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公开(公告)号：WO2009126801A2
公开(公告)日：2009-10-15
申请号：PCT/US2009/040059
申请日：2009-04-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SWISTON, Albert, Joseph , RUBNER, Michael, F. , COHEN, Robert, Edward , IRVINE, Darrell, J.
CPC分类号： C12N5/0006 , C12N5/0634 , C12N2533/30
摘要： Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells remain viable after attachment of the functional patch. The patch does not completely occlude the cellular surface from the surrounding environment. Functional payloads carried by the patch may include, for example, drugs or other small molecules, peptides, proteins, thermally responsive polymers, and nanoparticles, or any other material that can be incorporated in a polymer patch of subcellular dimensions. The patch can include one or more polyelectrolyte multilayers (PEMs).
摘要翻译： 均匀的功能性聚合物贴剂可以附着在活细胞表面积的一部分。 这些表面修饰的细胞在附着功能性贴片后保持活性。 贴片不会完全遮挡周围环境中的细胞表面。 由贴片携带的功能性有效载荷可以包括例如药物或其它小分子，肽，蛋白质，热响应聚合物和纳米颗粒，或可并入亚细胞尺寸的聚合物贴片中的任何其它材料。 贴剂可以包括一种或多种聚电解质多层（PEM）。
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公开(公告)号：WO2008069848A2
公开(公告)日：2008-06-12
申请号：PCT/US2007/017669
申请日：2007-08-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GEMICI, Zekeriyya , RUBNER, Michael, F. , COHEN, Robert, E.
CPC分类号： G02B1/118 , B82Y20/00 , B82Y30/00 , C03C17/006 , C03C17/3411 , C03C2217/42 , C03C2217/734 , C03C2217/75 , C03C2218/11 , C09D1/00 , C09D5/00 , G02B1/18 , G02B27/0006 , G02B2207/101 , G02B2207/107
摘要： A superhydrophilic coating on a substrate can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can include oppositely charge inorganic nanoparticles, and can be substantially free of an organic polymer. The coating can be made mechanically robust by a hydrothermal calcination.
摘要翻译： 基底上的超亲水性涂层可以是抗反射和防雾的。 涂层可以长时间保持抗反射和防雾。 涂层可以包括相反电荷的无机纳米颗粒，并且可以基本上不含有机聚合物。 可以通过水热煅烧使涂层机械地坚固。
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公开(公告)号：WO2011116099A1
公开(公告)日：2011-09-22
申请号：PCT/US2011/028676
申请日：2011-03-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GEMICI, Zekeriyya , RUBNER, Michael, F. , COHEN, Robert, E.
IPC分类号： B05D5/00
摘要： A superhydrophilic coating can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can have a graded refractive index. The coating for wafer-level optics can be for targeted capillary condensation in nanoparticle containing reflow-compatible coatings.
摘要翻译： 超亲水涂层可以是抗反射和防雾的。 涂层可以长时间保持抗反射和防雾。 涂层可以具有渐变折射率。 用于晶片级光学器件的涂层可用于含纳米颗粒的回流焊相容涂层中的目标毛细管冷凝。
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公开(公告)号：WO2010141594A1
公开(公告)日：2010-12-09
申请号：PCT/US2010/037083
申请日：2010-06-02
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NUERAJI, Nuerxiati , SWISTON, Albert, J. , RUBNER, Michael, F. , COHEN, Robert, E.
IPC分类号： C09D5/00
CPC分类号： G02B1/18 , C08B11/12 , C08B37/003 , C08L33/02 , C08L33/26 , C08L39/00 , C09D5/00 , C09D101/286 , C09D105/08 , C09D133/02 , C09D133/064 , C09D133/14 , C09D133/26 , C09D139/00 , G02B1/10 , G02B27/0006 , Y10T428/31645 , Y10T428/31649 , Y10T428/31725 , Y10T428/31855 , Y10T428/31935 , Y10T428/31971 , C08L2666/02 , C08L1/00 , C08L1/286 , C08L5/08 , C08L51/003
摘要： A hydrophilic coating can be applied to virtually any surface to produce a long-lasting, durable antifog effect. The coating includes a molecular-level blend of hydrophilic polymers. The coating can be assembled using a layer-by-layer assembly process.
