公开(公告)号：WO2008143513A1

公开(公告)日：2008-11-27

申请号：PCT/NL2008/050309

申请日：2008-05-23

Applicant: PLANT RESEARCH INTERNATIONAL B.V. ,  BOSCH, Hendrik Jan ,  VAN DER KROL, Alexander, Ronald ,  HENQUET, Maurice, Gerard, Leon ,  FLORACK, Dionisius, Elisabeth, Antonius

Inventor： BOSCH, Hendrik Jan ,  VAN DER KROL, Alexander, Ronald ,  HENQUET, Maurice, Gerard, Leon ,  FLORACK, Dionisius, Elisabeth, Antonius

IPC: C12N9/10 ,  C12N15/82 ,  C12P21/00 ,  A01H5/00

CPC classification number: C12N15/8257 ,  C07K14/59 ,  C12N9/1051 ,  C12N15/8218 ,  C12N15/8245 ,  C12P21/005

Abstract: The present invention relates to a method to produce proteins reduced in high mannose type glycans in a plant or plant cell by partially inhibiting the expression of the Alg3 gene in said plant or plant cell. Said partial inhibition can be provided for by inserting the Alg3 mutant gene from Arabidopsis as derived from the plant line Salk_040296c or by partially inhibiting the endogenous Alg3 gene by providing the plant or plant cell either with an antisense expression, a sense co-suppressing or with an RNA inhibition genetic construct. Optionally also tissue-specific expression of said inhibiting constructs can yield partial inhibition in a plant.

Abstract translation: 本发明涉及在植物或植物细胞中通过部分抑制Alg3基因在所述植物或植物细胞中的表达来产生在高甘露糖型聚糖中还原的蛋白质的方法。 所述部分抑制可以通过将源自拟南芥属植物系Salk_040296c的拟南芥的Alg3突变体基因插入或通过向植物或植物细胞提供反义表达，感觉共抑制或与 RNA抑制遗传构建体。 任选地，所述抑制构建体的组织特异性表达可以在植物中产生部分抑制。

公开(公告)号：WO2007030001A1

公开(公告)日：2007-03-15

申请号：PCT/NL2005/000644

申请日：2005-09-06

Applicant: PLANT RESEARCH INTERNATIONAL B.V. ,  AHARONI, Asaph ,  DIXIT, Shital ,  TRIJATMIKO, Kurniawan, Rudi ,  HIEMSTRA, Jelle ,  PEREIRA, Andy

Inventor： AHARONI, Asaph ,  DIXIT, Shital ,  TRIJATMIKO, Kurniawan, Rudi ,  HIEMSTRA, Jelle ,  PEREIRA, Andy

IPC: C12N15/82 ,  C07K14/415 ,  C12N15/29 ,  A01H5/00 ,  A01H5/10

CPC classification number: C12N15/8273 ,  C07K14/415 ,  C12N15/8261 ,  C12N15/827 ,  C12N15/8279 ,  C12N15/8282 ,  Y02A40/146

Abstract: The present invention relates to the field of transgenic plants with novel phenotypes, especially plants with enhanced drought and pathogen resistance. Provided are transgenic crop plants comprising integrated in their genome a chimeric gene, characterized by said chimeric gene comprising a transcription regulatory sequence active in plant cells operably linked to a nucleic acid sequence encoding a protein having the sequence of SEQ ID NO: 3 or a protein at least 70 % identical to SEQ ID NO: 3, or an ortholog protein or a functional fragment thereof. In addition to enhanced drought tolerance the transgenic plants may show enhanced disease resistance and enhanced root structure.

Abstract translation: 本发明涉及具有新型表型的转基因植物领域，特别是具有增强的干旱和病原体抗性的植物。 提供了包含在其基因组中整合嵌合基因的转基因作物植物，其特征在于所述嵌合基因包含与编码具有SEQ ID NO：3的序列的蛋白质的核酸序列可操作地连接的植物细胞中的转录调控序列或蛋白质 与SEQ ID NO：3至少70％相同，或直系同源蛋白或其功能片段。 除了增强耐旱性外，转基因植物可以显示增强的抗病性和增强的根结构。

公开(公告)号：WO2006080842A3

公开(公告)日：2006-08-03

申请号：PCT/NL2006/000044

申请日：2006-01-26

Applicant: Plant Research International B.V. ,  FLORACK, Dionisius Elisabeth Antonius ,  BOSCH, Hendrik Jan

Inventor： FLORACK, Dionisius Elisabeth Antonius ,  BOSCH, Hendrik Jan

IPC: A61K39/12 ,  A61K39/385 ,  C12N15/82

Abstract: The invention relates to the development, composition and production of mucosal (oral) vaccines for fish. More specifically, the invention relates to protein complexes for the delivery of antigens to and across mucosal surfaces of fish for the induction of an immune response, and to the production of said complexes in a host cell, preferably plants. Provided is the use of a protein complex comprising an antigen of interest fused to the B-subunit of Vibrio cholerae cholera toxin (CT-B), or Escherichia coli heat-labile enterotoxin (LT-B) for the manufacture of an oral fish vaccine. Also provided is fish feed comprising a protein complex of the invention

