公开(公告)号：WO2013158638A1

公开(公告)日：2013-10-24

申请号：PCT/US2013/036775

申请日：2013-04-16

Applicant: MYLAN, INC. ,  REYNOLDS, Thomas Daniel ,  LI, Boyong

Inventor： REYNOLDS, Thomas Daniel ,  LI, Boyong

IPC: A61K9/52

CPC classification number: A61K9/5047 ,  A61K9/5078 ,  A61K31/135 ,  A61K31/137 ,  A61K31/27 ,  A61K31/4178 ,  A61K31/421 ,  A61K31/5513

Abstract: A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant, such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed along with a method of preparation therefor. The dosage form comprises active core particles which are individually surrounded by a water insoluble polymer coating which lacks plasticizer.

Abstract translation: 用于以延长或持续释放的方式将骨骼肌松弛剂（例如盐酸环苯扎林）输送到体内的单位剂型，包括一种或多种含药颗粒群（珠粒，丸粒， 颗粒等）与其制备方法一起公开。 剂型包括活性核心颗粒，其由不含增塑剂的水不溶性聚合物涂层包围。

公开(公告)号：WO2011133935A2

公开(公告)日：2011-10-27

申请号：PCT/US2011/033671

申请日：2011-04-22

Applicant: THE JOHNS HOPKINS UNIVERSITY ,  AMERICAN INTERNATIONAL BIOTECHNOLOGY SERVICES ,  MELTZER, Stephen, J. ,  JIN, Zhe ,  CHEN, Yula ,  JACOBS-HELBER, Sarah, Margaret ,  REYNOLDS, Thomas, Robert

Inventor： MELTZER, Stephen, J. ,  JIN, Zhe ,  CHEN, Yula ,  JACOBS-HELBER, Sarah, Margaret ,  REYNOLDS, Thomas, Robert

IPC: C12Q1/68 ,  C12N15/11

CPC classification number: C12Q1/6883 ,  C12Q2600/178

Abstract: The present invention is based on the seminal discovery of a set of biomarker assays to predict the risk of esophageal cancer or ad vanced precancerous esophageal lesions in patients with Barrett's esophagus (BE). The present invention includes, but is not restricted to biomarkers based on gene hypermethylation (CH3), as well as biomarkers based on loss of heterozygosity (LOH), both occurring in Barrett's esophagus tissue biopsy samples. Results of the assay provide patients and their caregivers with an assessment of the likelihood of future neoplastic (irankiy cancerous or advanced precancerous) progression.

Abstract translation: 本发明基于一组生物标志物测定法的精确发现，用于预测Barrett食管（BE）患者食管癌或高级癌前食管损伤的风险。 本发明包括但不限于基于基因超甲基化（CH3）的生物标志物，以及基于在巴雷特食管组织活组织检查样品中发生的杂合性损失（LOH）的生物标志物。 测定结果为患者及其护理人员评估未来肿瘤（非癌性癌性或晚期癌前期）进展的可能性。

公开(公告)号：WO2010039450A2

公开(公告)日：2010-04-08

申请号：PCT/US2009057386

申请日：2009-09-18

Applicant: UOP LLC ,  COHEN ALAN P ,  REYNOLDS THOMAS M ,  DAVIS MARK M

Inventor： COHEN ALAN P ,  REYNOLDS THOMAS M ,  DAVIS MARK M

IPC: B01D53/02 ,  B01D53/92 ,  B01J20/18

CPC classification number: C07C29/76 ,  B01D53/02 ,  B01D53/0476 ,  B01D53/261 ,  B01D2253/108 ,  B01D2256/24 ,  B01J20/186 ,  B01J20/2803 ,  B01J20/2808 ,  B01J20/3408 ,  G01N5/02 ,  C07C31/08

Abstract: This invention involves the use of a more effective adsorbent to dehydrate ethanol. The most common use for the ethanol is an additive to gasoline. The preferred adsorbent is a type 3A adsorbent that has been ion exchanged with potassium at a level of 0.6. Surprisingly, this adsorbent has a significantly improved resistance to damage by water upset events.

