公开(公告)号：WO2016029112A3

公开(公告)日：2016-05-06

申请号：PCT/US2015046291

申请日：2015-08-21

Applicant: CASWELL MICHAEL ROBERT ,  HODOR MICHAEL ,  PHILLIPS DAVID H

Inventor： CASWELL MICHAEL ROBERT ,  HODOR MICHAEL ,  PHILLIPS DAVID H

IPC: F25D31/00 ,  B67D3/00 ,  F25B1/00 ,  F25D3/00

CPC classification number: B67D3/0009 ,  F25D31/003 ,  F25D2303/081 ,  F25D2331/811

Abstract: Exemplary embodiments are generally directed to beverage chillers for chilling a hot beverage so that the hot beverage can be served as a chilled beverage in real time on demand fashion. The beverage chillers include a beverage collection section, a heat exchanger section, and a dispensing section fluidically connected relative to each other. The beverage collection section receives a beverage in a hot state. The heat exchanger section chills the beverage from the hot state to a predetermined chilled temperature. The dispensing section dispenses the beverage at or near the predetermined chilled temperature. Exemplary embodiments are also directed to methods and systems for chilling a hot beverage in real time on demand fashion.

Abstract translation: 示例性实施例通常涉及用于冷却热饮料的饮料冷却器，使得热饮料可以根据需求实时地作为冷饮饮料。 饮料冷却器包括彼此流体连接的饮料收集部分，热交换器部分和分配部分。 饮料收集部分接收处于热状态的饮料。 热交换器部分将饮料从热态冷却至预定的冷冻温度。 分配部分以预定冷冻温度或接近预定冷冻温度分配饮料。 示例性实施例还涉及用于根据需要实时冷却热饮料的方法和系统。

公开(公告)号：WO2011044034A1

公开(公告)日：2011-04-14

申请号：PCT/US2010/051303

申请日：2010-10-04

Applicant: THE POPULATION COUNCIL, INC. ,  MAGUIRE, Robin, A. ,  THORN, Mitchell ,  PHILLIPS, David, M. ,  RUTENBERG, Naomi

Inventor： MAGUIRE, Robin, A. ,  THORN, Mitchell ,  PHILLIPS, David, M. ,  RUTENBERG, Naomi

IPC: A61K9/00 ,  A61K9/08 ,  A61K47/36 ,  A61K31/7072 ,  A61K33/00

CPC classification number: A61K9/08 ,  A61K9/0031 ,  A61K9/0034 ,  A61K31/715 ,  A61K31/731 ,  A61K45/06 ,  A61K47/36 ,  A61K2300/00

Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contain one or more polyanionic microbicides, such as carrageenans, including lambda carrageenan, as well as water-soluble metal salts and specified antiretro viral agents comprising NNRTIs and NRTIs. Also disclosed are methods for making and using the compositions.

Abstract translation: 公开了用于抑制含有一种或多种聚阴离子杀微生物剂如角叉菜胶（包括λ角叉菜胶）以及水溶性金属盐和包含NNRTI和NRTI的特定抗逆转录病毒剂的性传播感染传播的组合物。 还公开了制备和使用组合物的方法。

公开(公告)号：WO2009042962A9

公开(公告)日：2009-04-02

申请号：PCT/US2008/078014

申请日：2008-09-26

Applicant: PORTOLA PHARMACEUTICALS, INC. ,  LU, Genmin ,  PHILLIPS, David R. ,  ANDRE, Patrick ,  SINHA, Uma

Inventor： LU, Genmin ,  PHILLIPS, David R. ,  ANDRE, Patrick ,  SINHA, Uma

IPC: C12N9/64 ,  A61P7/04

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

公开(公告)号：WO2008137791A1

公开(公告)日：2008-11-13

申请号：PCT/US2008/062565

申请日：2008-05-02

Applicant: PORTOLA PHARMACEUTICALS, INC. ,  PHILLIPS, David, R. ,  ANDRE, Patrick ,  HOMCY, Charles, J.

Inventor： PHILLIPS, David, R. ,  ANDRE, Patrick ,  HOMCY, Charles, J.