公开(公告)号：WO2004065945A1

公开(公告)日：2004-08-05

申请号：PCT/EP2003/000785

申请日：2003-01-24

Applicant: PLANT RESEARCH INTERNATIONAL B.V. ,  VAN DER KRIEKEN, Wilhelmus, Maria ,  KOK, Cornelis, Johannes

Inventor： VAN DER KRIEKEN, Wilhelmus, Maria ,  KOK, Cornelis, Johannes

IPC: G01N21/64

CPC classification number: B82Y20/00 ,  B82Y10/00 ,  G01N21/6428 ,  G01V15/00

Abstract: The invention relates to a method for providing plants and/or plant parts with an identification label, comprising contacting the plant or plant part with a product, comprising one or more types of tracer molecules, preferably fluorescent tracer molecules, and allowing the plant or plant part to take up the tracer molecules either inside the plant or plant parts or on the surface thereof. The invention further relates to products for use in the method and plant and plant parts treated with the method and to methods for identifying plants or plant parts carrying an identification label.

Abstract translation: 本发明涉及用于向植物和/或植物部分提供鉴定标签的方法，包括使植物或植物部分与产品接触，所述产品包含一种或多种类型的示踪剂分子，优选荧光示踪剂分子，并允许植物或植物 部分在植物或植物部分内或其表面上吸收示踪剂分子。 本发明还涉及用于该方法的产品，以及用该方法处理的植物和植物部分以及识别携带识别标签的植物或植物部分的方法。

公开(公告)号：WO2003078614A2

公开(公告)日：2003-09-25

申请号：PCT/IB2003/001562

申请日：2003-03-18

Applicant: PLANT RESEARCH INTERNATIONAL B.V. ,  BAKKER, Hendrikus, Antonius, Cornelus ,  FLORACK, Dionisius, Elisabeth, Antonius ,  BOSCH, Hendrik, Jan

Inventor： BAKKER, Hendrikus, Antonius, Cornelus ,  FLORACK, Dionisius, Elisabeth, Antonius ,  BOSCH, Hendrik, Jan

IPC: C12N9/00

CPC classification number: C12N15/8243 ,  C12N9/1051 ,  C12N15/8257 ,  C12P21/02

Abstract: The invention relates to the field of glycoprotein processing in transgenic plants used as cost efficient and contamination safe factories for the production of recombinant biopharmaceutical proteins or pharmaceutical compositions comprising these glycoproteins. The invention provides a plant comprising a functional mammalian enzyme providing mammalian GnTIII that is normally not present in plants, said plant additionally comprising at least a second mammalian protein or functional fragment thereof that is normally not present in plants.

Abstract translation: 本发明涉及用作生产重组生物药物蛋白质或包含这些糖蛋白的药物组合物的成本效益和污染安全的工厂的转基因植物中的糖蛋白加工领域。 本发明提供了一种植物，其包含功能哺乳动物酶，其提供通常不存在于植物中的哺乳动物GnTIII，所述植物另外包含至少一种通常不存在于植物中的哺乳动物蛋白质或其功能片段。

公开(公告)号：WO2009077613A1

公开(公告)日：2009-06-25

申请号：PCT/EP2008/067975

申请日：2008-12-19

Applicant: DSM IP Assets B.V. ,  Plant Research International B.V. ,  STARK, Jacobus ,  VAN RIJN, Ferdinand Theodorus Jozef ,  VAN DER KRIEKEN, Wilhelmus Maria ,  STEVENS, Lucas Henricus

Inventor： STARK, Jacobus ,  VAN RIJN, Ferdinand Theodorus Jozef ,  VAN DER KRIEKEN, Wilhelmus Maria ,  STEVENS, Lucas Henricus

IPC: A01N43/90 ,  A01N57/12 ,  A01N59/06 ,  A01N59/26 ,  A01N63/02 ,  A01P3/00 ,  A23B7/153

CPC classification number: A01N43/90 ,  A01N57/12 ,  A01N59/06 ,  A01N59/26 ,  A01N2300/00

Abstract: The present invention relates to the treatment of banana and potato plants with a composition containing natamycin and at least one phosphite containing compound.

Abstract translation: 本发明涉及用含有游霉素和至少一种含亚磷酸盐化合物的组合物处理香蕉和马铃薯植物。

公开(公告)号：WO2008009657A2

公开(公告)日：2008-01-24

申请号：PCT/EP2007/057330

申请日：2007-07-16

Applicant: DSM IP Assets B.V. ,  Plant Research International B.V. ,  STARK, Jacobus ,  RIJN, VAN, Ferdinand Theodorus Jozef ,  KRIEKEN, VAN DER, Wilhelmus Maria ,  STEVENS, Lucas Henricus

Inventor： STARK, Jacobus ,  RIJN, VAN, Ferdinand Theodorus Jozef ,  KRIEKEN, VAN DER, Wilhelmus Maria ,  STEVENS, Lucas Henricus

IPC: A01N43/90 ,  A01N59/26 ,  A01N63/02

CPC classification number: A01N59/26 ,  A01N43/90 ,  A01N25/30 ,  A01N2300/00

Abstract: The present invention relates to a process for the treatment of an agricultural product which comprises the addition of a composition which comprises phosphite and natamycin to the agricultural product wherein the composition comprises preferably less than 0.1 g lignosulphonate, more preferably less than 0.1 g polyphenol, per gram natamycin and is still more preferably free of lignosulphonate and most preferably free of polyphenol.

