公开(公告)号：WO2010138411A1

公开(公告)日：2010-12-02

申请号：PCT/US2010/035750

申请日：2010-05-21

Applicant: COOK INCORPORATED ,  CHAMBERS, Sean, D. ,  MAGNUSON, Mark, A. ,  PARKER, Fred, T.

Inventor： CHAMBERS, Sean, D. ,  MAGNUSON, Mark, A. ,  PARKER, Fred, T.

IPC: A61F2/84

CPC classification number: A61F2/95 ,  A61F2/958 ,  A61F2002/9522 ,  Y10T29/49908

Abstract: A two-stage method of compressing a stent entails providing an expandable stent (100,105) in a radially expanded state. An outward pressure is applied to an inner surface of the tubular framework to support the stent, and a diameter of the stent is reduced to a first compressed diameter (Dl) while applying the outward pressure. The outward pressure is halted after reaching the first compressed diameter. According to an embodiment in which the stent is balloon-expandable, a delivery balloon catheter (130) comprising an uninflated balloon in a delivery configuration is inserted into the lumen after halting the outward pressure. The diameter of the stent is reduced to a second compressed diameter (D2) smaller than the first compressed diameter to crimp the stent onto the delivery balloon catheter.

Abstract translation: 压缩支架的两级方法需要提供处于放大状态的可扩张支架（100,105）。 向管状框架的内表面施加向外的压力以支撑支架，并且在施加向外的压力的同时将支架的直径减小到第一压缩直径（D1）。 达到第一压缩直径后，向外的压力停止。 根据其中支架是球囊可膨胀的实施例，包括具有输送构型的未膨胀气囊的输送气囊导管（130）在停止向外的压力之后插入腔内。 支架的直径减小到小于第一压缩直径的第二压缩直径（D2），以将支架卷曲到输送球囊导管上。

公开(公告)号：WO2010120644A3

公开(公告)日：2010-10-21

申请号：PCT/US2010/030520

申请日：2010-04-09

Applicant: COOK INCORPORATED ,  PARKER, Fred, T.

Inventor： PARKER, Fred, T.

IPC: A61L29/12

Abstract: A medical device including a tube having a coil fitted around at least a part of an inner liner, such as PTFE, and a braid extending over at least part of the coil. A polymeric layer is positioned over the braid to adhere to the inner liner. A portion of the coil advantageously comprises a polymer, such as PEEK, while the coil may also have a metal portion. The polymer coil may extend along at least at the proximal region of the tube, and the metal coil may extend along at least at the distal region of the tube. A polymer coil, a metal coil or any combination thereof can extend along the intermediate region of the tube. The polymer coil can be configured so that the tube is longitudinally splittable with a cutting instrument.

公开(公告)号：WO2005011535A3

公开(公告)日：2006-03-16

申请号：PCT/US2004024969

申请日：2004-07-30

Applicant: COOK INC ,  CASE BRIAN C ,  OSBORNE THOMAS A ,  FLAGLE JACOB A ,  PARKER FRED T

Inventor： CASE BRIAN C ,  OSBORNE THOMAS A ,  FLAGLE JACOB A ,  PARKER FRED T

IPC: A61F2/06 ,  A61F2/24 ,  A61F2/90

CPC classification number: A61F2/2418 ,  A61F2/2475 ,  A61F2220/0008 ,  A61F2220/0016 ,  A61F2230/0067 ,  A61F2230/0078 ,  A61F2230/008 ,  A61F2250/0063

Abstract: Prosthetic valves for implantation in a body vessel are provided. Prosthetic valves according to the invention comprise first and second frame members and a graft member at least partially disposed between the first and second frame members. The graft member forms a valve that permits fluid flow through the body vessel in a first direction and substantially prevents fluid flow through the body vessel in a second, opposite direction.

Abstract translation: 提供用于植入体内的假体瓣膜。 根据本发明的假体瓣膜包括第一和第二框架构件以及至少部分地设置在第一和第二框架构件之间的移植构件。 移植物构件形成允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体血管。

公开(公告)号：WO2006014768A1

公开(公告)日：2006-02-09

申请号：PCT/US2005/025825

申请日：2005-07-22

Applicant: COOK INCORPORATED ,  PARKER, Fred, T.

