公开(公告)号：WO2008134495A2

公开(公告)日：2008-11-06

申请号：PCT/US2008061540

申请日：2008-04-25

申请人： UNIV OHIO STATE ,  LIU JUN ,  ROBERTS CYNTHIA J

发明人： LIU JUN ,  ROBERTS CYNTHIA J

CPC分类号： A61B8/10

摘要： A system and a method for non-invasively ultrasonically measuring biomechanical properties of ocular tissue in vivo is presented. The method comprises positioning an ultrasonic transducer proximally to the ocular tissue. Reflections of the ocular tissue can be ultrasonically obtained using the ultrasonic transducer. The ultrasonic reflections can be converted into reflection spectra. Biomechanical properties of the ocular tissue, such as, for example, thickness, corneal stiffness, density, and longitudinal modulus, can be determined based on the reflection spectra. A wave propagation model can be developed to simulate ultrasound propagation of ocular tissue in vivo. The ultrasonic non-destructive evaluation method and system for the non-invasive measuring of reflection spectra and determining biomechanical properties of ocular tissue in vivo can provide information for ocular disease management and therapeutic and refractive procedures.

摘要翻译： 提出了非侵入式超声波测量体内眼组织生物力学性质的系统和方法。 该方法包括将超声波换能器向近侧定位到眼组织。 可以使用超声波换能器超声波获得眼组织的反射。 超声波反射可以转换为反射光谱。 基于反射光谱可以确定眼组织的生物力学性质，例如厚度，角膜刚度，密度和纵向模量。 可以开发波传播模型，以模拟体内眼组织的超声波传播。 用于非侵入式测量反射光谱的超声波无损检测方法和系统，并确定体内组织的生物力学性质，可为眼病治疗和治疗和屈光手术提供信息。

公开(公告)号：WO2006034336A1

公开(公告)日：2006-03-30

申请号：PCT/US2005/033802

申请日：2005-09-21

申请人： THE OHIO STATE UNIVERSITY ,  ROBERTS, Cynthia, J. ,  MC CALLUM, Grant, A.

发明人： ROBERTS, Cynthia, J. ,  MC CALLUM, Grant, A.

IPC分类号： A61B3/113 ,  A61B5/11

CPC分类号： A61B5/68 ,  A61B3/113 ,  A61B5/1107 ,  A61B5/6821

摘要： A sensing system and method to detect and determine magnitude and direction of ciliary body movement within an eye of a patient is disclosed. The invention comprises a permanent magnet (PM) positioned in the ciliary body, and a sensing device (SD) positioned adjacent the ciliary body and configured to detect displacement of the permanent magnet relative to the sensing device via movement of the ciliary body. The invention also comprises a data processing device (DPD) configured to determine magnitude and direction of the ciliary body movement based on the displacement of the permanent magnet detected by the sensing device.

摘要翻译： 公开了一种用于检测并确定患者眼睛内的睫状体运动的大小和方向的感测系统和方法。 本发明包括定位在睫状体中的永磁体（PM）和邻近睫状体定位的感测装置（SD），并被配置为通过睫状体的运动来检测永久磁体相对于感测装置的位移。 本发明还包括数据处理装置（DPD），其被配置为基于由感测装置检测到的永磁体的位移来确定睫状体运动的大小和方向。

公开(公告)号：WO2011109029A1

公开(公告)日：2011-09-09

申请号：PCT/US2010/026915

申请日：2010-03-11

申请人： VISION OPTIMIZATION, LLC ,  ROBERTS, Cynthia, J. ,  MAROUS, James, Richard ,  MAHMOUD, Ashraf, Mostafa

发明人： ROBERTS, Cynthia, J. ,  MAROUS, James, Richard ,  MAHMOUD, Ashraf, Mostafa

IPC分类号： A61B3/107

CPC分类号： A61B3/165 ,  G01B11/167 ,  G01B11/2513 ,  G01N2203/0089 ,  G06T7/521

摘要： Apparatus and methods for measuring a dynamic deformation characteristic of a deformable target surface during a deformation interval. The measurement principles may be applied to a large variety of organic and inorganic materials having a surface that can be deformed by an applied non-contact force. The surface may be light diffusing and non-transparent or non-diffusing and transparent. A device for measuring a dynamic deformation characteristic of an in-vivo cornea during a deformation interval includes a corneal topographer and an air puff generator that are operationally integrated. Use of the inventive device enables a method for making a measurement of a deformation characteristic of the in-vivo cornea during a deformation interval, further allowing a determination of spatially-resolved in-vivo corneal biomechanical and biodynamic properties such as corneal elasticity and corneal viscosity.

