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1.发明申请METHODS AND COMPOSITIONS TO PRODUCE SS-RNAI ACTIVITY WITH ENHANCED POTENCY 审中-公开生产具有增强磷酸化的SS-RNAI活性的方法和组合物
公开(公告)号：WO2014066915A2
公开(公告)日：2014-05-01
申请号：PCT/US2013/067153
申请日：2013-10-28
Applicant: SMITH, Larry, J.
Inventor： SMITH, Larry, J.
IPC: A61K48/00
CPC classification number: C12N15/113 , C12N15/111 , C12N15/1137 , C12N2310/14 , C12N2310/32 , C12N2320/50 , C12N2320/51 , C12N2320/52
Abstract: Compositions and methods for down modulating expression of target nucleic acids are disclosed.
Abstract translation: 公开了用于降低靶核酸表达的组合物和方法。
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2.发明申请COMPOSITIONS AND METHODS FOR SUPPRESSING GENE EXPRESSION OF P53 AND CLUSTERIN 审中-公开用于抑制P53和聚集体基因表达的组合物和方法
公开(公告)号：WO2013009979A3
公开(公告)日：2014-05-01
申请号：PCT/US2012046463
申请日：2012-07-12
Applicant: SMITH HOLDINGS LLC , SMITH LARRY J
Inventor： SMITH LARRY J
CPC classification number: C12N15/1135 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/3231 , C12N2310/3233 , C12N2310/331 , C12N2310/332 , C12N2310/3513 , C12N2320/30 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
Abstract: Compositions and methods for inhibition of p53 and clusterin expression in target cells for the treatment of disease are disclosed.
Abstract translation: 公开了用于抑制靶细胞中p53和簇蛋白表达的组合物和方法用于治疗疾病。
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3.发明申请
公开(公告)号：WO2012145729A3
公开(公告)日：2012-10-26
申请号：PCT/US2012/034595
申请日：2012-04-20
Applicant: SMITH HOLDINGS, LLC , SMITH, Larry, J.
Inventor： SMITH, Larry, J.
Abstract: Compositions and methods for downmodulating expression of target nucleic acids are disclosed.
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4.发明申请METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING COMPONENTS THAT SELF ASSEMBLE IN CELLS AND PRODUCE RNAI ACTIVITY 审中-公开使用自身在细胞中组装并产生RNAi活性的组分调节基因表达的方法和组合物
公开(公告)号：WO2012145729A2
公开(公告)日：2012-10-26
申请号：PCT/US2012034595
申请日：2012-04-20
Applicant: SMITH HOLDINGS LLC , SMITH LARRY J
Inventor： SMITH LARRY J
IPC: A61K48/00
CPC classification number: C12N15/113 , A61K31/7105 , C12N15/111 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2310/141 , C12N2310/322 , C12N2310/50 , C12N2320/30 , C12N2320/51 , C12N2320/52
Abstract: Compositions and methods for downmodulating expression of target nucleic acids are disclosed.
Abstract translation: 公开了用于下调靶核酸表达的组合物和方法。
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5.发明申请METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION USING OLIGONUCLEOTIDE BASED DRUGS ADMINISTERED IN VIVO OR IN VITRO 审中-公开用VIVO或体外应用基于寡核苷酸的药物调节基因表达的方法和组合物
公开(公告)号：WO2011046983A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/052399
申请日：2010-10-12
Applicant: SMITH HOLDINGS, LLC , SMITH, Larry, J.
Inventor： SMITH, Larry, J.
IPC: A61K48/00
CPC classification number: C12N15/113 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2310/321 , Y10S977/915 , C12N2310/3521
Abstract: Compositions and methods for down modulating target gene expression are disclosed.
Abstract translation: 公开了用于降低靶基因表达的组合物和方法。
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Patent Agency Ranking6.发明申请COMPOSITIONS AND METHODS FOR SUPPRESSING GENE EXPRESSION OF P53 AND CLUSTERIN 审中-公开用于抑制P53和聚集体基因表达的组合物和方法
公开(公告)号：WO2013009979A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046463
申请日：2012-07-12
Applicant: SMITH HOLDINGS, LLC , SMITH, Larry J.
Inventor： SMITH, Larry J.
