公开(公告)号：WO2012054284A2

公开(公告)日：2012-04-26

申请号：PCT/US2011/056063

申请日：2011-10-13

Applicant: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION ,  PFEFFER, Lawrence ,  FAN, Meiyun ,  PFEFFER, Susan, R. ,  HANDORF, Charles

Inventor： PFEFFER, Lawrence ,  FAN, Meiyun ,  PFEFFER, Susan, R. ,  HANDORF, Charles

IPC: C12Q1/68

CPC classification number: G01N33/6866 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: The present invention is a method and kit for determining responsiveness of a subject to treatment with a Type I interferon based upon the expression of gene signatures shown to be stimulated by interferon. A method for testing the propensity of a test compound to induce a Type I interferon response is also provided.

Abstract translation: 本发明是用于基于显示受干扰素刺激的基因标记的表达确定受试者对用I型干扰素治疗的应答​​性的方法和试剂盒。 还提供了测试测试化合物诱导I型干扰素应答倾向的方法。

公开(公告)号：WO2012054284A3

公开(公告)日：2012-07-05

申请号：PCT/US2011056063

申请日：2011-10-13

Applicant: UNIV TENNESSEE RES FOUNDATION ,  PFEFFER LAWRENCE ,  FAN MEIYUN ,  PFEFFER SUSAN R ,  HANDORF CHARLES

Inventor： PFEFFER LAWRENCE ,  FAN MEIYUN ,  PFEFFER SUSAN R ,  HANDORF CHARLES

IPC: C12Q1/68 ,  G01N33/53

CPC classification number: G01N33/6866 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: The present invention is a method and kit for determining responsiveness of a subject to treatment with a Type I interferon based upon the expression of gene signatures shown to be stimulated by interferon. A method for testing the propensity of a test compound to induce a Type I interferon response is also provided.

Abstract translation: 本发明是一种用于根据显示被干扰素刺激的基因特征的表达来确定受试者与I型干扰素治疗的反应性的方法和试剂盒。 还提供了测试化合物诱导I型干扰素应答倾向的方法。