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    DEVICES FOR TREATING BRUXISM
    1.
    发明申请
    DEVICES FOR TREATING BRUXISM 审中-公开
    用于处理BRUXISM的设备

    公开(公告)号：WO2014074519A1

    公开(公告)日：2014-05-15

    申请号：PCT/US2013/068519

    申请日：2013-11-05

    Applicant: JACE MEDICAL, LLC ,  SCHLATTER, Daniel ,  MAY, Justin, James ,  STEFFENSMEIER, Scott

    Inventor： SCHLATTER, Daniel ,  MAY, Justin, James ,  STEFFENSMEIER, Scott

    IPC: A61C5/14

    CPC classification number: A61F5/566 ,  A61B5/4557 ,  A61B5/486 ,  A61B5/682 ,  A61B5/7405 ,  A61B5/7455 ,  A61B2560/0214 ,  A61B2562/0247 ,  A61B2562/164 ,  A61B2562/168 ,  A61B2562/227 ,  A61F5/56 ,  A61F2005/563

    Abstract: The present disclosure relates to devices that aid a user in ceasing bruxism. The devices may be placed between a user's teeth, such as during sleep, and alert the user when the user clenches his/her teeth. In an aspect, a device includes a housing containing a battery power source, a vibration device, and an electrical contact mechanism having a movable element which closes a circuit to actuate the vibration device. A disk-shaped portion adapted to be emplaced in a person's mouth between a cheek and adjacent teeth is disposed around the housing. A resilient bite portion extends from the housing and is adapted to be emplaced between upper and lower teeth. A compressible element is disposed in the bite portion and causes the movable element of the electrical contact to close to actuate the vibration device in response to compression of the bite portion.

    Abstract translation: 本公开涉及帮助用户停止磨牙症的装置。 设备可以放置在用户的牙齿之间，例如在睡眠期间，并且当使用者握住他/她的牙齿时警告用户。 一方面，一种装置包括容纳电池电源的壳体，振动装置和具有闭合电路以起动振动装置的可移动元件的电接触机构。 适于被放置在人的嘴中的盘形部分在脸颊和相邻的牙齿之间设置在壳体周围。 弹性咬合部从壳体延伸并且适于放置在上下齿之间。 可压缩元件设置在咬合部分中，并使电接触件的可移动元件关闭，以响应于咬合部分的压缩而致动振动装置。

    NEW CHYMASE BINDING COMPOUNDS AND MEDICAL USES THEREOF
    2.
    发明申请
    NEW CHYMASE BINDING COMPOUNDS AND MEDICAL USES THEREOF 审中-公开
    新型化合物结合物及其医疗用途

    公开(公告)号：WO2012159836A1

    公开(公告)日：2012-11-29

    申请号：PCT/EP2012/057489

    申请日：2012-04-24

    Applicant: COVAGEN AG ,  BRACK, Simon ,  BATEY, Sarah ,  GRABULOVSKI, Dragan ,  BERTSCHINGER, Julian ,  SCHLATTER, Daniel ,  BENZ, Jörg ,  BANNER, David ,  HENNIG, Michael

    Inventor： BRACK, Simon ,  BATEY, Sarah ,  GRABULOVSKI, Dragan ,  BERTSCHINGER, Julian ,  SCHLATTER, Daniel ,  BENZ, Jörg ,  BANNER, David ,  HENNIG, Michael

    IPC: C07K14/47 ,  C12N9/12

    CPC classification number: C12N9/12 ,  C07K14/4703 ,  C12N9/1205 ,  G01N33/573

    Abstract: The present invention relates to a polypeptide binding to a chymase (EC 3.4.21.39), wherein the polypeptide comprises or consists of an amino acid sequence selected from the group consisting of: (a) GVTLFVALYDY(X 1 )A(X 2 )(X 3 )(X 4 )(X 5 )(X 6 )LSFHKGEKFQIL(X 7 )(X 8 )(X 9 )(X 10 ) (X 11 )(X 12 )G(X 13 )(X 14 )WEARSLTTGETGYIPSNYVAPVDSIQ (SEQ ID NO: 1), wherein (X 1 ) is R, N, Q, E, K, H, S, T, C, or D; (X 2 ) is E, T, D, Q, L, P, A, S, C, M, N, E, G, A, V or I; (X 3 ) is R, T, H, N, K, S, C, N or Q; (X 4 ) is S, W, T, C, N, Q, F or Y; (X 5 ) is T, H, L, F, C, S, M, N, Q, R, K, G, A, V, I, P, Y or W; (X 6 ) is D, Q, H, E, S, T, C, N, R or K; (X 7 ) is D, N, R, E, Q, S, T, C, K or D; (X 8 ) is M, W, G, F, A, S, T, C, S, N, Q, Y, V, L, I or P; (X 9 ) is T, H, S, D, C, N, Q, R, K, E or absent; (X 10 ) is V, T, Q, G, A, L, I, P, S, C, M, N or absent; (X 11 ) is P, A, D, G, K, V, L, I, E, R, M, H or absent; (X 12 ) is N, V, P, I, E, T, S, A, G, L, C, M, Q or D; (X 13 ) is D, E, T, P, G, A, V, L, I, S, C, M, N or Q, and (X 14 ) is W, Y, L, G, A, V, I, P, M, or F; (b) an amino acid sequence which is at least 85% identical to the amino acid sequence of (a), wherein the identity determination excludes amino acid positions (X 1 ) to (X 14 ).

    Abstract translation: 本发明涉及与胃促胰酶（EC 3.4.21.39）结合的多肽，其中所述多肽包含选自以下的氨基酸序列或由以下组成：（a）GVTLFVALYDY（X1）A（X2）（X3） （X4）（X5）（X6）（X7）（X8）（X9）（X10）（X11）（X12）G（X13）（X14）WEARSLTGG ，N，Q，E，K，H，S，T，C或D; （X2）是E，T，D，Q，L，P，A，S，C，M，N，E，G，A，V或I; （X3）为R，T，H，N，K，S，C，N或Q; （X4）为S，W，T，C，N，Q，F或Y; （X5）是T，H，L，F，C，S，M，N，Q，R，K，G，A，V，I，P，Y或W; （X6）为D，Q，H，E，S，T，C，N，R或K; （X7）为D，N，R，E，Q，S，T，C，K或D; （X8）为M，W，G，F，A，S，T，C，S，N，Q，Y，V，L，I或P; （X9）为T，H，S，D，C，N，Q，R，K，E或不存在; （X10）为V，T，Q，G，A，L，I，P，S，C，M，N或不存在; （X11）为P，A，D，G，K，V，L，I，E，R，M，H或不存在; （X12）为N，V，P，I，E，T，S，A，G，L，C，M，Q或D; （X13）是D，E，T，P，G，A，V，L，I，S，C，M，N或Q，（X14）是W，Y，L，G，A，V，I ，P，M或F; （b）与（a）的氨基酸序列至少85％相同的氨基酸序列，其中所述身份确定不包括氨基酸位置（X1）至（X14）。

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