摘要翻译： 用于在变形间隔期间测量可变形目标表面的动态变形特性的装置和方法。 测量原理可以应用于具有可通过施加的非接触力而变形的表面的各种有机和无机材料。 该表面可以是光漫射和不透明或不扩散和透明的。 用于在变形间隔期间测量体内角膜的动态变形特性的装置包括可操作地集成的角膜地形图和气泡发生器。 使用本发明的装置能够实现在变形间隔期间测量体内角膜的变形特性的方法，还允许确定空间分辨的体内角膜生物力学和生物力学性质，例如角膜弹性和角膜粘度 。

公开(公告)号：WO2007053826A3

公开(公告)日：2007-11-08

申请号：PCT/US2006060381

申请日：2006-10-31

申请人： CRS & ASSOCIATES ,  ROBERTS CYNTHIA J

发明人： ROBERTS CYNTHIA J

IPC分类号： A61B3/10

CPC分类号： A61B3/165 ,  A61B3/0008 ,  A61B3/107

摘要： Embodiments of the invention are generally directed to apparatus and methods for measuring a deformation characteristic of a deformable target surface. The measurement principles of the invention may be applied to a large variety of organic (e.g., human, animal or plant tissue) and inorganic materials having a surface that can be deformed by an applied non-contact force. The surface may be light diffusing and non-transparent or non-diffusing and transparent. An illustrative embodiment of the invention is directed to a device for measuring a deformation characteristic of a cornea. The device comprises a corneal topographer and a non-contact tonometer that is operationally integrated with the corneal topographer. In an aspect, the corneal topographer is a rasterstereography-based topographer. Use of the inventive device enables a method for measuring a deformation characteristic of the cornea. In addition to the measurable deformation characteristics listed above, dioptric power, intraocular pressure, corneal hysteresis, corneal elasticity, corneal viscosity and various known corneal topography characteristics can be measured.

摘要翻译： 本发明的实施例一般涉及用于测量可变形目标表面的变形特性的装置和方法。 本发明的测量原理可以应用于各种各样的有机（例如，人，动物或植物组织）和具有可通过施加的非接触力而变形的表面的无机材料。 该表面可以是光漫射和不透明或不扩散和透明的。 本发明的说明性实施例涉及一种用于测量角膜变形特性的装置。 该装置包括角膜地形图和与角膜地形图操作地集成的非接触式眼压计。 在一方面，角膜地形图是基于栅格摄影的地形图。 使用本发明的装置能够测量角膜的变形特性的方法。 除了上述可测量的变形特征之外，还可以测量屈光度，眼内压，角膜滞后，角膜弹性，角膜粘度和各种已知的角膜形貌特征。

公开(公告)号：WO2005034730A3

公开(公告)日：2005-07-07

申请号：PCT/US2004032897

申请日：2004-10-06

申请人： CRS & ASSOCIATES ,  ROBERTS CYNTHIA J ,  SARVER EDWIN J ,  MAROUS JAMES R

发明人： ROBERTS CYNTHIA J ,  SARVER EDWIN J ,  MAROUS JAMES R

IPC分类号： A61B20060101 ,  A61B3/107 ,  A61B18/18 ,  A61B19/00 ,  A61F9/01 ,  A61F9/013 ,  A61M31/00

CPC分类号： A61B3/0025 ,  A61F9/00808 ,  A61F9/00821 ,  A61F9/00838 ,  A61F9/013 ,  A61F2009/00853 ,  A61F2009/00857 ,  A61F2009/00872 ,  A61F2009/00895

