公开(公告)号：WO2021011834A1

公开(公告)日：2021-01-21

申请号：PCT/US2020/042430

申请日：2020-07-16

申请人： SILVERBACK THERAPEUTICS, INC.

发明人： SMITH, Sean Wesley ,  COBURN, Craig Alan ,  BAUM, Peter Robert ,  DUBOSE, Robert Finley

IPC分类号： C07D401/14 ,  C07D405/14 ,  C07D471/04 ,  A61K31/437 ,  A61K47/68 ,  A61P35/00

摘要： ALK5 inhibitor compounds, conjugates, and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating ALK5. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.

公开(公告)号：WO2019084060A1

公开(公告)日：2019-05-02

申请号：PCT/US2018/057175

申请日：2018-10-23

申请人： SILVERBACK THERAPEUTICS, INC.

发明人： THOMPSON, Peter Armstrong ,  DUBOSE, Robert Finley ,  BAUM, Peter Robert ,  ODEGARD, Valerie

IPC分类号： A61K47/68 ,  A61P35/00

CPC分类号： A61K47/6889 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  A61P35/00

摘要： Various compositions are disclosed. The compositions of conjugates comprising immune-modulatory agents are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating disorders, such as cancer and fibrosis.

公开(公告)号：WO2019227059A1

公开(公告)日：2019-11-28

申请号：PCT/US2019/034024

申请日：2019-05-24

申请人： SILVERBACK THERAPEUTICS, INC.

发明人： SMITH, Sean Wesley ,  COBURN, Craig Alan ,  BAUM, Peter Robert ,  DUBOSE, Robert Finley

IPC分类号： C07D401/14 ,  C07D413/14 ,  A61K31/497 ,  A61P35/00 ,  A61P37/00

摘要： Amino-pyrazinecarboxamide compounds of formula (I), conjugates, and pharmaceutical compositions for use in the treatment of disease such as cancer, are disclosed herein. The disclosed compounds are useful, among other things, in the treating of cancer and fibrosis and modulating TGFpR2. Additionally, compounds incorporated into a conjugate with an antibody construct are described herein.

公开(公告)号：WO2019195278A1

公开(公告)日：2019-10-10

申请号：PCT/US2019/025370

申请日：2019-04-02

申请人： SILVERBACK THERAPEUTICS, INC.

发明人： SMITH, Sean Wesley ,  COBURN, Craig Alan ,  DUBOSE, Robert Finley

IPC分类号： C07D471/04 ,  C07F5/02 ,  A61P35/00 ,  A61K31/437 ,  A61K47/68

摘要： Compounds, conjugates and pharmaceutical compositions for use in the treatment of disease, such as cancer, are disclosed herein. The disclosed compounds may be useful, among other things, in treating of cancer and inhibiting ALK5. Compounds incorporated into a conjugate with an antibody construct are also described herein.

公开(公告)号：WO2019118884A1

公开(公告)日：2019-06-20

申请号：PCT/US2018/065768

申请日：2018-12-14

申请人： SILVERBACK THERAPEUTICS, INC.

发明人： THOMPSON, Peter Armstrong ,  ODEGARD, Valerie ,  DUBOSE, Robert Finley ,  SMITH, Sean Wesley ,  COBURN, Craig Alan

IPC分类号： C07K16/08 ,  C07K16/10 ,  C07K16/28 ,  A61K47/68 ,  C07D223/32 ,  C07D471/00 ,  C07F5/02

CPC分类号： C07K16/28 ,  A61K47/6803 ,  A61K47/6807 ,  A61K47/6839 ,  A61K47/6841 ,  A61K47/6849 ,  A61K47/6889 ,  A61K2039/505 ,  A61K2039/58 ,  A61K2039/627 ,  A61P31/12 ,  A61P31/20 ,  C07D215/38 ,  C07D223/16 ,  C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  C07K16/082 ,  C07K16/109 ,  C07K16/2851 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/569 ,  C07K2317/90 ,  C07K2317/92

摘要： Various compositions are disclosed for the treatment of viral infections. The compositions comprise antibody constructs directed to the liver, attached to myeloid cell agonists, specifically TLR7 and TLR8 agonists, via a linker. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating viral infections, such as viral liver diseases.