公开(公告)号：WO2021260068A1

公开(公告)日：2021-12-30

申请号：PCT/EP2021/067248

申请日：2021-06-23

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

发明人： GILLES, Nicolas ,  CIOLEK, Justyna ,  DROCTOVÉ, Laura ,  MAILLERE, Bernard ,  NOZACH, Hervé

IPC分类号： A61K38/17 ,  C07K14/435 ,  A61P13/12 ,  A61P35/00 ,  A61P9/04 ,  A61K38/00 ,  C07K14/46 ,  G01N2333/726 ,  G01N33/5008

摘要： The present disclosure relates to a peptide comprising a sequence having 80% or more amino acid identity with the amino acid sequence of SEQ ID NO. 1 below : RPSX1CNLPVKPGPCX2GFFSAFYYSQKX3NKCHSFTYGGCAGNANRFSTX4EKCRRTCX5X6 wherein, - X1 means the amino acid residue F or G, - X2 means any amino acid residue, excepted a basic amino acid residue, - X3 means the amino acid residue T or D, - X4 means the amino acid residue I, L or E, - (i) X5 means V and X6 means G or (ii) X5 means G and X6 means V, and - the amino acid located at position 39 is A. The disclosure also pertains to various diagnostic and therapeutic uses thereof.

公开(公告)号：WO2021150686A1

公开(公告)日：2021-07-29

申请号：PCT/US2021/014322

申请日：2021-01-21

申请人： FIRMENICH INCORPORATED

发明人： SERVANT, Guy ,  WILLIAMS, Mark ,  SERVANT, Nicole

IPC分类号： G01N33/50 ,  G01N33/74 ,  G01N2333/726 ,  G01N33/5008

摘要： The present disclosure relates generally to methods and materials for the identification of compounds that modulate (e.g., enhance, agonize, or antagonize) G protein-coupled receptor (GPCRs), such as those involved in taste. Examples of such GPCR include the TAS1R proteins and the TAS2R proteins that are involved in sensing sweet taste. In certain aspects, the disclosure provides cell-based and label-free assays that use highly sensitive biosensors to detect candidate taste modulator compounds by their alteration of GPCR activity. In some embodiments, such cell-based and label-free assays may be used to detect changes in cell mass distribution, cell adhesion, or cell morphology, resulting from contact with a candidate taste modulator compound. In some embodiments, such assays detect GPCR activation with greatly improved sensitivity compared to conventional assay methods.

公开(公告)号：WO2020252444A1

公开(公告)日：2020-12-17

申请号：PCT/US2020/037708

申请日：2020-06-15

申请人： SANFORD HEALTH

发明人： DE LA PUENTE, Pilar ,  BHATTACHARYA, Somshuvra ,  CALAR, Kristin

IPC分类号： C12N5/00 ,  C12N5/09 ,  G01N33/50 ,  A61K35/16 ,  C12N2502/30 ,  C12N2513/00 ,  C12N2533/56 ,  C12N5/0062 ,  C12N5/0693 ,  G01N33/5008

摘要： The disclosure provides three-dimensional cross-linked scaffolds generated from peripheral blood plasma, and methods for making and using such scaffolds.

公开(公告)号：WO2023283599A2

公开(公告)日：2023-01-12

申请号：PCT/US2022/073510

申请日：2022-07-07

申请人： MEDIC LIFE SCIENCES INC.

发明人： HAN, Kyuho ,  LEE, Hong-Pyo

IPC分类号： A61P35/00 ,  C07K14/705 ,  C07K16/28 ,  C12N15/10 ,  C12N15/11 ,  C12Q1/68 ,  C40B20/04 ,  C40B40/06 ,  C07K14/70532 ,  C07K16/2803 ,  C07K16/2809 ,  C07K19/00 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/035 ,  C07K2319/33 ,  C07K2319/60 ,  C12N15/1037 ,  C12N15/1065 ,  C12N15/1075 ,  C12N15/111 ,  C12N2310/20 ,  C12N2330/31 ,  C40B40/02 ,  G01N2500/04 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502

摘要： The present disclosure provides a high-throughput screening system and method for identification of novel drugs and drug targets. The method enables large-scale analysis of interactions between allogeneic pairs of target cells and immune cells by using an immune-bridge protein, library of guide RNA, and/or 3D tumor model. The immune-bridge protein comprises (a) a scFv against an immune cell marker, preferably for CD3 or NKp46 (b) a transmembrane domain, preferably from B7, (c) a cytoplasmic domain, preferably from B7 and (d) a reporter domain, preferably a fluorescent protein.

公开(公告)号：WO2022200804A2

公开(公告)日：2022-09-29

申请号：PCT/GB2022/050750

申请日：2022-03-24

申请人： LILIUMX LTD.

