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1.发明申请
公开(公告)号：WO2008082613A9
公开(公告)日：2008-08-21
申请号：PCT/US2007026425
申请日：2007-12-27
Applicant: NEKTAR THERAPEUTICS AL CORP , BOSSARD MARY J , STEPHENSON GAYLE
Inventor： BOSSARD MARY J , STEPHENSON GAYLE
CPC classification number: C08G65/33337 , A61K47/60 , C08G65/3332 , C08G65/33396 , C08G65/3348 , C08L2203/02
Abstract: The present invention provides Factor IX moiety-polymer conjugates having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
Abstract translation: 本发明提供具有可释放键的因子IX部分 - 聚合物共轭物。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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2.发明申请VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE 审中-公开具有可释放链接的VON WILLEBRAND因子和因子VIII聚合物
公开(公告)号：WO2008082669A2
公开(公告)日：2008-07-10
申请号：PCT/US2007/026522
申请日：2007-12-27
Applicant: NEKTAR THERAPEUTICS AL, CORPORATION , BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA , BOSSARD, Mary, J. , STEPHENSON, Gayle , FANG, Zhihao , ZAPPE, Harold , MITCHELL, Stacy , ZHANG, Ping , SCHEIFLINGER, Fritz , TURECEK, Peter , SIEKMANN, Juergen , VARADI, Katalin , GRITSCH, Herbert
Inventor： BOSSARD, Mary, J. , STEPHENSON, Gayle , FANG, Zhihao , ZAPPE, Harold , MITCHELL, Stacy , ZHANG, Ping , SCHEIFLINGER, Fritz , TURECEK, Peter , SIEKMANN, Juergen , VARADI, Katalin , GRITSCH, Herbert
CPC classification number: C07K14/755 , A61K47/60
Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
Abstract translation: 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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公开(公告)号：WO2007117685A3
公开(公告)日：2007-10-18
申请号：PCT/US2007/008738
申请日：2007-04-06
Inventor： BOSSARD, Mary, J. , STEPHENSON, Gayle
IPC: A61K39/395 , A61K39/44
Abstract: Conjugates of an anti-TNF antibody and one or more nonpeptidic water soluble polymers are provided. Typically, the nonpeptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.
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公开(公告)号：WO2007117685A2
公开(公告)日：2007-10-18
申请号：PCT/US2007008738
申请日：2007-04-06
Applicant: NEKTAR THERAPEUTICS AL CORP , BOSSARD MARY J , STEPHENSON GAYLE
Inventor： BOSSARD MARY J , STEPHENSON GAYLE
IPC: A61K39/395 , C07K16/46
CPC classification number: A61K39/44 , A61K39/3955 , A61K47/60 , C07K16/241 , C07K2317/40 , C07K2317/94
Abstract: Conjugates of an anti-TNF antibody and one or more nonpeptidic water soluble polymers are provided. Typically, the nonpeptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, and methods of administering compositions to a patient.
Abstract translation: 提供抗TNF抗体和一种或多种非肽水溶性聚合物的缀合物。 通常，非肽类水溶性聚合物是聚（乙二醇）或其衍生物。 还提供了包括缀合物的组合物，制备缀合物的方法和向患者施用组合物的方法。
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公开(公告)号：WO2006005058A3
公开(公告)日：2006-01-12
申请号：PCT/US2005/023745
申请日：2005-06-30
Inventor： BOSSARD, Mary, J. , STEPHENSON, Gayle
Abstract: Conjugates of a Factor IX moiety and one or more water-solute e polymers are provided. Typically, the water-soluble polymer is polyethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates.
