公开(公告)号：WO2022212271A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022170

申请日：2022-03-28

Applicant: SANFORD HEALTH

Inventor： BRUDVIG, Jon ,  WEIMER, Jill

IPC: A61K31/16 ,  A61K31/5375 ,  A61P3/00

Abstract: The present disclosure provides methods and compositions for treating or limiting development of a lysosomal storage disorder, by administering to a subject that has or is at risk of a lysosomal storage disorder thereof an amount effective of a p75 neurotrophin receptor (NGFR) modulator to treat or limit development of the lysosomal storage disorder.

公开(公告)号：WO2020252445A1

公开(公告)日：2020-12-17

申请号：PCT/US2020/037709

申请日：2020-06-15

Applicant: SANFORD HEALTH

Inventor： BAACK, Michelle ,  DE LA PUENTE, Pilar ,  GANDY, Tyler

IPC: C12N5/00 ,  C12N5/09 ,  G01N33/50 ,  A61K35/16

Abstract: The disclosure provides three-dimensional cross-linked scaffolds generated from cord blood plasma, and methods for making and using such scaffolds.

公开(公告)号：WO2020251916A8

公开(公告)日：2020-12-17

申请号：PCT/US2020/036744

申请日：2020-06-09

Applicant: SANFORD HEALTH ,  INANOVATE, INC.

Inventor： EGLAND, Kristi ,  EVANS, Rick ,  THIRUPPATHI, Eagappanath ,  URE, David ,  KOSTURA, Matt ,  GNIMPIEBA, Etienne

IPC: G01N33/574 ,  G01N2333/8125 ,  G01N33/57415

Abstract: Methods and related reagents are disclosed for diagnosing cancer, prognosing cancer occurrence or recurrence, and/or monitoring cancer therapy, involving contacting a bodily fluid sample from a subject at risk of having cancer or cancer recurrence, or from a subject that has been treated for cancer wl fit (a)one or more first antibody detection marker molecules that hind to human autoantibodies against at least one tumor associated antigen (TAA); and (fa) one or more second antibody detection marker molecules that bind to human autoantibodies against at least one extractable nuclear antigen (ENA).

公开(公告)号：WO2020077337A1

公开(公告)日：2020-04-16

申请号：PCT/US2019/056102

申请日：2019-10-14

Applicant: SANFORD HEALTH

Inventor： BRIGGS, Steven ,  KELLY, Patrick, W.

IPC: A61B17/72 ,  A61B17/80 ,  A61F2/28 ,  A61B17/88 ,  A61B17/16

Abstract: The disclosure provides example methods, systems and apparatus for stabilization of a rib. An example method includes: (a) accessing a medullary canal of a rib having a fracture, (b) advancing a guidewire into the medullary canal across the fracture, (c) advancing a delivery catheter containing a stent over the guidewire into the medullary canal and across the fracture, (d) retracting the delivery catheter relative to the stent, and (e) expanding the stent in the medullary canal.

公开(公告)号：WO2019090206A1

公开(公告)日：2019-05-09

申请号：PCT/US2018/059162

申请日：2018-11-05

Applicant: SANFORD HEALTH

Inventor： NAHABET, Chawki

IPC: A61B5/107 ,  A61B5/00

CPC classification number: A61B5/435 ,  A61B5/1076

Abstract: The present disclosure provides an apparatus including a first clip configured to move between an open position and a closed position. The apparatus also includes a second clip configured to move between an open position and a closed position. The apparatus also includes an elongated connector that is semi-rigid and deformable and that has a first end and a second end. The first end of the elongated connector is coupled to the first clip, and the second end of the elongated connector is coupled to the second clip. The apparatus also includes a sensor coupled to the elongated connector between the first end and the second end.

公开(公告)号：WO2019046541A1

公开(公告)日：2019-03-07

申请号：PCT/US2018/048768

申请日：2018-08-30

Applicant: SANFORD HEALTH

Inventor： KELLY, Patrick, W.