IPC: C12N9/02

CPC classification number: A61K31/422 ,  A61K31/20 ,  A61K31/405 ,  A61K31/4406 ,  A61K31/444 ,  A61K45/06

Abstract: The present invention provides methods and compositions useful in the treatment or prevention of cardiovascular disorders in individuals for whom therapy with a COX-1 enzyme inhibitor is not feasible due to sensitivity, intolerance, or resistance to the inhibitor. Additionally, the invention provides methods of treating cardiovascular disorders in an individual who is receiving a therapeutically effective dose of a TP modulator and is instructed or advised to avoid and/or not to take aspirin or another COX-1 inhibitor.

Abstract translation: 本发明提供了用于治疗或预防由于敏感性，不耐受性或对抑制剂的抗性而使用COX-1酶抑制剂治疗是不可行的个体的心血管疾病的方法和组合物。 另外，本发明提供治疗正在接受治疗有效剂量的TP调节剂的个体的心血管疾病的方法，并被指示或建议避免和/或不服用阿司匹林或另一种COX-1抑制剂。

公开(公告)号：WO2006065739A3

公开(公告)日：2008-11-13

申请号：PCT/US2005044908

申请日：2005-12-14

Applicant: MILLENNIUM PHARM INC ,  ANDRE PATRICK ,  LUEDEMANN HANS ,  PHILLIPS DAVID R ,  SHAPURIAN GOLNAZ ,  MUIR GRAIG

Inventor： ANDRE PATRICK ,  LUEDEMANN HANS ,  PHILLIPS DAVID R ,  SHAPURIAN GOLNAZ ,  MUIR GRAIG

IPC: A61B5/00

CPC classification number: G01N1/31 ,  B01L3/5027 ,  C12Q1/56 ,  G01N33/86 ,  G01N2015/0084 ,  G01N2015/0092 ,  G06T7/0012 ,  G06T7/62

Abstract: An instrument for capturing an image of thrombus formation, blood coagulation, recruitment of circulating inflammatory or tumour cells in a blood sample. The instrument comprises a member defining a channel therethrough, a fluid handling assembly that permits the blood sample to move through the channel at a flow rate, and an imaging assembly including a microscopy device. The imaging assembly is disposed relative to the channel so as to capture light rays defining the image of thrombus formation in the channel.

Abstract translation: 用于捕获血液样品中血栓形成，凝血，循环炎性或肿瘤细胞募集图像的仪器。 仪器包括限定穿过其中的通道的构件，允许血液样本以流速移动通过通道的流体处理组件，以及包括显微镜装置的成像组件。 成像组件相对于通道布置，以便捕获限定通道中血栓形成图像的光线。

公开(公告)号：WO2008125210A1

公开(公告)日：2008-10-23

申请号：PCT/EP2008/002564

申请日：2008-04-01

Applicant: UCB PHARMA, S.A. ,  DAVENPORT, Richard, John ,  RATCLIFFE, Andrew, James ,  PHILLIPS, David, Jonathan

Inventor： DAVENPORT, Richard, John ,  RATCLIFFE, Andrew, James ,  PHILLIPS, David, Jonathan

IPC: C07D215/12 ,  C07D405/12 ,  C07D405/14 ,  A61K31/47 ,  A61K31/4709 ,  A61P11/06 ,  A61P29/00

CPC classification number: C07D215/12 ,  C07D405/12 ,  C07D405/14

Abstract: The present invention concerns naphthalene and quinoline derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals. R, R 1 , R 2 , R 3 , R 4 , X and W are defined as in claim I.

