公开(公告)号：WO03007887A3

公开(公告)日：2003-04-17

申请号：PCT/US0223230

申请日：2002-07-16

Applicant: MERCK & CO INC ,  FINKE PAUL E ,  MILLS SANDER G ,  PLUMMER CHRISTOPHER W ,  SHAH SHRENIK K ,  TRUONG QUANG T

Inventor： FINKE PAUL E ,  MILLS SANDER G ,  PLUMMER CHRISTOPHER W ,  SHAH SHRENIK K ,  TRUONG QUANG T

IPC: A61P21/04 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/30 ,  C07D233/90 ,  C07D405/12 ,  C08K5/34 ,  A61K31/415

CPC classification number: C07D405/12 ,  C07D233/90

Abstract: The use of compounds of the present invention as antagonists and/or inverse agonists of the Cannabinoid-1 (CB1)receptor particularly in the treatment, prevention and suppression of diseases mediated by the Cannabinoid-1 (CB1) receptor. The invention is concerned with the use of these novel compounds to selectively antagonize the Cannabinoid-1 (CB1) receptor. As such, compounds of the present invention are useful as psychotropic drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith. Novel compounds of structural formula (I) are also claimed.

Abstract translation: 使用本发明的化合物作为大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，特别是用于治疗，预防和抑制由大麻素-1（CB1）受体介导的疾病。 本发明涉及这些新化合物选择性拮抗大麻素-1（CB1）受体的用途。 因此，本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症的精神药物。 血管意外和头部创伤，焦虑障碍，压力，癫痫，帕金森病和精神分裂症。 这些化合物也可用于治疗药物滥用障碍，特别是鸦片剂，酒精和尼古丁。 所述化合物还可用于治疗与过量食物摄入和与其相关的并发症相关的肥胖或进食障碍。 还要求新的结构式（I）化合物。

公开(公告)号：WO2019204179A1

公开(公告)日：2019-10-24

申请号：PCT/US2019/027423

申请日：2019-04-15

Applicant: MERCK SHARP & DOHME CORP. ,  CHANG, Wonsuk ,  PARISH, Craig, A. ,  SIU, Tony ,  TRUONG, Quang, T. ,  WANG, Hongwu ,  WASSERMANN, Anne Mai

Inventor： CHANG, Wonsuk ,  PARISH, Craig, A. ,  SIU, Tony ,  TRUONG, Quang, T. ,  WANG, Hongwu ,  WASSERMANN, Anne Mai

IPC: C12N15/113 ,  C12N15/117

Abstract: This invention provides compositions, compounds, and uses thereof, wherein said compounds comprise a single strand oligonucleotide that may form a short oligonucleotide hairpin or stem loop molecule with self complementary base pairing of less than 12 base pairs that bind to RIG-I and activate the RIG-I pathway.

公开(公告)号：WO2019195063A1

公开(公告)日：2019-10-10

申请号：PCT/US2019/024455

申请日：2019-03-28

Applicant: MERCK SHARP & DOHME CORP. ,  ALTMAN, Michael, D. ,  CASH, Brandon, D. ,  CUMMING, Jared, N. ,  DEMONG, Duane, E. ,  HAIDLE, Andrew, M. ,  JEWELL, James, P. ,  LARSEN, Matthew, A. ,  LU, Min ,  OTTE, Ryan, D. ,  TAOKA, Brandon, M. ,  TROTTER, Benjamin Wesley ,  TRUONG, Quang, T.

Inventor： ALTMAN, Michael, D. ,  CASH, Brandon, D. ,  CUMMING, Jared, N. ,  DEMONG, Duane, E. ,  HAIDLE, Andrew, M. ,  JEWELL, James, P. ,  LARSEN, Matthew, A. ,  LU, Min ,  OTTE, Ryan, D. ,  TAOKA, Brandon, M. ,  TROTTER, Benjamin Wesley ,  TRUONG, Quang, T.

IPC: C07D333/64 ,  C07D409/06 ,  C07D409/12

Abstract: Compounds of general formula (I), and their pharmaceutically acceptable salts, wherein R 1 , R 2 , R 3 , R 5 , R 6 , R 8 , R 9 , A, X 1 , X 2 , and X 3 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.

