公开(公告)号：WO2013166121A1

公开(公告)日：2013-11-07

申请号：PCT/US2013/039025

申请日：2013-05-01

Applicant: MERCK SHARP & DOHME CORP. ,  TELLERS, David ,  COLLETTI, Steven, L. ,  DUDKIN, Vadim ,  IKEMOTO, Norihiro ,  LIAO, Hongbiao ,  PARISH, Craig ,  PEI, Tao ,  SHAW, Anthony ,  TRUONG, Quang ,  WANG, Lijun ,  YUAN, Yu ,  ZHU, Man

Inventor： TELLERS, David ,  COLLETTI, Steven, L. ,  DUDKIN, Vadim ,  IKEMOTO, Norihiro ,  LIAO, Hongbiao ,  PARISH, Craig ,  PEI, Tao ,  SHAW, Anthony ,  TRUONG, Quang ,  WANG, Lijun ,  YUAN, Yu ,  ZHU, Man

IPC: C07H19/056

CPC classification number: C12N15/113 ,  A61K47/549 ,  C07H15/26 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/351

Abstract: Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

Abstract translation: 本文公开了一种模块化组合物，其包含：1）寡核苷酸; 2）一种或多种式（I）的四加仑配体，其可以相同或不同; 任选地，3）一个或多个可以相同或不同的接头; 和任选地，4）一种或多种靶向配体，增溶剂，药代动力学增强剂，脂质和/或掩蔽剂。

公开(公告)号：WO2019199628A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/026252

申请日：2019-04-08

Applicant: MERCK SHARP & DOHME CORP. ,  BOGA, Sobhana Babu ,  KEKEC, Ahmet ,  LIN, Songnian ,  PARISH, Craig, A. ,  TANG, Weijuan ,  YAN, Lin

Inventor： BOGA, Sobhana Babu ,  KEKEC, Ahmet ,  LIN, Songnian ,  PARISH, Craig, A. ,  TANG, Weijuan ,  YAN, Lin

IPC: A61K38/28 ,  A61K47/06 ,  A61K47/22 ,  A61K47/26 ,  A61K47/48 ,  A61K47/61

Abstract: The present invention relates to insulin analogues and processes of making such insulin analogues by direct conversion of a free amine to an azide via diazo-transfer with an azotransfer agent.

公开(公告)号：WO2019204179A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/027423

申请日：2019-04-15

Applicant: MERCK SHARP & DOHME CORP. ,  CHANG, Wonsuk ,  PARISH, Craig, A. ,  SIU, Tony ,  TRUONG, Quang, T. ,  WANG, Hongwu ,  WASSERMANN, Anne Mai

Inventor： CHANG, Wonsuk ,  PARISH, Craig, A. ,  SIU, Tony ,  TRUONG, Quang, T. ,  WANG, Hongwu ,  WASSERMANN, Anne Mai

IPC: C12N15/113 ,  C12N15/117

Abstract: This invention provides compositions, compounds, and uses thereof, wherein said compounds comprise a single strand oligonucleotide that may form a short oligonucleotide hairpin or stem loop molecule with self complementary base pairing of less than 12 base pairs that bind to RIG-I and activate the RIG-I pathway.

公开(公告)号：WO2009025733A1

公开(公告)日：2009-02-26

申请号：PCT/US2008/009610

申请日：2008-08-12

Applicant: MERCK & CO., INC. ,  MERCK SHARP & DOHME DE ESPANA, SA ,  MERCK FROSST CANADA LTD. ,  BILLS, Gerald, F. ,  COLLADO, Javier ,  PARISH, Craig, A. ,  PELAEZ, Fernando ,  PLATAS, Gonzalo ,  ROEMER, Terry

Inventor： BILLS, Gerald, F. ,  COLLADO, Javier ,  PARISH, Craig, A. ,  PELAEZ, Fernando ,  PLATAS, Gonzalo ,  ROEMER, Terry

IPC: A01N43/80 ,  A61K31/42

CPC classification number: A01N65/04 ,  A01N43/90 ,  A01N65/00 ,  A61K31/42 ,  C07D498/16

Abstract: Novel isoxazolidinone compounds useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops are described. Two novel strains of fungi, ATCC No. PAT-7894 and ATCC No. PAT-7895, are disclosed for the preparation of the described isoxazolidinone compounds.

Abstract translation: 描述了可用于治疗和/或预防人和动物真菌感染以及作物中植物病原真菌控制的新型异恶唑烷酮化合物。 公开了两种真菌菌株，ATCC No.PAT-7894和ATCC No.PAT-7895，用于制备所述的异恶唑烷酮化合物。

公开(公告)号：WO2019182942A1

公开(公告)日：2019-09-26

申请号：PCT/US2019/022684

申请日：2019-03-18

Applicant: MERCK SHARP & DOHME CORP. ,  KEKEC, Ahmet ,  KEVIN, Nancy Jo ,  LI, Bing ,  LIN, Songnian ,  PARISH, Craig A. ,  TANG, Weijuan

Inventor： KEKEC, Ahmet ,  KEVIN, Nancy Jo ,  LI, Bing ,  LIN, Songnian ,  PARISH, Craig A. ,  TANG, Weijuan

IPC: A61K38/00 ,  A61K38/28 ,  A61K47/00 ,  A61K47/06

Abstract: The present invention relates to tyrosine-specific functionalized insulin analogs and processes of making such tyrosine-specific functionalized insulin analogs using R-3H-1,2,4-triazoline-3,5-(4H)diones (PTAD).

公开(公告)号：WO2012068187A1

公开(公告)日：2012-05-24

申请号：PCT/US2011/060893

申请日：2011-11-16

Applicant: MERCK SHARP & DOHME CORP. ,  BARRETT, Stephanie, E. ,  BUSUEK, Marina ,  COLLETTI, Steven, L. ,  GARBACCIO, Robert, M. ,  GUIDRY, Erin, N. ,  KOWTONIUK, Robert, A. ,  LIAO, Jing ,  PARISH, Craig, A. ,  PARMAR, Rubina, G. ,  PEI, Tao ,  SCHLOSSER, Kevin, M. ,  TELLERS, David, M. ,  TOBIAS, Sandra, C. ,  TRUONG, Quang, T. ,  WALDMAN, Jacob, H. ,  WANG, Weimin ,  WILLIAMS, J. Michael

Inventor： BARRETT, Stephanie, E. ,  BUSUEK, Marina ,  COLLETTI, Steven, L. ,  GARBACCIO, Robert, M. ,  GUIDRY, Erin, N. ,  KOWTONIUK, Robert, A. ,  LIAO, Jing ,  PARISH, Craig, A. ,  PARMAR, Rubina, G. ,  PEI, Tao ,  SCHLOSSER, Kevin, M. ,  TELLERS, David, M. ,  TOBIAS, Sandra, C. ,  TRUONG, Quang, T. ,  WALDMAN, Jacob, H. ,  WANG, Weimin ,  WILLIAMS, J. Michael

IPC: A61K31/7088

CPC classification number: A61K47/48092 ,  A61K47/549 ,  C08G69/10 ,  C08G73/028 ,  C08L79/02

Abstract: The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.

Abstract translation: 本发明提供用于递送用于治疗目的的寡核苷酸的聚（酰胺）聚合物，多偶联物，组合物和方法。