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公开(公告)号：WO2014074932A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/069316
申请日：2013-11-08
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , TAXIS PHARMACEUTICALS, INC. , LAVOIE, Edmond J. , PARHI, Ajit , PILCH, Daniel S. , ZHANG, Yongzheng , KAUL, Malvika
IPC分类号： C07D413/12 , C07D417/12 , C07C235/88 , C07D277/64 , C07D513/04 , A61P31/04 , A61K31/422 , A61K31/428
CPC分类号： C07D513/04 , C07C235/88 , C07D277/64 , C07D413/12 , C07D417/12
摘要： The invention provides compounds of formula (I): wherein R 1 -R 3 , n, and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
摘要翻译： 本发明提供式（I）化合物：其中R1-R3，n和W具有说明书中定义的任何值及其盐。 该化合物具有良好的溶解性，可用于治疗细菌感染。
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公开(公告)号：WO2013142712A1
公开(公告)日：2013-09-26
申请号：PCT/US2013/033343
申请日：2013-03-21
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , LAVOIE, Edmond J. , PARHI, Ajit , ZHANG, Yongzheng , PILCH, Daniel S. , KAUL, Malvika
IPC分类号： C07D263/56 , C07D417/04 , C07D417/12 , C07D263/34 , C07D277/24 , C07D277/64 , C07D513/04 , A61K31/427 , A61K31/429 , A61K31/437 , A61K31/4439 , A61P31/04
CPC分类号： C07D277/64 , C07D263/32 , C07D263/34 , C07D263/56 , C07D277/24 , C07D277/30 , C07D417/04 , C07D417/12 , C07D513/04
摘要： The invention provides compounds of formual (I): wherein R 1 -R 7 and W have any of the values defined in the specification, and salts thereof. The compounds have good solubility and are useful for treating bacterial infections.
摘要翻译： 本发明提供式（I）化合物：其中R1-R7和W具有说明书中定义的任何值及其盐。 该化合物具有良好的溶解性，可用于治疗细菌感染。
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公开(公告)号：WO2017147335A1
公开(公告)日：2017-08-31
申请号：PCT/US2017/019198
申请日：2017-02-23
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , TAXIS PHARMACEUTICALS, INC. , LAVOIE, Edmond J. , PARHI, Ajit , BLANKSON, Gifty A. , WANG, Liping , CHEN, Xiao , ZHANG, Yongzheng , KAUL, Malvika , PILCH, Daniel S.
发明人： LAVOIE, Edmond J. , PARHI, Ajit , BLANKSON, Gifty A. , WANG, Liping , CHEN, Xiao , ZHANG, Yongzheng , KAUL, Malvika , PILCH, Daniel S.
IPC分类号： A61K31/13 , A61K31/155
CPC分类号： A61K31/137 , A61K31/138 , A61K31/14 , A61K45/06 , C07C211/27 , C07C211/29 , C07C217/42 , Y02A50/475
摘要： Disclosed herein are compounds of formula I: and salts thereof. Also disclosed are compositions comprising compounds of formula I and methods using compounds of formula I.
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公开(公告)号：WO2011163610A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041862
申请日：2011-06-24
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , LAVOIE, Edmond J. , PARHI, Ajit , PILCH, Daniel S.
发明人： LAVOIE, Edmond J. , PARHI, Ajit , PILCH, Daniel S.
IPC分类号： C07D213/30 , C07D215/10 , C07D215/20 , C07D217/10 , C07D221/18 , C07D239/26 , C07D307/52 , C07D405/10 , C07D407/10 , C07D471/04 , A61K31/47 , A61K31/495 , A61P31/04
CPC分类号： C07D215/14 , A61K9/0019 , A61K9/12 , A61K9/1623 , A61K9/2054 , A61K9/4858 , C07C211/27 , C07C211/29 , C07C211/45 , C07C211/52 , C07C211/63 , C07C211/64 , C07C217/70 , C07C217/78 , C07C217/80 , C07C217/94 , C07C229/38 , C07C257/14 , C07C279/04 , C07C279/06 , C07C279/08 , C07C279/14 , C07C2601/02 , C07D213/20 , C07D213/30 , C07D215/10 , C07D215/20 , C07D217/10 , C07D221/18 , C07D239/26 , C07D307/52 , C07D405/10 , C07D407/10 , C07D471/04 , C07D491/056 , Y02A50/401 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： The invention provides a compound of formula I:or a salt thereof, wherein R 3 -R 8 and X and Y have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.