Abstract translation: 本发明涉及式（I）的萘和喹啉衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。 R 1，R 1，R 2，R 3，R 4，X和W如权利要求1中所定义， 一世。

公开(公告)号：WO2008045785A1

公开(公告)日：2008-04-17

申请号：PCT/US2007/080572

申请日：2007-10-05

Applicant: DAVIDSON HYDRANT TECHNOLOGIES INC. ,  DAVIDSON, Tom, R., Sr. ,  WALDEN, David, Michael ,  FERRARI, Anthony ,  PHILLIPS, David ,  SIMS, O., G. ,  ROSE, Matthew, Jesse

Inventor： DAVIDSON, Tom, R., Sr. ,  WALDEN, David, Michael ,  FERRARI, Anthony ,  PHILLIPS, David ,  SIMS, O., G. ,  ROSE, Matthew, Jesse

IPC: E03B9/16

CPC classification number: E03B9/16 ,  F16K27/006 ,  Y10T137/1654 ,  Y10T137/5327 ,  Y10T137/5485 ,  Y10T137/5491 ,  Y10T137/88054

Abstract: Wet barrel fire hydrants (10) which feature additional structure for reducing the potential that those with ill intent can foul municipal water supplies by- introducing toxins or other materials into fire hydrants. Various embodiments include valves which close off portions of the hydrant or water conduit otherwise available for receipt of toxic or other materials when the fire hydrant nozzle cap is unscrewed and open and/or a pump is connected to the nozzle (14). Such valves preferably open automatically when water is flowing from the water supply through the nozzle (14), but close off portions of the barrel when the nozzle (14) is open and water is not flowing through the nozzle (14).

Abstract translation: 湿桶消火栓（10）具有额外的结构，以减少潜在的意图，可能会通过将毒素或其他材料引入消防栓来污染市政供水。 各种实施例包括当消防栓喷嘴帽被拧开和打开时和/或泵连接到喷嘴（14）时封闭消防栓或水管道的部分可用于接收有毒或其它材料的阀。 当水从供水通过喷嘴（14）流动时，这种阀门优选地自动打开，但是当喷嘴（14）打开并且水没有流过喷嘴（14）时，这些阀门关闭桶的部分。

公开(公告)号：WO2006038001A1

公开(公告)日：2006-04-13

申请号：PCT/GB2005/003827

申请日：2005-10-04

Applicant: CELLTECH R & D LIMITED ,  RATCLIFFE, Andrew, James ,  ALAM, Mahbub ,  BEEVERS, Rebekah, Elisabeth ,  DAVENPORT, Richard, John ,  DAVIES, Natasha ,  HAUGHAN, Alan, Findlay ,  JONES, Mark, William ,  LOWE, Christopher ,  PERRY, Benjamin, Garfield ,  PHILLIPS, David, Jonathan ,  PITT, William, Ross ,  SHARPE, Andrew

Inventor： RATCLIFFE, Andrew, James ,  ALAM, Mahbub ,  BEEVERS, Rebekah, Elisabeth ,  DAVENPORT, Richard, John ,  DAVIES, Natasha ,  HAUGHAN, Alan, Findlay ,  JONES, Mark, William ,  LOWE, Christopher ,  PERRY, Benjamin, Garfield ,  PHILLIPS, David, Jonathan ,  PITT, William, Ross ,  SHARPE, Andrew

IPC: C07D401/14

CPC classification number: C07D409/14 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04

Abstract: A compound of formula (I) or a pharmaceutically acceptable salt, solvate or N-­oxide thereof: wherein A represents a pyrrole, pyrazole, imidazole or triazole ring; B represents a benzene, pyridine or pyrimidine ring; M represents the residue of an azetidine, pyrrolidine or piperidine ring; E represents a covalent bond or an optionally substituted straight or branched alkylene chain containing from 1 to 4 carbon atoms; Z represents hydrogen, -CORa, -C0 2 R b , -CONK c R d , -CONR c OR b , -COCO 2 R b , - COCONR c R d , -COCH2NR c R d , -COCH2NR c CONK c R d , COCH2NR c CO 2 R b , -NR c COR a , - NR c CO2R b , -NR c CONR c R d , -S0 2 R e , -SO 2 NR c R d or -SO2NR c C0 2 R b ; or Z represents an optionally substituted phenyl, heteroaryl or C 3-7 heterocycloalkyl group; R 1 and R 2 independently represent hydrogen, halogen, cyano, nitro, C 1-6 alkyl, trifluoromethyl, hydroxy, C 1-6 alkoxy, difluoromethoxy, trifluoromethoxy, C 1-6 alkylsulphonyl, amino, C 1-6 alkylamino, di(C 1-6 )alkylamino, aminocarbonyl or C 2-6 alkoxycarbonyl; R 3 represents hydrogen, C 1-6 alkyl, -CH2CONR c R d or -SO 2 R e ; R 4 represents hydrogen, C 1-6 alkoxy, oxo, -CO2R b or -CONK c R d . The compounds of the present invention are potent inhibitors of JNK.

