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    SPECIES-SPECIFIC, GENUS-SPECIFIC AND UNIVERSAL DNA PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL AND FUNGAL PATHOGENS AND ASSOCIATED ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR DIAGNOSIS IN MICROBIOLOGY LABORATORIES
    1.
    发明申请
    SPECIES-SPECIFIC, GENUS-SPECIFIC AND UNIVERSAL DNA PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL AND FUNGAL PATHOGENS AND ASSOCIATED ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR DIAGNOSIS IN MICROBIOLOGY LABORATORIES 审中-公开
    特异性，特异性和通用DNA探针和放大引物，用于快速检测和鉴定常见细菌和真菌病原体和相关抗生素耐药基因，用于诊断微生物实验室临床样本

    公开(公告)号：WO1998020157A2

    公开(公告)日：1998-05-14

    申请号：PCT/CA1997000829

    申请日：1997-11-04

    Applicant: INFECTIO DIAGNOSTIC (I.D.I.) INC. ,  BERGERON, Michel, G. ,  PICARD, François, J. ,  OUELLETTE, Marc ,  ROY, Paul, H.

    Inventor： INFECTIO DIAGNOSTIC (I.D.I.) INC.

    IPC: C12Q01/68

    CPC classification number: C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12Q1/6895 ,  C12Q2600/156

    Abstract: DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of bla?tem?, bla?rob?, bla?shv?, bla?oxa?, blaZ, aadB, aacC1, aacC2, aacC3, aacA4, aac6'-IIa, ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6'-aph(2''), aad(6'), vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes are all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes are also claimed.

    Abstract translation: 基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量来自（i）任何细菌的测试样品DNA，（ii）无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏球菌，单核细胞增生利斯特氏菌和白色念珠菌 ，和（iii）任何种属的链球菌属，葡萄球菌属，肠球菌属，奈瑟球菌属和假丝酵母属。 基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量测试样品抗生素抗性基因，其选自bla？tem，bla？rob？bla？shv？，bla？oxa？，blaZ ，aadB，aacC1，aacC2，aacC3，aacA4，aac6'-IIa，ermA，ermB，ermC，mecA，vanA，vanB，vanC，satA，aac（6'-aph（2“），aad（6' 大肠杆菌，vga，mrrA，sul和int也被公开，上述微生物种类，属和抗性基因在各种临床标本中都是临床相关的，常见于这些基因，这些基于DNA的检测是快速，准确的，可用于 临床微生物实验室用于常规诊断这些新型诊断工具应该有助于提高微生物感染诊断的速度和准确性，从而允许更有效的治疗。诊断试剂盒用于（i）细菌的普遍检测和定量，和/或 ii）上述细菌的检测，鉴定和定量 和/或类，和/或（iii）上述抗生素抗性基因的检测，鉴定和定量也被要求保护。

    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
    3.
    发明申请
    Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories 审中-公开
    物种特异性，属特异性和通用DNA探针和扩增引物，用于快速检测和鉴定临床标本中常见的细菌和真菌病原体和相关抗生素抗性基因，用于微生物实验室的诊断

    公开(公告)号：WO9820157A3

    公开(公告)日：1998-08-13

    申请号：PCT/CA9700829

    申请日：1997-11-04

    Applicant: INFECTIO DIAGNOSTIC INC ,  BERGERON MICHEL G ,  PICARD FRANCOIS J ,  OUELETTE MARC ,  ROY PAUL H

    Inventor： BERGERON MICHEL G ,  PICARD FRANCOIS J ,  OUELLETTE MARC ,  ROY PAUL H

    IPC: C12N15/09 ,  C07K14/195 ,  C07K14/21 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C12N1/21 ,  C12Q1/68 ,  C12R1/01

    CPC classification number: C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12Q1/6895 ,  C12Q2600/156

    Abstract: DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample DNA from (i) any bacterium, (ii) the species Streptococcus agalactiae, Staphylococcus saprophyticus, Enterococcus faecium, Neisseria meningitidis, Listeria monocytogenes and Candida albicans, and (iii) any species of the genera Streptococcus, Staphylococcus, Enterococcus, Neisseria and Candida are disclosed. DNA-based methods employing amplification primers or probes for detecting, identifying, and quantifying in a test sample antibiotic resistance genes selected from the group consisting of blatem, blarob, blashv, blaoxa, blaZ, aadB, aacC1, aacC2, aacC3, aacA4, aac6'-IIa, ermA, ermB, ermC, mecA, vanA, vanB, vanC, satA, aac(6'-aph(2''), aad(6'), vat, vga, msrA, sul and int are also disclosed. The above microbial species, genera and resistance genes are all clinically relevant and commonly encountered in a variety of clinical specimens. These DNA-based assays are rapid, accurate and can be used in clinical microbiology laboratories for routine diagnosis. These novel diagnostic tools should be useful to improve the speed and accuracy of diagnosis of microbial infections, thereby allowing more effective treatments. Diagnostic kits for (i) the universal detection and quantification of bacteria, and/or (ii) the detection, identification and quantification of the above-mentioned bacterial and fungal species and/or genera, and/or (iii) the detection, identification and quantification of the above-mentioned antibiotic resistance genes are also claimed.

