公开(公告)号：WO2015163966A1

公开(公告)日：2015-10-29

申请号：PCT/US2015/014374

申请日：2015-02-04

Applicant: KOSAREK, Frank J. ,  RIVERA, Michelle L. ,  KOSAREK, Frank J., Jr.

Inventor： KOSAREK, Frank J. ,  RIVERA, Michelle L. ,  KOSAREK, Frank J., Jr.

IPC: A61F2/30

CPC classification number: A61F2/30942 ,  A61B5/055 ,  A61B6/032 ,  A61B8/0875 ,  A61B10/025 ,  A61B17/1764 ,  A61B17/1767 ,  A61B17/1771 ,  A61F2/30756 ,  A61F2/4618 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30948 ,  A61F2002/30985

Abstract: A process for fabricating size-specific, customized bio-printed musculoskeletal tissue using three dimensional data collected from radiologic imaging is provided. Also, provided is a guide that is created from radiological imaging that demarcates the area of surgical interest. The guide is 3D printed according to guide dimensions collected from radiological imaging, including, but not limited to, CT imaging scans, CT arthrography, ultrasound, MRI, MR arthrography, or any other imaging modality used to image the musculoskeletal system.

Abstract translation: 提供了使用从放射学成像收集的三维数据来制造尺寸特异性，定制的生物印刷肌肉骨骼组织的方法。 另外，提供了从放射学成像创建的指南，其区分手术感兴趣的区域。 该指南根据从放射成像收集的指导尺寸进行3D打印，包括但不限于CT成像扫描，CT关节造影术，超声，MRI，MR关节造影术或用于对肌肉骨骼系统进行成像的任何其他成像模式。

公开(公告)号：WO2012103881A3

公开(公告)日：2013-02-28

申请号：PCT/DE2012000415

申请日：2012-04-17

Applicant: HILDEBRANDT BERNHARD

Inventor： HILDEBRANDT BERNHARD

IPC: A61F2/30 ,  A61F2/34 ,  A61F2/36 ,  A61F2/46 ,  C12M3/00

CPC classification number: A61F2/30756 ,  A61F2/30749 ,  A61F2/3094 ,  A61F2/34 ,  A61F2/3603 ,  A61F2/4609 ,  A61F2002/30448 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/30878 ,  A61F2002/3092 ,  A61F2002/30971 ,  A61F2002/3401 ,  A61F2002/4628 ,  A61F2002/4685 ,  A61F2002/485 ,  A61F2002/487 ,  A61F2310/00011 ,  A61F2310/00293 ,  A61F2310/00371 ,  A61F2310/00982 ,  A61L27/3612 ,  A61L27/3817 ,  A61L27/3821 ,  A61L27/3843 ,  A61L27/3891 ,  A61L2430/24

Abstract: The present invention overcomes the problems of conventional mechanical endoprostheses and the drawbacks of current methods of cartilage replacement by making provisions for the production of a complete biological joint replacement. In order to produce a biological joint replacement having hyaline cartilage, which can cope with heavy loads, devices are used for the shaping, the promotion of diffusion and in particular the compression of the joint replacement that is to be produced, i.e. a compression with alternating pressures and eventually a sliding movement of the walker on the surface of the joint replacement. The invention also relates to substances and methods for promoting the formation of hyaline cartilage tissue. The biological joint replacement is currently preferably suited for implantation in the shoulder and the hip, but can also be applied to other joints by using multi-dimensional milling techniques.

Abstract translation: 通过提供生产完整的生物关节置换物，本发明克服了传统机械内置假体的问题和以前的软骨置换方法的局限性。 为了生产具有透明软骨的可靠的生物关节替代物，使用了提供成形，扩散促进以及尤其是要生产的关节替代物的弯曲的装置， 交替施加压力并且步行者可能在关节置换物的表面上滑动。 还设想了促进透明软骨组织形成的物质和程序。 生物关节置换目前优选用于植入肩和髋，但也可以通过使用多维铣削技术用于其他关节。

公开(公告)号：WO2010094128A1

公开(公告)日：2010-08-26

申请号：PCT/CA2010/000231

申请日：2010-02-19

Applicant: QUEEN'S UNIVERSITY AT KINGSTON ,  WALDMAN, Stephen, D. ,  KHAN, Aasma A.