摘要： A method and apparatus related to enhancing corneal accommodation to address the effect of presbyopia. Corneal/scleral topology measurements in accommodation and non-accommodating states are indicative of a presbyopic subject's nominal corneal accommodative power. A desired accommodative power intended to improve on the effect of presbyopia can be determined, suggesting a selective biomechanical intervention in the corneal structure outside of the optical zone to create flexure regions. These flexure regions would allow enhanced corneal accommodation upon presentation of an accommodating stimulus. Intervention could be in the form of, for example, corneal surface ablation, intrastromal ablation, conductive kerastoplasty (CK), laser thermal kerastoplasty (LTK), and corneal and/or scleral implants. An improved topology measuring apparatus having an improved field of view and other attributes is disclosed.

摘要翻译： 一种与增强角膜适应度相关的方法和装置，以解决老花眼的影响。 在适应状态和不适应状态下的角膜/巩膜拓扑结构测量表明老花眼受试者的标称角膜调节能力。 可以确定旨在改善老花眼效果的期望的调节力，这表明在光学区域外的角膜结构中的选择性生物力学干预以产生弯曲区域。 这些弯曲区域将允许在呈现适应刺激时增强角膜适应。 干预可以是例如角膜表面消融，基质内消融，导电性乳房成形术（CK），激光热乳头成形术（LTK）和角膜和/或巩膜植入物的形式。 公开了具有改进的视野和其他属性的改进的拓扑测量装置。

公开(公告)号：WO2005034730A2

公开(公告)日：2005-04-21

申请号：PCT/US2004/032897

申请日：2004-10-06

申请人： CRS & ASSOCIATES ,  ROBERTS, Cynthia, J. ,  SARVER, Edwin, J. ,  MAROUS, James, R.

发明人： ROBERTS, Cynthia, J. ,  SARVER, Edwin, J. ,  MAROUS, James, R.

IPC分类号： A61B

CPC分类号： A61B3/0025 ,  A61F9/00808 ,  A61F9/00821 ,  A61F9/00838 ,  A61F9/013 ,  A61F2009/00853 ,  A61F2009/00857 ,  A61F2009/00872 ,  A61F2009/00895

摘要： A method and apparatus related to enhancing corneal accommodation to address the effect of presbyopia. Corneal/scleral topology measurements in accommodation and non-accommodating states are indicative of a presbyopic subject’s nominal corneal accommodative power. A desired accommodative power intended to improve on the effect of presbyopia can be determined, suggesting a selective biomechanical intervention in the corneal structure outside of the optical zone to create flexure regions. These flexure regions would allow enhanced corneal accommodation upon presentation of an accommodating stimulus. Intervention could be in the form of, for example, corneal surface ablation, intrastromal ablation, conductive kerastoplasty (CK), laser thermal kerastoplasty (LTK), and corneal and/or scleral implants. An improved topology measuring apparatus having an improved field of view and other attributes is disclosed.

摘要翻译： 与增强角膜调节以解决老花眼效应有关的方法和设备。 在适应状态和非适应状态下的角膜/巩膜拓扑测量结果表明老花眼受试者的名义角膜调节能力。 可以确定旨在改善老花眼效果的期望调节力，这表明在光学区外部的角膜结构中进行选择性生物力学干预以产生挠曲区域。 这些弯曲区域将允许在呈现适应性刺激时增强角膜调节。 干预可以是例如角膜表面消融，基质内消融，导电角膜成形术（CK），激光热角膜成形术（LTK）和角膜和/或巩膜植入物的形式。 公开了一种改进的拓扑测量装置，其具有改进的视场和其他属性。

公开(公告)号：WO2009124231A1

公开(公告)日：2009-10-08

申请号：PCT/US2009/039409

申请日：2009-04-03

申请人： BATTELLE MEMORIAL INSTITUTE ,  MCGINNISS, Vincent, D. ,  RISSER, Steven, M. ,  ROBERTS, Cynthia, J. ,  THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION

发明人： MCGINNISS, Vincent, D. ,  RISSER, Steven, M. ,  ROBERTS, Cynthia, J.

