-
1.发明申请COATING OF NANOPARTICLE SURFACES WITH CYCLOPEPTIDES FOR IMPROVING DELIVERY OF AGENTS VIA THE ORAL ROUTE 审中-公开具有环肽的纳米颗粒表面涂层用于改善通过口服途径给药的作用
公开(公告)号：WO2018065085A1
公开(公告)日：2018-04-12
申请号：PCT/EP2017/001119
申请日：2017-09-19
Applicant: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Inventor： UHL, Philipp , MIER, Walter , HABERKORN, Uwe , SAUTER, Max
Abstract: The present invention relates to a surface-coated nanoparticle comprising biodegradable polymer chains and cyclopeptides, wherein the cyclopeptides are covalently attached to the biodegradable polymer chains forming the nanoparticle, thereby coating the surface of the nanoparticle. The present invention further relates to the use of said surface-coated nanoparticle as a capsule for an agent for improving the oral delivery thereof. In another aspect, the present invention relates to the surface-coated nanoparticle for use in the treatment or prevention of a disorder or disease in a patient, wherein the treatment or prevention is achieved by mucosal uptake of the surface-coated nanoparticle via the oral route.
Abstract translation: 本发明涉及包含生物可降解聚合物链和环肽的表面涂布纳米粒子，其中环肽共价连接至形成纳米粒子的生物可降解聚合物链，由此涂布纳米粒子的表面。 本发明进一步涉及所述表面涂覆的纳米颗粒作为用于改善其口服递送的药剂的胶囊的用途。 另一方面，本发明涉及用于治疗或预防患者病症或疾病的表面包被的纳米颗粒，其中所述治疗或预防通过口服途径通过粘膜摄取表面包被的纳米颗粒来实现
-
2.发明申请
公开(公告)号：WO2017167626A1
公开(公告)日：2017-10-05
申请号：PCT/EP2017/056886
申请日：2017-03-22
Inventor： LEUCHS, Barbara , MARCHINI, Antonio , ROMMELAERE, Jean , ANGELOVA, Assia , JÄGER, Dirk , WICK, Wolfgang
IPC: A61K39/00 , A61K39/395 , A61K35/768
Abstract: The present invention concerns a pharmaceutical composition where a checkpoint inhibitor is combined with an oncolytic virus and the use of said combination for the treatment of cancer.
Abstract translation: 本发明涉及一种药物组合物，其中检查点抑制剂与溶瘤病毒组合，以及所述组合用于治疗癌症的用途。
-
3.发明申请
公开(公告)号：WO2017102906A1
公开(公告)日：2017-06-22
申请号：PCT/EP2016/081117
申请日：2016-12-15
Applicant: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Inventor： URBAN, Stephan , NI, Yi , MIER, Walter
CPC classification number: A61K51/088 , A61K38/00 , A61K49/0056 , C07K7/06 , C07K7/08 , C07K7/50 , C07K7/64 , C07K14/005 , C12N2730/10111 , C12N2730/10141 , Y02A50/409 , Y02A50/411 , Y02A50/423 , Y02A50/463
Abstract: The present invention relates to cyclic NTCP targeting peptides which are preS-derived peptides of hepatitis B virus (HBV). The present invention further relates to pharmaceutical compositions comprising at least one cyclic peptide. The present invention further relates to medical uses of said cyclic peptides and the pharmaceutical compositions, such as in the diagnosis, prevention and/or treatment of a liver disease or condition, and/or in the inhibition of HBV and/or HDV infection. The present invention further relates to methods of diagnosis, prevention and/or treatment of a liver disease or condition and/or the inhibition of HBV and/or HDV infection.