Inventor： WALDMAN, Stephen, D. ,  KHAN, Aasma A.

IPC: C12N5/077 ,  A61K35/32 ,  A61P19/04

CPC classification number: A61F2/30756 ,  A61F2/30942 ,  A61F2002/30762 ,  A61F2310/00365 ,  A61K35/12 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/3895 ,  A61L2430/06 ,  C12N5/0655 ,  C12N2500/34 ,  C12N2500/60

Abstract: Bioreactors are useful for cartilage tissue engineering because traditional batch culture is not optimal for cartilage tissue growth. The present invention attempts to maximize diffusive transport to engineered cartilage constructs by replenishing the culture medium in a continuous flow bioreactor. The medium is supplemented to maintain a pH of 7.0 to 7.6 until the construct reaches a size of at least 1.5 square centimetres. Chondrocytes can be directly cultured from a biopsy without a separate expansion phase. Subject-specific cartilage constructs can be produced from autologous cells. Phenotypically stable, large-sized engineered cartilage constructs that are not hyper-cellularized can be produced. These constructs are desired for articular cartilage repair of damaged joints

Abstract translation: 生物反应器对于软骨组织工程是有用的，因为传统的分批培养对于软骨组织生长不是最佳的。 本发明试图通过在连续流动生物反应器中补充培养基来最大程度地扩散到工程化软骨构建体中。 补充培养基以保持7.0至7.6的pH，直到构建体达到至少1.5平方厘米的尺寸。 软骨细胞可以从没有单独扩张期的活组织检查直接培养。 受试者特异性软骨构建体可以由自体细胞产生。 可以产生不是超细胞化的表型稳定的大型工程软骨构建体。 这些构造是关节损伤关节软骨修复所需的

公开(公告)号：WO2006017176A2

公开(公告)日：2006-02-16

申请号：PCT/US2005/024269

申请日：2005-07-08

Applicant: WILLIAM MARSH RICE UNIVERSITY ,  ATHANASIOU, Kyriacos, A. ,  HU, Jerry, C.

Inventor： ATHANASIOU, Kyriacos, A. ,  HU, Jerry, C.

IPC: A61B19/00

CPC classification number: A61L27/3654 ,  A61F2002/30762 ,  A61F2310/00365 ,  A61L27/3608 ,  A61L27/3817 ,  A61L27/3852 ,  A61L27/52 ,  C12N5/0655 ,  C12N2533/76

Abstract: A process for culturing chondrocytes to form constructs which contain higher percentages of cells that retain the chondrocytic phenotype are disclosed. The tissue engineered constructs may be formed into neocartilage-containing compositions for a variety of in vitro and in vivo purposes. Methods of treating individuals in need of articular cartilage growth by implanting a new composition are disclosed.

Abstract translation: 公开了培养软骨细胞以形成含有较高百分比的保留软骨细胞表型的细胞的构建体的方法。 组织工程改造的构建体可以形成含有Neocartilage的组合物，用于各种<

公开(公告)号：WO0009179A3

公开(公告)日：2000-06-02

申请号：PCT/EP9905993

申请日：1999-08-16

Applicant: VERIGEN TRANSPLANTATION SERV

Inventor： GIANETTI BRUNO ,  BEHRENS PETER ,  ASCULAI SAMUEL

IPC: A61B17/56 ,  A61B17/00 ,  A61B17/06 ,  A61B17/064 ,  A61B17/22 ,  A61B17/68 ,  A61B17/86 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61F2/38 ,  A61F2/46 ,  A61K9/00 ,  A61K35/32 ,  A61K47/42 ,  A61L24/00 ,  A61L27/38 ,  A61L31/04