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Patent Agency Ranking6.发明申请VON WILLEBRAND FACTOR- AND FACTOR VIII-POLYMER CONJUGATES HAVING A RELEASABLE LINKAGE 审中-公开具有可释放链接的VON WILLEBRAND因子和因子VIII聚合物
公开(公告)号：WO2008082669A3
公开(公告)日：2009-04-09
申请号：PCT/US2007026522
申请日：2007-12-27
Applicant: NEKTAR THERAPEUTICS AL CORP , BAXTER INT , BAXTER HEALTHCARE SA , BOSSARD MARY J , STEPHENSON GAYLE , FANG ZHIHAO , ZAPPE HAROLD , MITCHELL STACY , ZHANG PING , SCHEIFLINGER FRITZ , TURECEK PETER , SIEKMANN JUERGEN , VARADI KATALIN , GRITSCH HERBERT
Inventor： BOSSARD MARY J , STEPHENSON GAYLE , FANG ZHIHAO , ZAPPE HAROLD , MITCHELL STACY , ZHANG PING , SCHEIFLINGER FRITZ , TURECEK PETER , SIEKMANN JUERGEN , VARADI KATALIN , GRITSCH HERBERT
CPC classification number: C07K14/755 , A61K47/60
Abstract: The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
Abstract translation: 本发明提供了von Willebrand因子 - 聚合物共轭物和因子VIII-聚合物缀合物，其各自具有可释放的连接。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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公开(公告)号：WO2006089228A3
公开(公告)日：2006-08-24
申请号：PCT/US2006/005850
申请日：2006-02-16
Inventor： BOSSARD, Mary, J. , STEPHENSON, Gayle
IPC: A61K47/48
Abstract: Conjugates of an EPO moiety and one or more non-peptidic water soluble polymers are provided. Typically, the non-peptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of making conjugates, and methods of administering compositions comprising such conjugates to a patient.
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8.发明申请FACTOR IX MOIETY-POLYMER CONJUGATES HAVING A RELEASEABLE LINKAGE 审中-公开具有可释放链接的因子IX MOIETY-POLYMER CONJUGATE
公开(公告)号：WO2008082613A2
公开(公告)日：2008-07-10
申请号：PCT/US2007026425
申请日：2007-12-27
Applicant: NEKTAR THERAPEUTICS AL CORP , BOSSARD MARY J , STEPHENSON GAYLE
Inventor： BOSSARD MARY J , STEPHENSON GAYLE
CPC classification number: C08G65/33337 , A61K47/60 , C08G65/3332 , C08G65/33396 , C08G65/3348 , C08L2203/02
Abstract: The present invention provides Factor IX moiety-polymer conjugates having a releaseable linkage. Methods of making conjugates, methods for administering conjugates, are also provided.
Abstract translation: 本发明提供具有可释放键的因子IX部分 - 聚合物共轭物。 还提供了制备缀合物的方法，用于施用缀合物的方法。
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公开(公告)号：WO2006089228A2
公开(公告)日：2006-08-24
申请号：PCT/US2006005850
申请日：2006-02-16
Applicant: NEKTAR THERAPEUTICS AL CORP , BOSSARD MARY J , STEPHENSON GAYLE
Inventor： BOSSARD MARY J , STEPHENSON GAYLE
IPC: A61K47/48
CPC classification number: C08G65/333 , A61K38/00 , A61K47/60 , C07K14/505 , C08G65/329
Abstract: Conjugates of an EPO moiety and one or more non-peptidic water soluble polymers are provided. Typically, the non-peptidic water soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of making conjugates, and methods of administering compositions comprising such conjugates to a patient.
Abstract translation: 提供了EPO部分和一种或多种非肽水溶性聚合物的共轭物。 通常，非肽水溶性聚合物是聚（乙二醇）或其衍生物。 还提供了包含这种缀合物的组合物，制备缀合物的方法，以及向患者施用包含这种缀合物的组合物的方法。
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公开(公告)号：WO2006005058A2
公开(公告)日：2006-01-12
申请号：PCT/US2005023745
申请日：2005-06-30
Applicant: NEKTAR THERAPEUTICS AL CORP , BOSSARD MARY J , STEPHENSON GAYLE
Inventor： BOSSARD MARY J , STEPHENSON GAYLE
CPC classification number: A61K47/48215 , A61K38/4846 , A61K47/60 , C12N9/644 , C12N9/96 , C12Y304/21022
Abstract: Conjugates of a Factor IX moiety and one or more water-solute e polymers are provided. Typically, the water-soluble polymer is polyethylene glycol) or a derivative thereof. Also provided (among other things) are compositions comprising the conjugates, methods of making the conjugates, and methods of administering to a patient compositions comprising the conjugates.
Abstract translation: 提供因子IX部分和一种或多种水溶质聚合物的共轭物。 通常，水溶性聚合物是聚乙二醇）或其衍生物。 还提供（尤其是）包含缀合物的组合物，制备缀合物的方法，以及给予包含缀合物的组合物的方法。
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