摘要翻译： 本发明提供式I化合物或其盐，其中R3-R8和X和Y具有说明书中所述的任何值，以及包含式I化合物的组合物。该化合物可用作抗菌剂 。
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公开(公告)号：WO2011156626A1
公开(公告)日：2011-12-15
申请号：PCT/US2011/039839
申请日：2011-06-09
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , LAVOIE, Edmond, J. , PARHI, Ajit , PILCH, Daniel, S.
IPC分类号： C07D217/14 , C07D217/22 , C07D405/10 , A61K31/472 , A61K31/4725 , A61P31/04
CPC分类号： C07D405/10 , C07D217/14 , C07D217/22
摘要： The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein R 1 , R 4 -R 8 , R 10 , R 2' -R 6' , W, and A have any of the values described in the specification, as well as compositions comprising a compound of formula (I). The compounds are useful as antibacterial agents.
摘要翻译： 本发明提供式（I）化合物或其盐或前药，其中R1，R4-R8，R10，R2'-R6'，W和A具有说明书中描述的任何值，以及 组合物，其包含式（I）化合物。 这些化合物可用作抗菌剂。
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公开(公告)号：WO2013106761A3
公开(公告)日：2013-10-10
申请号：PCT/US2013021300
申请日：2013-01-11
申请人： UNIV RUTGERS , UNIV NEW JERSEY MED , TAXIS PHARMACEUTICALS INC , LAVOIE EDMOND J , PARHI AJIT , PILCH DANIEL S , ZHANG YOUNGZHENG , KAUL MALVIKA
发明人： LAVOIE EDMOND J , PARHI AJIT , PILCH DANIEL S , ZHANG YOUNGZHENG , KAUL MALVIKA
IPC分类号： A61K31/131 , A61K31/14 , A61K31/155 , A61K31/417 , A61P31/04
CPC分类号： C07D417/06 , A61K31/135 , A61K31/14 , A61K31/155 , A61K31/4164 , A61K31/4178 , A61K31/4196 , A61K31/425 , A61K31/427 , A61K31/428 , A61K31/44 , A61K31/495 , C07C211/27 , C07C211/64 , C07C279/04 , C07C279/08 , C07C279/10 , C07D213/58 , C07D233/60 , C07D277/28 , C07D277/64 , C07D295/096
摘要： The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a compound of formula I: [formula should be inserted here] wherein A, B, and X have any of the meanings defined in the specification; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供了治疗哺乳动物细菌感染的方法，包括向哺乳动物施用式I化合物：其中A，B和X具有本说明书中定义的任何含义; 或其药学上可接受的盐，以及式I的新化合物及其盐和包含式I化合物或其药学上可接受的盐的药物组合物。
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公开(公告)号：WO2013106756A3
公开(公告)日：2013-10-10
申请号：PCT/US2013021295
申请日：2013-01-11
申请人： UNIV RUTGERS , UNIV NEW JERSEY MED , LAVOIE EDMOND J , PARHI AJIT , PILCH DANIEL S , KAUL MALVIKA
发明人： LAVOIE EDMOND J , PARHI AJIT , PILCH DANIEL S , KAUL MALVIKA
IPC分类号： A61K31/4375 , A61P31/04
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/498 , C07D237/30 , C07D239/74 , C07D241/42 , C07D241/44
摘要： The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a substituted bicyclic heteroaromatic ring compound of formula I: wherein two of X1 to X8 are N and the remaining of X1 to X8 are CH; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供了治疗哺乳动物细菌感染的方法，包括给哺乳动物施用式I的取代的双环杂芳族环化合物：其中X 1至X 8中的两个是N并且其余的X 1至X 8是CH; 或其药学上可接受的盐，以及新的式I化合物及其盐，以及包含式I化合物或其药学上可接受的盐的药物组合物。
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公开(公告)号：WO2013106761A2
公开(公告)日：2013-07-18
申请号：PCT/US2013/021300
申请日：2013-01-11