CPC classification number: A61L27/3852 ,  A61B17/00491 ,  A61B17/06166 ,  A61B17/0642 ,  A61B17/221 ,  A61B17/68 ,  A61B17/86 ,  A61B2017/00004 ,  A61B2017/0647 ,  A61B2017/2215 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/38 ,  A61F2/4618 ,  A61F2002/009 ,  A61F2002/30006 ,  A61F2002/30013 ,  A61F2002/30028 ,  A61F2002/30062 ,  A61F2002/30293 ,  A61F2002/30448 ,  A61F2002/30761 ,  A61F2002/30762 ,  A61F2002/30764 ,  A61F2002/30932 ,  A61F2002/4624 ,  A61F2002/4627 ,  A61F2002/4635 ,  A61F2210/0004 ,  A61F2220/005 ,  A61F2230/0091 ,  A61F2250/0015 ,  A61F2250/0024 ,  A61F2250/0051 ,  A61F2310/00365 ,  A61L27/3817 ,  A61L31/04 ,  A61L2430/06 ,  C08L67/04

Abstract: The present invention provides a method for the effective treatment of articulating joint surface cartilage in an animal by the transplantation of an implantable article including chondrocyte cells retained to an absorbable support matrix. The present invention is also directed to an instrument for placing and manipulating the implantable article at the site of implantation, and a retention device for securing the implantable article to the site of implantation. The present invention is also directed to an implantable article for cartilage repair in an animal, the implantable article including chondrocyte cells retained on an absorbable support matrix, and a method of making same. This invention also encompasses, in general, an article comprising an absorbable flexible support matrix for living cells grown and adhered thereto.

Abstract translation: 本发明提供了一种通过移植包含保留在可吸收支持基质中的软骨细胞的可植入制品来有效治疗动物中的关节连接表面软骨的方法。 本发明还涉及一种用于在植入位置放置和操纵可植入物品的仪器，以及用于将可植入物品固定到植入部位的保持装置。 本发明还涉及用于动物软骨修复的可植入制品，包括保留在可吸收支撑基质上的软骨细胞的可植入制品及其制备方法。 本发明一般还包括一种包含用于生长和粘附于其上的活细胞的可吸收的柔性支撑基质的制品。

公开(公告)号：WO00021470A1

公开(公告)日：2000-04-20

申请号：PCT/US1999/023732

申请日：1999-10-12

IPC: A61L27/00 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61L27/46 ,  A61L27/56 ,  B29C67/00

CPC classification number: A61L27/46 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2/468 ,  A61F2002/0086 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30004 ,  A61F2002/30011 ,  A61F2002/30062 ,  A61F2002/30199 ,  A61F2002/30301 ,  A61F2002/30678 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/3093 ,  A61F2002/30952 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30971 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2230/0063 ,  A61F2230/0095 ,  A61F2240/001 ,  A61F2250/0014 ,  A61F2250/0023 ,  A61F2310/00179 ,  A61F2310/00203 ,  A61F2310/00293 ,  A61F2310/00365 ,  A61L27/56 ,  B29C64/165 ,  B29L2031/7532 ,  B33Y70/00 ,  B33Y80/00 ,  A61L27/58 ,  A61L27/54

Abstract: Composite devices for tissue engineering are provided having a gradient of one or more of the following: materials, macroarchitecture, microarchitecture, or mechanical properties, which can be used to select or promote attachment of specific cell types on and in the devices prior to and/or after implantation. In various embodiments, the gradient forms a transition zone in the device from a region composed of materials or having properties best suited for one type of tissue to a region composed of materials or having properties suited for a different type of tissue. The devices are made in a continuous process that imparts structural integrity as well as a unique gradient of materials in the architecture. The gradient may relate to the materials, the macroarchitecture, the microarchitecture, the mechanical properties of the device, or several of these together. The devices disclosed herein typically are made using solid free form processes, especially three-dimensional printing process (3DP ). The device can be manufactured in a single continuous process such that the transition from one form of tissue regeneration scaffold and the other form of tissue regeneration scaffold have no "seams" and are not subject to differential swelling along an axis once the device is implanted into physiological fluid.