Abstract translation: 本发明涉及使用更有效的吸附剂来使乙醇脱水。 乙醇最常见的用途是汽油添加剂。 优选的吸附剂是已经用0.6水平的钾离子交换的3A型吸附剂。 令人惊讶的是，这种吸附剂具有显着提高的抗水破坏事件损害抵抗力。

公开(公告)号：WO2007008449A1

公开(公告)日：2007-01-18

申请号：PCT/US2006/025522

申请日：2006-06-29

Applicant: ELECTRO SCIENTIFIC INDUSTRIES, INC. ,  REYNOLDS, Thomas Leonard ,  JOHNSON, Jay

Inventor： REYNOLDS, Thomas Leonard ,  JOHNSON, Jay

IPC: F02M3/07

CPC classification number: H02M3/155 ,  H02M2001/007 ,  Y10T307/438 ,  Y10T307/625

Abstract: A charge pump (200) can be used with a bus-powered device connected to a bus. The charge pump (200) comprises a power connection (210) from the bus carrying a DC power signal constrained to not exceed a given current limit and a given voltage limit, a DC-to-DC step-down voltage converter (300), a capacitor (C1), and a DC-to-DC step-up voltage converter (400). The step-down converter (300) has an input connected to the power connection (210) and produces an intermediate signal having a voltage the same or less than the voltage of the power signal. The capacitor (C1) is connected to the output of the step-down converter (300). The step-up converter (400) has an input connected to the output of the step-down converter (300) and to the capacitor (C1), and produces a final output signal having a voltage greater than the given voltage limit. The output of the step-up converter (400) is connected to and provides DC power to the device.

Abstract translation: 电荷泵（200）可以与连接到总线的总线供电设备一起使用。 电荷泵（200）包括来自总线的电力连接（210），该总线承载被限制为不超过给定电流限制的DC电力信号和给定的电压限制，DC-DC降压电压转换器（300） 电容器（C1）和DC-DC升压电压转换器（400）。 降压转换器（300）具有连接到电力连接（210）的输入端并产生具有与电源信号的电压相同或更小的电压的中间信号。 电容器（C1）连接到降压转换器（300）的输出端。 升压转换器（400）具有连接到降压转换器（300）的输出和电容器（C1）的输入端，并且产生具有大于给定电压极限的电压的最终输出信号。 升压转换器（400）的输出与设备连接并提供直流电力。

公开(公告)号：WO2005023971A1

公开(公告)日：2005-03-17

申请号：PCT/US2004/028316

申请日：2004-09-01

Applicant: JOHNSONDIVERSEY, INC. ,  SUTTON, David, C. ,  BROWN, Lance, D. ,  KENG, William, Y. ,  REYNOLDS, Thomas

Inventor： SUTTON, David, C. ,  BROWN, Lance, D. ,  KENG, William, Y. ,  REYNOLDS, Thomas

IPC: C11D3/20

CPC classification number: C11D3/046 ,  C11D3/0057 ,  C11D3/044 ,  C11D3/06 ,  C11D3/08 ,  C11D3/10 ,  C11D3/2003 ,  C11D3/2044 ,  C11D3/2048 ,  C11D3/2065 ,  C11D3/43 ,  C11D7/02 ,  C11D7/06 ,  C11D7/10 ,  C11D7/12 ,  C11D7/14 ,  C11D7/16 ,  C11D7/261 ,  C11D7/5013 ,  C11D7/5022 ,  C11D11/0023

Abstract: A cleaning composition is provided comprising a solvent system and at least one inorganic alkaline salt, wherein the solvent system includes at least one polyhydric alcohol. The inventive composition may also include a thickener, a corrosion-inhibition system, surfactant. The invention also provides a method of cleaning soil from a cooking related surface comprising, applying a cleaning composition to the surface, allowing the cleaning composition to remain on the surface for a period of time and removing the composition from the surface along with the soil. After application of the composition, the surface can be heated prior to removal of the composition and soil from the surface.