Abstract translation: 式（I）化合物或其药学上可接受的盐，溶剂合物或N-氧化物：其中A表示吡咯，吡唑，咪唑或三唑环; B代表苯，吡啶或嘧啶环; M表示氮杂环丁烷，吡咯烷或哌啶环的残基; E表示共价键或含有1至4个碳原子的任选取代的直链或支链亚烷基链; Z表示氢，-CORa，-C0

公开(公告)号：WO2005102215A1

公开(公告)日：2005-11-03

申请号：PCT/US2005/013006

申请日：2005-04-18

Applicant: PORTOLA PHARMACEUTICALS, INC. ,  ANDRE, Patrick ,  PHILLIPS, David, R. ,  HOMCY, Charles

Inventor： ANDRE, Patrick ,  PHILLIPS, David, R. ,  HOMCY, Charles

IPC: A61F2/02

CPC classification number: A61K31/473 ,  A61K31/4745 ,  A61K31/52 ,  A61L27/34 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L2300/434

Abstract: The present invention provides novel compositions and methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient undergoing a vascular intervention. More particularly, the present invention provides intravascular devices coated with one or more spleen tyrosine kinase (Syk) inhibitors. Methods for inhibiting restenosis, thrombosis, and/or inflammation in a patient by treatment with such intravascular devices are also provided. In addition, the present invention provides methods for treating sickle cell disease using Syk inhibitors.

Abstract translation: 本发明提供了用于在经历血管干预的患者中抑制再狭窄，血栓形成和/或炎症的新型组合物和方法。 更具体地，本发明提供涂覆有一种或多种脾脏酪氨酸激酶（Syk）抑制剂的血管内装置。 还提供了通过用这种血管内装置治疗来抑制患者再狭窄，血栓形成和/或炎症的方法。 此外，本发明提供了使用Syk抑制剂治疗镰状细胞病的方法。

公开(公告)号：WO03093322A9

公开(公告)日：2004-07-08

申请号：PCT/US0313456

申请日：2003-04-30

Applicant: POPULATION COUNCIL INC ,  FMC CORP ,  MAGUIRE ROBIN A ,  THORN MITCHELL ,  PHILLIPS DAVID M ,  BLAKEMORE WILLIAM R ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  MODLISZEWSKI JAMES J ,  BUBNIS WILLIAM A

Inventor： MAGUIRE ROBIN A ,  THORN MITCHELL ,  PHILLIPS DAVID M ,  BLAKEMORE WILLIAM R ,  BALLARD ARTHUR D ,  SEWALL CHRISTOPHER J ,  MODLISZEWSKI JAMES J ,  BUBNIS WILLIAM A

IPC: A01N59/16 ,  A61K31/57 ,  A61K31/715 ,  A61K31/731 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  C08B37/00 ,  C08L5/00 ,  C08L5/12 ,  A61F13/02 ,  A61K9/70 ,  A61L15/44 ,  C07H1/06 ,  C07H1/08 ,  C07H5/04 ,  C07H5/08

CPC classification number: C08L5/00 ,  A01N59/16 ,  A61K9/0031 ,  A61K9/0034 ,  A61K31/57 ,  A61K31/715 ,  A61K31/731 ,  A61K33/30 ,  A61K33/34 ,  A61K33/38 ,  A61K45/06 ,  C08B37/0042 ,  C08L5/12 ,  A61K2300/00 ,  A01N25/10 ,  A01N2300/00

Abstract: Disclosed are compositions for inhibiting transmission of a sexually transmitted infection that contains one or more carrageenans, including lambda carrageenan. Also disclosed are methods for making and using the compositions.

Abstract translation: 公开了抑制含有一种或多种角叉菜胶（包括λ角叉菜胶）的性传播感染传播的组合物。 还公开了制备和使用组合物的方法。