Inventor： PARKER, Fred, T.

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91516 ,  A61F2002/91525 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/91591 ,  A61F2230/0054 ,  A61F2250/0098

Abstract: A marker and pushing member are provided with lateral extensions connected to a connecting portion. The connecting portion connects the marker/pushing member to a proximal or distal end of the stent. The lateral extensions distribute forces applied to the marker/pushing member so that part of the force is applied to the connecting member and part of the force is applied to a portion of the stent structure that is not directly connected to the connecting member.

Abstract translation: 标记和推动构件设置有连接到连接部分的侧向延伸部。 连接部分将标记/推动构件连接到支架的近端或远端。 横向延伸部分布施加到标记/推动构件的力，使得一部分力被施加到连接构件，并且一部分力被施加到未直接连接到连接构件的支架结构的一部分。

公开(公告)号：WO2004096335A1

公开(公告)日：2004-11-11

申请号：PCT/US2004/012837

申请日：2004-04-26

Applicant: COOK INCORPORATED ,  PARKER, Fred, T.

Inventor： PARKER, Fred, T.

IPC: A61M25/00

CPC classification number: A61M25/0045 ,  A61M25/005 ,  A61M25/0052

Abstract: A flexible, kink-resistant, delivery catheter or sheath (83) for percutaneously delivering implantable medical devices. The delivery catheter sheath includes a flat wire coil (95) with uniform spacing between the turns, which is compression fitted about and proximal the distal portion of an inner, lubricous material polytetrafluoroethylene tube (84). The delivery catheter or sheath further includes an outer tube (85) of a heat formable polyamide material, which is heat formed and compressed through the spaces between the turns of the wire coil to mechanically connect to the roughened outer surface of the inner tube. The distal portion (87) of the innertube is expanded and everted or folded-back over itself and connected to the distal end of the outer tube to form a lumen having a larger diameter than the rest of the catheter.

Abstract translation: 一种用于经皮输送可植入医疗装置的柔性，扭结输送导管或护套（83）。 输送导管鞘包括在匝之间具有均匀间隔的扁平线圈（95），其在内部润滑的材料聚四氟乙烯管（84）的远侧部分附近压缩配合。 输送导管或护套还包括可热成型聚酰胺材料的外管（85），其通过线圈的匝之间的空间热形成和压缩，以机械地连接到内管的粗糙化的外表面。 内管的远端部分（87）被膨胀和旋转或折叠回自身并且连接到外管的远端以形成具有比导管的其余部分更大的直径的管腔。

公开(公告)号：WO2010039456A1

公开(公告)日：2010-04-08

申请号：PCT/US2009/057443

申请日：2009-09-18

Applicant: COOK INCORPORATED ,  PARKER, Fred, T. ,  JANTZEN, Alexandra, Elizabeth

Inventor： PARKER, Fred, T. ,  JANTZEN, Alexandra, Elizabeth

IPC: A61M25/00 ,  A61F2/84

CPC classification number: A61M25/001 ,  A61F2/95 ,  A61F2002/9665 ,  A61M25/0069 ,  A61M2025/0681

Abstract: A catheter tip assembly (50) is provided with a catheter tip (56) and an inner catheter (54). The catheter tip (56) has a tapered proximal end, an elongate center portion, and a tapered distal end. The inner catheter (54) includes a narrow proximal portion, a narrow elongate center portion (66), and a wide distal end (68). The catheter tip (56) is disposed within the wide distal end (68) of the inner catheter (54). One advantage of the catheter tip assembly is that no proximal-facing edge is formed at the transition between the narrow elongate center portion of the inner catheter and the catheter tip, which may help reduce the risk of the catheter tip snagging on a stent during use.