Abstract translation: 提供了包含溶剂系统和至少一种无机碱性盐的清洁组合物，其中溶剂体系包括至少一种多元醇。 本发明的组合物还可以包括增稠剂，腐蚀抑制体系，表面活性剂。 本发明还提供了一种从烹饪相关表面清洗土壤的方法，包括：将清洁组合物施用于表面，允许清洁组合物在表面上保留一段时间，并与土壤一起从表面除去组合物。 在施用组合物之后，可以在从表面去除组合物和土壤之前加热表面。

公开(公告)号：WO0198541A3

公开(公告)日：2003-06-19

申请号：PCT/US0119763

申请日：2001-06-21

Applicant: HARRIS ROBERT B ,  REYNOLDS THOMAS R

Inventor： HARRIS ROBERT B ,  REYNOLDS THOMAS R

IPC: C12Q1/48 ,  C12Q1/68 ,  C12Q1/70

CPC classification number: C12Q1/48 ,  C12Q1/703

Abstract: In clinical settings as well as in a drug-discovery context, the impact of an agent that may affect reverse transcriptase (RT) can be measured and even quantified by bringing a sample, which may contain an RT, into contact with an RNA template, a primer complementary to the RNA template, and appropriate oligonucleotide-specific primers, under conditions such that they react, in the presence of RT, to form a cDNA product in inverse proportion to the effect of the agent. The amount of any resultant cDNA product then can be measured. The approach is readily implemented as a real-time, quantitative kinetic assay for RT activity.

Abstract translation: 在临床环境以及药物发现环境中，可以通过将可能含有RT的样品与RNA模板接触来测量并甚至定量可能影响逆转录酶（RT）的试剂的影响， 与RNA模板互补的引物，以及合适的寡核苷酸特异性引物，在RT的存在下反应，形成与试剂效果成反比的cDNA产物。 然后可以测量任何得到的cDNA产物的量。 该方法很容易实现为RT活性的实时定量动力学测定。

公开(公告)号：WO02072064A3

公开(公告)日：2003-03-06

申请号：PCT/US0200264

申请日：2002-01-03

Applicant: DOW GLOBAL TECHNOLOGIES INC ,  MITCHELL SHAWN A ,  DASBACH TINA P ,  REYNOLDS THOMAS D

Inventor： MITCHELL SHAWN A ,  DASBACH TINA P ,  REYNOLDS THOMAS D

IPC: A61K9/16 ,  A61K9/20

CPC classification number: A61K9/1652 ,  A61K9/1694 ,  A61K9/2054 ,  A61K9/2077

Abstract: The dissolution rate of a therapeutically active compound in an aqueous liquid is increased by: i) preparing an essentially dry mixture consisting essentially of a) a therapeutically active compound and b) a cellulose ether, ii) compacting the resulting mixture under pressure and iii) comminuting the compacted mixture.

Abstract translation: 治疗活性化合物在水性液体中的溶解速率通过以下方式增加：i）制备基本上干燥的混合物，其基本上由a）治疗活性化合物和b）纤维素醚组成，ii）在压力下压实所得混合物，iii） 粉碎压实的混合物。

公开(公告)号：WO0014205A2

公开(公告)日：2000-03-16

申请号：PCT/US9920524

申请日：1999-09-07

Applicant: TARGETED GENETICS CORP ,  ATKINSON EDWARD MORROW ,  FUNG VICTOR P ,  WILKINS PERRY C ,  TAKEYA RYAN K ,  REYNOLDS THOMAS C

Inventor： ATKINSON EDWARD MORROW ,  FUNG VICTOR P ,  WILKINS PERRY C ,  TAKEYA RYAN K ,  REYNOLDS THOMAS C

IPC: C12N15/09 ,  C07K14/015 ,  C12N5/10 ,  C12N7/02 ,  C12R1/91 ,  C12N15/86

CPC classification number: C07K14/005 ,  C12N7/00 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14151 ,  C12N2750/14152

Abstract: The invention described herein provides methods of producing rAAV particles by culturing producer cells under conditions, such as temperature and pH, that promote release of virus.