Abstract translation: 提供了用于组织工程的复合装置，其具有以下一种或多种的梯度：材料，宏结构，微结构或机械性质，其可用于选择或促进特定细胞类型附着在装置之前和/ 或植入后。 在各种实施方案中，梯度在由材料组成的区域或具有最适合于一种类型的组织的特性的区域中形成过渡区域到由材料构成的区域或具有适于不同类型组织的性质的区域。 这些设备是在连续的过程中制造的，在架构中赋予结构完整性以及唯一的材料梯度。 梯度可能与材料，宏建筑结构，微架构，设备的机械性能或其中几种有关。 本文公开的装置通常使用固体自由形式工艺，特别是三维印刷工艺（3DP TM）制成。 该装置可以在单个连续过程中制造，使得来自组织再生支架的一种形式的过渡和组织再生支架的另一种形式不存在“接缝”，并且一旦将该装置植入，就不会沿着轴发生不同的肿胀 生理液体

公开(公告)号：WO00015194A1

公开(公告)日：2000-03-23

申请号：PCT/US1999/021182

申请日：1999-09-14

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61F2/46 ,  A61K9/00 ,  A61K9/14 ,  A61K9/20 ,  A61K39/00 ,  A61K39/39 ,  A61K47/02 ,  A61L24/02 ,  A61L27/12 ,  A61L27/38 ,  A61L27/42 ,  A61L27/54 ,  A61L27/58 ,  C01B25/16 ,  C01B25/32 ,  A01N25/00 ,  A61K45/00 ,  A61K47/00

CPC classification number: A61K39/39 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/30062 ,  A61F2002/30762 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2310/00293 ,  A61K9/143 ,  A61K9/2009 ,  A61K47/02 ,  A61L24/02 ,  A61L27/12 ,  A61L27/425 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/426 ,  A61L2300/438 ,  A61L2400/06 ,  A61L2430/02 ,  C01B25/16 ,  C01B25/32 ,  C01B25/321 ,  C01B25/325

Abstract: An improved calcium phosphate delivery vehicle or adjuvant with incorporated adjuvanticity enhancing means and methods of producing same are disclosed. The adjuvant can be fabricated to desired formulations as appropriate and based on the intended purpose. Particle sizes can be adjusted to enhance adjuvant activity. Other supplemental materials may be added as desired and in appropriate proportions to selectively elicit preferred components of the immune system and to enhance the adjuvant's effect on the host response.

Abstract translation: 公开了一种改进的磷酸钙递送载体或具有引入佐剂性增强方法的佐剂及其制备方法。 佐剂可以根据预期的目的适当地制备成所需的制剂。 可以调整粒径以增强佐剂活性。 可以根据需要和适当的比例添加其它补充材料以选择性地引发免疫系统的优选组分并增强佐剂对宿主反应的影响。

公开(公告)号：WO1989012472A1

公开(公告)日：1989-12-28

申请号：PCT/SE1989000333

申请日：1989-06-13

Applicant: AB IDEA ,  BRUCE, Lars ,  BRUCE, Ingrid

Inventor： AB IDEA

IPC: A61L27/00

CPC classification number: A61L27/3608 ,  A61C8/0012 ,  A61C8/0013 ,  A61C13/0003 ,  A61F2/28 ,  A61F2/30756 ,  A61F2002/30762 ,  A61F2002/30841 ,  A61F2002/30892 ,  A61F2002/30957 ,  A61F2002/4648 ,  A61F2310/00023 ,  A61L27/28 ,  A61L27/3645 ,  A61L27/3683