Abstract translation: 本发明涉及一种用于处理农产品的方法，其包括向农产品中加入包含亚磷酸酯和游霉素的组合物，其中组合物优选含有少于0.1g木素磺酸盐，更优选小于0.1g多酚 格那那他霉素，更优选不含木素磺酸盐，最优选不含多酚。

公开(公告)号：WO2007145523A3

公开(公告)日：2007-12-21

申请号：PCT/NL2007/050286

申请日：2007-06-15

Applicant: PLANT RESEARCH INTERNATIONAL B.V. ,  ROUWENDAL, Gerard Johan Adolph ,  BOSCH, Hendrik Jan ,  FLORACK, Dionisius Elisabeth Antonius

Inventor： ROUWENDAL, Gerard Johan Adolph ,  BOSCH, Hendrik Jan ,  FLORACK, Dionisius Elisabeth Antonius

IPC: C12N15/82 ,  A01H5/00

Abstract: The invention comprises a method to produce a Lewis X epitope on N-linked glycans on glycoproteins in a plant, plant part or plant cells, comprising expression of a nucleotide sequence encoding a galactosyltransferase, which catalyzes the addition of galactose in βl,4-linkage to N-linked glycans, and expression of a nucleotide sequence encoding a fucosy transferase, which catalyzes the addition of fucose in αl,3-linkage to the N-acetylglucosamine of GalBl-4GlcNAc structures on N-linked glycans, and expression of one or more nucleotide sequences encoding one or more glycoproteins, which are able to be provided with an N-linked glycan, in said plant, plant part or plant cell. The fucosyltransferase comprises preferably the catalyticaal active domain of FUT9 from T. nigroviridis . Also part of the invention are hybrid enzymes with said domain and an N-terminal part which confers expression in the Golgi apparatus.

公开(公告)号：WO2005120215A1

公开(公告)日：2005-12-22

申请号：PCT/NL2005/000418

申请日：2005-06-09

Applicant: PLANT RESEARCH INTERNATIONAL B.V. ,  AHARONI, Asaph ,  DIXIT, Shital ,  PEREIRA, Andy

Inventor： AHARONI, Asaph ,  DIXIT, Shital ,  PEREIRA, Andy

IPC: A01H1/00

CPC classification number: C07K14/415 ,  C12N15/8273

Abstract: The present invention relates to the field of transgenic plants with given phenotypes, especially plants with enhanced drought tolerance. Provided are SHINE proteins and nucleic acid sequences encoding these, which are useful in conferring these phenotypes to plants.

Abstract translation: 本发明涉及具有给定表型的转基因植物领域，特别是具有增强的耐旱性的植物。 提供了SHINE蛋白质和编码这些的核酸序列，其可用于赋予植物这些表型。

公开(公告)号：WO2005052577A1

公开(公告)日：2005-06-09

申请号：PCT/NL2004/000825

申请日：2004-11-26

Applicant: PLANT RESEARCH INTERNATIONAL B.V. ,  BOSCH, Hendrik, Jan ,  VAN DER KROL, Alexander, Ronald

Inventor： BOSCH, Hendrik, Jan ,  VAN DER KROL, Alexander, Ronald

IPC: G01N33/50

CPC classification number: G01N33/6803 ,  G01N33/6842 ,  G01N33/92 ,  G01N2333/91091 ,  G01N2400/00

Abstract: This invention relates to identifying a biomolecular profile of an organism. In particular, the invention relates to targeted and selected proteomics. Provided is a method for identifying a molecular profile comprising a set of molecules of an organism, said method comprising the steps of: a) providing an organism with at least one heterologous modifying activity capable of tagging at least part of said molecules with at least one tag which is otherwise not displayed in said organism, wherein said modifying activity is regulated by at least one regulatory element that allows for tagging a spatially addressable and/or temporally restricted set of molecules; b) isolating the tagged molecules to obtain a library of tagged molecules; and c) characterizing said tagged molecules.

Abstract translation: 本发明涉及鉴定生物体的生物分子谱。 特别地，本发明涉及靶向和选择的蛋白质组学。 提供了一种用于鉴定包含生物体分子集合的分子谱的方法，所述方法包括以下步骤：a）向生物体提供至少一种异源修饰活性，所述异源修饰活性能够用至少一种所述分子标记所述分子的至少一部分 标签，否则不显示在所述生物体中，其中所述修饰活性由允许标记空间可寻址和/或时间限制的分子组的至少一种调节元件调节; b）分离标​​记的分子以获得标记分子的文库; 和c）表征所述标记分子。