公开(公告)号：WO2017098310A1

公开(公告)日：2017-06-15

申请号：PCT/IB2015/059542

申请日：2015-12-11

Applicant: PHARMAPLAST SAE

Inventor： ATTEIA, Mamdouh ,  GAD, Wassim ,  AZIZ, Dina ,  ZAKI, Mena

IPC: A61F13/00

CPC classification number: A61F13/00029 ,  A61F13/00008 ,  A61F13/00987 ,  A61F13/00995

Abstract: A wound dressing laminate (2, 2a, 2b) serves especially to manufacture body-shape wound dressings. The wound dressing laminate comprises a wound-facing non-woven layer (7a, 7b) composed of non-thermoplastic carboxymethyl cellulose fibres (8) which are combined into a coherent laminate structure with a non-woven backing layer (9a, 9b) composed of thermoplastic fibres (10) selected from the group of fibres comprising polyurethane fibres, hydrophobic polypropylene fibres and/or spunlaced fibres. The wound-facing non-woven layer (7a, 7b) and the non-woven backing layer (9a, 9b) are laminated together by needle-punching.

Abstract translation: 伤口敷料层压材料（2,2a，2b）特别用于制造身体形状的伤口敷料。 伤口敷料层压材料包括由非热塑性羧甲基纤维素纤维（8）构成的面向伤口的非织造层（7a，7b），所述非织造材料组合成具有无纺背衬层（9a，9b）的粘合层压结构 的热塑性纤维（10），其选自包含聚氨酯纤维，疏水性聚丙烯纤维和/或射流喷网纤维的纤维组。 通过针刺将面向伤口的无纺布层（7a，7b）和无纺背衬层（9a，9b）层压在一起。

公开(公告)号：WO2011121394A1

公开(公告)日：2011-10-06

申请号：PCT/IB2010/051414

申请日：2010-03-31

Applicant: PHARMAPLAST SAE ,  ATTEIA, Mamdouh H.

Inventor： ATTEIA, Mamdouh H.

IPC: A61F13/00

CPC classification number: A61F13/0263 ,  A61F13/0213 ,  A61F13/0223 ,  A61F13/0279 ,  A61F13/069 ,  A61F2013/00157 ,  A61F2013/00217 ,  A61F2013/00263 ,  A61F2013/00519 ,  A61F2013/00523 ,  A61F2013/00536 ,  A61F2013/0054 ,  A61F2013/00587 ,  A61F2013/00604 ,  A61F2013/0074 ,  A61F2013/00804 ,  A61F2013/00876

Abstract: A wound care dressing comprising at least a separating film layer sheet (2) having a topside (4) and a bottom side (3) both provided with an adhesive (5,6), a hydrogel layer sheet (7) attached to the bottom side (3) of the separating film layer sheet (2) to form a combined matrix layer (16), and where the matrix layer (16) has a plurality of perforations (9), serves for improved wound care regime in particular when used at moist and/or exuding wounds. A foam layer sheet (14a) is attached to the topside (4) of the separating layer sheet (2) and covered by a cover film layer sheet (14b; 43) to allow fluid to pass via the perforations (9) into the foam layer sheet (14a) and to evaporate through the cover film layer sheet (14b;43). A method and a production line are also disclosed. Preferred embodiments include perforations made by means of ultrasound.

Abstract translation: 一种伤口护理敷料，其至少包括具有顶侧（4）和底侧（3）的分离膜层片（2），两者均设有粘合剂（5,6），水凝胶层片（7）附接到底部 （2）的侧面（3）以形成组合的基质层（16），并且其中基质层（16）具有多个穿孔（9），用于改善伤口护理方案，特别是当使用时 在潮湿和/或渗出伤口。 泡沫层片（14a）附着到分离层片（2）的顶侧（4）上并被覆盖膜层片（14b; 43）覆盖，以使流体经由穿孔（9）穿过泡沫层 并且通过覆盖膜层片（14b; 43）蒸发。 还公开了一种方法和生产线。 优选实施例包括通过超声波制造的穿孔。

公开(公告)号：WO2017137808A1

公开(公告)日：2017-08-17

申请号：PCT/IB2016/050752

申请日：2016-02-12

Applicant: PHARMAPLAST SAE ,  HOLME NIELSEN, Marianne

Inventor： ATTEIA, Mamdouh ,  AZIZ, Dina ,  ZAKI, Mena ,  ADEL, Mina ,  GAD, Wassim

IPC: A61L15/26 ,  A61L15/42 ,  A61L15/44

CPC classification number: A61L15/425 ,  A61L15/26 ,  A61L15/44 ,  A61L2300/104 ,  C08L75/04

Abstract: A method of manufacturing a pharmaceutical active prepolymer formulation includes the steps of combining in a reactor at least one polyol compound, at least one aromatic di-isocyanate compound, and/or at least one aliphatic di-isocyanate compound, and a pharmaceutical active agent having a water or moisture content of maximum 1.0 wt/wt%. Then the at least one polyol compound and/or the at least one di-isocyanate compound is allowed to prepolymerize to integrate the pharmaceutical active agent to obtain the pharmaceutical active prepolymer formulation. The pharmaceutical active prepolymer formulation can be made into a foam for use in pharmaceutical active wound dressings.

