公开(公告)号：WO2008006073A2

公开(公告)日：2008-01-10

申请号：PCT/US2007072972

申请日：2007-07-06

Applicant: EDSA MICRO CORP ,  RADIBRATOVIC BRANISLAV ,  PAN JUN ,  NASLE ADIB

Inventor： RADIBRATOVIC BRANISLAV ,  PAN JUN ,  NASLE ADIB

IPC: G06F19/00 ,  G06F17/10

CPC classification number: G05B17/02

Abstract: A system for making real-time predictions about an arc flash event on an electrical system is disclosed. The system includes a data acquisition component, an analytics server and a client terminal. The data acquisition component is communicatively connected to a sensor configured to acquire real-time data output from the electrical system. The analytics server is communicatively connected to the data acquisition component and is comprised of a virtual system modeling engine, an analytics engine and an arc flash simulation engine.

Abstract translation: 公开了一种用于对电气系统上的电弧闪光事件进行实时预测的系统。 该系统包括数据采集组件，分析服务器和客户终端。 数据采集​​部件通信地连接到被配置为获取从电气系统输出的实时数据的传感器。 分析服务器通信地连接到数据采集组件，并且包括虚拟系统建模引擎，分析引擎和电弧闪光模拟引擎。

公开(公告)号：WO0146906A3

公开(公告)日：2002-02-21

申请号：PCT/US0042574

申请日：2000-12-06

Applicant: NINTENDO CO LTD ,  LI XIN ,  ABOU SAMRA SAMIR ,  CHAMPAGNE ROBERT ,  COMAIR CLAUDE ,  FAM SUN TJEN ,  GHALI PRASANNA ,  PAN JUN

Inventor： LI XIN ,  ABOU-SAMRA SAMIR ,  CHAMPAGNE ROBERT ,  COMAIR CLAUDE ,  FAM SUN TJEN ,  GHALI PRASANNA ,  PAN JUN

IPC: G06T13/00 ,  G06T15/04 ,  G06T15/70

CPC classification number: G06T13/00 ,  G06T15/04 ,  G06T2210/44

Abstract: A fast, texture morphing algorithm for real-time computer simulation and video games dynamically generates objects "on the fly" by simplifying and reducing the computational load required for a texture morphing/blending process. Incremental interpolation techniques compute a morh parameter based on previous value and morph change rate. Precomputed initial and incremental morph parameter values for each texel component are applied during real-time morphing procedures using integer arithmetic. Approximation errors are reduced by incrementing/decrementing by an extra integer value when the number of morph iterations is a multiple of a frame counter. The frame counter avoids over-runs, and the morphing procedure is "snapped" the texel value to the precise texture target value to prevent under-runs and corresponding artifacts. Interlacing (applying interpolation to a subset of the texels each frame) significantly reduces computational load without introducing significant image artifacts. The morph texture buffer data structure is initially decomposed off-line to reduce the number of real-time calculations required to manipulate texel component data.

Abstract translation: 用于实时计算机模拟和视频游戏的快速，纹理变形算法通过简化和减少纹理变形/混合过程所需的计算负荷来“动态地”生成对象。 增量插值技术基于先前的值和变形率计算morh参数。 使用整数算法在实时变形过程中应用每个纹素分量的预计算初始和渐变变形参数值。 当变形迭代次数是帧计数器的倍数时，通过递增/递减额外的整数值来减少近似误差。 帧计数器避免过度运行，并且变形过程将纹素值“拍”到精确的纹理目标值，以防止运行不足和相应的伪像。 隔行扫描（将插值应用于每个帧的纹素集的子集）可显着降低计算负荷，而不引入显着的图像伪像。 变形纹理缓冲器数据结构最初是离线分解的，以减少操纵纹理分量数据所需的实时计算的数量。

公开(公告)号：WO2020132197A1

公开(公告)日：2020-06-25

申请号：PCT/US2019/067403

申请日：2019-12-19

Applicant: INCYTE CORPORATION ,  PAN, Jun ,  ROACH, Jeremy ,  MEI, Song ,  HE, Chunhong ,  WU, Liangxing ,  YAO, Wenqing

Inventor： PAN, Jun ,  ROACH, Jeremy ,  MEI, Song ,  HE, Chunhong ,  WU, Liangxing ,  YAO, Wenqing

IPC: C07D471/04 ,  C07D487/04 ,  C07D519/00 ,  A61P35/00 ,  A61K31/5025 ,  A61K31/437

Abstract: Disclosed are compounds of Formula (I), methods of using the compounds for inhibiting ALK2 activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with ALK2 activity such as cancer.

