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公开(公告)号：WO2022182988A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/017906
申请日：2022-02-25
发明人： BANERJEE, Debjyoti , LIN, C. Huie
摘要： A catheter control system may include a containment structure, a sensor coupled to the containment structure, and a plurality of actuators coupled to the containment structure. The containment structure may define a lumen configured to allow a fluid to flow therethrough, and a plurality of openings in fluid communication with the lumen. The sensor may be configured to detect a current position and/or orientation of the containment structure. Each of the actuators may be associated with at least one respective opening of the plurality of openings and configured to regulate fluid flow through the at least one respective opening.
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公开(公告)号：WO2021262931A1
公开(公告)日：2021-12-30
申请号：PCT/US2021/038816
申请日：2021-06-24
摘要： The present disclosure is directed to devices used for transplanting or recruiting cells, in addition to methods for making said devices and for using said devices in the treatment of medical disorders.
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3.发明申请
公开(公告)号：WO2021155151A1
公开(公告)日：2021-08-05
申请号：PCT/US2021/015713
申请日：2021-01-29
发明人： LI, Zheng
IPC分类号： C07D401/14 , C07D405/14 , A61K49/00
摘要： Methods for probing the distribution and distance of the cell surface receptors and using the same to make multivalent ligands targeting said receptors are disclosed. Methods for making the multivalent ligands and detecting or imaging cells expressing receptors using the compounds are also provided.
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公开(公告)号：WO2020243527A1
公开(公告)日：2020-12-03
申请号：PCT/US2020/035260
申请日：2020-05-29
IPC分类号： A61B5/103
摘要： Embodiments described herein generally relate to devices, methods and systems for determining differential blood oxygenation for early detection of pressure ulcers. By applying near infrared radiation of an appropriate wavelength to the tissue and determining the absorbance at a plurality of points where the distance between the source of the near infrared radiation and the detector are known, the oxygenation state of the hemoglobin can be determined based on position in a three-dimensional space.
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公开(公告)号：WO2020146906A2
公开(公告)日：2020-07-16
申请号：PCT/US2020/013417
申请日：2020-01-13
发明人： WANG, Rongfu , WANG, Yicheng , ZHU, Motao , ZHAO, Ruifang
摘要： Disclosed are self-assembling nanoparticle compositions that comprise a plurality of cationic cell penetrating peptides, each covalently linked to a hydrophobic therapeutic molecule (e.g., an antigenic peptide, mRNA, siRNA, DNA, or the like), and optionally, non- covalently bound to at least one TLR (Toll-like receptor) ligand. Also disclosed are methods for use of the nanoparticle compositions in the treatment, prophylaxis, and/or the amelioration of one or more symptoms of a mammalian disease, including, without limitation, cancer, infection, inflammation, and related diseases and abnormal conditions.
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公开(公告)号：WO2020061059A1
公开(公告)日：2020-03-26
申请号：PCT/US2019/051529
申请日：2019-09-17
发明人： CHEN, Shu-Hsia
IPC分类号： A61K39/395
摘要： Antibodies and antibody fragments that specifically bind to LILRB2 are disclosed. Also provided herein are compositions comprising antibodies and antibody fragments that specifically bind to LILRB2 and methods of use thereof. Also provided are related chimeric antigen receptors (CARs) and cells comprising same (e.g., T cells, natural killer cells, or macrophages), and uses of the CARs and cells in targeting tumors and killing them, asthma treatment, or in targeting and removing infected cells (e.g., to treat infections or infectious diseases), or in suppressing immune system cells, as involved in autoimmune disease or transplant rejection.
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公开(公告)号：WO2019217916A1
公开(公告)日：2019-11-14
申请号：PCT/US2019/031858
申请日：2019-05-10
发明人： APPEL, Stanley H. , BEERS, David R.
摘要： The present disclosure relates generally to methods for the prognosis and management of amyotrophic lateral sclerosis (ALS), as well as associated compositions, kits, solid supports and uses.
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公开(公告)号：WO2018151930A1
公开(公告)日：2018-08-23
申请号：PCT/US2018/015742
申请日：2018-01-29
发明人： HU, Ye , LIU, Chang , MA, Xin , LI, Yaojun
IPC分类号： B82Y15/00 , B82Y30/00 , G01N33/543 , G01N33/68
摘要： Provided herein are nanoparticles configured for the rapid detection of disease-specific peptides from patient samples, including blood-based samples. Also provided are methods of measuring the level of an infection by isolation and quantification of disease-specific peptides from patient samples. The nanoparticles may act as a co-matrix for matrix assisted laser desorption/ionization mass spectrometry.
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公开(公告)号：WO2018140826A9
公开(公告)日：2018-08-02
申请号：PCT/US2018/015601
申请日：2018-01-26
发明人： SHEN, Haifa
摘要： Disclosed are biocompatible core/shell compositions suitable for the delivery of populations of mRNA molecules to mammalian cells. The disclosed core-shell structured multicomponent compositions are optimized for the delivery of mRNAs encoding one or more cancer- or tumor-specific antigens to a population of antigen presenting cells, including, for example, human dendritic cells, macrophages and B cells. Also disclosed are methods for use of these compositions as therapeutic cancer vaccines.
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10.发明申请
公开(公告)号：WO2018035524A1
公开(公告)日：2018-02-22
申请号：PCT/US2017/047805
申请日：2017-08-21
发明人： XIA, James Jiong , GATENO, Jaime , YUAN, Peng
摘要： Systems and methods for orthognathic surgical planning are described herein. An example computer-implemented method can include generating a composite three-dimensional (3D) model of a subject's skull, defining a global reference frame for the composite 3D model, performing a cephalometric analysis on the composite 3D model to quantify at least one geometric property of the subject's skull, performing a virtual osteotomy to separate the composite 3D model into a plurality of segments, performing a surgical simulation using the osteotomized segments, and designing a surgical splint or template for the subject.
摘要翻译： 本文描述了用于正颌手术计划的系统和方法。 示例的计算机实现的方法可以包括：生成对象头骨的复合三维（3D）模型;定义用于复合3D模型的全局参考帧;对复合3D模型执行头影测量分析以量化至少一个几何性质 执行虚拟截骨术以将复合3D模型分成多个节段，使用截骨切割节段执行手术模拟，以及为受治疗者设计手术夹板或模板。
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