Abstract translation: 导管末端组件（50）设置有导管尖端（56）和内部导管（54）。 导管尖端（56）具有锥形近端，细长中心部分和锥形远端。 内导管（54）包括窄的近端部分，细长的中心部分（66）和宽的远端（68）。 导管尖端（56）设置在内导管（54）的宽远端（68）内。 导管末端组件的一个优点是在内导管的窄细长中心部分与导管尖端之间的过渡处没有形成面向近端的边缘，这有助于降低在使用期间导管末端在支架上阻塞的风险 。

公开(公告)号：WO2008070130A1

公开(公告)日：2008-06-12

申请号：PCT/US2007/024932

申请日：2007-12-04

Applicant: COOK INCORPORATED ,  WILLIAM COOK EUROPE ApS ,  MAGNUSON, Mark, A. ,  PARKER, Fred, T. ,  HANSEN, Palle, M.

Inventor： MAGNUSON, Mark, A. ,  PARKER, Fred, T. ,  HANSEN, Palle, M.

IPC: A61F2/82 ,  C22F1/00 ,  C22F1/10

CPC classification number: C22F1/006 ,  A61F2/95 ,  A61F2002/9522 ,  A61F2210/0014 ,  A61F2250/0042 ,  C22F1/00 ,  C22F1/10 ,  Y10T29/4976 ,  Y10T29/49865

Abstract: A process to load a medical device comprising a shape memory material into a delivery system is described herein. According to one aspect, the method includes applying a force to the medical device to obtain a delivery configuration thereof, where the device is at a first temperature within an R-phase temperature range of the shape memory material during application of the force. The medical device is cooled in the delivery configuration to a second temperature at or below a martensite finish temperature of the shape memory material. The force is then removed from the medical device, and the device is loaded into a delivery system. Preferably, the medical device substantially maintains the delivery configuration during the loading process.

Abstract translation: 本文描述了将包括形状记忆材料的医疗装置加载到递送系统中的过程。 根据一个方面，所述方法包括向所述医疗装置施加力以获得其输送构型，其中所述装置在所述力的施加期间处于所述形状记忆材料的R相温度范围内的第一温度。 医疗装置在输送构型中被冷却到等于或低于形状记忆材料的马氏体终止温度的第二温度。 然后将力从医疗装置中取出，将装置装载到输送系统中。 优选地，医疗装置在装载过程中基本维持输送构型。

公开(公告)号：WO2006113863A2

公开(公告)日：2006-10-26

申请号：PCT/US2006/014864

申请日：2006-04-20

Applicant: COOK INCORPORATED ,  PAL, Dharmendra ,  AGNEW, Charles, W. ,  FLAGLE, Jacob, A. ,  LENTZ, D., Christian ,  MELSHEIMER, Jeffry, S. ,  OSBORNE, Thomas, A. ,  PARKER, Fred, T.

Inventor： PAL, Dharmendra ,  AGNEW, Charles, W. ,  FLAGLE, Jacob, A. ,  LENTZ, D., Christian ,  MELSHEIMER, Jeffry, S. ,  OSBORNE, Thomas, A. ,  PARKER, Fred, T.

CPC classification number: A61M25/0662 ,  A61F2/95 ,  A61F2002/9517 ,  A61M25/0045 ,  A61M25/005 ,  A61M25/0053

Abstract: Delivery systems for self-expanding devices are provided having a system proximal portion with a handle, an elongate middle section delivery device with an outer sheath and inner compression member, and a system distal portion including an outer guide channel member with first and second end portions defining a guide channel that slidably receives an inner guide channel member having a guide channel, the guide channels being substantially aligned. A mounting region for self-expanding devices is disposed radially between the inner and outer guide channel members. The outer guide channel member has a stepped profile from a first outer diameter to a second smaller outer diameter located near a transition region having a breech position opening for passage of a wire guide, catheter, or other medical instrument. The outer member is axially slideable relative to the inner member to deploy a self-expanding device. Methods of using and manufacturing are also provided.

