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    INHALERS
    2.
    发明申请
    INHALERS 审中-公开
    吸入器

    公开(公告)号：WO2002089880A2

    公开(公告)日：2002-11-14

    申请号：PCT/EP2002/005186

    申请日：2002-05-10

    Applicant: VECTURA DELIVERY DEVICES LIMITED ,  EASON, Stephen, William ,  HARMER, Quentin, John ,  SARKAR, Matthew, Neil ,  PINON, John ,  DUNKLEY, Michael, John ,  CLARKE, Roger, William ,  HILL, Stephen, Henry

    Inventor： EASON, Stephen, William ,  HARMER, Quentin, John ,  SARKAR, Matthew, Neil ,  PINON, John ,  DUNKLEY, Michael, John ,  CLARKE, Roger, William ,  HILL, Stephen, Henry

    IPC: A61M15/00

    CPC classification number: A61M15/0028 ,  A61M11/002 ,  A61M11/06 ,  A61M15/0086 ,  A61M15/0091 ,  A61M2202/064 ,  A61M2205/073 ,  A61M2206/16

    Abstract: An inhaler for producing an inhalable aerosol of a ∼ powdered medicament includes an aerosolising device in the form of a cylindrical vortex chamber 1. The vortex chamber 1 has a tangential inlet port 3 and an axial exit port 2. The ratio of the diameter of the vortex chamber 1 to the diameter of the exit port 2 is between 4 and 12. The length of the exit port 2 is less than its diameter. The cross-section of the inlet port 3 is rectangular and is defined at the bottom and at the radially outermost edge by the walls of the vortex chamber 1. The cross-sectional area of the inlet conduit 7, which supplies the medicament in a gas flow to the inlet port 3, decreases in the direction towards the vortex chamber 1. The inlet conduit 7 may be curved. The inhaler is capable of repeat ably producing an aerosol of a medicament with a high proportion of particles in the range 1 to 3 microns, while using a 20 relatively small amount of energy.

    Abstract translation: 用于生产类似粉末状药物的可吸入气溶胶的吸入器包括呈圆柱形涡流室1形式的气雾化装置。涡流室1具有切向入口3和轴向出口2。 涡流室1到出口2的直径在4和12之间。出口2的长度小于其直径。 入口3的横截面是矩形的，并且通过涡流室1的壁限定在底部和径向最外边缘处。入口导管7的横截面积，其以气体供应药物 流入入口3的方向在朝向涡流室1的方向上减小。入口导管7可以是弯曲的。 吸入器能够重复地使用具有1至3微米范围内的高比例颗粒的药物气溶胶，同时使用20个较小量的能量。

    POWDER INHALER
    6.
    发明申请
    POWDER INHALER 审中-公开
    粉末吸入器

    公开(公告)号：WO2004012801A8

    公开(公告)日：2004-04-29

    申请号：PCT/EP0308432

    申请日：2003-07-30

    Applicant: CHIESI FARMA SPA ,  PINON JOHN ,  SHIRGAONKAR SAMEER ,  SMITH CHRISTOPHER JAMES ,  BURGE SIMON ,  MIDDLETON MAX WILLIAM ,  AHERN DAVID ,  SARKAR MATTHEW NEIL ,  ARLETT BEN ,  LYE EMMA LESLEY ,  SMITH SIMON

    Inventor： PINON JOHN ,  SHIRGAONKAR SAMEER ,  SMITH CHRISTOPHER JAMES ,  BURGE SIMON ,  MIDDLETON MAX WILLIAM ,  AHERN DAVID ,  SARKAR MATTHEW NEIL ,  ARLETT BEN ,  LYE EMMA LESLEY ,  SMITH SIMON

    IPC: A61M15/00 ,  G06M1/04 ,  G06M1/24

    CPC classification number: A61M15/0065 ,  A61M15/0026 ,  A61M15/0075 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2206/16 ,  G06M1/04 ,  G06M1/045 ,  G06M1/248

