公开(公告)号：WO2006047466A3

公开(公告)日：2006-09-21

申请号：PCT/US2005038287

申请日：2005-10-21

Applicant: UNIV DUKE ,  TOONE ERIC J ,  EPSTEIN DAVID L ,  CHALLA PRATAP ,  SNYDER PHILLIP W ,  CHEN XIN ,  DELONG MITCHELL A

Inventor： TOONE ERIC J ,  EPSTEIN DAVID L ,  CHALLA PRATAP ,  SNYDER PHILLIP W ,  CHEN XIN ,  DELONG MITCHELL A

IPC: A61K31/7024 ,  A61K31/7042 ,  A61P27/06 ,  C07C69/712 ,  C07H13/04

CPC classification number: A61K31/225 ,  A61K31/712 ,  C07C69/712 ,  C07C69/738 ,  C07H13/04

Abstract: The present invention relates generally to ophthamological drugs. More specifically, the invention relates to a method of modifying (derivatizing) ophthamological drugs so as to increase their penetration through the cornea. The invention also relates to drugs modified (derivatized) in accordance with the instant method and to the use of same in treating conditions associated with elevated intraocular pressure, particularly, glaucoma.

Abstract translation: 本发明一般涉及眼科药物。 更具体地，本发明涉及一种改变（衍生化）眼科药物以增加其穿透角膜的方法。 本发明还涉及根据本发明方法修饰（衍生化）的药物，以及在治疗与眼内压升高相关的病症，特别是青光眼中的用途。

公开(公告)号：WO2006047466A2

公开(公告)日：2006-05-04

申请号：PCT/US2005/038287

申请日：2005-10-21

Applicant: DUKE UNIVERSITY ,  TOONE, Eric, J. ,  EPSTEIN, David, L. ,  CHALLA, Pratap ,  SNYDER, Phillip, W. ,  CHEN, Xin ,  DELONG, Mitchell, A.

Inventor： TOONE, Eric, J. ,  EPSTEIN, David, L. ,  CHALLA, Pratap ,  SNYDER, Phillip, W. ,  CHEN, Xin ,  DELONG, Mitchell, A.

CPC classification number: A61K31/225 ,  A61K31/712 ,  C07C69/712 ,  C07C69/738 ,  C07H13/04

Abstract: The present invention relates generally to ophthamological drugs. More specifically, the invention relates to a method of modifying (derivatizing) ophthamological drugs so as to increase their penetration through the cornea. The invention also relates to drugs modified (derivatized) in accordance with the instant method and to the use of same in treating conditions associated with elevated intraocular pressure, particularly, glaucoma.

Abstract translation: 本发明一般涉及眼科药物。 更具体地说，本发明涉及修饰（衍生）眼科药物以增加它们穿过角膜的渗透的方法。 本发明还涉及根据本发明方法改性（衍生化）的药物及其在治疗与眼内压升高相关的病症，尤其是青光眼相关病症中的用途。

公开(公告)号：WO2009006409A2

公开(公告)日：2009-01-08

申请号：PCT/US2008068797

申请日：2008-06-30

Applicant: HARVARD COLLEGE ,  PHILLIPS SCOTT T ,  WHITESIDES GEORGE M ,  MIRICA KATHERINE A ,  CARRILHO EMANUEL ,  MARTINEZ ANDRES W ,  SHEVKOPLYAS SERGEY S ,  SNYDER PHILLIP W ,  PEREZ-CASTILLEJOS RAQUEL ,  GUPTA MALANCHA ,  WINKLEMAN ADAM ,  GUDIKSEN KATHERINE L

Inventor： PHILLIPS SCOTT T ,  WHITESIDES GEORGE M ,  MIRICA KATHERINE A ,  CARRILHO EMANUEL ,  MARTINEZ ANDRES W ,  SHEVKOPLYAS SERGEY S ,  SNYDER PHILLIP W ,  PEREZ-CASTILLEJOS RAQUEL ,  GUPTA MALANCHA ,  WINKLEMAN ADAM ,  GUDIKSEN KATHERINE L

IPC: G01N33/53

CPC classification number: G01N33/5434 ,  B01L3/502761 ,  B01L3/502776 ,  B01L3/50825 ,  B01L2200/0652 ,  B01L2300/045 ,  B01L2300/0877 ,  B01L2300/089 ,  B01L2400/043 ,  B01L2400/0457 ,  B01L2400/0487 ,  G01N33/54333 ,  G01R33/1269

Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.

Abstract translation: 描述了悬浮在使用不均匀磁场的含有顺磁性阳离子的溶液中的反磁性粒子悬浮，分离和检测密度变化的能力。 该分离装置的主要优点是：i）它是一种不需要电力的简单装置（一组永磁体和重力足以使抗磁分离和收集系统工作）; ii）它与简单的光学检测兼容（只要透明材料用于制造分离发生的容器/通道; iii）收集分离的颗粒以便进一步处理是简单的; iv）它不需要磁性标记颗粒/材料; 和v）它小巧便携。 所提供的方法和试剂盒用于分离和收集不同密度的物质，用于检测感兴趣分析物的诊断，固体支持的化学反应的监测以及固体和液体混合物密度的测定。

公开(公告)号：WO2009006409A3

公开(公告)日：2009-01-08

申请号：PCT/US2008/068797

申请日：2008-06-30

Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  PHILLIPS, Scott, T. ,  WHITESIDES, George, M. ,  MIRICA, Katherine, A. ,  CARRILHO, Emanuel ,  MARTINEZ, Andres, W. ,  SHEVKOPLYAS, Sergey, S. ,  SNYDER, Phillip, W. ,  PEREZ-CASTILLEJOS, Raquel ,  GUPTA, Malancha ,  WINKLEMAN, Adam ,  GUDIKSEN, Katherine, L.

Inventor： PHILLIPS, Scott, T. ,  WHITESIDES, George, M. ,  MIRICA, Katherine, A. ,  CARRILHO, Emanuel ,  MARTINEZ, Andres, W. ,  SHEVKOPLYAS, Sergey, S. ,  SNYDER, Phillip, W. ,  PEREZ-CASTILLEJOS, Raquel ,  GUPTA, Malancha ,  WINKLEMAN, Adam ,  GUDIKSEN, Katherine, L.

IPC: B01D35/06

Abstract: The ability to levitate, to separate, and to detect changes in density using diamagnetic particles suspended in solutions containing paramagnetic cations using an inhomogeneous magnetic field is described. The major advantages of this separation device are that: i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) it is compatible with simple optical detection (provided that transparent materials are used to fabricate the containers/channels where separation occurs; iii) it is simple to collect the separated particles for further processing; iv) it does not require magnetic labeling of the particles/materials; and v) it is small, portable. The method and kits provided provide for separation and collection of materials of different densities, diagnostics for detection of analytes of interest, monitoring of solid-supported chemical reactions and determination of densities of solid and liquid mixtures.