公开(公告)号：WO2013024316A2

公开(公告)日：2013-02-21

申请号：PCT/HU2012000076

申请日：2012-08-21

Applicant: PECSI TUDOMANYEGYETEM ,  ALMASI GABOR ,  HEBLING JANOS ,  TOEKE CSABA

Inventor： ALMASI GABOR ,  HEBLING JANOS ,  TOEKE CSABA

IPC: H05G2/00

CPC classification number: H01S3/0959 ,  H01S3/0903 ,  H05G2/00

Abstract: The invention relates to a method for generating electromagnetic radiation, to an optical short-period undulator and to a free-electron laser comprising the latter. To accomplish the method, a high-energy electrically charged particle beam is provided, and high-intensity electromagnetic pulses (7) are generated, and by interfering said pulses with one another an electromagnetic standing wave is created, wherein said standing wave has an electric field strength of a pre-determined peak value. The particle beam is directed through the non-steady electromagnetic field of the standing wave in or in the vicinity of a plane spanned by nodes with maximal electric field strength of said electromagnetic standing wave. Meanwhile, by the electromagnetic field of the standing wave, the particle beam is forced to travel along an undulating path and thereby, in the form of radiation emitted by said particle beam, electromagnetic radiation that propagates in the propagation direction of the particle beam is generated. Said short-period undulator (10) comprises a pulse source (2) to emit high- intensity pulses falling into the terahertz frequency range and an interaction region to direct a high-energy electrically charged particle beam, in particular an electron beam, through the undulator with undulator effect. The undulator effect is provided in the interaction region through a dynamic effect developing in or in the vicinity of a plane spanned by nodes with maximal electric field strength of an electromagnetic standing wave created by the interference of high-intensity pulses falling into the terahertz frequency range, emitted by said pulse source.

Abstract translation: 本发明涉及一种用于产生电磁辐射的方法，涉及一种光学短周期波动器和一种包括后者的自由电子激光器。 为了实现该方法，提供了高能带电粒子束，产生高强度电磁脉冲（7），并且通过相互干扰所述脉冲，产生电磁驻波，其中所述驻波具有电 预测峰值的场强。 粒子束通过所述电磁驻波的最大电场强度的节点跨越平面的平面内或附近的驻波的非稳定电磁场引导。 同时，通过驻波的电磁场，粒子束被迫沿着起伏的路径行进，从而以所述粒子束发射的辐射的形式，产生沿粒子束的传播方向传播的电磁辐射 。 所述短周期波动器（10）包括用于发射落入太赫兹频率范围内的高强度脉冲的脉冲源（2）和相互作用区域，以引导高能量带电粒子束，特别是电子束，通过 起伏器具有起伏效应。 波动器效应通过在由具有由落入太赫兹频率范围的高强度脉冲的干扰产生的电磁驻波的最大电场强度的节点跨越的平面中或其附近发展的动态效应来提供。 ，由所述脉冲源发射。

公开(公告)号：WO2009022191A3

公开(公告)日：2009-04-16

申请号：PCT/HU2008000095

申请日：2008-08-01

Applicant: PECSI TUDOMANYEGYETEM ,  BARDOS TAMAS ,  BELLYEI ARPAD ,  ILLES TAMAS ,  NEMETH PETER

Inventor： BARDOS TAMAS ,  BELLYEI ARPAD ,  ILLES TAMAS ,  NEMETH PETER

IPC: A61F2/30 ,  A61B17/16 ,  A61B17/32

CPC classification number: A61F2/30756 ,  A61B17/00491 ,  A61B17/06166 ,  A61B17/32 ,  A61B17/322 ,  A61B17/68 ,  A61B2017/00969 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/4202 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/3096

Abstract: The articular cartilage according to the invention is made of pure cartilage and is provided with incisions (12) on the surface facing the bone. The cartilage cells are preferably seeded on the surface provided with incisions (12). The method for producing the articular cartilage comprises the step of collecting cartilage from joints, wherein pure cartilage is collected without bone, and incisions are made on the surface of the cartilage intended to face the bone. It is preferably fresh frozen until use. The device for harvesting articular cartilage, comprises handle and cutting blade, wherein the cutting blade (4) is curvilinear and is pro-vided with spacer elements (5), meanwhile the device for producing incisions in articular cartilages comprises handle (2) and a bridge (3) connected to said handle (2) and being provided with one or more cutting blade(s) (4). During the method for applying the articular cartilage the articular cartilage is fixed by thin surgical yarn stitches, by fibrin glue or by small anchors (Fig.8).