公开(公告)号：WO2017201683A1

公开(公告)日：2017-11-30

申请号：PCT/CN2016/083265

申请日：2016-05-25

Applicant: MERCK SHARP & DOHME CORP. ,  ADAMS, Gregory L. ,  COX, Jason M. ,  DEBENHAM, John S. ,  EDMONDSON, Scott ,  GILBERT, Eric ,  GUO, Yan ,  JIANG, Yu ,  JOSIEN, Hubert ,  KIM, Hyunjin M. ,  LAN, Ping ,  MIAO, Shouwu ,  PLUMMER, Christopher W. ,  RAJAGOPALAN, Murali ,  SHAH, Unmesh ,  SUN, Zhongxiang ,  SUZUKI, Takao ,  TRUONG, Quang T. ,  UJJAINWALLA, Feroze ,  VELAZQUEZ, Francisco ,  VENKATRAMAN, Srikanth ,  WANG, Nengxue

Inventor： ADAMS, Gregory L. ,  COX, Jason M. ,  DEBENHAM, John S. ,  EDMONDSON, Scott ,  GILBERT, Eric ,  GUO, Yan ,  JIANG, Yu ,  JOSIEN, Hubert ,  KIM, Hyunjin M. ,  LAN, Ping ,  MIAO, Shouwu ,  PLUMMER, Christopher W. ,  RAJAGOPALAN, Murali ,  SHAH, Unmesh ,  SUN, Zhongxiang ,  SUZUKI, Takao ,  TRUONG, Quang T. ,  UJJAINWALLA, Feroze ,  VELAZQUEZ, Francisco ,  VENKATRAMAN, Srikanth ,  WANG, Nengxue

IPC: C07D217/16 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  C07D413/04 ,  C07D417/12 ,  C07D417/14 ,  A61K31/4725 ,  A61P3/04 ,  A61P3/10 ,  A61P3/00

Abstract: Disclosed are compounds represented by formula (I) and pharmaceutically acceptable salts thereof. The compounds are agonists of the G-protein coupled receptor GPR120 and are useful for treating or preventing diabetes, hyperlipidemia, obesity, NASH, inflammation related disorders, and related diseases and conditions.

Abstract translation: 公开了由式（I）表示的化合物及其药学上可接受的盐。 这些化合物是G蛋白偶联受体GPR120的激动剂，可用于治疗或预防糖尿病，高脂血症，肥胖症，NASH，炎症相关病症和相关疾病和病症。

公开(公告)号：WO2010082959A1

公开(公告)日：2010-07-22

申请号：PCT/US2009/056258

申请日：2009-09-08

Applicant: ALLOY SURFACES COMPANY, INC. ,  DILLARD, David, P. ,  FISCHER, Jason, A. ,  SHAH, Rajesh, D. ,  SCANLON, John, J. ,  SMITH, Eric, M. ,  DINH, Truong, Quang ,  MACHAMER, David, L.

Inventor： DILLARD, David, P. ,  FISCHER, Jason, A. ,  SHAH, Rajesh, D. ,  SCANLON, John, J. ,  SMITH, Eric, M. ,  DINH, Truong, Quang ,  MACHAMER, David, L.

IPC: F42B4/26 ,  H01Q15/00

CPC classification number: F42B12/70 ,  F41J2/02 ,  F42B4/26 ,  F42B12/36

Abstract: The present invention relates to decoys for heat-seeking missiles and methods of producing and using the same. The decoys are designed to be kinematic or pseudo- kinematic, producing one or more infra-red radiation emitting clouds that give the appearance of a moving infra-red target in the airspace in which the decoy has been released.

Abstract translation: 本发明涉及用于寻热导弹的诱饵及其制造和使用方法。 诱饵被设计为运动学或伪运动学，产生一个或多个红外线辐射云，使得在诱杀被释放的空域中出现移动的红外目标。

公开(公告)号：WO2007098131A2

公开(公告)日：2007-08-30

申请号：PCT/US2007/004314

申请日：2007-02-16

Applicant: SHURFLO, LLC ,  MEZA, Humberto, V. ,  GANDHI, Nikhil, Jitendra ,  TRUONG, Quang, Minh

Inventor： MEZA, Humberto, V. ,  GANDHI, Nikhil, Jitendra ,  TRUONG, Quang, Minh

IPC: F04B49/06

CPC classification number: F04B43/0081 ,  F04B43/0054 ,  F04B43/026 ,  F04B43/04 ,  F04B49/065 ,  F04B2203/0201 ,  F04B2203/0208 ,  F04B2205/04

Abstract: A method and apparatus for a pump and a pump control system. The apparatus includes a pressure sensor and a temperature sensor coupled to a pump control system. For the method of the invention, the microcontroller provides a pulse-width modulation control signal to an output power stage in order to selectively control the power provided to the pump.