Abstract: An implant (prosthesis) comprises biological material in its surface intended to face the body tissue. The surface is formed of a layer (3) consisting of a mixture of grains (5) of tissue-compatible type and disintegrated tissue-compatible biological material (4). In a method of making the implant, an implant body (2) and amixture of grains (5) of tissue-compatible type and disintegrated tissue-compatible biological material (4) as well as a nutrient solution (6) for the latter are placed in a mould (8). The biological material is allowed to grow in the mould, both out to the boundary wall of the mould cavity and in to the implant body.

Abstract translation: 植入物（假体）在其表面中包含旨在面向身体组织的生物材料。 表面由由组织相容型的颗粒（5）和分解的组织相容的生物材料（4）的混合物组成的层（3）形成。 在制造植入物的方法中，放置植入体（2）和组织相容型的颗粒（5）和分解的组织相容的生物材料（4）以及用于后者的营养液（6）的混合物 在模具（8）中。 允许生物材料在模具中生长，两者到达模腔的边界壁和植入体。

公开(公告)号：WO2016118604A1

公开(公告)日：2016-07-28

申请号：PCT/US2016/014094

申请日：2016-01-20

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： BHUMIRATANA, Sarindr ,  VUNJAK-NOVAKOVIC, Gordana

IPC: A61L27/36 ,  A61F2/30

CPC classification number: A61L27/3612 ,  A61F2/30756 ,  A61F2/3094 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61L27/3608 ,  A61L27/3834 ,  A61L27/425 ,  A61L27/46 ,  A61L27/50 ,  A61L27/56 ,  A61L2400/06 ,  A61L2430/06 ,  A61L2430/10 ,  C08L89/06

Abstract: Medical devices having engineered mechanically functional cartilage from adult human mesenchymal stem cells and method for making same.

Abstract translation: 具有来自成体人间充质干细胞的机械功能性软骨的医疗装置及其制造方法。

公开(公告)号：WO2011031642A2

公开(公告)日：2011-03-17

申请号：PCT/US2010047881

申请日：2010-09-03

Applicant: MUSCULOSKELETAL TRANSPLANT ,  SEMLER ERIC J ,  GERTZMAN ARTHUR A ,  HUANG YEN-CHEN ,  YANNARIELLO-BROWN JUDITH ,  TRUNCALE KATHERINE GOMES

Inventor： SEMLER ERIC J ,  GERTZMAN ARTHUR A ,  HUANG YEN-CHEN ,  YANNARIELLO-BROWN JUDITH ,  TRUNCALE KATHERINE GOMES

IPC: A61L27/22

CPC classification number: A61L27/3616 ,  A61F2/30756 ,  A61F2/3872 ,  A61F2002/30762 ,  A61K35/32 ,  A61K38/1841 ,  A61L27/225 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/48 ,  A61L2430/06 ,  A61K2300/00

Abstract: A meniscus repair composition for application to a meniscus injury to promote growth of new tissue at the meniscus injury site is provided. The composition comprises: from about 10 to about 50 percent by weight of allograft meniscus particles having an average particle size of from about 10 µm to about 500 µm; and a carrier comprising a solid fibrin web matrix. When introduced to a defect site in a meniscus, the composition is non-adhering to the defect site. A method for repairing a meniscus injury comprises administering a meniscus repair composition to the injury site.

Abstract translation: 提供一种用于应用于半月板损伤以促进半月板损伤部位新组织生长的半月板修复组合物。 组合物包含：约10至约50重量％的平均粒度为约10μm至约500μm的同种异体移植物弯月面颗粒; 和包含固体纤维蛋白网状基质的载体。 当引入弯液面中的缺陷部位时，组合物不粘附于缺陷部位。 修复半月板损伤的方法包括向损伤部位施用半月板修复组合物。