Abstract translation: 根据本发明的关节软骨由纯软骨制成并且在面向骨的表面上设有切口（12）。 软骨细胞优选接种在设有切口（12）的表面上。 用于制造关节软骨的方法包括从关节收集软骨的步骤，其中收集无骨的纯软骨，并且在旨在面向骨的软骨表面上形成切口。 它最好是新鲜冷冻直到使用。 用于收获关节软骨的装置包括手柄和切割刀片，其中切割刀片（4）为曲线形并且具有间隔元件（5），同时用于在关节软骨中产生切口的装置包括手柄（2）和 连接到所述手柄（2）并且设有一个或多个切割刀片（4）的桥（3）。 在施用关节软骨的方法中，关节软骨通过薄手术纱线缝合，纤维蛋白胶或小锚固定（图8）。

公开(公告)号：WO2014041385A2

公开(公告)日：2014-03-20

申请号：PCT/HU2013000093

申请日：2013-09-13

Applicant: PECSI TUDOMANYEGYETEM

Inventor： BAGDAN VIKTOR ,  CZIMERMAN LASZLO ,  MATHE KALMAN ,  PYTEL JOZSEF

CPC classification number: H04R3/04 ,  H03G5/165 ,  H03G9/025

Abstract: The invention relates to a device and a method to process audio signals. Said device comprising an input, an output and a continuous signal propagation path extending from the input to the output for audio signals applied to said input. The device further comprises in the signal propagation path from said input towards said output in the given order a first linear distortion generating unit (20) having first transfer characteristics, a nonlinear distortion generating unit (30) having nonlinear transfer characteristics to generate frequency-dependent distortion of the linearly distorted audio signal, and a second linear distortion generating unit (40) having second transfer characteristics, wherein said second transfer characteristics corresponds essentially to the inverse of said first transfer characteristics. The inventive method comprising subjecting said audio signals to first linear distortion characterized by first transfer characteristics, then subjecting the obtained linearly distorted audio signals to frequency-dependent nonlinear distortion, and then subjecting the thus obtained nonlinearly distorted audio signals to second linear distortion characterized by second transfer characteristics, said second transfer characteristics being provided essentially as the inverse of said first transfer characteristics.

Abstract translation: 本发明涉及一种处理音频信号的装置和方法。 所述装置包括从输入端延伸到输出端的输入端，输出端和连续信号传播路径，用于施加到所述输入端的音频信号。 该装置还包括在以给定顺序从所述输入到所述输出的信号传播路径中具有第一传输特性的第一线性失真产生单元（20），具有非线性传输特性以产生频率依赖性的非线性失真产生单元（30） 线性失真的音频信号的失真以及具有第二传送特性的第二线性失真产生单元（40），其中所述第二传送特性基本上对应于所述第一传输特性的倒数。 本发明的方法包括使所述音频信号经历以第一传输特性为特征的第一线性失真，然后对获得的线性失真的音频信号进行频率相关的非线性失真，然后将由此获得的非线性失真的音频信号进行第二线性失真， 传输特性，所述第二传输特性基本上被提供为所述第一传输特性的倒数。

公开(公告)号：WO2010001186A4

公开(公告)日：2010-03-11

申请号：PCT/HU2009000055

申请日：2009-07-01

Applicant: PECSI TUDOMANYEGYETEM ,  GALLYAS FERENC ,  SUEMEGI BALAZS ,  VETOE SARA ,  ACS PETER ,  KOMOLY SAMUEL ,  ILLES ZSOLT

Inventor： GALLYAS FERENC ,  SUEMEGI BALAZS ,  VETOE SARA ,  ACS PETER ,  KOMOLY SAMUEL ,  ILLES ZSOLT

IPC: A61K45/06

CPC classification number: A61K45/06 ,  A61K31/05 ,  A61K31/565 ,  A61K31/65 ,  A61K2300/00