摘要翻译： 亲水涂层可以应用于几乎任何表面，以产生持久耐用的防雾效果。 涂层包括亲水聚合物的分子水平共混物。 可以使用逐层组装方法组装涂层。
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5.发明申请
公开(公告)号：WO2004056403A3
公开(公告)日：2004-09-23
申请号：PCT/EP0314531
申请日：2003-12-18
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MIT MASSACHUSETTS INST OF TECH , RUBNER MICHAEL F , YANG SUNG YUN , QIU YONGXING , WINTERTON LYNN COOK , LALLY JOHN MARTIN
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having -COOAg groups and/or silver nanoparticles formed by reducing Ag ions associated with the -COO groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
摘要翻译： 本发明提供了一种在医疗装置上制备具有抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包括至少一层带负电荷的聚离子材料层， -COOAg基团和/或银纳米颗粒通过还原与负电聚合物材料的-COO - 基团相关的Ag +离子而形成。 此外，本发明提供了根据本发明的方法制备的医疗装置。
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6.发明申请
公开(公告)号：WO2004056403A2
公开(公告)日：2004-07-08
申请号：PCT/EP2003/014531
申请日：2003-12-18
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , MIT MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RUBNER, Michael, F. , YANG, Sung, Yun , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin
发明人： RUBNER, Michael, F. , YANG, Sung, Yun , QIU, Yongxing , WINTERTON, Lynn, Cook , LALLY, John, Martin
IPC分类号： A61L27/34
CPC分类号： A61K9/5015 , A61K31/14 , A61L27/34 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/45 , A61L2300/608 , A61L2300/61 , A61L2300/624 , G02B1/043 , Y10T428/31678 , Y10T428/31681 , Y10T428/31692
摘要： The present invention provides a method for preparing a medical device, preferably a contact lens, having an antimicrobial metal-containing LbL coating on a medical device, wherein the antimicrobial metal-containing LbL coating comprises at least one layer of a negatively charged polyionic material having -COOAg groups and/or silver nanoparticles formed by reducing Ag + ions associated with the -COO - groups of the negatively charged polyionic material. In addition, the present invention provides a medical device prepared according to a method of the invention.
摘要翻译： 本发明提供了用于制备在医疗装置上具有含抗微生物金属的LbL涂层的医疗装置，优选隐形眼镜的方法，其中所述含抗微生物金属的LbL涂层包含至少一种 具有-COOAg基团的负电荷聚离子材料层和/或通过还原与负电荷聚离子材料的-COO - 基团缔合的Ag + +离子形成的银纳米颗粒。 另外，本发明提供了根据本发明的方法制备的医疗装置。
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公开(公告)号：WO2010005642A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/045473
申请日：2009-05-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GEMICI, Zekeriyya , RUBNER, Michael, F. , COHEN, Robert, E.
CPC分类号： G02B1/18 , B82Y20/00 , B82Y30/00 , C03C17/007 , C03C2217/42 , C03C2217/445 , C03C2217/477 , C03C2217/478 , C03C2217/73 , C03C2218/32 , C23C18/1225 , C23C18/127 , C23C18/1295 , G02B1/111 , G02B27/0006 , Y10T428/24942 , Y10T428/249953 , Y10T428/249954 , Y10T428/249993
摘要： A superhydrophilic coating can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can have a graded refractive index. The coating for wafer-level optics can be for targeted capillary condensation in nanoparticle containing reflow-compatible coatings.
摘要翻译： 超亲水涂层可以是抗反射和防雾的。 涂层可以长时间保持抗反射和防雾。 涂层可以具有渐变折射率。 用于晶片级光学器件的涂层可用于含纳米颗粒的回流焊相容涂层中的目标毛细管冷凝。
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公开(公告)号：WO2008069848A3
公开(公告)日：2008-07-31
申请号：PCT/US2007017669
申请日：2007-08-09
CPC分类号： G02B1/118 , B82Y20/00 , B82Y30/00 , C03C17/006 , C03C17/3411 , C03C2217/42 , C03C2217/734 , C03C2217/75 , C03C2218/11 , C09D1/00 , C09D5/00 , G02B27/0006 , G02B2207/101 , G02B2207/107
摘要： A superhydrophilic coating on a substrate can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can include oppositely charge inorganic nanoparticles, and can be substantially free of an organic polymer. The coating can be made mechanically robust by a hydrothermal calcination.
摘要翻译： 基材上的超亲水涂层可以是抗反射和防雾的。 涂层可以长时间保持抗反射和防雾。 该涂层可以包含相反电荷的无机纳米粒子，并且可以基本上不含有机聚合物。 通过水热煅烧可以使涂层机械稳定。
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公开(公告)号：WO2008021817A3
公开(公告)日：2008-02-21
申请号：PCT/US2007/075341
申请日：2007-08-07
IPC分类号： B32B5/16
摘要： A superhydrophilic coating on a substrate can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can include oppositely charge inorganic nanoparticles, and can be substantially free of an organic polymer.
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公开(公告)号：WO2010005642A3
公开(公告)日：2010-05-14
申请号：PCT/US2009045473
申请日：2009-05-28
CPC分类号： G02B1/111 , B82Y20/00 , B82Y30/00 , C03C17/007 , C03C2217/42 , C03C2217/445 , C03C2217/477 , C03C2217/478 , C03C2217/73 , C03C2218/32 , C23C18/1225 , C23C18/127 , C23C18/1295 , G02B27/0006 , Y10T428/24942 , Y10T428/249953 , Y10T428/249954 , Y10T428/249993
摘要： A superhydrophilic coating can be antireflective and antifogging. The coating can remain antireflective and antifogging for extended periods. The coating can have a graded refractive index. The coating for wafer-level optics can be for targeted capillary condensation in nanoparticle containing reflow-compatible coatings.
摘要翻译： 超亲水涂层可以是抗反射和防雾的。 涂层可以长时间保持抗反射和防雾。 涂层可以具有渐变折射率。 用于晶圆级光学器件的涂层可以用于含有回流兼容涂层的纳米颗粒中的目标毛细管冷凝。
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