IPC: A61M25/00

CPC classification number: A61M25/0074 ,  A61M25/001 ,  A61M25/0069

Abstract: The present disclosure provides a catheter tip (100) including a flexible housing (102) defining a cavity (104) extending between an expandable opening (106) arranged at a first end (108) of the catheter tip and a second end (110) of the catheter tip. The catheter tip further includes a plurality of pivotable arms (112) coupled to and extending longitudinally along the flexible housing. The plurality of pivotable arms are arranged to taper inwardly at the first end of the catheter tip toward a longitudinal axis of the flexible housing. The expandable opening is configured to increase in diameter from a first position to a second position in response to application of an external force to the second end of the flexible housing.

公开(公告)号：WO2022212268A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022165

申请日：2022-03-28

Applicant: SANFORD HEALTH

Inventor： BRUDVIG, Jon ,  WEIMER, Jill

IPC: A61K31/166 ,  A61K31/192 ,  A61P3/00

Abstract: The present disclosure provides methods and compositions for treating or limiting development of a lysosomal storage disorder, by administering to a subject that has or is at risk of a lysosomal storage disorder thereof an amount effective of a sortilin (SORT1) inhibitor to treat or limit development of the lysosomal storage disorder.

公开(公告)号：WO2020252444A1

公开(公告)日：2020-12-17

申请号：PCT/US2020/037708

申请日：2020-06-15

Applicant: SANFORD HEALTH

Inventor： DE LA PUENTE, Pilar ,  BHATTACHARYA, Somshuvra ,  CALAR, Kristin

IPC: C12N5/00 ,  C12N5/09 ,  G01N33/50 ,  A61K35/16 ,  C12N2502/30 ,  C12N2513/00 ,  C12N2533/56 ,  C12N5/0062 ,  C12N5/0693 ,  G01N33/5008

Abstract: The disclosure provides three-dimensional cross-linked scaffolds generated from peripheral blood plasma, and methods for making and using such scaffolds.

公开(公告)号：WO2018237003A1

公开(公告)日：2018-12-27

申请号：PCT/US2018/038503

申请日：2018-06-20

Applicant: SANFORD HEALTH

Inventor： SAVINOV, Alexei ,  RADICHEV, Ilian ,  AMATYA, Christina

IPC: C12N5/02 ,  C12N5/0783 ,  C07K19/00 ,  C12N15/12 ,  C12N5/10 ,  A61K38/17 ,  A61K39/395 ,  A61K35/17 ,  A61P37/00

CPC classification number: A61P37/00 ,  A61K35/17 ,  C07K14/70532 ,  C07K16/2809 ,  C07K16/2818 ,  C07K19/00 ,  C07K2317/74 ,  C07K2319/02 ,  C12N5/0637 ,  C12N2501/2302 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2501/998 ,  C12N2510/00

Abstract: Disclosed herein are methods for producing induced T regulatory cells (iTregs), involving contacting naive CD4 + CD25 - T cells and/or naive CD8 + CD25 - T cells in vitro with (i) a polypeptide comprising an Ig-C domain from a B7-H4 protein (also known as VTCNl, B7x or B7S 1), wherein the polypeptide is not the full B7-H4 protein and does not include the B7-H4 protein IgV domain, (ii) anti-CD3 antibodies, (iii) anti-CD28 antibodies, and (iv) interleukin-2 (IL-2), wherein the contacting occurs for a time and under conditions sufficient to cause conversion of naive CD4 + CD25 - T cells and/or naive CD8 + CD25 - T cells into iTregs.

公开(公告)号：WO2018145059A1

公开(公告)日：2018-08-09

申请号：PCT/US2018/016979

申请日：2018-02-06

Applicant: SANFORD HEALTH

Inventor： BRIGGS, Steven ,  KELLY, Patrick, W.

IPC: A61J15/00

CPC classification number: A61J15/0015 ,  A61J15/0042

Abstract: The present disclosure provides a device that includes: (a) a tube having a first end and a second end, (b) a stopper coupled to a surface of the tube adjacent to the second end of the tube, where the stopper is configured to extend radially from the surface of the tube, (c) a first rib coupled to the surface of the tube, and (d) a second rib coupled to the surface of the tube, where the first rib and the second rib are positioned opposite one another on the surface of the tube between the first end of the tube and the stopper.