Abstract translation: 制备药物活性预聚物制剂的方法包括以下步骤：在反应器中混合至少一种多元醇化合物，至少一种芳族二异氰酸酯化合物和/或至少一种脂族二异氰酸酯 化合物和水或水分含量最大为1.0wt / wt％的药物活性剂。 然后使至少一种多元醇化合物和/或至少一种二异氰酸酯化合物预聚合以整合药物活性剂以获得药物活性预聚物制剂。 药物活性预聚物制剂可制成用于药物活性伤口敷料的泡沫。

公开(公告)号：WO2013164016A1

公开(公告)日：2013-11-07

申请号：PCT/EP2012/057956

申请日：2012-05-01

Applicant: PHARMAPLAST SAE ,  FARES, Wassim ,  AZIZ, Dina

Inventor： FARES, Wassim ,  AZIZ, Dina

IPC: A61F13/00

CPC classification number: A61F13/00063 ,  A61F13/00991 ,  A61F13/00995 ,  A61F2013/00225 ,  A61F2013/00238 ,  A61F2013/00548 ,  A61F2013/00604 ,  A61F2013/00744 ,  A61F2013/00748 ,  A61F2013/0091

Abstract: A wound dressing laminate (1') comprises a layer (3) impregnated with an antimicrobial agent (4) inserted between an apertured wound-contacting layer (2) and an absorbent non-woven layer (5;6). Wound dressings made of the wound dressing laminate prevent infection of a wound, do not induce maceration, and absorb exudates at controlled level so as to continuously cleanse the wound bed without drying the wound. Manual cleansing during dressing changes, if any at all, is usually not necessary and significant nursing time can be saved. The laminate is manufactured using the steps of providing the layer (3) impregnated with an antimicrobial agent (4), providing an apertured wound-contacting layer (2) adjacent one side of the layer (3) impregnated with the antimicrobial agent (4), providing an absorbent non-woven layer (5) adjacent the opposite side of the layer (3) impregnated with the antimicrobial agent (4), and laminating the layers (2;3;5) together mechanically.

Abstract translation: 伤口敷料层压板（1'）包括浸渍有插入有孔的缠绕接触层（2）和吸收性无纺布层（5; 6）之间的抗微生物剂（4）的层（3）。 由伤口敷料层压制成的伤口敷料可防止伤口感染，不诱发浸渍，并以受控水平吸收渗出物，以不伤害伤口而连续清洁伤口床。 换药期间手动清洁（如果有的话）通常不是必需的，可以节省显着的护理时间。 使用以下步骤制造层压体：使浸渍有抗菌剂（4）的层（3）提供的步骤，在浸渍有抗微生物剂（4）的层（3）的一侧附近提供有孔的缠绕接触层（2） 提供与浸渍有抗微生物剂（4）的层（3）的相对侧相邻的吸收性非织造层（5），并且将层（2; 3; 5）机械地层压在一起。

公开(公告)号：WO2011067626A1

公开(公告)日：2011-06-09

申请号：PCT/IB2009/055482

申请日：2009-12-03

Applicant: PHARMAPLAST SAE ,  ATTEIA, Mamdouh H. ,  FARIS, Wassim

Inventor： ATTEIA, Mamdouh H. ,  FARIS, Wassim

IPC: A61F13/02

CPC classification number: A61F13/0276 ,  A61F13/0213 ,  A61F13/0223 ,  A61F13/0226 ,  A61F13/025 ,  A61F13/0259 ,  A61F2013/0057 ,  A61F2013/00578 ,  A61F2013/00587 ,  A61F2013/00608 ,  A61F2013/00782 ,  A61F2013/00834 ,  A61F2013/00846 ,  A61F2013/00868 ,  A61F2013/00876 ,  A61F2013/0091 ,  A61F2013/00927 ,  A61F2013/00936 ,  A61F2013/00982 ,  Y10T156/12

Abstract: A wound dressing (1;15;18) comprising a polyurethane film sheet (2;19) having a wound facing side (3) and an opposite side (4). The wound facing side (3) has a peripheral rim zone (5) provided with an adhesive (6) or an adhesive means (16), the peripheral rim zone (5) encircles a central sheet part (11) free of adhesive (6) or adhesive means (16), and the wound dressing (1) has a moisture vapor transmission rate of at least 1,200 g/m 2 /24 hour at the adhesive- coated or adhesive-means provided rim zone (5) and a moisture vapor transmission rate at the central sheet part (12) of at least 3,000 g/m 2 /24 hour. A method and production line for manufacturing various embodiments of wound dressings are also disclosed.

Abstract translation: 1.一种伤口敷料（1; 15; 18），包括具有面向伤口的侧面（3）和相对侧（4）的聚氨酯膜片（2; 19）。 伤口面对侧（3）具有设置有粘合剂（6）或粘合装置（16）的外围边缘区域（5），周边边缘区域（5）围绕不含粘合剂（6）的中心片部分 ）或粘合剂装置（16），并且伤口敷料（1）在粘合剂涂覆或粘合剂装置的边缘区域（5）处具有至少1200g / m 2/24小时的湿气透过率和湿气 中心片部分（12）处的蒸汽透过率至少为3,000g / m 2/24小时。 还公开了用于制造伤口敷料的各种实施例的方法和生产线。