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1.发明申请REPLICATION-DEFECTIVE FLAVIVIRUS VACCINE VECTORS AGAINST RESPIRATORY SYNCYTIAL VIRUS 审中-公开与呼吸道感染病毒相关的副作用的病毒性烟草疫苗
公开(公告)号：WO2010107847A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/027552
申请日：2010-03-16
申请人： SANOFI PASTEUR BIOLOGICS CO. , SANOFI PASTEUR LIMITED , PUGACHEV, Konstantin, V. , RUMYANTSEV, Alexander, A. , GIEL-MOLONEY, Maryann , PARRINGTON, Mark , ZHANG, Linong
发明人： PUGACHEV, Konstantin, V. , RUMYANTSEV, Alexander, A. , GIEL-MOLONEY, Maryann , PARRINGTON, Mark , ZHANG, Linong
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/54 , A61K2039/545 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2760/18534 , C12N2760/20134 , C12N2770/24143 , C12N2770/24162
摘要： Replication-defective vaccine vectors against respiratory syncytial virus (RSV) are disclosed. Corresponding compositions and methods employing the vaccine vectors are also disclosed.
摘要翻译： 公开了针对呼吸道合胞病毒（RSV）的复制缺陷型疫苗载体。 还公开了使用疫苗载体的相应组合物和方法。
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2.发明申请METHODS USING ION EXCHANGE AND GEL FILTRATION CHROMATOGRAPHY FOR POXVIRUS PURIFICATION 审中-公开使用离子交换和凝胶过滤色谱法进行POXVIRUS纯化的方法
公开(公告)号：WO2009100521A1
公开(公告)日：2009-08-20
申请号：PCT/CA2009/000141
申请日：2009-02-12
发明人： XIONG, Yelin
IPC分类号： C12N7/02 , C12N7/00 , C12N15/863
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/24043 , C12N2710/24051
摘要： Provided herein are methods for purifying poxviruses using one or more chromatographic steps including, but not limited to, gel filtration and / or ion exchange chromatography.
摘要翻译： 本文提供了使用一个或多个色谱步骤来纯化痘病毒的方法，包括但不限于凝胶过滤和/或离子交换层析。
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公开(公告)号：WO2007056847A1
公开(公告)日：2007-05-24
申请号：PCT/CA2006/001855
申请日：2006-11-15
发明人： CIGARINI, Sandrine
CPC分类号： A61K39/0011 , A61K39/12 , A61K47/18 , A61K47/183 , A61K47/26 , A61K47/32 , A61K2039/5256 , C12N7/00 , C12N2710/24021 , C12N2710/24041 , C12N2710/24051 , Y02A50/386 , Y02A50/388 , Y02A50/394 , Y02A50/401 , Y02A50/403 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/466 , Y02A50/469 , Y02A50/478 , Y02A50/484 , Y02A50/491
摘要： This invention relates to preparations of viruses, e.g. for vaccine or other pharmaceutical or research use, to their stabilization, and to processes of producing such preparations, as well as to their use, e.g. as vaccines or as virus vectors. The formulations comprise a sugar, a preservative, a dispersing agent, a thermal stability agent, a buffer, and up to three distinct types of amino acids without impacting the structural appearance of the lyophilized product.
摘要翻译： 本发明涉及病毒的制备，例如 用于疫苗或其他药物或研究用途，用于其稳定化，以及生产此类制剂的方法，以及其用途，例如， 作为疫苗或病毒载体。 制剂包含糖，防腐剂，分散剂，热稳定剂，缓冲剂和最多三种不同类型的氨基酸，而不影响冻干产品的结构外观。
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4.发明申请
公开(公告)号：WO2019180618A1
公开(公告)日：2019-09-26
申请号：PCT/IB2019/052232
申请日：2019-03-19
摘要： Methods and systems for determining the concentration of compounds, such as proteins, in compositions comprising adjuvanted complexes of the compounds are provided. The methods and systems generally comprise (i) measuring the intrinsic fluorescence of a composition comprising adjuvanted complexes of the compound and (ii) comparing the measured fluorescence intensity value to a calibration curve prepared using known concentrations of the compound. Also provided are methods and systems for determining percent adsorption of a selected compound to an adjuvant.
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公开(公告)号：WO2013177172A3
公开(公告)日：2013-11-28
申请号：PCT/US2013/042039
申请日：2013-05-21
发明人： ANDERSON, Stephen , DELAGRAVE, Simon , HAMBERGER, John , LI, Qinglian , MUNDLE, Sophia , RAHMAN, Nausheen
IPC分类号： C12N7/00
摘要： The present disclosure relates to liquid and dried compositions comprising a live, attenuated or genetically modified herpesvirus and methods of preparing such compositions, in one aspect, the composition comprises at ieast two or more pharmaceutically acceptable exctpients, at ieast one of which is histidsne and at least one of which is a sugar or sugar alcohol. The composstions retain a sufficiently high infectious titre following storage or large-scale manufacturing steps, such as lyophilization.
