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    COMPOSITIONS AND METHODS FOR DIAGNOSING AND/OR TREATING INFLUENZA INFECTION
    3.
    发明申请
    COMPOSITIONS AND METHODS FOR DIAGNOSING AND/OR TREATING INFLUENZA INFECTION 审中-公开
    诊断和/或治疗流感感染的组合物和方法

    公开(公告)号：WO2011003100A3

    公开(公告)日：2011-02-24

    申请号：PCT/US2010040978

    申请日：2010-07-02

    Applicant: MASSACHUSETTS INST TECHNOLOGY ,  JAYARAMAN AKILA ,  VISWANATHAN KARTHIK ,  RAMAN RAHUL ,  SHRIVER ZACHARY H ,  SASISEKHARAN RAM

    Inventor： JAYARAMAN AKILA ,  VISWANATHAN KARTHIK ,  RAMAN RAHUL ,  SHRIVER ZACHARY H ,  SASISEKHARAN RAM

    IPC: A61K39/00

    CPC classification number: G01N33/56983 ,  C07K14/005 ,  C12N2760/16122 ,  G01N2333/11 ,  G01N2800/50

    Abstract: [00336] The present invention provides HA polypeptides (e.g., Hl HA polypeptides) that bind to umbrella- topology glycans, and reagents and methods relating thereto. The present invention provides binding agents that bind to HA polypeptides (e.g., Hl HA polypeptides), and reagents and methods relating thereto. The present invention provides interfering agents that inhibit the binding of HA polypeptides (e.g., Hl HA polypeptides) to HA receptors, and reagents and methods relating thereto. The present invention provides compositions and methods for treating, preventing, and/or diagnosing influenza infection utilizing HA polypeptides, HA polypeptide binding agents, HA polypeptide interfering agents, and/or vaccine compositions comprising any of the foregoing.

    Abstract translation: 本发明提供了结合伞形拓扑聚糖的HA多肽（例如H1HA多肽），以及与其相关的试剂和方法。 本发明提供了结合HA多肽（例如H1HA多肽）的结合剂，以及与其相关的试剂和方法。 本发明提供了抑制HA多肽（例如H1HA多肽）与HA受体结合的干扰剂，以及与其相关的试剂和方法。 本发明提供了利用HA多肽，HA多肽结合剂，HA多肽干扰剂，和/或包含前述任一种的疫苗组合物治疗，预防和/或诊断流感感染的组合物和方法。

    2-O SULFATASE COMPOSITIONS AND RELATED METHODS
    5.
    发明申请
    2-O SULFATASE COMPOSITIONS AND RELATED METHODS 审中-公开
    2-O硫酸盐组合物及相关方法

    公开(公告)号：WO2004062592A2

    公开(公告)日：2004-07-29

    申请号：PCT/US2004/000332

    申请日：2004-01-07

    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  SASISEKHARAN, Ram ,  MYETTE, James, R. ,  SHRIVER, Zachary ,  VENKATARAMAN, Ganesh

    Inventor： SASISEKHARAN, Ram ,  MYETTE, James, R. ,  SHRIVER, Zachary ,  VENKATARAMAN, Ganesh

    IPC: A61K

    CPC classification number: C12N9/16 ,  A61K38/00 ,  C12P19/04 ,  G01N33/5041 ,  G01N2400/40

    Abstract: The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGS) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.

    Abstract translation: 本发明涉及2-O硫酸酯酶及其用途。 特别地，本发明涉及编码这些分子的重组产生的2-O硫酸酯酶，功能变体和核酸分子。 本发明还提供了用于各种目的的2-O硫酸酯酶的方法，包括降解和分析样品中存在的糖胺聚糖（GAGS）。 例如，2-O硫酸酯酶可用于测定样品中存在的糖胺聚糖的纯度，同一性，组成和顺序。 本发明还涉及抑制血管生成和细胞增殖的方法以及使用2-O硫酸酯酶降解产生的2- O硫酸酯酶和/或GAG片段来治疗癌症，神经变性疾病，动脉粥样硬化和微生物感染的方法。

    METHODS OF EVALUATING PEPTIDE MIXTURES
    10.
    发明申请
    METHODS OF EVALUATING PEPTIDE MIXTURES 审中-公开

    公开(公告)号：WO2007127977A3

    公开(公告)日：2007-11-08

    申请号：PCT/US2007/067777

    申请日：2007-04-30

    Applicant: MOMENTA PHARMACEUTICALS, INC. ,  SHRIVER, Zachary ,  VENKATARAMAN, Ganesh ,  LANSING, Jonathan, C. ,  BAUER, Corinne ,  ZHU, Xiangping

    Inventor： SHRIVER, Zachary ,  VENKATARAMAN, Ganesh ,  LANSING, Jonathan, C. ,  BAUER, Corinne ,  ZHU, Xiangping

    IPC: G01N33/68

    Abstract: The presently disclosed subject matter provides methods for evaluating and characterizing peptides, peptide mixtures, and polypeptide mixtures. More particularly, the presently disclosed subject matter provides methods for evaluating or characterizing complex peptide or polypeptide mixtures comprising glutamic acid, alanine, tyrosine, and lysine, e.g., Copolymer-1 or glatiramer acetate, including, but not limited to, methods of identifying, isolating, quantifying, and purifying amino acids, peptides, polypeptides, and combinations thereof having a diethylamide group instead of a carboxyl group present on the C-terminus. The presently disclosed methods can be used to determine the mole percent of polypeptides having a diethylamide group at a C-terminus thereof and can be used to evaluate one or more properties of a sample of one polypeptide mixture as compared to one or more properties of a different sample of a polypeptide mixture.

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