IPC分类号： A61F2/16

CPC分类号： A61F2/1627 ,  A61F2/1635 ,  A61F2/1659 ,  A61F2002/16965 ,  A61L27/50 ,  A61L2430/16 ,  G02B1/043

摘要： Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.

摘要翻译： 公开了用于改变诸如人工晶状体的透镜的功率的方法和装置。 在一种方法中，透镜包含含有可交联侧基的单一聚合物基质，其中当交联时聚合物基体的体积增加。 镜头不含有游离单体。 当暴露于紫外线辐射时，交联使得透镜的暴露部分体积增加，导致折射率增加。 在另一种方法中，透镜包含含有可光漂白的发色团的聚合物基质。 在紫外线照射下，光漂白导致曝光部分的折射率降低，透镜厚度没有变化。 这些方法避免了等待发生扩散以改变透镜形状的需要，并且避免了第二次暴露于辐射以锁定透镜变化的需要。

公开(公告)号：WO2008134495A3

公开(公告)日：2008-11-06

申请号：PCT/US2008/061540

申请日：2008-04-25

申请人： THE OHIO STATE UNIVERSITY ,  LIU, Jun ,  ROBERTS, Cynthia, J.

发明人： LIU, Jun ,  ROBERTS, Cynthia, J.

IPC分类号： A61B8/10

摘要： A system and a method for non-invasively ultrasonically measuring biomechanical properties of ocular tissue in vivo is presented. The method comprises positioning an ultrasonic transducer proximally to the ocular tissue. Reflections of the ocular tissue can be ultrasonically obtained using the ultrasonic transducer. The ultrasonic reflections can be converted into reflection spectra. Biomechanical properties of the ocular tissue, such as, for example, thickness, corneal stiffness, density, and longitudinal modulus, can be determined based on the reflection spectra. A wave propagation model can be developed to simulate ultrasound propagation of ocular tissue in vivo. The ultrasonic non-destructive evaluation method and system for the non-invasive measuring of reflection spectra and determining biomechanical properties of ocular tissue in vivo can provide information for ocular disease management and therapeutic and refractive procedures.

公开(公告)号：WO2007053826A2

公开(公告)日：2007-05-10

申请号：PCT/US2006/060381

申请日：2006-10-31

申请人： CRS & ASSOCIATES ,  ROBERTS, Cynthia, J.

发明人： ROBERTS, Cynthia, J.

IPC分类号： A61B3/10

CPC分类号： A61B3/165 ,  A61B3/0008 ,  A61B3/107

摘要： Embodiments of the invention are generally directed to apparatus and methods for measuring a deformation characteristic of a deformable target surface. The measurement principles of the invention may be applied to a large variety of organic (e.g., human, animal or plant tissue) and inorganic materials having a surface that can be deformed by an applied non-contact force. The surface may be light diffusing and non-transparent or non-diffusing and transparent. An illustrative embodiment of the invention is directed to a device for measuring a deformation characteristic of a cornea. The device comprises a corneal topographer and a non-contact tonometer that is operationally integrated with the corneal topographer. In an aspect, the corneal topographer is a rasterstereography-based topographer. Use of the inventive device enables a method for measuring a deformation characteristic of the cornea. In addition to the measurable deformation characteristics listed above, dioptric power, intraocular pressure, corneal hysteresis, corneal elasticity, corneal viscosity and various known corneal topography characteristics can be measured.

摘要翻译： 本发明的实施例通常针对用于测量可变形目标表面的变形特性的装置和方法。 本发明的测量原理可以应用于具有可以通过施加的非接触力而变形的表面的多种有机（例如人类，动物或植物组织）和无机材料。 表面可以是光漫射和不透明或不漫射和透明的。 本发明的说明性实施例涉及用于测量角膜的变形特征的装置。 该装置包括角膜地形图仪和与角膜地形图仪可操作集成的非接触式眼压计。 在一个方面，角膜地形图工作者是一位以rasterstereography为基础的地形学家。 使用本发明的装置使得能够测量角膜的变形特征的方法。 除了上面列出的可测量的变形特性之外，可以测量屈光度，眼内压，角膜滞后，角膜弹性，角膜粘度和各种已知的角膜地形特征。