Abstract translation: 提供了一种用于自扩张装置的输送系统，其具有带手柄的系统近端部分，具有外护套和内部压缩构件的细长中间部分输送装置，以及包括具有第一和第二端部的外部引导通道构件的系统远端部分 限定了可滑动地容纳具有引导通道的内部引导通道构件的引导通道，所述引导通道基本对齐。 用于自膨胀装置的安装区域径向地设置在内引导通道构件和外引导通道构件之间。 外引导通道构件具有从第一外径到第二较小外径的阶梯轮廓，位于具有用于导线器，导管或其他医疗器械通过的后膛位置开口的过渡区域附近。 外部构件相对于内部构件可轴向滑动以展开自扩张装置。 还提供了使用和制造方法。

公开(公告)号：WO2006014767A1

公开(公告)日：2006-02-09

申请号：PCT/US2005/025824

申请日：2005-07-22

Applicant: COOK INCORPORATED ,  PARKER, Fred, T.

Inventor： PARKER, Fred, T.

IPC: A61F2/06

CPC classification number: A61F2/91 ,  A61F2/86 ,  A61F2/915 ,  A61F2/95 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9665 ,  A61F2220/0041 ,  A61F2230/0054 ,  A61F2250/0039

Abstract: A stent delivery system includes a stept having at least one eyelet and at feast one rivet and a holder supporting the stept, wherein the holder includes a first section having a first diameter and a second section having a second diameter. A sheath covers the stept and the holder. The rivets are attached to each of the eyelets. A first inner diameter of the stent at the position of the rivets is smaller than a second inner diameter of the stept at other positions because the rivets protrude inwardly. A shoulder is formed on the holder due to the difference between the first diameter and the second diameter of the holder. The shoulder is positioned distally adjacent the rivets. The shoulder interferes with the protruding rivets, thereby restraining the longitudinal movement of the stept relative to the holder. Although the sheath is pulled back, the stem does not jump out of the stem delivery system. As a result, the stem delivery system allows the stem to be released in a controlled manner upon its deployment.

Abstract translation: 支架输送系统包括具有至少一个孔眼并且盛装一个铆钉的踏板和支撑踏板的支架，其中该支架包括具有第一直径的第一部分和具有第二直径的第二部分。 护套覆盖梯子和支架。 铆钉附着在每个孔眼上。 铆钉的位置处的支架的第一内径小于其他位置处的踏板的第二内径，因为铆钉向内突出。 由于保持器的第一直径和第二直径之间的差异，在支架上形成有肩部。 肩部位于远离铆钉的位置。 肩部干涉突出的铆钉，从而限制纵向的i /

公开(公告)号：WO2010120671A1

公开(公告)日：2010-10-21

申请号：PCT/US2010/030696

申请日：2010-04-12

Applicant: COOK INCORPORATED ,  WILLIAM COOK EUROPE APS ,  PARKER, Fred, T. ,  HANSEN, Palle, M.

Inventor： PARKER, Fred, T. ,  HANSEN, Palle, M.

IPC: A61F2/84

CPC classification number: A61F2/97 ,  A61F2/95 ,  A61F2/966 ,  A61F2002/9517 ,  A61F2002/9522 ,  A61F2250/0039 ,  A61L29/085

Abstract: A stent deployment system, handle, and method of loading of a medical device are provided. The system includes an outer catheter having an inner liner extending past the end of the outer catheter and an inner catheter disposed within the outer catheter. The inner liner is inverted and attached to the inner catheter. Relative movement between the outer and the inner catheters can urge the inner liner to peel away from the medical device. A handle is disposed at the proximal end of the outer catheter, and may include a splitter configured to slice the wall of the tubular member. The handle may also include a rotatable mechanism that can be attached to the tubular member. Rotation of the rotatable mechanism retracts a portion of the tubular member into the handle and winds the sliced portion about the rotatable mechanism.

Abstract translation: 提供了支架部署系统，手柄和装载医疗装置的方法。 该系统包括具有延伸穿过外导管的端部的内衬套和设置在外导管内的内导管的外导管。 内衬被倒置并连接到内导管上。 外导管和内导管之间的相对运动可促使内衬从医疗装置剥离。 手柄设置在外导管的近端处，并且可以包括被配置为切割管状构件的壁的分流器。 手柄还可以包括可连接到管状构件的可旋转机构。 可旋转机构的旋转将管状构件的一部分缩回到手柄中并围绕可旋转机构卷绕切片部分。