发明人： SCHEU, Arne Hagen August ,  KHAIRIL ANUAR, Irsyad Noor Abadi Bin ,  LIM, Sheryl Ying Ting

IPC分类号： C07K14/78 ,  A61K38/00 ,  C07K14/315 ,  G01N33/68 ,  C07K2319/70 ,  G01N33/5008

摘要： Provided herein are multivalent protein scaffolds useful as therapeutics, and useful in identifying new therapeutic compounds. The invention also relates to multi-domain polypeptide constructs having multiple binding domains and a structural domain. Also provided herein are methods of using the provided multivalent protein scaffolds to identify new candidate therapeutics, and new therapeutics thereby identified.

公开(公告)号：WO2021191674A2

公开(公告)日：2021-09-30

申请号：PCT/IB2021/000134

申请日：2021-03-25

申请人： THE UNIVERSITY OF BRITISH COLUMBIA ,  INSTITUTE FOR BIOENGINEERING OF CATALONIA ,  CATALAN INSTITUTION FOR RESEARCH AND ADVANCED STUDIES ,  MIRAZIMI, Ali ,  IMBA-INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH

发明人： PENNINGER, Josef M. ,  MONTSERRAT, Nuria

IPC分类号： G01N33/50 ,  A61K38/1709 ,  A61K38/4886 ,  A61P11/00 ,  A61P31/14 ,  G01N33/5008 ,  G01N33/5044

摘要： Provided herein are methods for screening of anti-virus reagent and vaccine candidates using organoids.

公开(公告)号：WO2021147977A1

公开(公告)日：2021-07-29

申请号：PCT/CN2021/073202

申请日：2021-01-22

申请人： 清华大学

发明人： 姚骏 ,  沈伟 ,  王秋文 ,  刘要南

IPC分类号： C12Q1/68 ,  A61K38/17 ,  A61P25/18 ,  A61P25/24 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  A01K67/0276 ,  A61K38/1709 ,  A61K49/0008 ,  C12N2503/02 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2333/47 ,  G01N2500/10 ,  G01N2800/304 ,  G01N2800/52 ,  G01N33/5008 ,  G01N33/6893

摘要： 提供了一种用于双向情感障碍的生物标志物，包括Syt7基因和/或其表达产物。还提供了Syt7基因和/或其表达产物在制备药物中的用途，所述药物用于治疗双向情感障碍。通过监控Syt7基因和/或其表达产物，可用于筛选用于治疗双向情感障碍的药物，为能够靶向Syt7分子的诊断和治疗提供帮助。

公开(公告)号：WO2023057474A1

公开(公告)日：2023-04-13

申请号：PCT/EP2022/077624

申请日：2022-10-05

申请人： FIRMENICH SA

发明人： WANG, Qi ,  CHEN, Dong-Fang ,  YUAN, Yong Ming ,  WU, Yongtao ,  ZUCCA, Frederic

IPC分类号： A61K36/15 ,  A61K36/03 ,  A61K36/185 ,  A61K36/282 ,  A61K36/537 ,  A61K36/61 ,  A61K36/67 ,  A61K36/73 ,  A61K36/82 ,  A61K36/9066 ,  A61P31/12 ,  C12Q1/00 ,  G01N33/569 ,  G01N33/5008

摘要： The present invention relates to a composition for use in the prevention or treatment of a viral infection, wherein the composition comprises an extract, wherein said extract: (i) is a botanical extract; (ii) reduces viral infection into a host cell, with an IC50 of ppm or less; and (iii) has a zeta potential of (10) mV or less. Consumer goods and methods of using the composition of the invention are also claimed.

公开(公告)号：WO2022267942A1

公开(公告)日：2022-12-29

申请号：PCT/CN2022/098836

申请日：2022-06-15

申请人： 呈诺再生医学科技（珠海横琴新区）有限公司

发明人： 尹乐 ,  顾雨春 ,  吴理达

IPC分类号： C07K14/00 ,  C07K19/00 ,  C12N15/11 ,  C12N15/85 ,  C12N5/10 ,  C12N5/074 ,  C12Q1/02 ,  C12N2501/998 ,  C12N5/0696 ,  G01N33/5008 ,  G01N33/5011

摘要： 提供了特定空间结构多肽及其在制备iPSC中的应用，该特定空间结构多肽氨基酸序列如SEQ ID NO.1-5。还提供了编码所述多肽的核酸分子、包含核酸分子的构建体、以及包含所述多肽的产品。通过表达具有特定空间结构的多肽序列可以诱导获得iPS，缩短诱导iPS细胞所需时间，同时提高诱导成功率。

公开(公告)号：WO2022212547A1

公开(公告)日：2022-10-06

申请号：PCT/US2022/022603

申请日：2022-03-30

申请人： EARLI INC.

发明人： SUHY, David ,  ESCARPE, Paul ,  ROEDING, Cyriac ,  LIN, Justin ,  HARWIG, Alex ,  RUDINA, Shireen ,  HARTWELL, Leland Harrison

IPC分类号： C12Q1/6883 ,  C12Q1/66 ,  C12Q1/42 ,  C12Q1/28 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/178 ,  G01N33/5008 ,  G01N33/5091

摘要： The present disclosure encompasses embodiments of nucleic acids comprising genetic elements which are useful for the detection of diseased cells.