CPC classification number: C12N15/1135 , A61K31/7088 , A61K31/713 , A61K45/06 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/3231 , C12N2310/3233 , C12N2310/331 , C12N2310/332 , C12N2310/3513 , C12N2320/30 , C12N2310/321 , C12N2310/3521 , C12N2310/322 , C12N2310/3533
Abstract: Compositions and methods for inhibition of p53 and clusterin expression in target cells for the treatment of disease are disclosed.
Abstract translation: 公开了用于抑制靶细胞中p53和簇蛋白表达的组合物和方法用于治疗疾病。
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7.发明申请METHODS AND COMPOSITIONS FOR THE TREATMENT OF MEDICAL CONDITIONS INVOLVING CELLULAR PROGRAMMING 审中-公开用于治疗涉及细胞程序的医疗条件的方法和组合
公开(公告)号：WO2010120262A1
公开(公告)日：2010-10-21
申请号：PCT/US2009/002365
申请日：2009-04-14
Applicant: SMITH HOLDINGS, LLC , SMITH, Larry, J.
Inventor： SMITH, Larry, J.
CPC classification number: C12Q1/6886 , C12Q2600/158
Abstract: The present invention provides a variety of nucleic acid based therapeutics and methods of use thereof which are effective to beneficially reprogram diseased cells such that they exhibit more desirable phenotypes. Also provided are compositions and methods to reprogram normal cells for medical and commercial purposes.
Abstract translation: 本发明提供了各种基于核酸的治疗剂及其使用方法，其有效地有益地重新编程患病细胞，使得它们表现出更期望的表型。 还提供了用于重新编程正常细胞用于医疗和商业目的的组合物和方法。
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公开(公告)号：WO2007149876A3
公开(公告)日：2008-02-21
申请号：PCT/US2007071590
申请日：2007-06-19
Applicant: DATALOGIC SCANNING INC , SMITH LARRY J
Inventor： SMITH LARRY J
IPC: G02B26/08
CPC classification number: G06K7/10722 , G06K7/10831 , H04N1/0464 , H04N2201/0432 , H04N2201/0446
Abstract: Disclosed are embodiments of methods, systems, and apparatus for providing multiple image fields or regions on an imaging array. In certain preferred embodiments, a high density imaging array may be partitioned into two or more regions, each of which may be used to render a separate view of the scan volume. This arrangement may provide an increase in the effective scan volume beyond the volume available with a single imager having a single point of view and may allow for reading of encoded symbols at a variety of orientations that would otherwise preclude accurate imaging with a single imager.
Abstract translation: 公开了用于在成像阵列上提供多个图像场或区域的方法，系统和装置的实施例。 在某些优选实施例中，高密度成像阵列可以被划分成两个或更多个区域，每个区域可用于呈现扫描体积的单独视图。 这种布置可以提高有效扫描体积超过具有单个视点的单个成像器可用的体积，并且可以允许以各种取向读取编码符号，否则将使用单个成像器排除准确的成像。
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9.发明申请METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT 审中-公开生产ssRNAi化合物的方法和改进，具有增强的活性，磷酸化和作用时间
公开(公告)号：WO2015168661A1
公开(公告)日：2015-11-05
申请号：PCT/US2015/028958
申请日：2015-05-01
Applicant: SMITH, Larry, J.
Inventor： SMITH, Larry, J.
CPC classification number: C12N15/113 , C07H21/04 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/344 , C12N2310/346 , C12N2320/50
Abstract: Compositions and methods for down modulating expression of target nucleic acids using a single strand oligoribonucleotide siRNA compound are disclosed.
Abstract translation: 公开了使用单链寡核糖核苷酸siRNA化合物降低靶核酸表达的组合物和方法。
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10.发明申请ANTISENSE P53 PHOSPHORODIAMIDATE MORPHOLINO COMPOSITITONS, METHODS AND INDICATIONS 审中-公开抗原P53磷酸二氢吡喃麦芽寡糖组合物，方法和适应症
公开(公告)号：WO2014011177A1
公开(公告)日：2014-01-16
申请号：PCT/US2012/046470
申请日：2012-07-12
Applicant: SMITH HOLDINGS, LLC , ELEOS, INC , SMITH, Larry, J. , IVERSEN, Patrick, L.
Inventor： SMITH, Larry, J. , IVERSEN, Patrick, L.
CPC classification number: A61K47/645
Abstract: Compositions and methods for down-modulating p53 expression for the treatment of disease are disclosed.
Abstract translation: 公开了用于下调p53表达以治疗疾病的组合物和方法。
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