    Abstract: A powder inhaler comprises a container (7) for storing a powdered medicament, a metering member (15) having a dosing recess (18) to be filled with a dose of the powdered medicament, and a mouthpiece (3) being in communication with an inhalation channel (27) of the powder inhaler. Furthermore, the powder inhaler comprises a protective member (19) which is slidingly moveable on the metering member (15) between a closed position, in which it at least covers the dosing recess (18) of the metering member (15) if the metering member (15) is in an inhalation position, and an open position, in which it exposes the dosing recess (18) thereby enabling inhalation of the dose of the powdered medicament contained in the dosing recess (18). The protective member (19) is preferably coupled to an inhalation actuated mechanism (21-23) in such a manner that the inhalation actuated mechanism (21-23) moves the protective member (19) from its closed position to its open position only if there is an inhalation suction force exerted by a user which exceeds a predetermined level. This prevents the dose contained in the dosing recess (18) from falling out of the dosing recess, unless there is no inhalation process initiated by the user. Therefore, the powder inhaler can also be operated reliably upside down. Furthermore, a deagglomerator arrangement (cyclone), which may be incorporated in such a powder inhaler, is proposed which comprises a vortex chamber (73) having a diameter between 6 mm and 8 mm, preferably 8 mm.

    Abstract translation: 粉末吸入器包括用于储存粉末药物的容器（7），具有待填充剂量的粉末药物的计量凹部（18）的计量构件（15），以及与一个 粉末吸入器的吸入通道（27）。 此外，粉末吸入器包括保护构件（19），该保护构件可在计量构件（15）之间在关闭位置之间滑动运动，在闭合位置中，其至少覆盖计量构件（15）的计量凹部（18），如果计量 构件（15）处于吸入位置，并且处于打开位置，在所述打开位置，所述打开位置暴露所述计量凹部（18），从而能够吸入所述剂量凹部（18）中所含的粉末状药物的剂量。 保护构件（19）优选地以这样的方式联接到吸入致动机构（21-23），使得吸入致动机构（21-23）仅当保护构件（19）从其关闭位置移动到其打开位置时才移动 存在超过预定水平的用户施加的吸入吸力。 这防止剂量凹陷（18）中包含的剂量从剂量凹槽中脱落，除非由用户发起吸入过程。 因此，粉末吸入器也可以可靠地上下颠倒地操作。 此外，提出了可以结合在这种粉末吸入器中的解聚器装置（旋风分离器），其包括直径在6mm和8mm之间，优选为8mm的涡流室（73）。

    POWDER INHALER
    7.
    发明申请
    POWDER INHALER 审中-公开
    粉末吸入器

    公开(公告)号：WO2004012801A1

    公开(公告)日：2004-02-12

    申请号：PCT/EP2003/008432

    申请日：2003-07-30

    Applicant: CHIESI FARMACEUTICI S.P.A. ,  PINON, John ,  SHIRGAONKAR, Sameer ,  SMITH, Christopher, James ,  BURGE, Simon ,  MIDDLETON, Max, William ,  AHERN, David ,  SARKAR, Matthew, Neil ,  ARLETT, Ben ,  LYE, Emma, Lesley ,  SMITH, Simon

    Inventor： PINON, John ,  SHIRGAONKAR, Sameer ,  SMITH, Christopher, James ,  BURGE, Simon ,  MIDDLETON, Max, William ,  AHERN, David ,  SARKAR, Matthew, Neil ,  ARLETT, Ben ,  LYE, Emma, Lesley ,  SMITH, Simon

    IPC: A61M15/00

    CPC classification number: A61M15/0065 ,  A61M15/0026 ,  A61M15/0075 ,  A61M2202/062 ,  A61M2202/064 ,  A61M2206/16 ,  G06M1/04 ,  G06M1/045 ,  G06M1/248