    Abstract translation: 基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量来自（i）任何细菌的测试样品DNA，（ii）无乳链球菌，腐生葡萄球菌，屎肠球菌，脑膜炎奈瑟氏球菌，单核细胞增生利斯特氏菌和白色念珠菌 ，和（iii）任何种属的链球菌属，葡萄球菌属，肠球菌属，奈瑟球菌属和假丝酵母属。 基于DNA的方法，使用扩增引物或探针来检测，鉴定和定量测试样品抗生素抗性基因，其选自bla tem，bla rob，bla shv，bla oxa，blaZ，aadB，aacC1，aacC2，aacC3 ，aacA4，aac6'-IIa，ermA，ermB，ermC，mecA，vanA，vanB，vanC，satA，aac（6'） - aph（2“），aad（6'），vat，vga，msrA， 上述微生物种类，属和抗性基因全部临床相关，常见于各种临床标本，这些基于DNA的检测方法快速，准确，可用于临床微生物实验室进行常规诊断。 诊断工具可用于提高微生物感染诊断的速度和准确性，从而允许更有效的治疗。诊断试剂盒用于（i）细菌的普遍检测和定量，和/或（ii）检测，鉴定和定量 的上述细菌 和/或类，和/或（iii）上述抗生素抗性基因的检测，鉴定和定量也被要求保护。

    SPECIFIC AND UNIVERSAL PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL PATHOGENS AND ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR ROUTINE DIAGNOSIS IN MICROBIOLOGY LABORATORIES
    5.
    发明申请
    SPECIFIC AND UNIVERSAL PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL PATHOGENS AND ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR ROUTINE DIAGNOSIS IN MICROBIOLOGY LABORATORIES 审中-公开
    特异性和通用探针和放大引物，用于快速检测和鉴定临床样本中常见细菌病原体和抗生素基因，用于微生物实验室中的常规诊断

    公开(公告)号：WO1996008582A2

    公开(公告)日：1996-03-21

    申请号：PCT/CA1995000528

    申请日：1995-09-12

    Applicant: BERGERON, Michel, G. ,  OUELLETTE, Marc ,  ROY, Paul, H.

    IPC: C12Q01/68

    CPC classification number: C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12N15/65 ,  C12Q2600/16

    Abstract: The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epiderminis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection of commonly encountered and clinically relevant bacterial antibiotic resistance genes directly from clinical specimens or, alternatively, from a bacterial colony. The above bacterial species can account for as much as 80 % of bacterial pathogens isolated in routine microbiology laboratories. The core of this invention consists primarily of the DNA sequences from all species-specific genomic DNA fragments selected by hybridization from genomic libraries or, alternatively, selected from data banks as well as any oligonucleotide sequences derived from these sequences which can be used as probes or amplification primers for PCR or any other nucleic acid amplification methods. This invention also includes DNA sequences from the selected clinically relevant antibiotic resistance genes.

    Abstract translation: 本发明涉及用于通用细菌检测的基于DNA的方法，用于特异性检测肺炎链球菌，绿脓假单胞菌，奇异变形杆菌，肺炎链球菌，金黄色葡萄球菌，肠球菌，粪肠球菌，腐生葡萄球菌，化脓性链球菌，流感嗜血杆菌和卡他莫拉菌 以及用于特异性检测临床标本或来自细菌菌落的常见和临床相关的细菌抗生素抗性基因。 上述细菌种类可以在常规微生物实验室中分离出多达80％的细菌病原体。 本发明的核心主要由来自基因组文库杂交选择的所有物种特异性基因组DNA片段的DNA序列组成，或者选自数据库，以及衍生自可用作探针的这些序列的任何寡核苷酸序列， 用于PCR的扩增引物或任何其它核酸扩增方法。 本发明还包括来自所选择的临床相关抗生素抗性基因的DNA序列。

    SPECIES-SPECIFIC DNA PROBE FOR THE DETECTION OF BRANHAMELLA CATARRHALIS
    6.
    发明申请
    SPECIES-SPECIFIC DNA PROBE FOR THE DETECTION OF BRANHAMELLA CATARRHALIS 审中-公开
    用于检测BRANHAMELLA CATARRHALIS的物种特异性DNA探针

    公开(公告)号：WO1990012114A1

    公开(公告)日：1990-10-18

    申请号：PCT/CA1990000101

    申请日：1990-03-27

    Applicant: BEAULIEU, Danielle ,  ROY, Paul, H. ,  BERGERON, Michel, G.