Abstract: The primary subject of the invention is the use of a PARP inhibitor and an Akt kinase activating compound in combination in the treatment of pathological conditions related to PARP activation and/or that could benefit from Akt activation. A further subject of the invention is the use of a PARP inhibitor and an Akt kinase activating compound in combination for the preparation of pharmaceutical composition or kit for the treatment of a pathological condition related to PARP activation. The invention also relates to pharmaceutical composition, which contains a PARP-inhibitor and an Akt kinase activating compound together with auxiliaries generally used in pharmacy.

Abstract translation: 本发明的主要目的是联合使用PARP抑制剂和Akt激酶化合物治疗与PARP激活相关的病理状态和/或可从Akt激活中受益的病理状态。 本发明的另一主题是PARP抑制剂和Akt激酶活化化合物联合用于制备用于治疗与PARP活化相关的病理状况的药物组合物或试剂盒的用途。 本发明还涉及药物组合物，其含有PARP抑制剂和Akt激酶活化化合物以及药物中常用的助剂。

公开(公告)号：WO2012153157A3

公开(公告)日：2013-03-07

申请号：PCT/HU2012000035

申请日：2012-05-08

Applicant: PECSI TUDOMANYEGYETEM ,  TUKORA BALAZS

Inventor： TUKORA BALAZS

IPC: G05B17/02

CPC classification number: G05B17/02 ,  G05B2219/33301 ,  G05B2219/37355 ,  G05B2219/37437 ,  G05B2219/49099

Abstract: The present invention relates to a computer-controlled milling machine comprising a milling tool (210) for machining a workpiece, a measuring unit (230) for measuring the cutting forces exerted by the milling tool (210) to the workpiece, a simulation module (240) for simulating the milling process to determine a contact area between the workpiece and the milling tool (210) by using a multi-dexel representation of the workpiece, a prediction module (250) for receiving the milling force measurements and the simulated geometrical data, and for generating predicted cutting forces from the measured cutting forces and the simulated cutting forces, and a control unit (220) for receiving the predicted cutting forces and for adjusting the operational parameters of the milling process according to the predicted cutting forces so as to reach optimum values for the actual cutting forces acting to milling tool (210).The invention also relates to a method of optimizing cutting forces in a milling process using the aforementioned computer-controlled milling machine.

Abstract translation: 本发明涉及一种计算机控制铣床，其包括用于加工工件的铣刀（210），用于测量由所述铣刀（210）施加到所述工件的切削力的测量单元（230），模拟模块 240），用于模拟铣削过程以通过使用工件的多指示表示来确定工件和铣刀（210）之间的接触面积;预测模块（250），用于接收铣削力测量值和模拟几何数据 并且用于根据所测量的切削力和模拟的切削力产生预测的切削力;以及控制单元（220），用于接收预测的切削力并根据预测的切削力调整铣削加工的操作参数，以便 达到作用于铣刀（210）的实际切削力的最佳值。本发明还涉及一种优化铣削加工中的切削力的方法 使用上述计算机控制的铣床。

公开(公告)号：WO2011124935A3

公开(公告)日：2012-01-12

申请号：PCT/HU2011000031

申请日：2011-04-07

Applicant: PECSI TUDOMANYEGYETEM ,  FUELOEP JOZSEF ,  ALMASI GABOR ,  HEBLING JANOS ,  TRINN TAMAS

Inventor： FUELOEP JOZSEF ,  ALMASI GABOR ,  HEBLING JANOS ,  TRINN TAMAS

IPC: G02F1/35

CPC classification number: G02F1/3544 ,  G02F1/39 ,  G02F2201/30 ,  G02F2201/305

Abstract: The invention relates to an optical device (100) for performing nonlinear optical processes, allowing especially broadband optical parametric amplification or frequency conversion, wherein one or more of several input beams exhibit angular dispersion and the angular dispersive element (105) of said optical device (100) is in direct optical contact with the nonlinear medium (107). The device according to the invention allows the construction of high efficiency, compact amplifiers and frequency converters with ultrahigh broadband that can be scaled for large beam sizes and high powers as well.

