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1.发明申请
公开(公告)号：WO2010046388A1
公开(公告)日：2010-04-29
申请号：PCT/EP2009/063789
申请日：2009-10-21
Applicant: GLAXO GROUP LIMITED , HENNESSY, Alan, Joseph , JONES, Graham Elgin , MARKWELL, Roger Edward , MILES, Timothy , PEARSON, Neil, David
Inventor： HENNESSY, Alan, Joseph , JONES, Graham Elgin , MARKWELL, Roger Edward , MILES, Timothy , PEARSON, Neil, David
IPC: C07D471/04 , C07D491/048 , C07D491/052 , C07D491/056 , C07D497/04 , C07D498/04 , C07D513/04 , A61K31/4704 , A61P31/04
CPC classification number: C07D513/04 , C07D471/04 , C07D491/052 , C07D491/056 , C07D497/04 , C07D498/04
Abstract: Bicyclic nitrogen containing compounds and their use as antibacterials.
Abstract translation: 双环含氮化合物及其作为抗菌剂的用途。
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公开(公告)号：WO2009090222A1
公开(公告)日：2009-07-23
申请号：PCT/EP2009/050436
申请日：2009-01-15
Applicant: GLAXO GROUP LIMITED , ALEMPARTE-GALLARDO, Carlos , BALLELL-PAGES, Lluis , BARROS-AGUIRRE, David , CACHO-IZQUIERDO, Monica , CASTRO-PICHEL, Julia , FIANDOR-ROMAN, Jose Maria , HENNESSY, Alan Joseph , PEARSON, Neil David , REMUINAN-BLANCO, Modesto Jesus
Inventor： ALEMPARTE-GALLARDO, Carlos , BALLELL-PAGES, Lluis , BARROS-AGUIRRE, David , CACHO-IZQUIERDO, Monica , CASTRO-PICHEL, Julia , FIANDOR-ROMAN, Jose Maria , HENNESSY, Alan Joseph , PEARSON, Neil David , REMUINAN-BLANCO, Modesto Jesus
IPC: C07D471/04 , A61K31/4375 , A61P31/04
CPC classification number: C07D471/04
Abstract: Compounds of Formula (I), wherein substituents R 1 , R 2 and R 5 are as defined, and Ar represents substituted phenyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, furanyl, imidazolyl and thiophenyl; compositions containing them, their use in therapy, including their use as antibacterials, for example in the treatment of tuberculosis, and methods for the preparation of such compounds, are provided.
Abstract translation: 吡啶基，哒嗪基，嘧啶基，吡嗪基，噻唑基，呋喃基，咪唑基和噻吩基的式（I）化合物，其中取代基R 1，R 2和R 5如上所定义。 提供含有它们的组合物，它们在治疗中的用途，包括它们作为抗菌剂的用途，例如用于治疗结核病，以及制备这些化合物的方法。
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公开(公告)号：WO2008128962A1
公开(公告)日：2008-10-30
申请号：PCT/EP2008/054667
申请日：2008-04-17
Applicant: GLAXO GROUP LIMITED , PEARSON, Neil, David
Inventor： PEARSON, Neil, David
IPC: C07D471/04 , C07D471/16 , A61K31/4375 , A61P31/04
CPC classification number: C07D471/04 , C07D471/16
Abstract: Tricyclic nitrogen containing compounds of formula (I) and their use as antibacterials.
Abstract translation: 式（I）的三环氮化合物及其作为抗菌剂的用途。
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公开(公告)号：WO2008128942A1
公开(公告)日：2008-10-30
申请号：PCT/EP2008/054621
申请日：2008-04-16
Applicant: GLAXO GROUP LIMITED , DAVIES, David, Evan , DAVIES, David, Thomas , GIORDANO, Ilaria , HENNESSY, Alan, Joseph , PEARSON, Neil, David
Inventor： DAVIES, David, Evan , DAVIES, David, Thomas , GIORDANO, Ilaria , HENNESSY, Alan, Joseph , PEARSON, Neil, David
IPC: C07D519/00 , C07D471/16 , C07D487/16 , A61K31/4985 , A61P31/00
CPC classification number: C07D471/16 , C07D487/16 , C07D519/00
Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials. Z 1 and Z 2 are independently selected from CH and N.
Abstract translation: 三环含氮化合物及其作为抗菌剂的用途。 Z 1和Z 2独立地选自CH和N.
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公开(公告)号：WO2008116815A2
公开(公告)日：2008-10-02
申请号：PCT/EP2008/053350
申请日：2008-03-20
Applicant: GLAXO GROUP LIMITED , BROWN, Pamela , DABBS, Steven , DAVIES, David, Thomas , PEARSON, Neil, David
Inventor： BROWN, Pamela , DABBS, Steven , DAVIES, David, Thomas , PEARSON, Neil, David
CPC classification number: C07D471/06 , C07D519/00
Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials.