公开(公告)号：WO2008078911A1

公开(公告)日：2008-07-03

申请号：PCT/KR2007/006708

申请日：2007-12-21

Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  LEE, Sang Yup ,  JEONG, Hawoong ,  KIM, Tae Yong ,  KIM, Pan-Jun ,  LEE, Kwang Ho

Inventor： LEE, Sang Yup ,  JEONG, Hawoong ,  KIM, Tae Yong ,  KIM, Pan-Jun ,  LEE, Kwang Ho

IPC: G01N33/48

CPC classification number: C12Q1/18 ,  G01N33/5038

Abstract: The present invention disclosed is a method for screening metabolites essential for the growth of microorganism using metabolic flux analysis. More specifically, the present invention relates to the method for screening metabolites essential for the growth of microorganism, by selecting a target microorganism, constructing a metabolic network model of the selected microorganism, inactivating the consumption reaction of each of metabolites in the constructed metabolic network model, analyzing the metabolic flux of the metabolites to select metabolites essential for the growth of the microorganism, and confirming the selected metabolites using the utilization of each of the metabolites, defined as flux sum (Φ ). According to the present invention, metabolites essential for the growth of microorganism, and genes involved in the essential metabolites, can be screened in a convenient manner, and drug-target genes against pathogenic microorganisms can be predicted by deleting genes associated with the metabolites screened according to the method.

Abstract translation: 所公开的本发明是使用代谢通量分析来筛选微生物生长所必需的代谢物的方法。 更具体地说，本发明涉及通过选择靶微生物，构建所选择的微生物的代谢网络模型，在构建的代谢网络模型中灭活各代谢物的消耗反应来筛选微生物生长所必需的代谢物的方法 分析代谢物的代谢通量以选择对微生物生长至关重要的代谢物，并使用定义为通量（F）的每种代谢物来确认所选择的代谢物。 根据本发明，可以以便利的方式筛选微生物生长所必需的代谢物和基本代谢物所涉及的基因，并且可以通过删除与代谢物相关的基因来预测针对病原微生物的药物靶基因 的方法。

公开(公告)号：WO2022266753A1

公开(公告)日：2022-12-29

申请号：PCT/CA2022/050991

申请日：2022-06-20

Applicant: RISEN (SUZHOU) PHARMA TECH CO., LTD. ,  LV, Jiasheng ,  SIYANG, Haixiao ,  YIN, Yijie ,  GUO, Wantao ,  LI, Haiming ,  CHEN, Dawei ,  GU, Jiamin ,  KONG, Xianqi ,  PAN, Jun ,  MA, Xinxin ,  SONG, Peiming ,  WU, Chun ,  FENG, Hui ,  YAO, Sheng

Inventor： LV, Jiasheng ,  SIYANG, Haixiao ,  YIN, Yijie ,  GUO, Wantao ,  LI, Haiming ,  CHEN, Dawei ,  GU, Jiamin ,  KONG, Xianqi ,  PAN, Jun ,  MA, Xinxin ,  SONG, Peiming ,  WU, Chun ,  FENG, Hui ,  YAO, Sheng

IPC: C07C275/16 ,  A61K47/54 ,  A61P3/00 ,  A61P9/00 ,  C07C233/47 ,  C07C237/22 ,  C07C271/02 ,  C07C279/14 ,  C07C323/59 ,  C07D207/416 ,  C07D249/04 ,  C07K16/00 ,  C12N15/113 ,  A61K47/542 ,  A61K47/545 ,  A61K47/549

Abstract: There are provided conjugates of Formula (V) wherein R1 is a triantennary targeting moiety comprising N-acetyl galactosamine and R2 is a bioactive agent which is preferably an oligonucleotide, as well as pharmaceutical compositions and methods of use of the conjugates for the treatment, inhibition, or prevention of diseases and disorders which are therapeutic targets of the bioactive agent. In preferred embodiments the conjugate preferentially binds to asiaglycoprotein receptors (ASGPR). In preferred embodiments, the oligonucleotide is SiRNA which targets the PCSK9 gene, providing treatment options for lipid disorders such as hyperlipidemia.

公开(公告)号：WO2018098751A1

公开(公告)日：2018-06-07

申请号：PCT/CN2016/108151

申请日：2016-11-30

Applicant: MICROSOFT TECHNOLOGY LICENSING, LLC ,  LU, Yumao ,  DENG, Yongjian ,  SHOU, Linjun ,  CAI, Wenbin ,  PAN, Jun ,  ZHOU, Jie ,  FAN, Baoquan

Inventor： LU, Yumao ,  DENG, Yongjian ,  SHOU, Linjun ,  CAI, Wenbin ,  PAN, Jun ,  ZHOU, Jie ,  FAN, Baoquan

IPC: G06F17/30

Abstract: A method and apparatus for providing recommended contents. The method comprises: A search query being received; an event being selected from a predetermined event set based on the search query; the recommended contents being provided in a structured template including one or more elements; each element is associated with a feature of the event; each feature of the event corresponds to a search intent. Each element includes one or more sub-contents, and each sub-content is correlated to corresponding recommended contents.