Abstract translation: 本发明涉及作为乙型肝炎病毒（HBV）的preS衍生肽的环状NTCP靶向肽。 本发明进一步涉及包含至少一种环肽的药物组合物。 本发明进一步涉及所述环肽和药物组合物的医疗用途，例如用于诊断，预防和/或治疗肝脏疾病或病症，和/或用于抑制HBV和/或HDV感染。 本发明还涉及诊断，预防和/或治疗肝脏疾病或病症和/或抑制HBV和/或HDV感染的方法。
-
公开(公告)号：WO2017029401A1
公开(公告)日：2017-02-23
申请号：PCT/EP2016/069733
申请日：2016-08-19
Applicant: METANOMICS GMBH , RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Inventor： SCHATZ, Philipp , WITT, Henning , PETER, Erik , DOSTLER, Martin , CARVALHO, Susan , TERNES, Philipp , MAPPES, Philipp , FISCHER, Jenny , KATUS, Hugo A. , WEIS, Tanja , FREY, Norbert
CPC classification number: G01N33/92 , G01N33/6893 , G01N2405/02 , G01N2405/04 , G01N2405/08 , G01N2560/00 , G01N2570/00 , G01N2800/325
Abstract: 0000078914WO0 -107 - Means and methods for diagnosing cardiac diseasein a subject Abstract The present invention relates to the field of diagnostic methods. Specifically, the present inven- tion contemplates a method for diagnosing a cardiac diseasein a subject based on determining the amounts of at least threelipid metabolitebiomarkersand at least one further cardiac bi- omarker. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
Abstract translation: 0000078914WO0-107 - 用于诊断受试者心脏疾病的方法和方法摘要本发明涉及诊断方法领域。 具体而言，本发明考虑了一种基于确定至少三胎素代谢物生物标志物和至少一种另外的心脏标志物的量来诊断受试者的心脏疾病的方法。 本发明还涉及用于执行上述方法的工具，例如诊断装置。
-
5.发明申请CHROMOGENIC AND FLUOROGENIC PEPTIDE SUBSTRATES FOR THE DETECTION OF SERINE PROTEASE ACTIVITY 审中-公开用于检测丝氨酸蛋白酶活性的染色体和荧光肽基质
公开(公告)号：WO2017021004A1
公开(公告)日：2017-02-09
申请号：PCT/EP2016/001334
申请日：2016-08-03
Applicant: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Inventor： KRÄMER, Roland , ARIAN, Dumitru , HARENBERG, Job
CPC classification number: C07K5/0812 , C07K5/06026 , C07K5/06165 , C07K5/0806 , C07K5/0808 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/0823 , C07K5/1008 , C07K5/101 , C12Q1/37
Abstract: The present invention relates to chromogenic and fluorogenic substrates that can be used for the highly sensitive and selective detection of the activity of serine proteases. The present invention further relates to methods for the detection of the activity of serine proteases, said methods using the substrates of the present invention. Furthermore, the present invention relates to diagnostic kits and test strips using the above substrates, as well as uses of said substrates.
Abstract translation: 本发明涉及可用于高灵敏度和选择性检测丝氨酸蛋白酶活性的显色和荧光底物。 本发明还涉及用于检测丝氨酸蛋白酶活性的方法，所述方法使用本发明的底物。 此外，本发明涉及使用上述底物的诊断试剂盒和测试条，以及所述基底的用途。
-
Patent Agency Ranking
公开(公告)号：WO2017020982A1
公开(公告)日：2017-02-09
申请号：PCT/EP2016/001151
申请日：2016-07-06
Applicant: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG , DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
Inventor： OSSWALD, Matthias , WICK, Wolfgang , WINKLER, Frank , JUNG, Erik , BLAES, Jonas
IPC: A61P35/00 , C12N15/113 , A61K31/155 , A61K31/495 , A61K31/4985 , A61K31/522 , A61K31/713
CPC classification number: C12N15/1138 , A61K31/155 , A61K31/495 , A61K31/4985 , A61K31/522 , A61K31/713 , C12N15/113 , C12N2310/14 , C12N2330/50
Abstract: The present invention relates to agents for use in the treatment of glioma, in particular astrocytoma WHO ΙΓ and 111 °, as well as IV0 (glioblastoma), in a subject.
Abstract translation: 本发明涉及用于治疗受试者中胶质瘤，特别是星形细胞瘤WHOΙΓ和111°以及IV0（胶质母细胞瘤）的药剂。
-
7.发明申请
公开(公告)号：WO2016207363A1
公开(公告)日：2016-12-29
申请号：PCT/EP2016/064691
申请日：2016-06-24
Inventor： VON KNEBEL DOEBERITZ, Magnus , KLOOR, Matthias , AHADOVA, Aysel , KOPITZ, Jürgen , KRAMMER, Peter , LI-WEBER, Min
IPC: A61K45/06 , A61K31/343 , A61K31/36 , A61K31/7004 , A61P35/00
CPC classification number: A61K31/7004 , A61K31/343 , A61K31/36 , A61K45/06 , A61K2300/00 , A61P35/00
Abstract: The present invention relates to a combined preparation comprising 2-deoxyglucose and a flavagline and to the use of said combined preparation as a medicament or in the treatment of cancer. Moreover, the present invention relates to a flavagline for use in a combination therapy against cancer comprising administration of 2-deoxyglucose; and to 2-deoxyglucose for use in a combination therapy against cancer comprising administration of a flavagline. Also, the present invention relates to methods for treating cancer and to processes for the preparation of a combined preparation according to the invention.