    IPC: C12Q01/68

    CPC classification number: C12Q1/689 ,  C07K14/212 ,  Y10T436/143333

    Abstract: There is provided by the present invention, a method for detecting the presence of Branhamella catarrhalis, said method comprising, depositing and fixing on an inert support a sample containing DNA fragments in substantially single stranded form, contacting said fixed single stranded genetic material with a labelled probe consisting of a fragment of B. catarrhalis chromosomal DNA, identified as ATCC 53879, being capable of hybridizing with B. catarrhalis DNA in the sample, said contacting being under hybridizing conditions at a pre-determined stringency; and detectiing duplex formation on said support by means of said label.

    SPECIFIC AND UNIVERSAL PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL PATHOGENS AND ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR ROUTINE DIAGNOSIS IN MICROBIOLOGY LABORATORIES
    7.
    发明申请
    SPECIFIC AND UNIVERSAL PROBES AND AMPLIFICATION PRIMERS TO RAPIDLY DETECT AND IDENTIFY COMMON BACTERIAL PATHOGENS AND ANTIBIOTIC RESISTANCE GENES FROM CLINICAL SPECIMENS FOR ROUTINE DIAGNOSIS IN MICROBIOLOGY LABORATORIES 审中-公开
    特异性和通用探针和放大引物，用于快速检测和鉴定临床样本中常见细菌病原体和抗生素基因，用于微生物实验室中的常规诊断

    公开(公告)号：WO9608582A3

    公开(公告)日：1996-07-18

    申请号：PCT/CA9500528

    申请日：1995-09-12

    Applicant: BERGERON MICHEL G ,  OUELLETTE MARC ,  ROY PAUL H

    Inventor： BERGERON MICHEL G ,  OUELLETTE MARC ,  ROY PAUL H

    IPC: C12N15/09 ,  C07K14/195 ,  C07K14/21 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C12N15/65 ,  C12Q1/06 ,  C12Q1/68 ,  C12R1/46 ,  C12N15/11

    CPC classification number: C12Q1/689 ,  C07K14/195 ,  C07K14/21 ,  C07K14/212 ,  C07K14/245 ,  C07K14/26 ,  C07K14/285 ,  C07K14/31 ,  C07K14/315 ,  C07K14/3156 ,  C12N15/65 ,  C12Q2600/16

    Abstract: The present invention relates to DNA-based methods for universal bacterial detection, for specific detection of the pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus aureus, Staphylococcus epiderminis, Enterococcus faecalis, Staphylococcus saprophyticus, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis as well as for specific detection of commonly encountered and clinically relevant bacterial antibiotic resistance genes directly from clinical specimens or, alternatively, from a bacterial colony. The above bacterial species can account for as much as 80 % of bacterial pathogens isolated in routine microbiology laboratories. The core of this invention consists primarily of the DNA sequences from all species-specific genomic DNA fragments selected by hybridization from genomic libraries or, alternatively, selected from data banks as well as any oligonucleotide sequences derived from these sequences which can be used as probes or amplification primers for PCR or any other nucleic acid amplification methods. This invention also includes DNA sequences from the selected clinically relevant antibiotic resistance genes. 00000

    Abstract translation: 本发明涉及用于通用细菌检测的基于DNA的方法，用于特异性检测肺炎链球菌，绿脓假单胞菌，奇异变形杆菌，肺炎链球菌，金黄色葡萄球菌，肠球菌，粪肠球菌，腐生葡萄球菌，化脓性链球菌，流感嗜血杆菌和卡他莫拉菌 以及用于特异性检测临床标本或来自细菌菌落的常见和临床相关的细菌抗生素抗性基因。 上述细菌种类可以在常规微生物实验室中分离出多达80％的细菌病原体。 本发明的核心主要由来自基因组文库杂交选择的所有物种特异性基因组DNA片段的DNA序列组成，或者选自数据库，以及衍生自可用作探针的这些序列的任何寡核苷酸序列， 用于PCR的扩增引物或任何其它核酸扩增方法。 本发明还包括来自所选择的临床相关抗生素抗性基因的DNA序列。 00000

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