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公开(公告)号：WO2011075822A1
公开(公告)日：2011-06-30
申请号：PCT/CA2010/001975
申请日：2010-12-20
申请人： SANOFI PASTEUR LIMITED , HARPER, Kevin , LJUTIC, Belma , GALLICHAN, Scott , OCHS, Martina, Ochs , MOREFIELD, Garry , AUSAR, Fernando , SALHA, Marie-Danielle
发明人： HARPER, Kevin , LJUTIC, Belma , GALLICHAN, Scott , OCHS, Martina, Ochs , MOREFIELD, Garry , SALHA, Marie-Danielle
CPC分类号： A61K39/39 , A61K9/0019 , A61K39/092 , A61K47/26 , A61K2039/55505
摘要： This disclosure relates to adjuvants for use in immunogenic compositions comprising at least one antigen and an aluminum compound comprising hydroxyl groups that has been treated with phosphate, carboxylate, carbonate, sulfate diphosphonate or a mixture of two or more of these compounds and methods of using these compositions for preventing and treating diseases are also provided.
摘要翻译： 本公开涉及用于免疫原性组合物的佐剂，其包含至少一种抗原和包含用磷酸盐，羧酸盐，碳酸盐，硫酸二膦酸盐或两种或更多种这些化合物的混合物处理的羟基的铝化合物及其使用方法 还提供了用于预防和治疗疾病的组合物。
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公开(公告)号：WO2010071986A1
公开(公告)日：2010-07-01
申请号：PCT/CA2009/001843
申请日：2009-12-22
发明人： OLOO, Eliud , COMEN, Raymond , OCHS, Martina , YETHON, Jeremy
IPC分类号： C07K14/315 , A61K39/09 , A61P31/04 , C07K16/12 , C12N15/31
CPC分类号： C07K14/3156 , A61K39/092 , A61K2039/505 , A61K2039/55505 , C07K14/315 , C07K16/1275 , C07K2317/76
摘要： This disclosure relates to modified Streptococcus pneumonia pneumolysm (PLY) proteins which lack hemolytic activity and can be used as immunogens in an immunogenic composition or vaccine against invasive pneumococcol diseases caused by S. pneumonia The modified pneumolysm proteins comprise ammo acid substitutions at threonine 65, glycine 293 and cysteine 428 Nucleic acids, polypeptides encoded thereby, compositions containing the same, methods for using such nucleic acids, polypeptides and compositions are also provided
摘要翻译： 本公开涉及缺乏溶血活性并可用作免疫原性组合物或针对由肺炎链球菌引起的侵袭性肺炎链球菌疾病的疫苗的免疫原的改良型肺炎链球菌肺炎球菌（PLY）蛋白。经修饰的肺炎球菌蛋白包括在苏氨酸65处的氨基酸取代，甘氨酸 293和半胱氨酸428也提供了核酸，由此编码的多肽，含有其的组合物，使用这些核酸，多肽和组合物的方法
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公开(公告)号：WO2009012588A1
公开(公告)日：2009-01-29
申请号：PCT/CA2008/001353
申请日：2008-07-23
IPC分类号： C12N15/31 , A61K39/09 , A61K39/395 , A61K9/72 , A61P31/04 , A61P37/04 , C07K14/315 , C07K16/10 , C12N15/63 , C12P21/08 , G01N33/577 , G01N33/68
CPC分类号： C07K16/1275 , A61K38/00 , A61K39/09 , A61K2039/505 , A61K2039/507 , C07K14/3156 , G01N33/56944
摘要： Provided herein are compositions and methods for eliciting an immune response against Streptococcus pneumoniae. More particularly, the compositions and methods relate to immunogenic polypeptides, including fragments of PhtD and variants thereof, and nucleic acids, vectors and transfected cells that encode or express the polypeptides. Methods of making and using the immunogenic polypeptides are also described.
摘要翻译： 本文提供了用于引发针对肺炎链球菌的免疫应答的组合物和方法。 更具体地，组合物和方法涉及免疫原性多肽，包括PhtD及其变体的片段，以及编码或表达多肽的核酸，载体和转染细胞。 还描述了制备和使用免疫原性多肽的方法。
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公开(公告)号：WO2006128296A1
公开(公告)日：2006-12-07
申请号：PCT/CA2006/000894
申请日：2006-06-01
IPC分类号： A61K39/118 , A61K31/711 , A61P31/04 , C07K14/295 , C12N15/85
CPC分类号： A61K39/118 , A61K2039/53 , A61K2039/541 , A61K2039/543 , A61K2039/55555 , A61K2039/6075 , A61K2300/00
摘要： Vaccines against Chlamydia are formulated based on the peptidoglycan-associated lipoprotein (PaL) . The vaccines contain PaL sequences from various Chlamydia strains, the sequences sharing immunologically significant epitopes.
摘要翻译： 基于肽聚糖相关脂蛋白（PaL）配制针对衣原体的疫苗。 疫苗含有来自各种衣原体菌株的PaL序列，该序列具有免疫学上显着的表位。
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公开(公告)号：WO2012075428A1
公开(公告)日：2012-06-07
申请号：PCT/US2011/063132
申请日：2011-12-02
IPC分类号： A61K39/09
CPC分类号： C07K14/3156 , A61K39/092 , A61K2039/55
摘要： This disclosure relates to a method of preventing or treating a recurrence of acute otitis media in a subject at risk comprising administering a therapeutically effective amount of a composition, at least once to the subject. The composition administered comprises at least one immunogenic polypeptide selected from the group consisting of Streptococcus pneumoniae PhtD, PhtE, PcpA, LytB and detoxified pneumolysis
摘要翻译： 本公开涉及预防或治疗患有风险的受试者的急性中耳炎复发的方法，包括向受试者施用至少一次治疗有效量的组合物。 所施用的组合物包含至少一种选自肺炎链球菌PhtD，PhtE，PcpA，LytB和解毒肺炎分解的免疫原性多肽
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