Abstract translation: 三环含氮化合物及其作为抗菌剂的用途。
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2008009700A1
公开(公告)日：2008-01-24
申请号：PCT/EP2007/057422
申请日：2007-07-18
Applicant: GLAXO GROUP LIMITED , BALLELL, Lluis , BARROS, David , BROOKS, Gerald , CASTRO PICHEL, Julia , DABBS, Steven , DAINES, Robert, A , DAVIES, David, Thomas , FIANDOR ROMAN, Jose Maria , GIORDANO, Ilaria , HENNESSY, Alan, Joseph , HOFFMAN, James, B , JONES, Graham, Elgin , MILES, Timothy, James , PEARSON, Neil, David , PENDRAK, Israil , REMUINAN BLANCO, Modesto, J , ROSSI, Jason, Anthony , ZHANG, Lihua(lily)
Inventor： BALLELL, Lluis , BARROS, David , BROOKS, Gerald , CASTRO PICHEL, Julia , DABBS, Steven , DAINES, Robert, A , DAVIES, David, Thomas , FIANDOR ROMAN, Jose Maria , GIORDANO, Ilaria , HENNESSY, Alan, Joseph , HOFFMAN, James, B , JONES, Graham, Elgin , MILES, Timothy, James , PEARSON, Neil, David , PENDRAK, Israil , REMUINAN BLANCO, Modesto, J , ROSSI, Jason, Anthony , ZHANG, Lihua(lily)
IPC: C07D491/04 , C07D497/04 , C07D498/04 , C07D513/04 , C07D519/00 , A61P31/04 , A61P31/06
CPC classification number: C07D491/04 , A61K31/519 , A61K31/538 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D471/04 , C07D497/04 , C07D498/04 , C07D513/04 , C07D519/00
Abstract: Bicyclic nitrogen containing compounds and their use as antibacterials.
Abstract translation: 双环含氮化合物及其作为抗菌剂的用途。
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公开(公告)号：WO2008003690A1
公开(公告)日：2008-01-10
申请号：PCT/EP2007/056664
申请日：2007-07-03
Applicant: GLAXO GROUP LIMITED , BROOKS, Gerald , MILES, Timothy, James , PEARSON, Neil, David
Inventor： BROOKS, Gerald , MILES, Timothy, James , PEARSON, Neil, David
IPC: C07D519/00 , A61K31/4375 , A61K31/5025 , A61K31/4985 , A61P31/04
CPC classification number: C07D519/00
Abstract: Tricyclic nitrogen containing compounds),of formula (I) or a pharmaceutically, acceptable salt, solvate and/or N-oxide thereof: and their use as antibacterials.
Abstract translation: 三环式含氮化合物），式（I）化合物或其药学上可接受的盐，溶剂合物和/或N-氧化物：及其作为抗菌剂的用途。
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公开(公告)号：WO2007081597A2
公开(公告)日：2007-07-19
申请号：PCT/US2006/060023
申请日：2006-10-17
Applicant: GLAXO GROUP LIMITED , CAILLEAU, Nathalie , DAVIES, David, Thomas , ESKEN, Joel, Michael , HENNESSY, Alan, Joseph , KUSALAKUMARI SUKUMAR, Senthil, Kumar , MARKWELL, Roger, Edward , MILES, Timothy, James , PEARSON, Neil, David
Inventor： CAILLEAU, Nathalie , DAVIES, David, Thomas , ESKEN, Joel, Michael , HENNESSY, Alan, Joseph , KUSALAKUMARI SUKUMAR, Senthil, Kumar , MARKWELL, Roger, Edward , MILES, Timothy, James , PEARSON, Neil, David
CPC classification number: C07D471/06 , C07D519/00
Abstract: Tricyclic nitrogen containing compounds and their use as antibacterials
Abstract translation: 三环含氮化合物及其作为抗菌剂的用途
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9.发明申请AMINOCYCLOHEXENE QUINOLINES AND THEIR AZAISOSTERIC ANALOGUES WITH ANTIBACTERIAL ACTIVITY 审中-公开氨基环己烯喹啉及其抗菌活性的类异构体类似物
公开(公告)号：WO2004014361A1
公开(公告)日：2004-02-19
申请号：PCT/EP2003/008153
申请日：2003-07-23
Applicant: GLAXO GROUP LIMITED , DAVIES, David, Thomas , ELDER, John, Stephen , FORREST, Andrew, Keith , JARVEST, Richard, Lewis , PEARSON, Neil, David , SHEPPARD, Robert, John
Inventor： DAVIES, David, Thomas , ELDER, John, Stephen , FORREST, Andrew, Keith , JARVEST, Richard, Lewis , PEARSON, Neil, David , SHEPPARD, Robert, John
IPC: A61K31/33
CPC classification number: C07D471/04 , C07D215/42 , C07D491/04 , C07D513/04
Abstract: Cyclohexene derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.
Abstract translation: 可用于治疗哺乳动物特别是人的细菌感染的方法中的环己烯衍生物及其药学上可接受的衍生物。
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公开(公告)号：WO2003010138A3
公开(公告)日：2003-02-06
申请号：PCT/EP2002/008319
申请日：2002-07-25
Applicant: SMITHKLINE BEECHAM PLC , DAVIES, David, Thomas , JONES, Graham, Elgin , MARKWELL, Roger, Edward , PEARSON, Neil, David
Inventor： DAVIES, David, Thomas , JONES, Graham, Elgin , MARKWELL, Roger, Edward , PEARSON, Neil, David
IPC: C07D471/04
Abstract: Piperidine derivatives (I) and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man. Formula (I):
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