Abstract translation: 一种用于泵和泵控制系统的方法和装置。 该装置包括压力传感器和耦合到泵控制系统的温度传感器。 对于本发明的方法，微控制器向输出功率级提供脉宽调制控制信号，以选择性地控制提供给泵的功率。

公开(公告)号：WO2017027646A1

公开(公告)日：2017-02-16

申请号：PCT/US2016/046444

申请日：2016-08-11

Applicant: MERCK SHARP & DOHME CORP. ,  ALTMAN, Michael, D. ,  ANDRESEN, Brian ,  CHANG, Wonsuk ,  CHILDERS, Matthew Lloyd ,  CUMMING, Jared, N. ,  HAIDLE, Andrew Marc ,  HENDERSON, Timothy, J. ,  JEWELL, James, P. ,  LIANG, Rui ,  LIM, Jongwon ,  LIU, Hong ,  LU, Min ,  NORTHRUP, Alan, B. ,  OTTE, Ryan, D. ,  SIU, Tony ,  TROTTER, Benjamin Wesley ,  TRUONG, Quang, T. ,  WALSH, Shawn, P. ,  ZHAO, Kake

Inventor： ALTMAN, Michael, D. ,  ANDRESEN, Brian ,  CHANG, Wonsuk ,  CHILDERS, Matthew Lloyd ,  CUMMING, Jared, N. ,  HAIDLE, Andrew Marc ,  HENDERSON, Timothy, J. ,  JEWELL, James, P. ,  LIANG, Rui ,  LIM, Jongwon ,  LIU, Hong ,  LU, Min ,  NORTHRUP, Alan, B. ,  OTTE, Ryan, D. ,  SIU, Tony ,  TROTTER, Benjamin Wesley ,  TRUONG, Quang, T. ,  WALSH, Shawn, P. ,  ZHAO, Kake

IPC: C07H21/00 ,  A61K31/7084 ,  A61P35/00

CPC classification number: C07H21/04 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K31/708 ,  A61K31/7084 ,  A61K39/39 ,  C07H19/20 ,  C07H19/23 ,  C07H21/00 ,  C07H21/02

Abstract: A class of polycyclic compounds of general formula (I), of general formula (I'), or of general formula (I"), wherein Base 1 , Base 2 , Y, Y a , X a , Xa 1 , X b , X b1 , X c , X c1 , X d , X d1 , R 1 , R 1a , R 2 , R 2a , R 3 , R 4 , R 4a , R 5 , R 6 , R 6a , R 7 , R 7a , R 8 , and R 8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.

Abstract translation: 一类通式（I），通式（I'）或通式（I“）的多环化合物，其中基团1，碱基2，Y，亚氨基，Xa，Xa1，Xb，Xb1，Xc，Xc1， Xd，Xd1，R1，R1a，R2，R2a，R3，R4，R4a，R5，R6，R6a，R7，R7a，R8和R8a在本文中定义，其可用作I型干扰素生产的电感器， 提供了STING活性剂，还提供了合成和使用化合物的方法。

公开(公告)号：WO2014062596A1

公开(公告)日：2014-04-24

申请号：PCT/US2013/064906

申请日：2013-10-15

Applicant: MERCK SHARP & DOHME CORP. ,  GIRIJAVALLABHAN, Vinay ,  BOGEN, Stephane ,  TRUONG, Quang, T. ,  CHEN, Ping ,  KEREKES, Angela ,  BENNETT, Frank ,  ESPOSITE, Sara ,  HONG, Qingmei ,  DAVIES, Ian