公开(公告)号：WO9911764A3

公开(公告)日：1999-06-10

申请号：PCT/US9818600

申请日：1998-09-04

Applicant: TARGETED GENETICS CORP ,  ATKINSON EDWARD MORROW ,  FUNG VICTOR P ,  WILKINS PERRY C ,  TAKEYA RYAN K ,  REYNOLDS THOMAS C

Inventor： ATKINSON EDWARD MORROW ,  FUNG VICTOR P ,  WILKINS PERRY C ,  TAKEYA RYAN K ,  REYNOLDS THOMAS C

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/00 ,  C12N5/10 ,  C12N7/00 ,  C12N7/02 ,  C12Q1/70

CPC classification number: C12N7/00 ,  C12N15/86 ,  C12N2750/14143 ,  C12N2750/14151

Abstract: This invention provides methods and compositions for producing high titer, substantially purified preparations of recombinant adeno-associated virus (AAV) that can be used as vectors for gene delivery. At the onset of vector production, AAV producer cells of this invention typically comprise one or more AAV packaging genes, an AAV vector comprising a heterelogous (i.e. non-AAV) transgene of interest, and a helper virus such as an adenovirus. The AAV vector preparations produced are generally replication incompetent but are capable of mediating delivery of a transgene of interest (such as a therapeutic gene) to any of a wide variety of tissues and cells. The AAV vector preparations produced according to this invention are also substantially free of helper virus as well as helper viral and cellular proteins and other contaminants. Also provided is a quantitative, high-throughput assay useful in the assessment of viral infectivity and replication, as well as in the screening of agents that affect viral infectivity and/or replication.

Abstract translation: 本发明提供了用于生产可用作基因递送载体的高滴度，基本上纯化的重组腺相关病毒（AAV）制备物的方法和组合物。 在载体产生开始时，本发明的AAV生产细胞通常包含一个或多个AAV包装基因，包含异源（即非AAV）目标转基因的AAV载体和辅助病毒如腺病毒。 产生的AAV载体制剂通常是复制缺陷型的，但能够介导感兴趣的转基因（例如治疗基因）向各种组织和细胞中的任何一种的递送。 根据本发明产生的AAV载体制剂也基本上不含辅助病毒以及辅助病毒和细胞蛋白以及其他污染物。 还提供了用于评估病毒感染性和复制以及筛选影响病毒感染性和/或复制的药剂的定量高通量测定。

公开(公告)号：WO2010033179A1

公开(公告)日：2010-03-25

申请号：PCT/US2009/005153

申请日：2009-09-16

Applicant: MYLAN LABORATORIES, INC. ,  LI, Boyong ,  REYNOLDS, Thomas D.

Inventor： LI, Boyong ,  REYNOLDS, Thomas D.

IPC: A61K9/14

CPC classification number: A61K9/2027 ,  A61K9/2018 ,  A61K9/2059 ,  A61K31/277

Abstract: A granulate for use in a pharmaceutical composition and a pharmaceutical composition manufacture using the granulate, where the granule comprises an active pharmaceutical ingredient (API) having a poor water solubility (i.e., less than about 1 mg/mL) which is intimately associated with at least one pharmaceutically acceptable hydrophilic polymer. The granule optionally contains one or more pharmaceutically acceptable excipients, such as disintegrants, wetting agents, diluents, binders, lubricants, glidants, coloring agents and flavoring agents. The invention also relates to a process for preparing the pharmaceutical granulate and pharmaceutical compositions containing the granulate.

Abstract translation: 用于药物组合物的颗粒和使用该颗粒的药物组合物制造，其中颗粒包含具有差的水溶性（即小于约1mg / mL）的活性药物成分（API），其与 至少一种药学上可接受的亲水性聚合物。 颗粒任选地含有一种或多种药学上可接受的赋形剂，例如崩解剂，润湿剂，稀释剂，粘合剂，润滑剂，助流剂，着色剂和调味剂。 本发明还涉及制备含有颗粒的药物颗粒和药物组合物的方法。