公开(公告)号：WO2009106640A3

公开(公告)日：2009-10-29

申请号：PCT/EP2009052426

申请日：2009-02-27

Applicant: MAASTRICHT UNIVERSITY ,  STW STICHTING VOOR DE TECH WET ,  UNIV EINDHOVEN TECH ,  ROUMEN LUC ,  PEETERS JORIS WILHELMUS ,  HERMANS JOHANNES JOZEPH ROBERT

Inventor： ROUMEN LUC ,  PEETERS JORIS WILHELMUS ,  HERMANS JOHANNES JOZEPH ROBERT

IPC: A61K31/4174 ,  A61P9/10 ,  C07D233/54

CPC classification number: A61K31/4174 ,  C07D233/58 ,  C07D233/60 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90

Abstract: The invention relates to the use of a N-benzyl 5-substituted imidazole derivative having the general formula (I) wherein R is (C1-3)alkyl, (C1-3)alkyloxy, halogen, nitro or cyano; R1 is formyl, (C1-6)alkyl, optionally substituted with OH, (C1-3)alkyloxy, (C1-3)alkylcarbonyloxy, (C1-3)alkyloxy- carbonyl or halogen, or (C1-3)alkyloxycarbonyl; or R1 is phenyl, optionally substituted with 1 -3 substituents independently selected from (C1-3)alkyl, (C1-3)alkyloxy, hydroxylmethyl and halogen; or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of a disorder or disease in a subject mediated by aldosterone synthase or responsive to inhibition of aldosterone synthase.

Abstract translation: 本发明涉及具有通式（I）的N-苄基5-取代的咪唑衍生物，其中R是（C 1-3）烷基，（C 1-3）烷氧基，卤素，硝基或氰基; 任选被OH，（C 1-3）烷氧基，（C 1-3）烷基羰基氧基，（C 1-3）烷氧基 - 羰基或卤素取代的（C 1-6）烷基，或（C 1-3）烷氧基羰基; 或R 1为苯基，任选被1-3个独立地选自（C 1-3）烷基，（C 1-3）烷氧基，羟甲基和卤素的取代基取代; 或其药学上可接受的盐，用于制备用于治疗由醛固酮合成酶介导的受试者或对醛固酮合酶的抑制作用的受试者的病症或疾病的药物。

公开(公告)号：WO2009113854A1

公开(公告)日：2009-09-17

申请号：PCT/NL2009/050116

申请日：2009-03-11

Applicant: LATEXFALT B.V. ,  LOMMERTS, Bert Jan ,  NEDERPEL, Quirinus Adrianus ,  SIKKEMA, Doetze Jakob ,  PEETERS, Joris Wilhelmus

Inventor： LOMMERTS, Bert Jan ,  NEDERPEL, Quirinus Adrianus ,  SIKKEMA, Doetze Jakob ,  PEETERS, Joris Wilhelmus

IPC: C08L95/00 ,  C09J195/00 ,  C08K5/19 ,  C08K5/42

CPC classification number: C08L95/005 ,  C08K5/19 ,  C08L5/00 ,  C08L21/00 ,  C08L2666/26 ,  C09J195/005

Abstract: The present invention relates to the use of a (1→3)-β-D-glucan as an emulsion stabiliser. The present invention further relates to emulsions comprising a (1→3)-β-D- glucan in an amount of 0.01 to 10 wt.%, based on the total weight of the emulsion. The present invention also relates to bitumen binder compositions comprising a (1→3)-β-D- glucan in an amount of 0.005 to less than 0.1 wt.%, based on the total weight of the bitumen binder composition. The present invention further relates to emulsions comprising a novel biodegradable emulsifying agent, in particular in combination with a (l→3)-β-D-glucan.

Abstract translation: 本发明涉及（1→3）-β-D-葡聚糖作为乳化稳定剂的用途。 本发明还涉及基于乳液的总重量，其含量为0.01至10重量％的（1→3）-β-D-葡聚糖的乳液。 本发明还涉及基于沥青粘合剂组合物的总重量，其含量为0.005至小于0.1重量％的（1→3）-β-D-葡聚糖的沥青粘合剂组合物。 本发明还涉及包含新的可生物降解的乳化剂，特别是与（l 3）-β-D-葡聚糖组合的乳液。

公开(公告)号：WO2009106640A2

公开(公告)日：2009-09-03

申请号：PCT/EP2009/052426

申请日：2009-02-27

Applicant: MAASTRICHT UNIVERSITY ,  STW (STICHTING VOOR DE TECHNISCHE WETENSCHAPPEN) ,  TECHNISCHE UNIVERSITEIT EINDHOVEN ,  ROUMEN, Luc ,  PEETERS, Joris Wilhelmus ,  HERMANS, Johannes Jozeph Robertus Maria

Inventor： ROUMEN, Luc ,  PEETERS, Joris Wilhelmus ,  HERMANS, Johannes Jozeph Robertus Maria

IPC: A61K31/4174 ,  C07D233/54 ,  A61P9/10

CPC classification number: A61K31/4174 ,  C07D233/58 ,  C07D233/60 ,  C07D233/64 ,  C07D233/68 ,  C07D233/90

Abstract: The invention relates to the use of a N-benzyl 5-substituted imidazole derivative having the general formula (I) wherein R is (C 1-3 )alkyl, (C 1-3 )alkyloxy, halogen, nitro or cyano; R 1 is formyl, (C 1-6 )alkyl, optionally substituted with OH, (C 1-3 )alkyloxy, (C 1-3 )alkylcarbonyloxy, (C 1-3 )alkyloxy- carbonyl or halogen, or (C 1-3 )alkyloxycarbonyl; or R 1 is phenyl, optionally substituted with 1 -3 substituents independently selected from (C 1-3 )alkyl, (C 1-3 )alkyloxy, hydroxylmethyl and halogen; or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for the treatment of a disorder or disease in a subject mediated by aldosterone synthase or responsive to inhibition of aldosterone synthase.

Abstract translation: 本发明涉及具有通式（I）的N-苄基5-取代的咪唑衍生物，其中R是（C 1-3）烷基，（C 1-3）烷氧基，卤素，硝基或氰基; 任选被OH，（C 1-3）烷氧基，（C 1-3）烷基羰基氧基，（C 1-3）烷氧基 - 羰基或卤素取代的（C 1-6）烷基，或（C 1-3）烷氧基羰基; 或R 1为苯基，任选被1-3个独立地选自（C 1-3）烷基，（C 1-3）烷氧基，羟甲基和卤素的取代基取代; 或其药学上可接受的盐，用于制备用于治疗由醛固酮合成酶介导的受试者或对醛固酮合酶的抑制作用的受试者的病症或疾病的药物。