    Abstract: A powder inhaler comprises a container (7) for storing a powdered medicament, a metering member (15) having a dosing recess (18) to be filled with a dose of the powdered medicament, and a mouthpiece (3) being in communication with an inhalation channel (27) of the powder inhaler. Furthermore, the powder inhaler comprises a protective member (19) which is slidingly moveable on the metering member (15) between a closed position, in which it at least covers the dosing recess (18) of the metering member (15) if the metering member (15) is in an inhalation position, and an open position, in which it exposes the dosing recess (18) thereby enabling inhalation of the dose of the powdered medicament contained in the dosing recess (18). The protective member (19) is preferably coupled to an inhalation actuated mechanism (21-23) in such a manner that the inhalation actuated mechanism (21-23) moves the protective member (19) from its closed position to its open position only if there is an inhalation suction force exerted by a user which exceeds a predetermined level. This prevents the dose contained in the dosing recess (18) from falling out of the dosing recess, unless there is no inhalation process initiated by the user. Therefore, the powder inhaler can also be operated reliably upside down. Furthermore, a deagglomerator arrangement (cyclone), which may be incorporated in such a powder inhaler, is proposed which comprises a vortex chamber (73) having a diameter between 6 mm and 8 mm, preferably 8 mm.

    Abstract translation: 粉末吸入器包括用于储存粉末状药剂的容器（7），具有用于填充一定剂量的粉末状药物的剂量凹槽（18）的计量构件（15），以及口部件 （3）与粉末吸入器的吸入通道（27）连通。 此外，粉末吸入器包括保护性构件（19），该保护性构件在计量构件（15）上在闭合位置和在计量构件（15）的计量凹槽（18）至少覆盖计量构件 构件15处于吸入位置和打开位置，在所述打开位置，构件15暴露定量凹槽18，从而能够吸入容纳在定量凹槽18中的粉末药剂的剂量。 保护构件（19）优选地以这样的方式联接到吸入致动机构（21-23），使得吸入致动机构（21-23）仅在如下情况下将保护构件（19）从其闭合位置移动到其打开位置 存在超过预定水平的用户施加的吸入吸力。 这防止了定量凹槽（​​18）中容纳的剂量从定量凹槽脱落，除非没有用户启动吸入过程。 因此，粉末吸入器也可以可靠地上下运行。 此外，提出了一种可结合在这种粉末吸入器中的分散器装置（旋风分离器），其包括直径在6mm和8mm之间，优选8mm的涡流腔（73）。

    INHALERS
    8.
    发明申请
    INHALERS 审中-公开
    吸入器

    公开(公告)号：WO0207805A3

    公开(公告)日：2002-06-13

    申请号：PCT/EP0108416

    申请日：2001-07-20

    Applicant: CAMBRIDGE CONSULTANTS ,  EASON STEPHEN WILLIAM ,  HARMER QUENTIN JOHN ,  SARKAR MATTHEW NEIL

    Inventor： EASON STEPHEN WILLIAM ,  HARMER QUENTIN JOHN ,  SARKAR MATTHEW NEIL

    IPC: A61M11/00 ,  A61M15/00 ,  A61M15/02 ,  A61M16/00

    CPC classification number: A61M15/02 ,  A61M11/002 ,  A61M15/002 ,  A61M15/0028 ,  A61M15/0036 ,  A61M15/0041 ,  A61M15/0086 ,  A61M16/0066 ,  A61M2202/064 ,  A61M2206/16

    Abstract: An inhaler for producing an inhalable aerosol of a powdered medicament comprises a cyclone (1) with a tangential air inlet (3) and an axial air outlet (4). The cyclone (1) aerosolises and retains an aerosol of powdered medicament in an airflow circulating between the inlet (3) and the outlet (4). The cyclone (1) has an exit port (2) which is open to atmosphere. When the aerosol is to be inhaled, the pressure in the cyclone (1) is increased by increasing the airflow to the inlet (3) which causes the aerosol to discharge through the exit port (2). The inhaler has the advantage that the rate of discharge of the aerosol can be controlled independently of the rate of airflow required to aerosolise the medicament.

    Abstract translation: 一种用于生产粉状药物的可吸入气溶胶的吸入器，包括具有切向空气入口（3）和轴向空气出口（4）的旋风分离器（1）。 旋风器（1）在入口（3）和出口（4）之间循环的气流中雾化并保持粉末药物的气溶胶。 旋风分离器（1）具有通向大气的出口（2）。 当气雾被吸入时，旋风分离器（1）中的压力通过增加通向入口（3）的气流而增加，这导致气溶胶通过出口（2）排出。 吸入器的优点在于，可以独立于雾化药物所需的气流速率来控制气溶胶的排出速率。

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