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , TAXIS PHARMACEUTICALS, INC. , LAVOIE, Edmond J. , PARHI, Ajit , PILCH, Daniel S. , ZHANG, Youngzheng , KAUL, Malvika
IPC分类号： A61K31/131 , A61K31/14 , A61K31/155 , A61K31/417 , A61P31/04
CPC分类号： C07D417/06 , A61K31/135 , A61K31/14 , A61K31/155 , A61K31/4164 , A61K31/4178 , A61K31/4196 , A61K31/425 , A61K31/427 , A61K31/428 , A61K31/44 , A61K31/495 , C07C211/27 , C07C211/64 , C07C279/04 , C07C279/08 , C07C279/10 , C07D213/58 , C07D233/60 , C07D277/28 , C07D277/64 , C07D295/096 , Y02A50/401 , Y02A50/475 , Y02A50/481
摘要： The invention provides methods of treating a bacterial infection in a mammal comprising administering to the mammal a compound of formula I: [formula should be inserted here] wherein A, B, and X have any of the meanings defined in the specification; or a pharmaceutically acceptable salt thereof, as well as novel compounds of formula I and salts thereof and pharmaceutical compositions comprising a compound of formula I or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供了治疗哺乳动物中的细菌感染的方法，包括给哺乳动物施用式I的化合物：[其中A，B和X具有任何含义 在说明书中定义; 或其药学上可接受的盐，以及新的式I化合物及其盐和包含式I化合物或其药学上可接受的盐的药物组合物。
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公开(公告)号：WO2011159926A1
公开(公告)日：2011-12-22
申请号：PCT/US2011/040744
申请日：2011-06-16
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , LAVOIE, Edmond, J. , PARHI, Ajit, K. , PILCH, Daniel, S.
CPC分类号： C07D217/14 , C07D217/16 , C07D217/22
摘要： The invention provides a compound of formula I: or a salt or prodrug thereof, wherein R 1 , R 4 -R 8 , R 10 , R 2' -R 6' , W, and A have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.
摘要翻译： 本发明提供式I化合物或其盐或前药，其中R1，R4-R8，R10，R2'-R6'，W和A具有说明书中描述的任何值，以及包含 该化合物可用作抗菌剂。
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公开(公告)号：WO2010083436A1
公开(公告)日：2010-07-22
申请号：PCT/US2010/021237
申请日：2010-01-15
申请人： RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY , UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY , PILCH, Daniel S. , LAVOIE, Edmond J. , KAUL, Malvika , PARHI, Ajit
IPC分类号： C07D221/12 , A61K31/473 , A61P31/04
CPC分类号： C07D221/12
摘要： The present invention provides compounds of formula I: formula (I) wherein X 1 - X 4 and R 1 -R 12 have any of the values defined in the specification, as well as salts and prodrugs thereof, which inhibit major molecular mechanisms associated with bacterial cell division and proliferation so as to be useful for the treatment and/or prevention of bacterial infections. The invention also provides compositions comprising these compounds as well as methods for using these compounds to inhibit bacterial cell division and proliferation and to treat bacterial infections.
摘要翻译： 本发明提供式I化合物：式（I）其中X 1 -X 4和R 1 -R 12具有说明书中定义的任何值，以及其盐和前药，其抑制与细菌细胞分裂相关的主要分子机制， 增殖，从而可用于治疗和/或预防细菌感染。 本发明还提供包含这些化合物的组合物以及使用这些化合物抑制细菌细胞分裂和增殖并治疗细菌感染的方法。
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