Abstract translation: 本发明涉及一种用于执行非线性光学处理的光学装置（100），允许特别是宽带光学参数放大或频率转换，其中多个输入光束中的一个或多个表现出角度色散和所述光学装置的角度色散元件（105） 100）与非线性介质（107）直接光学接触。 根据本发明的装置允许构建具有超高宽度的高效率，紧凑型放大器和变频器，其可以针对大光束尺寸和高功率进行缩放。

公开(公告)号：WO2011042764A1

公开(公告)日：2011-04-14

申请号：PCT/HU2010000104

申请日：2010-09-30

Applicant: PECSI TUDOMANYEGYETEM ,  TUKORA BALAZS

Inventor： TUKORA BALAZS

IPC: G05B19/4069

CPC classification number: G05B19/4069 ,  Y02P90/265

Abstract: A method for milling process simulation performed on a free-formed body is disclosed. In the method a three-dimensional multi-dexel representation of a free- formed body to be processed is generated by using a three-dimensional depth peeling algorithm at a first virtual camera position and a predetermined grid spacing (S110), wherein each of the dexels are stored independently of each other regarding their neighborhood relations, and each of the dexels is associated with at least the following pieces of information: information relating to the spatial position and direction of the dexel, preferably the display coordinates of the dexel and the depth coordinate of the end points of the dexels, geometric information relating to the workpiece surface intersected by the dexel at the starting point and the end point of the dexel. Then a volume representation of the tool or a volume representation the swept volume of the tool is generated by using a three- dimensional depth peeling algorithm (S120) at a second virtual camera position, wherein said second virtual camera position is identical to said first virtual camera position, and wherein the surface segments of the tool thus obtained are described by display coordinates and depth coordinates associated with said respective display coordinates. In predetermined positions of the tool along the tool path, the depth coordinates of each dexel are compared to the depth coordinates of the surface segments of the tool or the swept volume of the tool that have the same display coordinates as those ones of the dexel, and accordingly, for each of the dexels, the intersection points of the particular dexel and the surface segments of the tool (S130) are determined. A dexel is kept unchanged if the dexel has no intersection point with the tool surface (S131), or the respective parameters of the dexel are modified if the dexel has an intersection point with one surface segment of the tool (S132), or the dexel is converted into two or more shorter dexels if the dexel has multiple intersection points with more than one of said surface segments (S133). Thereby a modified three-dimensional dexel-volume representation of the workpiece is generated at a particular position of the tool.

Abstract translation: 公开了一种用于在自由成形体上执行的铣削过程模拟的方法。 在该方法中，通过在第一虚拟相机位置和预定网格间隔处使用三维深度剥离算法来生成待处理的自由形成的身体的三维多角形表示（S110），其中每个 相互独立地存储关于它们的邻域关系的dexels，并且每个dexels至少与以下几条信息相关联：关于指标的空间位置和方向的信息，优选指标的显示坐标和深度 刻度的终点的坐标，与起始点处的标线相交的工件表面相关的几何信息以及标线的终点。 然后，通过在第二虚拟照相机位置处使用三维深度剥离算法（S120）来生成工具的体积表示或工具的扫掠体积的体积表示，其中，所述第二虚拟照相机位置与所述第一虚拟 相机位置，并且其中如此获得的工具的表面段由与所述各个显示器坐标相关联的显示器坐标和深度坐标描述。 在沿着工具路径的工具的预定位置中，将每个等值线的深度坐标与工具的表面部分的深度坐标或具有与那些等值线的显示坐标相同的显示坐标的工具的扫掠体积进行比较， 并且因此，对于每个所述德塞克斯，确定所述特定的等值线与所述工具的表面片段的交点（S130）。 如果角标与工具表面没有交点（S131），或者如果角标与工具的一个表面段（S132）具有交点（或者角标）相对应，则角标的相应参数被修改， 如果该位移线与多于一个的所述表面片段具有多个交点，则被转换为两个或更多个更短的dexels（S133）。 由此在工具的特定位置处生成工件的修改的三维体素体积表示。

