂环化合物的组合物，制备杂环化合物的方法，以及使用这些杂环化合物治疗与例如细胞相关的多种病症和疾病状态的方法 增殖，炎症，糖苷酶表达或Perlecan的低表达。

公开(公告)号：WO03011119A3

公开(公告)日：2003-10-09

申请号：PCT/US0224424

申请日：2002-07-31

Applicant: REDDY US THERAPEUTICS INC ,  PILLARISETTI SIVARAM ,  WANG DONGYAN ,  SAXENA UDAY

Inventor： PILLARISETTI SIVARAM ,  WANG DONGYAN ,  SAXENA UDAY

IPC: A61K31/727 ,  C12Q1/34 ,  G01N33/53 ,  G01N33/573 ,  G01N33/574 ,  C12N9/26

CPC classification number: C12Q1/34 ,  G01N33/573 ,  G01N2333/924 ,  G01N2333/988 ,  G01N2400/00 ,  G01N2400/40

Abstract: The present invention is directed to methods and compositions for the diagnosis and treatment of vascular conditions, particularly diabetes and atherosclerosis. The present invention comprises methods and compositions for determining the expression or activity of enzymes effecting HSPG, preferably, heparanase (Figures 4A-D) . The invention also comprises methods and compositions for treatment of vasculophathic diseases comprising administration of therapeutic compounds that are effective in inhibiting the expression or activity of heparanase.

Abstract translation: 本发明涉及用于诊断和治疗血管病症，特别是糖尿病和动脉粥样硬化的方法和组合物。 本发明包括用于测定影响HSPG，优选乙酰肝素酶的酶的表达或活性的方法和组合物（图4A-D）。 本发明还包括用于治疗血管病变疾病的方法和组合物，包括施用有效抑制乙酰肝素酶的表达或活性的治疗化合物。

公开(公告)号：WO0202593A3

公开(公告)日：2003-08-07

申请号：PCT/US0120849

申请日：2001-06-29

Applicant: LONG ISLAND JEWISH RES INST ,  PILLARISETTI SIVARAM ,  GOLDBERG ITZHAK D

Inventor： PILLARISETTI SIVARAM ,  GOLDBERG ITZHAK D

IPC: C12N15/09 ,  A61K31/12 ,  A61K31/121 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4178 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4704 ,  A61K31/505 ,  A61K38/00 ,  A61K38/08 ,  A61K38/10 ,  A61K38/16 ,  A61K45/00 ,  A61K48/00 ,  A61K49/00 ,  A61P7/00 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P15/00 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07D215/22 ,  C07D239/42 ,  C07D261/18 ,  C07D409/06 ,  C07D413/06 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/47 ,  C07K14/475 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/11 ,  C12N15/63 ,  G01N33/68

CPC classification number: C07K14/4753 ,  A61K31/12 ,  A61K31/415 ,  A61K31/4178 ,  A61K31/42 ,  A61K31/422 ,  A61K31/4704 ,  A61K31/505 ,  A61K38/00 ,  A61K48/00 ,  A61K49/0004 ,  C07D231/12 ,  C07D261/18 ,  C07D405/04 ,  C07D409/06 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07K7/08 ,  C07K14/001

Abstract: The invention is directed to small organic molecules and peptides having the ability to mimic or agonize hepatocyte growth factor/ scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

Abstract translation: 本发明涉及具有模拟或激动肝细胞生长因子/分散因子（HGF / SF）活性或抑制或拮抗HGF / SF活性的能力的小有机分子和肽，前者可用于促进例如血管生成 用于促进伤口或组织愈合的组织或器官，或增加或恢复心肌梗死后心脏等缺血组织的血流。 抑制细胞生长或增殖在治疗例如炎性关节和皮肤疾病等炎性疾病以及诸如癌症的增生性增生性疾病中是有益的。

公开(公告)号：WO2006073973A3

公开(公告)日：2008-12-04

申请号：PCT/US2005047203

申请日：2005-12-28

Applicant: REDDY US THERAPEUTICS INC ,  BARUAH ANIMA ,  DE DIBYENDU ,  KHANNA ISH KUMAR ,  PILLARISETTI SIVARAM ,  MAITRA SANTANU ,  ALEXANDER CHRISTOPHER W ,  SREENU JENNEPALLI ,  DAGER INDU

Inventor： BARUAH ANIMA ,  DE DIBYENDU ,  KHANNA ISH KUMAR ,  PILLARISETTI SIVARAM ,  MAITRA SANTANU ,  ALEXANDER CHRISTOPHER W ,  SREENU JENNEPALLI ,  DAGER INDU

IPC: A61K31/44 ,  A61K31/47 ,  A61K31/495 ,  A61K31/4965 ,  C07D213/72 ,  C07D215/38 ,  C07D401/02 ,  C07D471/02

CPC classification number: A61K31/506 ,  A61K31/437 ,  A61K31/438 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  C07D213/73 ,  C07D213/74 ,  C07D215/38 ,  C07D221/04 ,  C07D239/78 ,  C07D241/20 ,  C07D401/12 ,  C07D413/12 ,  C07D417/12 ,  C07D471/04 ,  C07D498/04

Abstract: The present invention provides, among other things, new benzylamine compounds, compositions comprising benzylamine compounds, methods of making benzylamine compounds, and methods of using benzylamine compounds for treating or preventing a variety of conditions or diseases associated with lipoprotein metabolism.

Abstract translation: 本发明尤其提供了新的苄胺化合物，包含苄胺化合物的组合物，制备苄胺化合物的方法，以及使用苄胺化合物治疗或预防与脂蛋白代谢相关的各种病症或疾病的方法。