公开(公告)号：WO2012172436A3

公开(公告)日：2012-12-20

申请号：PCT/IB2012/001669

申请日：2012-06-15

Applicant: SMITHS DETECTION MONTREAL INC. ,  LEVIN, Daniel ,  SERGEYEV, Vlad ,  BONDARENKO, Volodimir ,  ATAMANCHUK, Bohdan ,  BIAN, Qunzhou ,  ZALESKI, Henryk ,  PINIARSKI, Mark ,  FELDBERG, Simon ,  JACKSON, Ronald

Inventor： LEVIN, Daniel ,  SERGEYEV, Vlad ,  BONDARENKO, Volodimir ,  ATAMANCHUK, Bohdan ,  BIAN, Qunzhou ,  ZALESKI, Henryk ,  PINIARSKI, Mark ,  FELDBERG, Simon ,  JACKSON, Ronald

IPC: G01N27/68 ,  H01J27/14 ,  H01J49/12 ,  H01J49/40

Abstract: Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions. In an implementation, an electrical ionization source includes a wire that is looped between electrical contacts. The wire is used to form a corona responsive to application of voltage between the wire and the walls of an ionization chamber. The corona can form when a sufficient voltage is applied between the wire and the walls. A difference in electrical potential between the wire and a wall forming an ionization chamber, in which wire is contained, can be used to draw the ions away from the wire. In embodiments, the wire can be heated to reduce the voltage used to strike the corona. The ions, subsequently, may ionize the molecules from the sample of interest. The looped corona source can also be used in mass spectrometers (MS).

公开(公告)号：WO2012056322A1

公开(公告)日：2012-05-03

申请号：PCT/IB2011/002895

申请日：2011-10-27

Applicant: ZALESKI, Henryk ,  PINIARSKI, Mark ,  FELDBERG, Simon ,  ANDERSON, Jeff ,  SAMARIN, Oleg

Inventor： ZALESKI, Henryk ,  PINIARSKI, Mark ,  FELDBERG, Simon ,  ANDERSON, Jeff ,  SAMARIN, Oleg

IPC: H01J49/06 ,  H01J3/04 ,  H01J49/40

CPC classification number: G01N27/622 ,  G01N23/00 ,  G06K9/0053 ,  H01J49/0031 ,  H01J49/025 ,  H01J49/04 ,  H01J49/06 ,  H01J49/061

Abstract: Systems and methods disclosed provide for methods of managing polarity switching in an ion mobility spectrometer, and provide for management of the repelling grid voltage, the gating grid voltage, and the fixed grid voltage during polarity switching. Systems and methods also provide for the management of the effect of dielectric relaxation in an insulator proximal to the collector, and provide for a preamplifier coupled to the collector including a switch, and a method of managing the collector output including the switch. Systems and methods consistent with the current disclosure further provide for a method of normalizing ion mobility data by determining fitting coefficients associated with a plurality of measurement data sets, and subtracting the curves determined by the fitting coefficients from the data acquired by the ion mobility spectrometer.

Abstract translation: 所公开的系统和方法提供了在离子迁移谱仪中管理极性切换的方法，并且在极性切换期间提供排斥电网电压，门控电网电压和固定电网电压的管理。 系统和方法还提供了在靠近集电极的绝缘体中对介电弛豫的影响的管理，并且提供耦合到集电器的前置放大器，包括开关，以及管理包括开关的集电极输出的方法。 与本公开一致的系统和方法进一步提供了通过确定与多个测量数据集相关联的拟合系数来归一化离子迁移率数据的方法，以及从由离子迁移谱仪获取的数据中减去由拟合系数确定的曲线。

公开(公告)号：WO2012172436A2

公开(公告)日：2012-12-20

申请号：PCT/IB2012001669

申请日：2012-06-15

Applicant: SMITHS DETECTION MONTREAL INC ,  LEVIN DANIEL ,  SERGEYEV VLAD ,  BONDARENKO VOLODIMIR ,  ATAMANCHUK BOHDAN ,  BIAN QUNZHOU ,  ZALESKI HENRYK ,  PINIARSKI MARK ,  FELDBERG SIMON ,  JACKSON RONALD

Inventor： LEVIN DANIEL ,  SERGEYEV VLAD ,  BONDARENKO VOLODIMIR ,  ATAMANCHUK BOHDAN ,  BIAN QUNZHOU ,  ZALESKI HENRYK ,  PINIARSKI MARK ,  FELDBERG SIMON ,  JACKSON RONALD

IPC: G01N27/68 ,  H01J49/40

CPC classification number: G01N27/622 ,  H01J49/12 ,  H01J49/168

Abstract: Looped ionization sources for ion mobility spectrometers are described. The ionization sources can be used to ionize molecules from a sample of interest in order to identify the molecules based on the ions. In an implementation, an electrical ionization source includes a wire that is looped between electrical contacts. The wire is used to form a corona responsive to application of voltage between the wire and the walls of an ionization chamber. The corona can form when a sufficient voltage is applied between the wire and the walls. A difference in electrical potential between the wire and a wall forming an ionization chamber, in which wire is contained, can be used to draw the ions away from the wire. In embodiments, the wire can be heated to reduce the voltage used to strike the corona. The ions, subsequently, may ionize the molecules from the sample of interest. The looped corona source can also be used in mass spectrometers (MS).

Abstract translation: 描述了用于离子迁移率光谱仪的环形电离源。 电离源可用于从感兴趣的样品中离子化分子，以便基于离子鉴定分子。 在一个实施方案中，电离电离源包括在电触头之间环绕的导线。 导线用于响应于在电线和电离室的壁之间施加电压而形成电晕。 当电线和墙壁之间施加足够的电压时，可以形成电晕。 电线和形成电离室的壁之间的电位差可以用于将离子从电线中拉出。 在实施例中，可以加热导线以降低用于击打电晕的电压。 随后，离子可以使目标样品中的分子离子化。 环状电晕源也可用于质谱仪（MS）。