公开(公告)号：WO2009071957A3

公开(公告)日：2009-08-27

申请号：PCT/HU2008000133

申请日：2008-11-18

Applicant: BIOSTATIN GYOGYSZERKUTATO FEJL ,  MTA I TAMOGATOTT KUTATOHELYEK ,  PECSI TUDOMANYEGYETEM ALTALANO ,  HORVATH ANIKO ,  KERI GYOERGY ,  SEPROEDI JANOS ,  VANTUS TIBOR ,  TANAI GYULANE ,  SZOLCSANYI JANOS ,  PINTER ERIKA ,  HELYES ZSUZSANNA ,  OKADA YOSHIO ,  TSUDA YUKO ,  MIYAZAKI ANNA ,  SZUETS TAMAS

Inventor： HORVATH ANIKO ,  KERI GYOERGY ,  SEPROEDI JANOS ,  VANTUS TIBOR ,  TANAI GYULANE ,  SZOLCSANYI JANOS ,  PINTER ERIKA ,  HELYES ZSUZSANNA ,  OKADA YOSHIO ,  TSUDA YUKO ,  MIYAZAKI ANNA ,  SZUETS TAMAS

IPC: C07C235/50 ,  A61K31/165 ,  A61K31/325 ,  A61K31/405 ,  A61K38/05 ,  A61K38/06 ,  A61P25/04 ,  C07C237/10 ,  C07C237/20 ,  C07C271/22 ,  C07D209/20 ,  C07D311/16 ,  C07K5/065 ,  C07K5/068 ,  C07K5/09

CPC classification number: C07C271/22 ,  C07C235/50 ,  C07C237/10 ,  C07C237/20 ,  C07C2603/74 ,  C07D209/20 ,  C07D209/22 ,  C07D311/18 ,  C07K5/06078

Abstract: The invention relates to novel compounds of general formula (I) with neurogenic or non-neurogenic anti-inflammatory, analgetic as well as tumour inhibiting effects as well as the salts and metal complexes of these compounds. In the above formula the most important meanings of the substituents are as follows: n stands for 0 or 1, and if n is 1, then Q1, Q2 and Q3 each stand for 0; R1 and R2 stand, independently from each other, for an amino acid; if n is 0, then Q1 and Q2 stand for an amino acid residue; Q3 stands for a valency bond or an amino acid residue; R1 stands for H or C1-3 acyl, benzyloxycarbonyl, tert-butyloxycarbonyl or 9-fluorenyl-methyloxycarbonyl; R2 stands for OH, -NH-R3 or -O-R4, wherein R3 stands for H, C1-6 alkyl, C6-10 cycloalkyl or C6-10 aryl; and R4 stands for C1-6 alkyl, benzyl or 9-fluorenylmethyl. Furthermore, the invention relates to a pharmaceutical composition for treating neurogenic or non-neurogenic inflammations, pains and tumour growth and to the use of the compounds of formula (I) and the salts and metal complexes thereof for preparing pharmaceuticals compositions and to a method for treating neurogenic and non-neurogenic inflammations, pains and tumour growth.

Abstract translation: 本发明涉及具有神经源性或非神经源性抗炎，止痛和肿瘤抑制作用的通式（I）的新化合物以及这些化合物的盐和金属络合物。 在上式中，取代基的最重要含义如下：n代表0或1，如果n是1，则Q1，Q2和Q3各自代表0; R1和R2彼此独立地代表氨基酸; 如果n为0，则Q1和Q2代表氨基酸残基; Q3代表价键或氨基酸残基; R1代表H或C1-3酰基，苄氧羰基，叔丁氧基羰基或9-芴基 - 甲氧基羰基; R2代表OH，-NH-R3或-O-R4，其中R3代表H，C1-6烷基，C6-10环烷基或C6-10芳基; R4代表C1-6烷基，苄基或9-芴基甲基。 此外，本发明涉及用于治疗神经源性或非神经源性炎症，疼痛和肿瘤生长以及式（I）化合物及其盐和金属络合物用于制备药物组合物的药物组合物和用于制备药物组合物的方法， 治疗神经源性和非神经源性炎症，疼痛和肿瘤生长。