Inventor： GIRIJAVALLABHAN, Vinay ,  BOGEN, Stephane ,  TRUONG, Quang, T. ,  CHEN, Ping ,  KEREKES, Angela ,  BENNETT, Frank ,  ESPOSITE, Sara ,  HONG, Qingmei ,  DAVIES, Ian

IPC: C07H19/067 ,  C07H19/073 ,  C07H19/10 ,  A61K31/7068 ,  A61K31/7072 ,  A61P31/14 ,  C07H19/06

CPC classification number: C07H19/06 ,  A61K31/7068 ,  A61K31/7072 ,  A61K45/06 ,  C07H19/067 ,  C07H19/073 ,  C07H19/10

Abstract: The present invention relates to 2'-Methyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R, R 1 , R 2 and R 3 , are as defined herein. The present invention also relates to compositions comprising at least one 2'-Methyl Substituted Nucleoside Derivative, and methods of using the 2'-Methyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.

Abstract translation: 本发明涉及式（I）的2'-甲基取代的核苷衍生物及其药学上可接受的盐，其中R，R 1，R 2和R 3如本文所定义。 本发明还涉及包含至少一种2'-甲基取代的核苷衍生物的组合物，以及使用2'-甲基取代的核苷衍生物治疗或预防患者HCV感染的方法。

公开(公告)号：WO2013166121A1

公开(公告)日：2013-11-07

申请号：PCT/US2013/039025

申请日：2013-05-01

Applicant: MERCK SHARP & DOHME CORP. ,  TELLERS, David ,  COLLETTI, Steven, L. ,  DUDKIN, Vadim ,  IKEMOTO, Norihiro ,  LIAO, Hongbiao ,  PARISH, Craig ,  PEI, Tao ,  SHAW, Anthony ,  TRUONG, Quang ,  WANG, Lijun ,  YUAN, Yu ,  ZHU, Man

Inventor： TELLERS, David ,  COLLETTI, Steven, L. ,  DUDKIN, Vadim ,  IKEMOTO, Norihiro ,  LIAO, Hongbiao ,  PARISH, Craig ,  PEI, Tao ,  SHAW, Anthony ,  TRUONG, Quang ,  WANG, Lijun ,  YUAN, Yu ,  ZHU, Man

IPC: C07H19/056

CPC classification number: C12N15/113 ,  A61K47/549 ,  C07H15/26 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/351

Abstract: Disclosed herein is a modular composition comprising 1) an oligonucleotide; 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different; optionally, 3) one or more linkers, which may be the same or different; and optionally, 4) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.

Abstract translation: 本文公开了一种模块化组合物，其包含：1）寡核苷酸; 2）一种或多种式（I）的四加仑配体，其可以相同或不同; 任选地，3）一个或多个可以相同或不同的接头; 和任选地，4）一种或多种靶向配体，增溶剂，药代动力学增强剂，脂质和/或掩蔽剂。

公开(公告)号：WO2009089413A1

公开(公告)日：2009-07-16

申请号：PCT/US2009/030544

申请日：2009-01-09

Applicant: SHURFLO, LLC ,  CARLSON, Kevin ,  TRUONG, Quang, Minh

Inventor： CARLSON, Kevin ,  TRUONG, Quang, Minh

IPC: F04B49/00

CPC classification number: F04B49/02 ,  F04B2203/0201

Abstract: Embodiments of the invention provide a stand-alone controller and a method for controlling a pump motor driven by an alternating current source. The stand-alone controller includes a power terminal for connection with the alternating current source and a load terminal for connection with the pump motor. The stand-alone controller further includes an enable switch to form a power line carrying power from the alternating current source to the pump motor. The stand-alone controller can store a first current being drawn through the power line by the pump motor when a control switch is actuated. A state of the enable switch is based on a comparison of the first current to a second current being drawn through the power line by the pump motor.

Abstract translation: 本发明的实施例提供了一种独立控制器和用于控制由交流电源驱动的泵马达的方法。 独立控制器包括用于与交流电源连接的电源端子和用于与泵电动机连接的负载端子。 独立控制器还包括使能开关以形成从交流电源向泵电动机承载动力的电力线。 当控制开关被致动时，独立控制器可以存储由泵电动机通过电力线吸取的第一电流。 使能开关的状态基于通过泵电动机通过电力线吸取的第一电流与第二电流的比较。