Abstract translation: 本发明涉及包含2-脱氧葡萄糖和黄长丝松的组合制剂以及所述组合制剂用作药物或用于治疗癌症的组合制剂。 此外，本发明涉及用于抗癌联合治疗的黄素，包括给予2-脱氧葡萄糖; 和用于组合治疗癌症的2-脱氧葡萄糖，包括施用黄素素。 此外，本发明还涉及治疗癌症的方法和本发明组合制剂的制备方法。
-
8.发明申请SELECTIVE INHIBITORS OF NEUTROPHIL ELASTASE FOR TREATING NEUROPATHIC PAIN AND CHRONIC PAIN STATES HARBOURING A NEUROPATHIC COMPONENT 审中-公开中性粒细胞弹性蛋白酶选择性抑制神经病理性疼痛和慢性疼痛状态的神经病理性组分
公开(公告)号：WO2016050835A2
公开(公告)日：2016-04-07
申请号：PCT/EP2015/072541
申请日：2015-09-30
Applicant: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Inventor： VICUNA, Lucas , SIMONETTI, Manuela , BALI, Kiran Kumar , MALL, Marcus A. , KUNER, Rohini
IPC: A61K45/00
CPC classification number: A61K45/06 , A61K31/222 , A61K31/454 , A61K31/4545 , A61K31/513 , A61K31/519 , A61K38/07
Abstract: The present invention relates to selective inhibitors of neutrophil elastase, also called leukocyte elastase (LE) for use in the diagnosis, prognosis, prevention and/or treatment of neuropathic pain and chronic pain states harbouring a neuropathic component. The present invention further relates to pharmaceutical compositions and methods of diagnosing, prognosing, preventing and/or treating neuropathic pain and chronic pain states harbouring a neuropathic component.
Abstract translation: 本发明涉及嗜中性粒细胞弹性蛋白酶的选择性抑制剂，也称为白细胞弹性蛋白酶（LE），用于诊断，预后，预防和/或治疗神经性疼痛和包含神经病性成分的慢性疼痛状态 。 本发明还涉及诊断，预后，预防和/或治疗神经性疼痛和携带神经性疾病成分的慢性疼痛状态的药物组合物和方法。
-
公开(公告)号：WO2016034600A1
公开(公告)日：2016-03-10
申请号：PCT/EP2015/069979
申请日：2015-09-01
Applicant: METANOMICS GMBH , RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
Inventor： SCHATZ, Philipp , WITT, Henning , DOSTLER, Martin , CARVALHO, Susan , PETER, Erik , TERNES, Philipp , MAPPES, Philipp , DUENGEN, Hans Dirk , TRIPPEL, Tobias Daniel , TAHIROVIC, Elvis , KATUS, Hugo , FREY, Norbert , WEIS, Tanja
IPC: G01N33/68
CPC classification number: G01N33/92 , G01N33/6893 , G01N2405/00 , G01N2405/02 , G01N2405/04 , G01N2405/08 , G01N2800/325
Abstract: The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing heart failure in a subject based on determining the amounts of at least three biomarkers. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
Abstract translation: 本发明涉及诊断方法领域。 具体而言，本发明考虑了基于确定至少三种生物标志物的量来诊断受试者的心力衰竭的方法。 本发明还涉及用于执行上述方法的工具，诸如诊断装置。
-
公开(公告)号：WO2015173402A1
公开(公告)日：2015-11-19
申请号：PCT/EP2015/060777
申请日：2015-05-15
Applicant: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG , DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS
Inventor： TURCHINOVICH, Andrey , SUROWY, Harald , BURWINKEL, Barbara
CPC classification number: C12N15/1093 , C12N15/1096 , C12Q1/6806 , C12Q2521/107 , C12Q2525/121 , C12Q2525/155 , C12Q2525/161 , C12Q2525/173 , C12Q2525/191 , C12Q2531/113 , C12Q2535/122
Abstract: The present invention relates to a method for the synthesis of double-stranded nucleic acids from a wide variety of samples and comprises the use of these nucleic acids for deep sequence analysis. Also, the present invention relates to specific reagents used in the method of the present invention. Further, the invention relates to kits comprising reagents for the method of the invention and use of said kits.
Abstract translation: 本发明涉及从多种样品合成双链核酸的方法，并且包括使用这些核酸进行深度序列分析。 另外，本发明涉及本发明方法中使用的具体试剂。 此外，本发明涉及包含用于本发明方法的试剂和所述试剂盒的用途的试剂盒。
-
-
-
-
-
-
-
-
-
Search Results
162
records
(took 0.024 seconds)
